STRINGSTRING
TNF TNF YBX1 YBX1 ICAM1 ICAM1 TJP1 TJP1 CLDN5 CLDN5 CDH5 CDH5 VCAM1 VCAM1 ADAMTS13 ADAMTS13 ANGPT1 ANGPT1 LOC111182630 LOC111182630 PECAM1 PECAM1 THBD THBD AGXT2 AGXT2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (233 aa)
YBX1Nuclease-sensitive element-binding protein 1. (324 aa)
ICAM1Intercellular adhesion molecule 1. (536 aa)
TJP1Tight junction protein ZO-1 isoform X1; Belongs to the MAGUK family. (1914 aa)
CLDN5Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (218 aa)
CDH5Cadherin-5; Cadherins are calcium-dependent cell adhesion proteins. (782 aa)
VCAM1Vascular cell adhesion protein 1. (739 aa)
ADAMTS13A disintegrin and metalloproteinase with thrombospondin motifs 13 isoform X4. (1472 aa)
ANGPT1Angiopoietin-1 isoform X1. (498 aa)
LOC111182630Platelet endothelial cell adhesion molecule-like isoform X2. (305 aa)
PECAM1Platelet endothelial cell adhesion molecule isoform X1. (701 aa)
THBDThrombomodulin. (584 aa)
AGXT2Alanine--glyoxylate aminotransferase 2, mitochondrial isoform X1; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (519 aa)
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
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