STRINGSTRING
C4BPB C4BPB C4BPA C4BPA NLRP10 NLRP10 CALML4 CALML4 ENSTTRP00000015187 ENSTTRP00000015187 MAPK10 MAPK10 TMED3 TMED3 MAPK1 MAPK1 CFL1 CFL1 PYCARD PYCARD RHOA RHOA MAPK9 MAPK9 ITGB2 ITGB2 GNAI3 GNAI3 SERPING1 SERPING1 RELA RELA NOS2 NOS2 ENSTTRP00000002341 ENSTTRP00000002341 IRF1 IRF1 C1QB C1QB NOS2-2 NOS2-2 CCDC125 CCDC125 LOC101326351 LOC101326351 CALM3 CALM3 ENSTTRP00000003621 ENSTTRP00000003621 ENSTTRP00000003631 ENSTTRP00000003631 ITGA5 ITGA5 IRAK1 IRAK1 C1S C1S C1R C1R C1RL C1RL ENSTTRP00000004690 ENSTTRP00000004690 MYD88 MYD88 IRF3 IRF3 MAPK3 MAPK3 CD14 CD14 C2 C2 IL12B IL12B C3 C3 ENSTTRP00000005623 ENSTTRP00000005623 GNAI1 GNAI1 ENSTTRP00000006141 ENSTTRP00000006141 ENSTTRP00000006769 ENSTTRP00000006769 ENSTTRP00000007008 ENSTTRP00000007008 GNAI2 GNAI2 FOS FOS TRAF6 TRAF6 IL6 IL6 IL12A IL12A ITGB1 ITGB1 IRAK4 IRAK4 C5 C5 NFKB1 NFKB1 TLR4 TLR4 IL1A IL1A IL1B IL1B NOD1 NOD1 CALML6 CALML6 JUN JUN CASP7 CASP7 CALM2 CALM2 IL10 IL10 MAPK12 MAPK12 MAPK11 MAPK11 ITGAM ITGAM LY96 LY96 NLRP3 NLRP3 CALM1 CALM1 MAPK8 MAPK8 TNF TNF CASP1 CASP1 MAPK14 MAPK14 MAPK13 MAPK13 ENSTTRP00000013721 ENSTTRP00000013721
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
C4BPBC4b-binding protein beta chain. (256 aa)
C4BPAC4b-binding protein alpha chain. (585 aa)
NLRP10LOW QUALITY PROTEIN: NACHT, LRR and PYD domains-containing protein 10. (530 aa)
CALML4Calmodulin-like protein 4 isoform X2. (195 aa)
ENSTTRP00000015187annotation not available (367 aa)
MAPK10Mitogen-activated protein kinase. (463 aa)
TMED3Transmembrane emp24 domain-containing protein 3. (216 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (320 aa)
CFL1Cofilin-2; Belongs to the actin-binding proteins ADF family. (166 aa)
PYCARDPYD and CARD domain containing. (195 aa)
RHOATransforming protein RhoA. (193 aa)
MAPK9Mitogen-activated protein kinase 9. (424 aa)
ITGB2Integrin beta. (750 aa)
GNAI3G protein subunit alpha i3. (354 aa)
SERPING1Plasma protease C1 inhibitor; Belongs to the serpin family. (520 aa)
RELARELA proto-oncogene, NF-kB subunit. (574 aa)
NOS2Nitric oxide synthase 2. (933 aa)
ENSTTRP00000002341annotation not available (267 aa)
IRF1Interferon regulatory factor. (318 aa)
C1QBComplement C1q B chain. (253 aa)
NOS2-2Nitric oxide synthase, inducible. (36 aa)
CCDC125Coiled-coil domain-containing protein 125 isoform X1. (512 aa)
LOC101326351Pulmonary surfactant-associated protein A-like isoform X1. (248 aa)
CALM3Calmodulin 3. (148 aa)
ENSTTRP00000003621annotation not available (129 aa)
ENSTTRP00000003631annotation not available (113 aa)
ITGA5Integrin subunit alpha 5. (1053 aa)
IRAK1LOW QUALITY PROTEIN: zinc finger protein 14-like. (708 aa)
C1SComplement C1s subcomponent; Belongs to the peptidase S1 family. (689 aa)
C1RLOW QUALITY PROTEIN: complement C1r subcomponent. (653 aa)
C1RLComplement C1r subcomponent; Belongs to the peptidase S1 family. (483 aa)
ENSTTRP00000004690annotation not available (362 aa)
MYD88MYD88 innate immune signal transduction adaptor. (296 aa)
IRF3Interferon regulatory factor 3. (438 aa)
MAPK3Mitogen-activated protein kinase 3. (382 aa)
CD14Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] (372 aa)
C2Complement C2. (751 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (328 aa)
C3Complement C3. (1656 aa)
ENSTTRP00000005623annotation not available (1355 aa)
GNAI1Guanine nucleotide-binding protein G(I) subunit alpha-1. (354 aa)
ENSTTRP00000006141annotation not available (161 aa)
ENSTTRP00000006769annotation not available (133 aa)
ENSTTRP00000007008annotation not available (158 aa)
GNAI2G protein subunit alpha i2. (351 aa)
FOSProto-oncogene c-Fos. (374 aa)
TRAF6TNF receptor associated factor 6. (523 aa)
IL6Interleukin-6. (208 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (253 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (786 aa)
IRAK4Interleukin-1 receptor-associated kinase 4 isoform X1. (460 aa)
C5Complement C5. (1606 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit isoform X1. (964 aa)
TLR4Toll-like receptor 4 isoform X1; Belongs to the Toll-like receptor family. (841 aa)
IL1AInterleukin-1; Belongs to the IL-1 family. (264 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (265 aa)
NOD1Nucleotide-binding oligomerization domain-containing protein 1 isoform X1. (953 aa)
CALML6Calmodulin-like protein 6. (179 aa)
JUNTranscription factor AP-1; Belongs to the bZIP family. (321 aa)
CASP7Caspase-7; Belongs to the peptidase C14A family. (302 aa)
CALM2Calmodulin 2. (148 aa)
IL10Interleukin-10. (178 aa)
MAPK12Mitogen-activated protein kinase. (367 aa)
MAPK11Mitogen-activated protein kinase. (364 aa)
ITGAMIntegrin alpha-M-like. (1139 aa)
LY96Lymphocyte antigen 96. (122 aa)
NLRP3NACHT, LRR and PYD domains-containing protein 3. (1039 aa)
CALM1Calmodulin; Belongs to the calmodulin family. (149 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (233 aa)
CASP1Caspase-1; Belongs to the peptidase C14A family. (404 aa)
MAPK14Mitogen-activated protein kinase 14. (360 aa)
MAPK13Mitogen-activated protein kinase. (365 aa)
ENSTTRP00000013721annotation not available (118 aa)
Your Current Organism:
Tursiops truncatus
NCBI taxonomy Id: 9739
Other names: Atlantic bottlenose dolphin, T. truncatus, bottle-nosed dolphin, common bottlenose dolphin
Server load: low (26%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.