STRINGSTRING
RASAL3 RASAL3 GLMP GLMP IL7 IL7 LRRC25 LRRC25 LY9 LY9 TIGIT TIGIT XCL1 XCL1 IL18 IL18 TLR7 TLR7 TLR8 TLR8 SIRT6 SIRT6 TAGAP TAGAP DPM3 DPM3 MAPK7 MAPK7 RNASET2 RNASET2 CXCR3 CXCR3 IER5 IER5 ALKBH5 ALKBH5 SASH3 SASH3 PTPRC PTPRC GDPD2 GDPD2 MLLT6 MLLT6 POU2F1 POU2F1 HSH2D HSH2D CD5L CD5L TMEM18 TMEM18 WDFY4 WDFY4 SELL SELL IRF7 IRF7 CD40 CD40 ACTB ACTB CD80 CD80 ITGA2B ITGA2B CTSD CTSD SYK SYK SH2D1B SH2D1B SBNO2 SBNO2 IL12B IL12B FUNDC2 FUNDC2 ELF4 ELF4 CD86 CD86 IL3RA IL3RA HMCES HMCES STK16 STK16 AP1S2 AP1S2 SP110 SP110 SLC11A1 SLC11A1 PLEKHM1 PLEKHM1 GZMM GZMM NKX2-3 NKX2-3 TNFAIP6 TNFAIP6 NPY2R NPY2R SYNE2 SYNE2 PIDD1 PIDD1 DTX3L DTX3L KLHL6 KLHL6 LOC111171790 LOC111171790 LOC111171171 LOC111171171 TLR3 TLR3 FKBP11 FKBP11 ADAM8 ADAM8 CCRL2 CCRL2 IRAK4 IRAK4 CASP7 CASP7 PDCD4 PDCD4 LOC111173518 LOC111173518 TLR9 TLR9 PIK3AP1 PIK3AP1 BLNK BLNK MTIF3 MTIF3 MYNN MYNN JAG2 JAG2 NSD3 NSD3 LOC111175407 LOC111175407 IFNG IFNG HELB HELB TBK1 TBK1 C1RL C1RL LOC111176754 LOC111176754 DNASE1L3 DNASE1L3 GLT6D1 GLT6D1 GIMAP1 GIMAP1 FYCO1 FYCO1 RBP5 RBP5 GPR132 GPR132 CLEC9A CLEC9A TLR4 TLR4 TRAF2 TRAF2 GAS6 GAS6 GPR18 GPR18 SELENOF SELENOF LOC111178659 LOC111178659 CNPY3 CNPY3 RIN3 RIN3 TSPAN33 TSPAN33 TRAF1 TRAF1 IMPDH1 IMPDH1 P2RY13 P2RY13 GAPDH GAPDH RSL24D1 RSL24D1 BANK1 BANK1 LOC111180454 LOC111180454 LPCAT1 LPCAT1 CCDC3 CCDC3 FGD2 FGD2 FAM13A FAM13A JAK1 JAK1 VASP VASP SLC9A9 SLC9A9 DHX36 DHX36 SPATA2L SPATA2L SDHAF3 SDHAF3 IL4I1 IL4I1 POU2F2 POU2F2 CD83 CD83 ZDHHC4 ZDHHC4 VSTM1 VSTM1 TRIM56 TRIM56 NCF1 NCF1 NUDCD1 NUDCD1 LOC111180604 LOC111180604 LOC111182106 LOC111182106 EIF3K EIF3K EMP3 EMP3 ITGAM ITGAM LY86 LY86 CSF2 CSF2 ANXA11 ANXA11 ACTG1 ACTG1 BMF BMF CD74 CD74 ACP2 ACP2 DBI DBI IL4 IL4 ZMIZ2 ZMIZ2 TMC8 TMC8 FCMR FCMR ATG16L2 ATG16L2 TPX2 TPX2 HSD17B4 HSD17B4 VSIR VSIR NSL1 NSL1 BLK BLK IL10 IL10 RASGRP2 RASGRP2 UBTD2 UBTD2 DSTYK DSTYK CCDC88B CCDC88B SLC43A2 SLC43A2 FTH1 FTH1 SCIMP SCIMP ALPK1 ALPK1 MKL1 MKL1 LOC111186271 LOC111186271 TMEM199 TMEM199 XAF1 XAF1 LOC111185989 LOC111185989 CTNS CTNS TMEM107 TMEM107 EED EED LOC111186270 LOC111186270 LRRK1 LRRK1 ZBP1 ZBP1 PLEKHG5 PLEKHG5 CCNL2 CCNL2 CNOT11 CNOT11 PLEK PLEK UCKL1 UCKL1 TLR2 TLR2 HMOX1 HMOX1 CD72 CD72 FT FT IL1B IL1B CD4 CD4 IL6 IL6 IL2 IL2 ACTBL2 ACTBL2 IFNLR1 IFNLR1 ACTL8 ACTL8 VPREB3 VPREB3 PSME1 PSME1 ADCY4 ADCY4 CD40LG CD40LG IL16 IL16 CTSH CTSH CCL5 CCL5 LOC111163733 LOC111163733 TMEM60 TMEM60 TMSB10 TMSB10 C1QB C1QB VAV1 VAV1 DPP9 DPP9 ACP5 ACP5 VMAC VMAC NLRC5 NLRC5 CLEC17A CLEC17A RACK1 RACK1 JAML JAML DNASE2 DNASE2 ARHGAP30 ARHGAP30 MAN2B1 MAN2B1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RASAL3RAS protein activator like-3 isoform X1. (1035 aa)
GLMPGlycosylated lysosomal membrane protein. (392 aa)
IL7Interleukin-7 isoform X1. (226 aa)
LRRC25Leucine-rich repeat-containing protein 25. (309 aa)
LY9T-lymphocyte surface antigen Ly-9 isoform X1. (653 aa)
TIGITT-cell immunoreceptor with Ig and ITIM domains. (243 aa)
XCL1Lymphotactin. (111 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
TLR7Toll-like receptor 7 isoform X1. (1086 aa)
TLR8Toll-like receptor 8; Belongs to the Toll-like receptor family. (1035 aa)
SIRT6NAD-dependent protein deacetylase sirtuin-6 isoform X3. (375 aa)
TAGAPT-cell activation Rho GTPase-activating protein. (722 aa)
DPM3Dolichol-phosphate mannosyltransferase subunit 3; Stabilizer subunit of the dolichol-phosphate mannose (DPM) synthase complex; tethers catalytic subunit to the ER. Belongs to the DPM3 family. (92 aa)
MAPK7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (775 aa)
RNASET2Ribonuclease T2 isoform X1; Belongs to the RNase T2 family. (248 aa)
CXCR3C-X-C chemokine receptor type 3; Belongs to the G-protein coupled receptor 1 family. (366 aa)
IER5Immediate early response gene 5 protein. (325 aa)
ALKBH5RNA demethylase ALKBH5. (394 aa)
SASH3SAM and SH3 domain-containing protein 3. (380 aa)
PTPRCReceptor-type tyrosine-protein phosphatase C isoform X1. (1258 aa)
GDPD2Glycerophosphoinositol inositolphosphodiesterase GDPD2 isoform X2. (539 aa)
MLLT6Protein AF-17 isoform X1. (1083 aa)
POU2F1POU domain protein. (756 aa)
HSH2DHematopoietic SH2 domain-containing protein isoform X1. (346 aa)
CD5LCD5 antigen-like. (341 aa)
TMEM18Transmembrane protein 18 isoform X1. (179 aa)
WDFY4LOW QUALITY PROTEIN: WD repeat- and FYVE domain-containing protein 4. (3182 aa)
SELLL-selectin; Calcium-dependent lectin that mediates cell adhesion by binding to glycoproteins on neighboring cells. Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia. (372 aa)
IRF7Interferon regulatory factor 7 isoform X1. (473 aa)
CD40Tumor necrosis factor receptor superfamily member 5 isoform X1. (284 aa)
ACTBActin, cytoplasmic 1. (375 aa)
CD80T-lymphocyte activation antigen CD80 isoform X1. (295 aa)
ITGA2BIntegrin alpha-IIb; Belongs to the integrin alpha chain family. (1034 aa)
CTSDCathepsin D; Belongs to the peptidase A1 family. (411 aa)
SYKTyrosine-protein kinase. (626 aa)
SH2D1BSH2 domain-containing protein 1B isoform X1. (138 aa)
SBNO2Protein strawberry notch homolog 2 isoform X1. (1383 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (329 aa)
FUNDC2FUN14 domain-containing protein 2. (189 aa)
ELF4ETS-related transcription factor Elf-4 isoform X1. (662 aa)
CD86T-lymphocyte activation antigen CD86 isoform X1. (344 aa)
IL3RAInterleukin-3 receptor subunit alpha isoform X1. (473 aa)
HMCESAbasic site processing protein HMCES; Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites. Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA. The HMCES DNA-protein cross- link is then degraded by the proteasome. Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from translesion synthesis (TLS) polymerases and endon [...] (350 aa)
STK16Serine/threonine-protein kinase 16 isoform X1. (305 aa)
AP1S2AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (160 aa)
SP110Sp110 nuclear body protein isoform X4. (777 aa)
SLC11A1Natural resistance-associated macrophage protein 1 isoform X1. (546 aa)
PLEKHM1Pleckstrin homology domain-containing family M member 1 isoform X1. (1089 aa)
GZMMGranzyme M; Belongs to the peptidase S1 family. (257 aa)
NKX2-3Homeobox protein Nkx-2.3. (366 aa)
TNFAIP6Tumor necrosis factor-inducible gene 6 protein isoform X1. (284 aa)
NPY2RNeuropeptide Y receptor type 2; Belongs to the G-protein coupled receptor 1 family. (384 aa)
SYNE2Nesprin-2 isoform X1. (6919 aa)
PIDD1P53-induced death domain-containing protein 1 isoform X1. (971 aa)
DTX3LE3 ubiquitin-protein ligase DTX3L. (742 aa)
KLHL6Kelch-like protein 6 isoform X1. (621 aa)
LOC111171790Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. (511 aa)
LOC111171171Integrin alpha-M-like. (296 aa)
TLR3Toll-like receptor 3; Belongs to the Toll-like receptor family. (905 aa)
FKBP11Peptidylprolyl isomerase. (204 aa)
ADAM8Disintegrin and metalloproteinase domain-containing protein 8 isoform X1. (838 aa)
CCRL2C-C chemokine receptor-like 2 isoform X2; Belongs to the G-protein coupled receptor 1 family. (366 aa)
IRAK4Interleukin-1 receptor-associated kinase 4 isoform X1. (460 aa)
CASP7Caspase-7; Belongs to the peptidase C14A family. (301 aa)
PDCD4Programmed cell death protein 4 isoform X1. (469 aa)
LOC111173518Histone-lysine N-methyltransferase NSD3-like. (218 aa)
TLR9LOW QUALITY PROTEIN: toll-like receptor 9. (1323 aa)
PIK3AP1Phosphoinositide 3-kinase adapter protein 1 isoform X1. (806 aa)
BLNKB-cell linker protein isoform X1. (528 aa)
MTIF3LOW QUALITY PROTEIN: translation initiation factor IF-3, mitochondrial. (370 aa)
MYNNMyoneurin isoform X1. (609 aa)
JAG2Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1233 aa)
NSD3Histone-lysine N-methyltransferase NSD3 isoform X1. (1438 aa)
LOC111175407Amine oxidase. (524 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
HELBDNA helicase B isoform X1. (1079 aa)
TBK1Serine/threonine-protein kinase TBK1. (729 aa)
C1RLComplement C1r subcomponent-like protein isoform X1; Belongs to the peptidase S1 family. (523 aa)
LOC111176754C-type lectin domain family 7 member A-like isoform X1. (244 aa)
DNASE1L3Deoxyribonuclease; Belongs to the DNase I family. (304 aa)
GLT6D1Glycosyltransferase 6 domain-containing protein 1 isoform X1. (371 aa)
GIMAP1GTPase IMAP family member 1 isoform X1. (318 aa)
FYCO1FYVE and coiled-coil domain-containing protein 1. (1461 aa)
RBP5LOW QUALITY PROTEIN: retinol-binding protein 5; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (135 aa)
GPR132Probable G-protein coupled receptor 132; Belongs to the G-protein coupled receptor 1 family. (342 aa)
CLEC9AC-type lectin domain family 9 member A isoform X1. (266 aa)
TLR4Toll-like receptor 4 isoform X1; Belongs to the Toll-like receptor family. (841 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (516 aa)
GAS6Growth arrest-specific protein 6. (671 aa)
GPR18N-arachidonyl glycine receptor; Belongs to the G-protein coupled receptor 1 family. (338 aa)
SELENOFSelenoprotein F isoform X1. (165 aa)
LOC111178659Antigen peptide transporter 2-like isoform X4. (758 aa)
CNPY3Protein canopy homolog 3. (286 aa)
RIN3Ras and Rab interactor 3 isoform X1. (1010 aa)
TSPAN33Tetraspanin. (283 aa)
TRAF1TNF receptor-associated factor. (415 aa)
IMPDH1Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. (522 aa)
P2RY13P2Y purinoceptor 13; Belongs to the G-protein coupled receptor 1 family. (333 aa)
GAPDHGlyceraldehyde-3-phosphate dehydrogenase. (333 aa)
RSL24D1Probable ribosome biogenesis protein RLP24. (163 aa)
BANK1B-cell scaffold protein with ankyrin repeats isoform X1. (785 aa)
LOC111180454Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. (172 aa)
LPCAT1Lysophosphatidylcholine acyltransferase 1 isoform X1. (534 aa)
CCDC3Coiled-coil domain-containing protein 3. (274 aa)
FGD2FYVE, RhoGEF and PH domain-containing protein 2 isoform X1. (732 aa)
FAM13AProtein FAM13A isoform X1. (1023 aa)
JAK1Tyrosine-protein kinase. (1153 aa)
VASPVasodilator-stimulated phosphoprotein isoform X1; Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration. Belongs to the Ena/VASP family. (384 aa)
SLC9A9Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (643 aa)
DHX36ATP-dependent RNA helicase DHX36 isoform X1. (1020 aa)
SPATA2LSpermatogenesis-associated protein 2-like protein. (405 aa)
SDHAF3Succinate dehydrogenase assembly factor 3, mitochondrial. (125 aa)
IL4I1L-amino-acid oxidase isoform X1. (653 aa)
POU2F2POU domain protein. (614 aa)
CD83CD83 antigen isoform X1. (195 aa)
ZDHHC4Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (365 aa)
VSTM1V-set and transmembrane domain-containing protein 1 isoform X1. (139 aa)
TRIM56E3 ubiquitin-protein ligase TRIM56. (755 aa)
NCF1Neutrophil cytosol factor 1 isoform X2. (405 aa)
NUDCD1nudC domain-containing protein 1 isoform X1. (583 aa)
LOC111180604Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. (172 aa)
LOC111182106Integrin alpha-X-like isoform X1; Belongs to the integrin alpha chain family. (1210 aa)
EIF3KEukaryotic translation initiation factor 3 subunit K; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF- 2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribos [...] (218 aa)
EMP3Epithelial membrane protein 3; Probably involved in cell proliferation and cell-cell interactions; Belongs to the PMP-22/EMP/MP20 family. (163 aa)
ITGAMIntegrin alpha-M; Belongs to the integrin alpha chain family. (872 aa)
LY86Lymphocyte antigen 86 isoform X1. (232 aa)
CSF2Granulocyte-macrophage colony-stimulating factor. (144 aa)
ANXA11Annexin. (503 aa)
ACTG1Actin, cytoplasmic 2. (375 aa)
BMFLOW QUALITY PROTEIN: bcl-2-modifying factor. (269 aa)
CD74HLA class II histocompatibility antigen gamma chain isoform X1. (278 aa)
ACP2Lysosomal acid phosphatase isoform X1; Belongs to the histidine acid phosphatase family. (423 aa)
DBIacyl-CoA-binding protein. (87 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family. (133 aa)
ZMIZ2Zinc finger MIZ domain-containing protein 2 isoform X1. (933 aa)
TMC8Transmembrane channel-like protein. (740 aa)
FCMRFas apoptotic inhibitory molecule 3 isoform X1. (462 aa)
ATG16L2Autophagy-related protein 16-2 isoform X1. (620 aa)
TPX2Targeting protein for Xklp2 isoform X1. (747 aa)
HSD17B4Peroxisomal multifunctional enzyme type 2 isoform X1. (736 aa)
VSIRV-type immunoglobulin domain-containing suppressor of T-cell activation. (311 aa)
NSL1Kinetochore-associated protein NSL1 homolog. (304 aa)
BLKTyrosine-protein kinase. (501 aa)
IL10Interleukin-10. (178 aa)
RASGRP2RAS guanyl-releasing protein 2 isoform X1. (684 aa)
UBTD2Ubiquitin domain-containing protein 2 isoform X1. (234 aa)
DSTYKDual serine/threonine and tyrosine protein kinase isoform X1. (929 aa)
CCDC88BCoiled-coil domain-containing protein 88B isoform X1. (1463 aa)
SLC43A2Large neutral amino acids transporter small subunit 4 isoform X1. (568 aa)
FTH1Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. (183 aa)
SCIMPSLP adapter and CSK-interacting membrane protein. (143 aa)
ALPK1Alpha-protein kinase 1 isoform X1. (1244 aa)
MKL1MKL/myocardin-like protein 1 isoform X1. (1165 aa)
LOC111186271GRB2-related adapter protein 2-like isoform X1. (105 aa)
TMEM199Transmembrane protein 199 isoform X1. (208 aa)
XAF1XIAP-associated factor 1 isoform X1. (387 aa)
LOC111185989Nitric oxide synthase; Produces nitric oxide (NO). (1146 aa)
CTNSCystinosin isoform X1. (411 aa)
TMEM107Transmembrane protein 107 isoform X1. (140 aa)
EEDPolycomb protein EED isoform X1. (466 aa)
LOC111186270GRB2-related adapter protein 2 isoform X1. (337 aa)
LRRK1Leucine-rich repeat serine/threonine-protein kinase 1. (2015 aa)
ZBP1Z-DNA-binding protein 1 isoform X1. (430 aa)
PLEKHG5Pleckstrin homology domain-containing family G member 5 isoform X1. (1101 aa)
CCNL2cyclin-L2 isoform X3; Belongs to the cyclin family. (561 aa)
CNOT11CCR4-NOT transcription complex subunit 11. (512 aa)
PLEKPleckstrin. (350 aa)
UCKL1Uridine-cytidine kinase; Belongs to the uridine kinase family. (619 aa)
TLR2Toll-like receptor 2; Belongs to the Toll-like receptor family. (785 aa)
HMOX1Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. (288 aa)
CD72B-cell differentiation antigen CD72. (364 aa)
FTFerritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. (175 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (266 aa)
CD4T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] (455 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (208 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells (By similarity); Belongs to the IL-2 family. (154 aa)
ACTBL2LOW QUALITY PROTEIN: beta-actin-like protein 2; Belongs to the actin family. (373 aa)
IFNLR1Interferon lambda receptor 1 isoform X1. (535 aa)
ACTL8Actin-like protein 8; Belongs to the actin family. (365 aa)
VPREB3pre-B lymphocyte protein 3. (121 aa)
PSME1Proteasome activator complex subunit 1. (249 aa)
ADCY4Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1237 aa)
CD40LGCD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching. (261 aa)
IL16Pro-interleukin-16; Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4. (1326 aa)
CTSHPro-cathepsin H; Belongs to the peptidase C1 family. (335 aa)
CCL5C-C motif chemokine. (91 aa)
LOC111163733C-C motif chemokine. (90 aa)
TMEM60Transmembrane protein 60. (133 aa)
TMSB10Thymosin beta; Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization. Belongs to the thymosin beta family. (42 aa)
C1QBComplement C1q subcomponent subunit B. (290 aa)
VAV1Proto-oncogene vav isoform X1. (845 aa)
DPP9Dipeptidyl peptidase 9 isoform X1; Belongs to the peptidase S9B family. (895 aa)
ACP5Tartrate-resistant acid phosphatase type 5. (349 aa)
VMACVimentin-type intermediate filament-associated coiled-coil protein. (169 aa)
NLRC5Protein NLRC5 isoform X1. (1850 aa)
CLEC17AC-type lectin domain family 17, member A isoform X1. (334 aa)
RACK1Receptor of activated protein C kinase 1. (317 aa)
JAMLJunctional adhesion molecule-like. (383 aa)
DNASE2Deoxyribonuclease-2-alpha. (352 aa)
ARHGAP30Rho GTPase-activating protein 30 isoform X1. (1125 aa)
MAN2B1Alpha-mannosidase. (1008 aa)
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
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