STRINGSTRING
ACTL8 ACTL8 TMPRSS2 TMPRSS2 KIAA1143 KIAA1143 NOVA1 NOVA1 TJP1 TJP1 UPK2 UPK2 AEN AEN MTMR1 MTMR1 TMEM156 TMEM156 ADAMTSL5 ADAMTSL5 HRAS HRAS SIGIRR SIGIRR ACTB ACTB MOB1A MOB1A SCN5A SCN5A ELF3 ELF3 GRPR GRPR POLE4 POLE4 ABI2 ABI2 TWNK TWNK DNAJB3 DNAJB3 EXOC5 EXOC5 ZDBF2 ZDBF2 STK11 STK11 ARPC2 ARPC2 CLDN1 CLDN1 BOK BOK TNKS TNKS MAK16 MAK16 CCDC198 CCDC198 CDK2 CDK2 HECTD2 HECTD2 CCNT2 CCNT2 ENDOU ENDOU HEMK1 HEMK1 KCNH7 KCNH7 IFNB1 IFNB1 CCDC171 CCDC171 XPO4 XPO4 LOXL4 LOXL4 TMEM158 TMEM158 YBX1 YBX1 WDR89 WDR89 ARID4A ARID4A ST3GAL3 ST3GAL3 PRIMA1 PRIMA1 PCSK9 PCSK9 DNAJB6 DNAJB6 LIPI LIPI TDRD9 TDRD9 TM9SF2 TM9SF2 RPS6KA5 RPS6KA5 FMNL3 FMNL3 CCDC122 CCDC122 KPNA6 KPNA6 NR1I2 NR1I2 ERP27 ERP27 SENP8 SENP8 BRCA2 BRCA2 SCNN1A SCNN1A ACSBG1 ACSBG1 FBXO28 FBXO28 TAS2R38 TAS2R38 MIER1 MIER1 THAP10 THAP10 GPRC5A GPRC5A CDKN1A CDKN1A ADAMTS13 ADAMTS13 NT5C3A NT5C3A CHIA CHIA OVGP1 OVGP1 DYNAP DYNAP VCAM1 VCAM1 CDH5 CDH5 ATR ATR ANGPT1 ANGPT1 TM4SF18 TM4SF18 PSMB8 PSMB8 NTN5 NTN5 SNAI3 SNAI3 LOC111180044 LOC111180044 NYAP1 NYAP1 BCL2 BCL2 MALT1 MALT1 PPP1R14D PPP1R14D NRAS NRAS ANKS4B ANKS4B SALL2 SALL2 TRRAP TRRAP NOVA2 NOVA2 CLDN3 CLDN3 LOC111182076 LOC111182076 LOC111182630 LOC111182630 NOL4 NOL4 ATOH7 ATOH7 ACTG1 ACTG1 CLDN4 CLDN4 PECAM1 PECAM1 CCND1 CCND1 LBHD1 LBHD1 SDHAF2 SDHAF2 TRIB3 TRIB3 ASPH ASPH SLC46A1 SLC46A1 LOC111185078 LOC111185078 LOC111184969 LOC111184969 VCPIP1 VCPIP1 EGFR EGFR CHIT1 CHIT1 DIP2A DIP2A MYO7A MYO7A THBD THBD DNAJB7 DNAJB7 MLC1 MLC1 CLVS1 CLVS1 PROCA1 PROCA1 TMEM98 TMEM98 NUP88 NUP88 ANXA5 ANXA5 UPK3A UPK3A AGXT2 AGXT2 ALB ALB TP53 TP53 TNF TNF IL6 IL6 NSUN7 NSUN7 TMEM27 TMEM27 CDC14B CDC14B CTNNB1 CTNNB1 PHTF2 PHTF2 PPFIBP2 PPFIBP2 ACE2 ACE2 C1GALT1C1 C1GALT1C1 ALG9 ALG9 S100A2 S100A2 PCDH17 PCDH17 ELAVL3 ELAVL3 JAK3 JAK3 KRCC1 KRCC1 LYVE1 LYVE1 ESR1 ESR1 F5 F5 BARX2 BARX2 LOC111164529 LOC111164529 SPAG9 SPAG9 DNM2 DNM2 ICAM1 ICAM1 FGFR3 FGFR3 LOC111163861 LOC111163861 LOC111165935 LOC111165935 PIGV PIGV LOC111165042 LOC111165042 TFF1 TFF1 COQ7 COQ7 ESS2 ESS2 CLDN5 CLDN5 ACTBL2 ACTBL2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ACTL8Actin-like protein 8; Belongs to the actin family. (365 aa)
TMPRSS2Transmembrane protease serine 2 isoform X4; Belongs to the peptidase S1 family. (528 aa)
KIAA1143Uncharacterized protein KIAA1143 homolog isoform X1. (171 aa)
NOVA1LOW QUALITY PROTEIN: RNA-binding protein Nova-1. (507 aa)
TJP1Tight junction protein ZO-1 isoform X1; Belongs to the MAGUK family. (1914 aa)
UPK2Uroplakin-2. (185 aa)
AENApoptosis-enhancing nuclease. (316 aa)
MTMR1Myotubularin-related protein 1 isoform X1. (685 aa)
TMEM156Transmembrane protein 156 isoform X1. (313 aa)
ADAMTSL5ADAMTS-like protein 5. (525 aa)
HRASGTPase HRas isoform X1. (189 aa)
SIGIRRSingle Ig IL-1-related receptor isoform X1. (479 aa)
ACTBActin, cytoplasmic 1. (375 aa)
MOB1AMOB kinase activator 1A. (216 aa)
SCN5ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (2016 aa)
ELF3ETS-related transcription factor Elf-3. (372 aa)
GRPRGastrin-releasing peptide receptor; Belongs to the G-protein coupled receptor 1 family. (384 aa)
POLE4DNA polymerase epsilon subunit 4 isoform X1. (116 aa)
ABI2Abl interactor 2 isoform X1. (544 aa)
TWNKTwinkle protein, mitochondrial isoform X1. (684 aa)
DNAJB3dnaJ homolog subfamily B member 3. (247 aa)
EXOC5Exocyst complex component 5. (708 aa)
ZDBF2DBF4-type zinc finger-containing protein 2. (2435 aa)
STK11Serine/threonine-protein kinase STK11 isoform X1. (544 aa)
ARPC2Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (300 aa)
CLDN1Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (211 aa)
BOKBcl-2-related ovarian killer protein. (213 aa)
TNKSPoly [ADP-ribose] polymerase. (1327 aa)
MAK16Protein MAK16 homolog; Belongs to the MAK16 family. (298 aa)
CCDC198Uncharacterized protein C14orf105 homolog isoform X1. (294 aa)
CDK2Cyclin-dependent kinase 2 isoform X1; Belongs to the protein kinase superfamily. (346 aa)
HECTD2Probable E3 ubiquitin-protein ligase HECTD2 isoform X1. (776 aa)
CCNT2cyclin-T2 isoform X1; Belongs to the cyclin family. (742 aa)
ENDOUpoly(U)-specific endoribonuclease isoform X1. (413 aa)
HEMK1hemK methyltransferase family member 1 isoform X1. (352 aa)
KCNH7Potassium voltage-gated channel subfamily H member 7 isoform X1. (1210 aa)
IFNB1Interferon beta. (185 aa)
CCDC171Coiled-coil domain-containing protein 171 isoform X1. (1333 aa)
XPO4Exportin-4 isoform X1. (1152 aa)
LOXL4Lysyl oxidase homolog 4 isoform X1. (765 aa)
TMEM158Transmembrane protein 158. (290 aa)
YBX1Nuclease-sensitive element-binding protein 1. (324 aa)
WDR89WD repeat-containing protein 89. (386 aa)
ARID4AAT-rich interactive domain-containing protein 4A isoform X2. (1279 aa)
ST3GAL3CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase isoform X1; Belongs to the glycosyltransferase 29 family. (383 aa)
PRIMA1Proline-rich membrane anchor 1 isoform X1. (197 aa)
PCSK9Proprotein convertase subtilisin/kexin type 9 isoform X1. (692 aa)
DNAJB6dnaJ homolog subfamily B member 6 isoform X1. (333 aa)
LIPILipase member I isoform X1. (460 aa)
TDRD9Putative ATP-dependent RNA helicase TDRD9 isoform X1. (1286 aa)
TM9SF2Transmembrane 9 superfamily member; Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family. (724 aa)
RPS6KA5Ribosomal protein S6 kinase. (800 aa)
FMNL3Formin-like protein 3 isoform X3. (1060 aa)
CCDC122Coiled-coil domain-containing protein 122 isoform X2. (278 aa)
KPNA6Importin subunit alpha; Functions in nuclear protein import. (577 aa)
NR1I2LOW QUALITY PROTEIN: nuclear receptor subfamily 1 group I member 2. (414 aa)
ERP27Endoplasmic reticulum resident protein 27 isoform X1. (282 aa)
SENP8Sentrin-specific protease 8. (212 aa)
BRCA2Breast cancer type 2 susceptibility protein. (3435 aa)
SCNN1AAmiloride-sensitive sodium channel subunit alpha; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (648 aa)
ACSBG1long-chain-fatty-acid--CoA ligase ACSBG1 isoform X1. (730 aa)
FBXO28F-box only protein 28. (368 aa)
TAS2R38Taste receptor type 2. (334 aa)
MIER1Mesoderm induction early response protein 1 isoform X10. (601 aa)
THAP10LOW QUALITY PROTEIN: THAP domain-containing protein 10. (380 aa)
GPRC5ARetinoic acid-induced protein 3. (357 aa)
CDKN1ACyclin-dependent kinase inhibitor 1. (164 aa)
ADAMTS13A disintegrin and metalloproteinase with thrombospondin motifs 13 isoform X4. (1472 aa)
NT5C3A5'-nucleotidase; Belongs to the pyrimidine 5'-nucleotidase family. (331 aa)
CHIAAcidic mammalian chitinase isoform X1; Belongs to the glycosyl hydrolase 18 family. (474 aa)
OVGP1LOW QUALITY PROTEIN: oviduct-specific glycoprotein; Belongs to the glycosyl hydrolase 18 family. (602 aa)
DYNAPDynactin-associated protein. (260 aa)
VCAM1Vascular cell adhesion protein 1. (739 aa)
CDH5Cadherin-5; Cadherins are calcium-dependent cell adhesion proteins. (782 aa)
ATRSerine/threonine-protein kinase ATR isoform X1; Belongs to the PI3/PI4-kinase family. (2655 aa)
ANGPT1Angiopoietin-1 isoform X1. (498 aa)
TM4SF18Transmembrane 4 L6 family member 18. (201 aa)
PSMB8Proteasome subunit beta. (276 aa)
NTN5Netrin-5. (489 aa)
SNAI3Zinc finger protein SNAI3. (320 aa)
LOC111180044F-box only protein 28-like isoform X1. (368 aa)
NYAP1LOW QUALITY PROTEIN: neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 1. (849 aa)
BCL2Apoptosis regulator Bcl-2. (233 aa)
MALT1Mucosa-associated lymphoid tissue lymphoma translocation protein 1 isoform X1. (850 aa)
PPP1R14DProtein phosphatase 1 regulatory subunit 14D isoform X1. (169 aa)
NRASGTPase NRas. (189 aa)
ANKS4BAnkyrin repeat and SAM domain-containing protein 4B isoform X1. (492 aa)
SALL2Sal-like protein 2 isoform X7. (1036 aa)
TRRAPTransformation/transcription domain-associated protein isoform X1; Belongs to the PI3/PI4-kinase family. (3885 aa)
NOVA2RNA-binding protein Nova-2. (492 aa)
CLDN3Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (220 aa)
LOC111182076Lysine-rich coiled-coil protein 1-like. (224 aa)
LOC111182630Platelet endothelial cell adhesion molecule-like isoform X2. (305 aa)
NOL4Nucleolar protein 4 isoform X1. (637 aa)
ATOH7Protein atonal homolog 7. (152 aa)
ACTG1Actin, cytoplasmic 2. (375 aa)
CLDN4Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (209 aa)
PECAM1Platelet endothelial cell adhesion molecule isoform X1. (701 aa)
CCND1G1/S-specific cyclin-D1; Belongs to the cyclin family. (295 aa)
LBHD1LBH domain-containing protein 1. (192 aa)
SDHAF2Succinate dehydrogenase assembly factor 2, mitochondrial; Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SDHA of the SDH catalytic dimer. (166 aa)
TRIB3LOW QUALITY PROTEIN: tribbles homolog 3. (357 aa)
ASPHAspartyl/asparaginyl beta-hydroxylase isoform X1. (769 aa)
SLC46A1Proton-coupled folate transporter. (459 aa)
LOC111185078Neuroendocrine convertase 2; Belongs to the peptidase S8 family. (638 aa)
LOC111184969Neuroendocrine convertase 2-like. (456 aa)
VCPIP1Deubiquitinating protein VCIP135. (1222 aa)
EGFRReceptor protein-tyrosine kinase. (1209 aa)
CHIT1LOW QUALITY PROTEIN: chitotriosidase-1; Belongs to the glycosyl hydrolase 18 family. (467 aa)
DIP2ADisco-interacting protein 2 homolog A isoform X1. (1615 aa)
MYO7AUnconventional myosin-VIIa isoform X1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2177 aa)
THBDThrombomodulin. (584 aa)
DNAJB7LOW QUALITY PROTEIN: dnaJ homolog subfamily B member 7. (304 aa)
MLC1Membrane protein MLC1 isoform X1. (369 aa)
CLVS1Clavesin-1. (354 aa)
PROCA1Protein PROCA1 isoform X1. (376 aa)
TMEM98Transmembrane protein 98. (226 aa)
NUP88Nuclear pore complex protein Nup88 isoform X3. (743 aa)
ANXA5Annexin. (370 aa)
UPK3AUroplakin-3a isoform X1. (287 aa)
AGXT2Alanine--glyoxylate aminotransferase 2, mitochondrial isoform X1; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (519 aa)
ALBSerum albumin. (607 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (387 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (233 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (208 aa)
NSUN7LOW QUALITY PROTEIN: putative methyltransferase NSUN7; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (771 aa)
TMEM27Collectrin isoform X2. (222 aa)
CDC14BDual specificity protein phosphatase CDC14B isoform X1. (553 aa)
CTNNB1Catenin beta-1. (781 aa)
PHTF2Putative homeodomain transcription factor 2 isoform X1. (747 aa)
PPFIBP2Liprin-beta-2 isoform X1. (925 aa)
ACE2Angiotensin-converting enzyme. (804 aa)
C1GALT1C1C1GALT1-specific chaperone 1. (318 aa)
ALG9Mannosyltransferase. (622 aa)
S100A2LOW QUALITY PROTEIN: protein S100-A2. (97 aa)
PCDH17Protocadherin-17 isoform X1. (1161 aa)
ELAVL3ELAV-like protein; Belongs to the RRM elav family. (367 aa)
JAK3Tyrosine-protein kinase. (1104 aa)
KRCC1Lysine-rich coiled-coil protein 1 isoform X1. (265 aa)
LYVE1Lymphatic vessel endothelial hyaluronic acid receptor 1 isoform X1. (322 aa)
ESR1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (595 aa)
F5Coagulation factor V isoform X1; Belongs to the multicopper oxidase family. (2169 aa)
BARX2Homeobox protein BarH-like 2. (278 aa)
LOC111164529Transmembrane 9 superfamily member; Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family. (698 aa)
SPAG9C-Jun-amino-terminal kinase-interacting protein 4 isoform X1. (1334 aa)
DNM2Dynamin-2 isoform X1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (871 aa)
ICAM1Intercellular adhesion molecule 1. (536 aa)
FGFR3Fibroblast growth factor receptor. (805 aa)
LOC111163861LOW QUALITY PROTEIN: interferon-induced GTP-binding protein Mx1-like; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (518 aa)
LOC111165935Ras-like protein isoform X1. (285 aa)
PIGVGPI mannosyltransferase 2; Mannosyltransferase involved in glycosylphosphatidylinositol- anchor biosynthesis. (493 aa)
LOC111165042Protein NDRG1. (374 aa)
TFF1Trefoil factor 1. (127 aa)
COQ75-demethoxyubiquinone hydroxylase, mitochondrial; Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6- methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides. Involved in lifespan determination in a ubiquinone- independent manner. (217 aa)
ESS2Protein DGCR14. (478 aa)
CLDN5Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (218 aa)
ACTBL2LOW QUALITY PROTEIN: beta-actin-like protein 2; Belongs to the actin family. (373 aa)
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
Server load: low (14%) [HD]