STRINGSTRING
IFNGR2 IFNGR2 CD40 CD40 HSPA2 HSPA2 TAB2 TAB2 MAPK9 MAPK9 AKT2 AKT2 STAT1 STAT1 BIRC2 BIRC2 LAMA2 LAMA2 GNAI3 GNAI3 BIRC7 BIRC7 XIAP XIAP CD40LG CD40LG IKBKB IKBKB RELA RELA NOS2 NOS2 NOS2-2 NOS2-2 BIRC3 BIRC3 PIK3CG PIK3CG LAMA1 LAMA1 MAP2K6 MAP2K6 LAMC3 LAMC3 LAMA4 LAMA4 LAMB1 LAMB1 LAMB4 LAMB4 HLA-DRA HLA-DRA LOC101328860 LOC101328860 HLA-DOB HLA-DOB LOC101335803 LOC101335803 HLA-DMA HLA-DMA HLA-DOA HLA-DOA TLR2 TLR2 IRAK1 IRAK1 CIITA CIITA BCL2 BCL2 MAP2K3 MAP2K3 MYD88 MYD88 MAPK3 MAPK3 CYCS CYCS HLA-DQB2 HLA-DQB2 PPIF PPIF IL12B IL12B GNAI1 GNAI1 IFNG IFNG ENSTTRP00000006141 ENSTTRP00000006141 PIK3R6 PIK3R6 PIK3R5 PIK3R5 IKBKG IKBKG STAT3 STAT3 LAMC1 LAMC1 LAMC2 LAMC2 GNAI2 GNAI2 BCL2L1 BCL2L1 NFKBIA NFKBIA PDPK1 PDPK1 CASP8 CASP8 IL10RA IL10RA TRAF6 TRAF6 LAMA3 LAMA3 IL12A IL12A LDLR LDLR TYK2 TYK2 JAK1 JAK1 IL10RB IL10RB ITGB1 ITGB1 LAMB2 LAMB2 CCR5 CCR5 LAMB3 LAMB3 MAPK1 MAPK1 IFNGR1 IFNGR1 MAPK10 MAPK10 CASP9 CASP9 MAP3K7 MAP3K7 TGFB3 TGFB3 TAB1 TAB1 TNFRSF1A TNFRSF1A MAPK13 MAPK13 MAPK14 MAPK14 AKT1 AKT1 HSPA6 HSPA6 HSPA1L HSPA1L TNF TNF MAPK8 MAPK8 TGFB2 TGFB2 LY96 LY96 GNAO1 GNAO1 TGFB1 TGFB1 MAPK11 MAPK11 MAPK12 MAPK12 IL10 IL10 CHUK CHUK NFKBIB NFKBIB ALOX5 ALOX5 ITGA6 ITGA6 JAK2 JAK2 AKT3 AKT3 HSPA8 HSPA8 LAMA5 LAMA5 TLR4 TLR4 NFKB1 NFKB1 BAD BAD IRAK4 IRAK4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IFNGR2Interferon gamma receptor 2. (311 aa)
CD40Tumor necrosis factor receptor superfamily member 5. (280 aa)
HSPA2Heat shock-related 70 kDa protein 2; Belongs to the heat shock protein 70 family. (634 aa)
TAB2TGF-beta-activated kinase 1 and MAP3K7-binding protein 2. (683 aa)
MAPK9Mitogen-activated protein kinase 9. (424 aa)
AKT2RAC-beta serine/threonine-protein kinase. (481 aa)
STAT1Signal transducer and activator of transcription. (720 aa)
BIRC2Baculoviral IAP repeat-containing protein 2. (621 aa)
LAMA2Laminin subunit alpha-2. (3120 aa)
GNAI3G protein subunit alpha i3. (354 aa)
BIRC7Baculoviral IAP repeat containing 7. (296 aa)
XIAPE3 ubiquitin-protein ligase XIAP isoform X2. (497 aa)
CD40LGCD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching. (261 aa)
IKBKBInhibitor of nuclear factor kappa-B kinase subunit beta. (735 aa)
RELARELA proto-oncogene, NF-kB subunit. (574 aa)
NOS2Nitric oxide synthase 2. (933 aa)
NOS2-2Nitric oxide synthase, inducible. (36 aa)
BIRC3Baculoviral IAP repeat-containing protein 3. (601 aa)
PIK3CGPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform; Belongs to the PI3/PI4-kinase family. (1103 aa)
LAMA1Laminin subunit alpha-1. (3051 aa)
MAP2K6Dual specificity mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
LAMC3Laminin subunit gamma-3. (1420 aa)
LAMA4Laminin subunit alpha-4 isoform X1. (1824 aa)
LAMB1Laminin subunit beta-1. (1799 aa)
LAMB4Laminin subunit beta 4. (1710 aa)
HLA-DRAMajor histocompatibility complex, class II, DR alpha. (252 aa)
LOC101328860SLA class II histocompatibility antigen, DQ haplotype D alpha chain-like isoform X2; Belongs to the MHC class II family. (255 aa)
HLA-DOBHLA class II histocompatibility antigen, DO beta chain isoform X1. (265 aa)
LOC101335803HLA class II histocompatibility antigen, DM beta chain isoform X2. (244 aa)
HLA-DMAHLA class II histocompatibility antigen, DM alpha chain; Belongs to the MHC class II family. (231 aa)
HLA-DOAMajor histocompatibility complex, class II, DO alpha. (250 aa)
TLR2Toll-like receptor 2; Belongs to the Toll-like receptor family. (785 aa)
IRAK1LOW QUALITY PROTEIN: zinc finger protein 14-like. (708 aa)
CIITAMHC class II transactivator. (1159 aa)
BCL2Apoptosis regulator Bcl-2 isoform X1. (233 aa)
MAP2K3Dual specificity mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (350 aa)
MYD88MYD88 innate immune signal transduction adaptor. (296 aa)
MAPK3Mitogen-activated protein kinase 3. (382 aa)
CYCSCytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
HLA-DQB2boLa class II histocompatibility antigen, DQB*0101 beta chain-like isoform X5. (230 aa)
PPIFPeptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (142 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (328 aa)
GNAI1Guanine nucleotide-binding protein G(I) subunit alpha-1. (354 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity); Belongs to the type II (or gamma) interferon family. (166 aa)
ENSTTRP00000006141annotation not available (161 aa)
PIK3R6Phosphoinositide 3-kinase regulatory subunit 6. (755 aa)
PIK3R5Phosphoinositide 3-kinase regulatory subunit 5. (836 aa)
IKBKGNF-kappa-B essential modulator. (424 aa)
STAT3Signal transducer and activator of transcription. (767 aa)
LAMC1Laminin subunit gamma-1. (1595 aa)
LAMC2Laminin subunit gamma-2 isoform X1. (1190 aa)
GNAI2G protein subunit alpha i2. (351 aa)
BCL2L1Bcl-2-like protein 1 isoform X1. (233 aa)
NFKBIANF-kappa-B inhibitor alpha. (314 aa)
PDPK13-phosphoinositide-dependent protein kinase 1 isoform X1. (558 aa)
CASP8Caspase-8 isoform X2; Belongs to the peptidase C14A family. (491 aa)
IL10RAInterleukin-10 receptor subunit alpha isoform X2. (579 aa)
TRAF6TNF receptor associated factor 6. (523 aa)
LAMA3Laminin subunit alpha-3 isoform X1. (3336 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (253 aa)
LDLRLow-density lipoprotein receptor. (842 aa)
TYK2Tyrosine kinase 2. (1182 aa)
JAK1Tyrosine-protein kinase. (1154 aa)
IL10RBInterleukin-10 receptor subunit beta isoform X1. (325 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (786 aa)
LAMB2Laminin subunit beta-2. (1803 aa)
CCR5C-C chemokine receptor type 5; Belongs to the G-protein coupled receptor 1 family. (352 aa)
LAMB3Laminin subunit beta-3. (1172 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (320 aa)
IFNGR1Interferon gamma receptor 1. (463 aa)
MAPK10Mitogen-activated protein kinase. (463 aa)
CASP9Caspase-9; Belongs to the peptidase C14A family. (365 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (411 aa)
TAB1TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (502 aa)
TNFRSF1ATumor necrosis factor receptor superfamily member 1A. (439 aa)
MAPK13Mitogen-activated protein kinase. (365 aa)
MAPK14Mitogen-activated protein kinase 14. (360 aa)
AKT1AKT serine/threonine kinase 1. (480 aa)
HSPA6LOW QUALITY PROTEIN: heat shock 70 kDa protein 6; Belongs to the heat shock protein 70 family. (641 aa)
HSPA1LHeat shock protein family A (Hsp70) member 1 like. (640 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (233 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (416 aa)
LY96Lymphocyte antigen 96. (122 aa)
GNAO1G protein subunit alpha o1. (354 aa)
TGFB1Transforming growth factor beta 1. (338 aa)
MAPK11Mitogen-activated protein kinase. (364 aa)
MAPK12Mitogen-activated protein kinase. (367 aa)
IL10Interleukin-10. (178 aa)
CHUKInhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1. (744 aa)
NFKBIBNF-kappa-B inhibitor beta. (359 aa)
ALOX5Arachidonate 5-lipoxygenase isoform X1. (672 aa)
ITGA6Integrin alpha-6 isoform X1; Belongs to the integrin alpha chain family. (1130 aa)
JAK2Tyrosine-protein kinase. (1132 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (462 aa)
HSPA8Heat shock cognate 71 kDa protein. (650 aa)
LAMA5Laminin subunit alpha-5-like. (3506 aa)
TLR4Toll-like receptor 4 isoform X1; Belongs to the Toll-like receptor family. (841 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit isoform X1. (964 aa)
BADBCL2 associated agonist of cell death. (150 aa)
IRAK4Interleukin-1 receptor-associated kinase 4 isoform X1. (460 aa)
Your Current Organism:
Tursiops truncatus
NCBI taxonomy Id: 9739
Other names: Atlantic bottlenose dolphin, T. truncatus, bottle-nosed dolphin, common bottlenose dolphin
Server load: low (32%) [HD]