STRINGSTRING
TGFB3 TGFB3 PRDX2 PRDX2 LAMA1 LAMA1 PIK3CD PIK3CD NOS2-2 NOS2-2 PRKCB PRKCB NOS2 NOS2 RELA RELA SMTNL1 SMTNL1 RAB5A RAB5A LAMA2 LAMA2 ITGB2 ITGB2 DCLK2 DCLK2 CTSG CTSG SMTNL2 SMTNL2 PLCB2 PLCB2 LAMB2 LAMB2 SPECC1 SPECC1 LAMB3 LAMB3 PIK3R1 PIK3R1 GNAS GNAS ARG2 ARG2 GNAL GNAL COL1A2 COL1A2 ENSTTRP00000003621 ENSTTRP00000003621 SERPINB6 SERPINB6 LOC101324400 LOC101324400 LAMC3 LAMC3 LAMA4 LAMA4 LAMB1 LAMB1 LAMB4 LAMB4 FN1 FN1 SERPINB8 SERPINB8 TLR2 TLR2 C8A C8A C8B C8B TRANK1 TRANK1 ENSTTRP00000004902 ENSTTRP00000004902 SERPINB10 SERPINB10 COL1A1 COL1A1 CD14 CD14 ENSTTRP00000005523 ENSTTRP00000005523 IL1R2 IL1R2 IL12B IL12B IL1R1 IL1R1 RAB17 RAB17 VCL VCL COL4A1 COL4A1 COL4A2 COL4A2 PIK3CB PIK3CB IFNG IFNG ENSTTRP00000006141 ENSTTRP00000006141 RAB5C RAB5C CSF2 CSF2 LAMC1 LAMC1 LAMC2 LAMC2 PRKCA PRKCA GNAQ GNAQ PRDX1 PRDX1 LAMA3 LAMA3 IL6 IL6 IL12A IL12A PLCB1 PLCB1 PTK2 PTK2 COL4A6 COL4A6 COL4A5 COL4A5 SMTN SMTN PLCB3 PLCB3 COL3A1 COL3A1 ENSTTRP00000009886 ENSTTRP00000009886 ACTN4 ACTN4 NFKB1 NFKB1 TLR4 TLR4 PRKCG PRKCG IL1B IL1B LAMA5 LAMA5 PRKACB PRKACB ARG1 ARG1 GNA14 GNA14 C9 C9 IL10 IL10 GNA11 GNA11 GNA15 GNA15 ACTN1 ACTN1 ITGAM ITGAM LOC101328351 LOC101328351 TGFB1 TGFB1 PIK3R3 PIK3R3 ADCY1 ADCY1 TGFB2 TGFB2 PLCB4 PLCB4 PIK3CA PIK3CA TNF TNF SPECC1L SPECC1L PRKACA PRKACA RAB5B RAB5B COL4A4 COL4A4 COL4A3 COL4A3 MFF MFF RAB7A RAB7A
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (411 aa)
PRDX2Peroxiredoxin-2. (195 aa)
LAMA1Laminin subunit alpha-1. (3051 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform; Belongs to the PI3/PI4-kinase family. (1049 aa)
NOS2-2Nitric oxide synthase, inducible. (36 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
NOS2Nitric oxide synthase 2. (933 aa)
RELARELA proto-oncogene, NF-kB subunit. (574 aa)
SMTNL1Smoothelin like 1. (445 aa)
RAB5ARas-related protein Rab-5A. (215 aa)
LAMA2Laminin subunit alpha-2. (3120 aa)
ITGB2Integrin beta. (750 aa)
DCLK2Serine/threonine-protein kinase DCLK2 isoform X1. (767 aa)
CTSGCathepsin G-like; Belongs to the peptidase S1 family. (254 aa)
SMTNL2Smoothelin like 2. (447 aa)
PLCB2Phosphoinositide phospholipase C. (1184 aa)
LAMB2Laminin subunit beta-2. (1803 aa)
SPECC1cytospin-B isoform X2. (930 aa)
LAMB3Laminin subunit beta-3. (1172 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (732 aa)
GNASGuanine nucleotide-binding protein G(S) subunit alpha isoforms XLas. (969 aa)
ARG2Arginase. (317 aa)
GNALG protein subunit alpha L. (261 aa)
COL1A2Collagen alpha-2(I) chain isoform X1. (1360 aa)
ENSTTRP00000003621annotation not available (129 aa)
SERPINB6Serpin B6; Belongs to the serpin family. (381 aa)
LOC101324400C-X-C motif chemokine. (104 aa)
LAMC3Laminin subunit gamma-3. (1420 aa)
LAMA4Laminin subunit alpha-4 isoform X1. (1824 aa)
LAMB1Laminin subunit beta-1. (1799 aa)
LAMB4Laminin subunit beta 4. (1710 aa)
FN1Fibronectin isoform X1. (2465 aa)
SERPINB8Serpin family B member 8. (374 aa)
TLR2Toll-like receptor 2; Belongs to the Toll-like receptor family. (785 aa)
C8AComplement component C8 alpha chain. (589 aa)
C8BComplement component C8 beta chain. (540 aa)
TRANK1TPR and ankyrin repeat-containing protein 1 isoform X1. (2361 aa)
ENSTTRP00000004902annotation not available (202 aa)
SERPINB10Serpin family B member 10. (398 aa)
COL1A1Collagen type I alpha 1 chain. (1462 aa)
CD14Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] (372 aa)
ENSTTRP00000005523annotation not available (722 aa)
IL1R2Interleukin-1 receptor type 2. (393 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (328 aa)
IL1R1Interleukin-1 receptor type 1 isoform X2. (572 aa)
RAB17Ras-related protein Rab-17. (212 aa)
VCLVinculin isoform X3. (1100 aa)
COL4A1Collagen alpha-1(IV) chain. (1666 aa)
COL4A2Collagen alpha-2(IV) chain. (1677 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1065 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity); Belongs to the type II (or gamma) interferon family. (166 aa)
ENSTTRP00000006141annotation not available (161 aa)
RAB5CRas-related protein Rab-5C. (216 aa)
CSF2Granulocyte-macrophage colony-stimulating factor. (144 aa)
LAMC1Laminin subunit gamma-1. (1595 aa)
LAMC2Laminin subunit gamma-2 isoform X1. (1190 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (667 aa)
GNAQGuanine nucleotide-binding protein G(Q) subunit alpha isoform X1. (329 aa)
PRDX1Peroxiredoxin-1. (199 aa)
LAMA3Laminin subunit alpha-3 isoform X1. (3336 aa)
IL6Interleukin-6. (208 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (253 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1183 aa)
PTK2Focal adhesion kinase 1 isoform X3; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1062 aa)
COL4A6Collagen alpha-6(IV) chain. (1666 aa)
COL4A5Collagen alpha-5(IV) chain isoform X1. (1690 aa)
SMTNSmoothelin. (939 aa)
PLCB3Phosphoinositide phospholipase C. (1230 aa)
COL3A1Collagen alpha-1(III) chain. (1464 aa)
ENSTTRP00000009886annotation not available (199 aa)
ACTN4Actinin alpha 4. (911 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit isoform X1. (964 aa)
TLR4Toll-like receptor 4 isoform X1; Belongs to the Toll-like receptor family. (841 aa)
PRKCGProtein kinase C gamma type. (697 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (265 aa)
LAMA5Laminin subunit alpha-5-like. (3506 aa)
PRKACBcAMP-dependent protein kinase catalytic subunit beta isoform X1; Belongs to the protein kinase superfamily. (397 aa)
ARG1Arginase. (311 aa)
GNA14Guanine nucleotide-binding protein subunit alpha-14. (328 aa)
C9Complement component C9 isoform X1. (564 aa)
IL10Interleukin-10. (178 aa)
GNA11G protein subunit alpha 11. (359 aa)
GNA15G protein subunit alpha 15. (325 aa)
ACTN1Alpha-actinin-1. (913 aa)
ITGAMIntegrin alpha-M-like. (1139 aa)
LOC101328351Mucin-2-like. (1431 aa)
TGFB1Transforming growth factor beta 1. (338 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma. (461 aa)
ADCY1Adenylate cyclase 1. (1088 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (416 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1192 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; Belongs to the PI3/PI4-kinase family. (1067 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (233 aa)
SPECC1Lcytospin-A isoform X2. (1066 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha. (351 aa)
RAB5BRas-related protein Rab-5B isoform X1. (215 aa)
COL4A4Collagen alpha-4(IV) chain. (1684 aa)
COL4A3Collagen alpha-3(IV) chain. (1658 aa)
MFFMitochondrial fission factor isoform X2. (342 aa)
RAB7ARas-related protein Rab-7a. (207 aa)
Your Current Organism:
Tursiops truncatus
NCBI taxonomy Id: 9739
Other names: Atlantic bottlenose dolphin, T. truncatus, bottle-nosed dolphin, common bottlenose dolphin
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