STRINGSTRING
GNG11 GNG11 ENSTTRP00000016529 ENSTTRP00000016529 CUL1 CUL1 CCR5 CCR5 RPS6KB1 RPS6KB1 CFL1 CFL1 SKP1 SKP1 TBK1 TBK1 MAPK1 MAPK1 ENSTTRP00000015784 ENSTTRP00000015784 CRK CRK NFATC1 NFATC1 IFNB1 IFNB1 PIK3R1 PIK3R1 ENSTTRP00000015348 ENSTTRP00000015348 PAK6 PAK6 AP1G1 AP1G1 CHEK1 CHEK1 TAB2 TAB2 MAPK9 MAPK9 AP1S1 AP1S1 AKT2 AKT2 GNG5 GNG5 PPP3CB PPP3CB AP1M1 AP1M1 CDK1 CDK1 RAC2 RAC2 BAX BAX LOC101334492 LOC101334492 MTOR MTOR DCAF1 DCAF1 GNAI3 GNAI3 GNB4 GNB4 RAC3 RAC3 SAMHD1 SAMHD1 IKBKB IKBKB RELA RELA PTK2B PTK2B GNG3 GNG3 TRAF2 TRAF2 PLCG1 PLCG1 PRKCB PRKCB PPP3CA PPP3CA CCNB1 CCNB1 CCDC125 CCDC125 CUL4B CUL4B LPXN LPXN PIK3CD PIK3CD PLVAP PLVAP GNG8 GNG8 CALM3 CALM3 MAP2K6 MAP2K6 CALR CALR ITPR2 ITPR2 PDIA3 PDIA3 STING1 STING1 CD3E CD3E TAP2 TAP2 CD3D CD3D CD3G CD3G TAP1 TAP1 TAPBP TAPBP CUL4A CUL4A TLR2 TLR2 GNGT2 GNGT2 TNFRSF1B TNFRSF1B IRAK1 IRAK1 CD4 CD4 GNB5 GNB5 GNB3 GNB3 ERAS ERAS RAC1 RAC1 BCL2 BCL2 CCNB2 CCNB2 MAP2K3 MAP2K3 CDC25C CDC25C MYD88 MYD88 IRF3 IRF3 MAPK3 MAPK3 CYCS CYCS ENSTTRP00000005342 ENSTTRP00000005342 GNG2 GNG2 CGAS CGAS ENSTTRP00000005523 ENSTTRP00000005523 ATM ATM ENSTTRP00000005802 ENSTTRP00000005802 GNB2 GNB2 GNAI1 GNAI1 PIK3CB PIK3CB ENSTTRP00000006141 ENSTTRP00000006141 ENSTTRP00000006413 ENSTTRP00000006413 PLCG2 PLCG2 ENSTTRP00000006436 ENSTTRP00000006436 BAK1 BAK1 ITPR3 ITPR3 IKBKG IKBKG GNG7 GNG7 ENSTTRP00000007008 ENSTTRP00000007008 GNAI2 GNAI2 NFATC2 NFATC2 FOS FOS GNG4 GNG4 BCL2L1 BCL2L1 NFKBIA NFKBIA AP1M2 AP1M2 FAS FAS LOC109552729 LOC109552729 LOC109549914 LOC109549914 PRKCA PRKCA NFATC4 NFATC4 LIMK1 LIMK1 GNAQ GNAQ CASP8 CASP8 TRAF6 TRAF6 PAK1 PAK1 CRKL CRKL ENSTTRP00000008904 ENSTTRP00000008904 PTK2 PTK2 WEE2 WEE2 ATR ATR MAP2K7 MAP2K7 IRAK4 IRAK4 MAP2K1 MAP2K1 GNG13 GNG13 TRADD TRADD LIMK2 LIMK2 BAD BAD CCNB3 CCNB3 AP1G2 AP1G2 ENSTTRP00000010130 ENSTTRP00000010130 NFKB1 NFKB1 TLR4 TLR4 PRKCG PRKCG DDB1 DDB1 HRAS HRAS CALML6 CALML6 AKT3 AKT3 JUN JUN ELOC ELOC CHUK CHUK AP1B1 AP1B1 RBX1 RBX1 CUL5 CUL5 CALM2 CALM2 RNF7 RNF7 FBXW11 FBXW11 GNA11 GNA11 MAPK12 MAPK12 MAPK11 MAPK11 AP1S2 AP1S2 KRAS KRAS PPP3CC PPP3CC PAK3 PAK3 PIK3R3 PIK3R3 RPS6KB2 RPS6KB2 AP1S3 AP1S3 TRAF5 TRAF5 GNAO1 GNAO1 CALM1 CALM1 MAPK8 MAPK8 PAK2 PAK2 PAK5 PAK5 PIK3CA PIK3CA TNF TNF AKT1 AKT1 MAPK14 MAPK14 MAPK13 MAPK13 ITPR1 ITPR1 TNFRSF1A TNFRSF1A ENSTTRP00000013721 ENSTTRP00000013721 TAB1 TAB1 NFATC3 NFATC3 BTRC BTRC PAK4 PAK4 GNG12 GNG12 WEE1 WEE1 MAP3K7 MAP3K7 ELOB ELOB NRAS NRAS CSDE1 CSDE1 B2M B2M CASP9 CASP9 ENSTTRP00000015100 ENSTTRP00000015100 CALML4 CALML4 MAPK10 MAPK10 GNGT1 GNGT1
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
GNG11Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (73 aa)
ENSTTRP00000016529annotation not available (169 aa)
CUL1Cullin-1; Belongs to the cullin family. (767 aa)
CCR5C-C chemokine receptor type 5; Belongs to the G-protein coupled receptor 1 family. (352 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
CFL1Cofilin-2; Belongs to the actin-binding proteins ADF family. (166 aa)
SKP1S-phase kinase-associated protein 1; Belongs to the SKP1 family. (163 aa)
TBK1Serine/threonine-protein kinase TBK1 isoform X1. (729 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (320 aa)
ENSTTRP00000015784annotation not available (149 aa)
CRKAdapter molecule crk isoform X4. (223 aa)
NFATC1Nuclear factor of activated T-cells, cytoplasmic 1. (904 aa)
IFNB1Interferon beta. (185 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (732 aa)
ENSTTRP00000015348annotation not available (321 aa)
PAK6P21 (RAC1) activated kinase 6. (675 aa)
AP1G1AP-1 complex subunit gamma. (824 aa)
CHEK1Serine/threonine-protein kinase Chk1 isoform X1; Belongs to the protein kinase superfamily. (475 aa)
TAB2TGF-beta-activated kinase 1 and MAP3K7-binding protein 2. (683 aa)
MAPK9Mitogen-activated protein kinase 9. (424 aa)
AP1S1Adaptor related protein complex 1 subunit sigma 1. (132 aa)
AKT2RAC-beta serine/threonine-protein kinase. (481 aa)
GNG5Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
PPP3CBSerine/threonine-protein phosphatase. (525 aa)
AP1M1AP-1 complex subunit mu-1 isoform X2; Belongs to the adaptor complexes medium subunit family. (420 aa)
CDK1Cyclin-dependent kinase 1 isoform X3; Belongs to the protein kinase superfamily. (301 aa)
RAC2Ras-related C3 botulinum toxin substrate 1. (192 aa)
BAXApoptosis regulator BAX. (198 aa)
LOC101334492DNA dC->dU-editing enzyme APOBEC-3B-like isoform X3. (178 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2442 aa)
DCAF1Protein VPRBP isoform X7. (1478 aa)
GNAI3G protein subunit alpha i3. (354 aa)
GNB4Guanine nucleotide-binding protein subunit beta-4. (340 aa)
RAC3Ras-related C3 botulinum toxin substrate 1 isoform X2. (192 aa)
SAMHD1Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 isoform X1. (627 aa)
IKBKBInhibitor of nuclear factor kappa-B kinase subunit beta. (735 aa)
RELARELA proto-oncogene, NF-kB subunit. (574 aa)
PTK2BProtein-tyrosine kinase 2-beta isoform X2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (941 aa)
GNG3Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (504 aa)
PLCG1Phosphoinositide phospholipase C. (1290 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
PPP3CASerine/threonine-protein phosphatase. (560 aa)
CCNB1G2/mitotic-specific cyclin-B1; Belongs to the cyclin family. (433 aa)
CCDC125Coiled-coil domain-containing protein 125 isoform X1. (512 aa)
CUL4Bcullin-4B; Belongs to the cullin family. (892 aa)
LPXNLeupaxin isoform X2; Belongs to the paxillin family. (386 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform; Belongs to the PI3/PI4-kinase family. (1049 aa)
PLVAPPlasmalemma vesicle-associated protein. (441 aa)
GNG8G protein subunit gamma 8. (70 aa)
CALM3Calmodulin 3. (148 aa)
MAP2K6Dual specificity mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
CALRCalreticulin. (417 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2697 aa)
PDIA3Protein disulfide-isomerase. (505 aa)
STING1Stimulator of interferon genes protein isoform X1. (288 aa)
CD3ET-cell surface glycoprotein CD3 epsilon chain. (187 aa)
TAP2Antigen peptide transporter 2 isoform X1. (484 aa)
CD3DT-cell surface glycoprotein CD3 delta chain. (171 aa)
CD3GT-cell surface glycoprotein CD3 gamma chain. (178 aa)
TAP1Antigen peptide transporter 1. (811 aa)
TAPBPTapasin isoform X2. (497 aa)
CUL4Acullin-4A isoform X1; Belongs to the cullin family. (677 aa)
TLR2Toll-like receptor 2; Belongs to the Toll-like receptor family. (785 aa)
GNGT2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (69 aa)
TNFRSF1BTumor necrosis factor receptor superfamily member 1B. (400 aa)
IRAK1LOW QUALITY PROTEIN: zinc finger protein 14-like. (708 aa)
CD4Tursiops truncatus CD4 molecule (CD4), mRNA. (454 aa)
GNB5Guanine nucleotide-binding protein subunit beta-5. (395 aa)
GNB3G protein subunit beta 3. (340 aa)
ERASES cell expressed Ras. (233 aa)
RAC1Ras-related C3 botulinum toxin substrate 1 isoform X1. (199 aa)
BCL2Apoptosis regulator Bcl-2 isoform X1. (233 aa)
CCNB2G2/mitotic-specific cyclin-B2 isoform X1; Belongs to the cyclin family. (371 aa)
MAP2K3Dual specificity mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (350 aa)
CDC25CM-phase inducer phosphatase 3 isoform X2. (475 aa)
MYD88MYD88 innate immune signal transduction adaptor. (296 aa)
IRF3Interferon regulatory factor 3. (438 aa)
MAPK3Mitogen-activated protein kinase 3. (382 aa)
CYCSCytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
ENSTTRP00000005342annotation not available (699 aa)
GNG2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (71 aa)
CGASCyclic GMP-AMP synthase isoform X1. (510 aa)
ENSTTRP00000005523annotation not available (722 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3043 aa)
ENSTTRP00000005802annotation not available (670 aa)
GNB2G protein subunit beta 2. (340 aa)
GNAI1Guanine nucleotide-binding protein G(I) subunit alpha-1. (354 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1065 aa)
ENSTTRP00000006141annotation not available (161 aa)
ENSTTRP00000006413annotation not available (364 aa)
PLCG2Phosphoinositide phospholipase C. (1264 aa)
ENSTTRP00000006436annotation not available (178 aa)
BAK1BCL2 antagonist/killer 1. (212 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3-like. (2669 aa)
IKBKGNF-kappa-B essential modulator. (424 aa)
GNG7Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
ENSTTRP00000007008annotation not available (158 aa)
GNAI2G protein subunit alpha i2. (351 aa)
NFATC2Nuclear factor of activated T-cells, cytoplasmic 2 isoform X2. (919 aa)
FOSProto-oncogene c-Fos. (374 aa)
GNG4Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
BCL2L1Bcl-2-like protein 1 isoform X1. (233 aa)
NFKBIANF-kappa-B inhibitor alpha. (314 aa)
AP1M2Adaptor related protein complex 1 subunit mu 2. (404 aa)
FASTumor necrosis factor receptor superfamily member 6 isoform X2. (350 aa)
LOC109552729H-2 class I histocompatibility antigen, alpha chain-like. (286 aa)
LOC109549914Interferon alpha-4-like. (189 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (667 aa)
NFATC4Nuclear factor of activated T cells 4. (746 aa)
LIMK1LIM domain kinase 1. (561 aa)
GNAQGuanine nucleotide-binding protein G(Q) subunit alpha isoform X1. (329 aa)
CASP8Caspase-8 isoform X2; Belongs to the peptidase C14A family. (491 aa)
TRAF6TNF receptor associated factor 6. (523 aa)
PAK1Serine/threonine-protein kinase PAK 1. (550 aa)
CRKLCrk-like protein. (303 aa)
ENSTTRP00000008904annotation not available (193 aa)
PTK2Focal adhesion kinase 1 isoform X3; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1062 aa)
WEE2Wee1-like protein kinase. (569 aa)
ATRSerine/threonine-protein kinase ATR isoform X2; Belongs to the PI3/PI4-kinase family. (2623 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (435 aa)
IRAK4Interleukin-1 receptor-associated kinase 4 isoform X1. (460 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1. (393 aa)
GNG13Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13. (67 aa)
TRADDTumor necrosis factor receptor type 1-associated DEATH domain protein. (262 aa)
LIMK2LIM domain kinase 2 isoform X4. (551 aa)
BADBCL2 associated agonist of cell death. (150 aa)
CCNB3Cyclin B3. (1237 aa)
AP1G2AP-1 complex subunit gamma-like 2. (787 aa)
ENSTTRP00000010130annotation not available (118 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit isoform X1. (964 aa)
TLR4Toll-like receptor 4 isoform X1; Belongs to the Toll-like receptor family. (841 aa)
PRKCGProtein kinase C gamma type. (697 aa)
DDB1DNA damage-binding protein 1 isoform X1. (1118 aa)
HRASGTPase HRas isoform X1. (189 aa)
CALML6Calmodulin-like protein 6. (179 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (462 aa)
JUNTranscription factor AP-1; Belongs to the bZIP family. (321 aa)
ELOCTranscription elongation factor B polypeptide 1; Belongs to the SKP1 family. (112 aa)
CHUKInhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1. (744 aa)
AP1B1Adaptor related protein complex 1 subunit beta 1. (948 aa)
RBX1E3 ubiquitin-protein ligase RBX1. (82 aa)
CUL5Cullin-5 isoform X6; Belongs to the cullin family. (780 aa)
CALM2Calmodulin 2. (148 aa)
RNF7RING-box protein 2 isoform X1. (113 aa)
FBXW11F-box/WD repeat-containing protein 11 isoform X2. (573 aa)
GNA11G protein subunit alpha 11. (359 aa)
MAPK12Mitogen-activated protein kinase. (367 aa)
MAPK11Mitogen-activated protein kinase. (364 aa)
AP1S2Adaptor related protein complex 1 subunit sigma 2. (158 aa)
KRASGTPase KRas. (189 aa)
PPP3CCSerine/threonine-protein phosphatase. (535 aa)
PAK3Serine/threonine-protein kinase PAK 3 isoform X1. (580 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma. (461 aa)
RPS6KB2Non-specific serine/threonine protein kinase. (486 aa)
AP1S3AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (142 aa)
TRAF5TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (559 aa)
GNAO1G protein subunit alpha o1. (354 aa)
CALM1Calmodulin; Belongs to the calmodulin family. (149 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
PAK2Non-specific serine/threonine protein kinase. (523 aa)
PAK5Non-specific serine/threonine protein kinase. (719 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; Belongs to the PI3/PI4-kinase family. (1067 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (233 aa)
AKT1AKT serine/threonine kinase 1. (480 aa)
MAPK14Mitogen-activated protein kinase 14. (360 aa)
MAPK13Mitogen-activated protein kinase. (365 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2752 aa)
TNFRSF1ATumor necrosis factor receptor superfamily member 1A. (439 aa)
ENSTTRP00000013721annotation not available (118 aa)
TAB1TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (502 aa)
NFATC3Nuclear factor of activated T-cells, cytoplasmic 3. (1071 aa)
BTRCF-box/WD repeat-containing protein 1A isoform X1. (605 aa)
PAK4P21 (RAC1) activated kinase 4. (591 aa)
GNG12Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (53 aa)
WEE1Wee1-like protein kinase. (646 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
ELOBTranscription elongation factor B polypeptide 2. (151 aa)
NRASNRAS proto-oncogene, GTPase. (152 aa)
CSDE1Cold shock domain-containing protein E1. (813 aa)
B2MBeta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. (118 aa)
CASP9Caspase-9; Belongs to the peptidase C14A family. (365 aa)
ENSTTRP00000015100annotation not available (189 aa)
CALML4Calmodulin-like protein 4 isoform X2. (195 aa)
MAPK10Mitogen-activated protein kinase. (463 aa)
GNGT1Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
Your Current Organism:
Tursiops truncatus
NCBI taxonomy Id: 9739
Other names: Atlantic bottlenose dolphin, T. truncatus, bottle-nosed dolphin, common bottlenose dolphin
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