STRINGSTRING
XBP1 XBP1 MAPKAPK5 MAPKAPK5 TRIB2 TRIB2 CEBPE CEBPE TRIB1 TRIB1 MAP2K7 MAP2K7 JUNB JUNB CREB3L4 CREB3L4 IER2 IER2 MAPK10 MAPK10 MAP3K5 MAP3K5 CREB3L3 CREB3L3 JUND JUND MAP2K3 MAP2K3 LRRC56 LRRC56 DUSP3 DUSP3 DUSP8 DUSP8 MAPK9 MAPK9 ATF6B ATF6B PTPN7 PTPN7 MAPK8 MAPK8 ATF6 ATF6 CREB1 CREB1 ATF1 ATF1 PTPRR PTPRR DDIT3 DDIT3 ATF7 ATF7 ATF2 ATF2 MAPKAPK3 MAPKAPK3 JUN JUN JDP2 JDP2 RPS6KA5 RPS6KA5 FOS FOS FOSL2 FOSL2 HSPA5 HSPA5 MAPK14 MAPK14 MAPK13 MAPK13 CREB3L2 CREB3L2 CREM CREM DUSP10 DUSP10 CEBPG CEBPG ATF5 ATF5 FOSB FOSB PTPN5 PTPN5 CREB5 CREB5 VRK3 VRK3 ERN1 ERN1 HSPB1 HSPB1 MAP2K6 MAP2K6 RPS6KA4 RPS6KA4 CREB3L1 CREB3L1 ATF3 ATF3 FOSL1 FOSL1 MAPKAPK2 MAPKAPK2 MAPK8IP1 MAPK8IP1 MAP2K4 MAP2K4 CREBBP CREBBP ATF4 ATF4 CREBRF CREBRF MAPK8IP3 MAPK8IP3 MAPK12 MAPK12 EP300 EP300 DUSP1 DUSP1 MAP3K1 MAP3K1 CEBPB CEBPB MAPK8IP2 MAPK8IP2 MAPK11 MAPK11 CREB3 CREB3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
XBP1LOW QUALITY PROTEIN: X-box-binding protein 1. (392 aa)
MAPKAPK5MAP kinase-activated protein kinase 5 isoform X1. (473 aa)
TRIB2Tribbles homolog 2. (343 aa)
CEBPECCAAT/enhancer-binding protein. (281 aa)
TRIB1Tribbles homolog 1. (372 aa)
MAP2K7Dual specificity mitogen-activated protein kinase kinase 7 isoform X1. (458 aa)
JUNBTranscription factor jun-B. (347 aa)
CREB3L4Cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1. (443 aa)
IER2Immediate early response gene 2 protein. (223 aa)
MAPK10Mitogen-activated protein kinase. (464 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5 isoform X1. (1366 aa)
CREB3L3Cyclic AMP-responsive element-binding protein 3-like protein 3. (457 aa)
JUNDTranscription factor jun-D. (345 aa)
MAP2K3Dual specificity mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (347 aa)
LRRC56Leucine-rich repeat-containing protein 56. (565 aa)
DUSP3Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (185 aa)
DUSP8Dual specificity protein phosphatase 8. (621 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
ATF6BLOW QUALITY PROTEIN: cyclic AMP-dependent transcription factor ATF-6 beta. (700 aa)
PTPN7LOW QUALITY PROTEIN: tyrosine-protein phosphatase non-receptor type 7. (361 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
ATF6Cyclic AMP-dependent transcription factor ATF-6 alpha. (654 aa)
CREB1Cyclic AMP-responsive element-binding protein 1 isoform X1. (341 aa)
ATF1Cyclic AMP-dependent transcription factor ATF-1 isoform X1. (336 aa)
PTPRRReceptor-type tyrosine-protein phosphatase R. (653 aa)
DDIT3DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...] (168 aa)
ATF7Cyclic AMP-dependent transcription factor ATF-7 isoform X1. (483 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2 isoform X1. (505 aa)
MAPKAPK3MAP kinase-activated protein kinase 3 isoform X1; Belongs to the protein kinase superfamily. (384 aa)
JUNTranscription factor AP-1; Belongs to the bZIP family. (343 aa)
JDP2Jun dimerization protein 2 isoform X1. (173 aa)
RPS6KA5Ribosomal protein S6 kinase. (800 aa)
FOSProto-oncogene c-Fos. (380 aa)
FOSL2Fos-related antigen 2 isoform X1. (327 aa)
HSPA578 kDa glucose-regulated protein; Belongs to the heat shock protein 70 family. (655 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
MAPK13Mitogen-activated protein kinase. (366 aa)
CREB3L2Cyclic AMP-responsive element-binding protein 3-like protein 2. (520 aa)
CREMcAMP-responsive element modulator isoform X1. (359 aa)
DUSP10Dual specificity protein phosphatase 10; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (482 aa)
CEBPGCCAAT/enhancer-binding protein gamma. (149 aa)
ATF5Cyclic AMP-dependent transcription factor ATF-5. (279 aa)
FOSBProtein fosB isoform X1. (341 aa)
PTPN5Tyrosine-protein phosphatase non-receptor type 5. (539 aa)
CREB5Cyclic AMP-responsive element-binding protein 5 isoform X1. (502 aa)
VRK3Inactive serine/threonine-protein kinase VRK3 isoform X1. (447 aa)
ERN1Serine/threonine-protein kinase/endoribonuclease IRE1. (975 aa)
HSPB1Heat shock protein beta-1; Belongs to the small heat shock protein (HSP20) family. (201 aa)
MAP2K6Dual specificity mitogen-activated protein kinase kinase 6 isoform X1; Belongs to the protein kinase superfamily. (368 aa)
RPS6KA4Ribosomal protein S6 kinase. (771 aa)
CREB3L1Cyclic AMP-responsive element-binding protein 3-like protein 1. (520 aa)
ATF3Cyclic AMP-dependent transcription factor ATF-3 isoform X1. (221 aa)
FOSL1Fos-related antigen 1. (271 aa)
MAPKAPK2LOW QUALITY PROTEIN: MAP kinase-activated protein kinase 2; Belongs to the protein kinase superfamily. (414 aa)
MAPK8IP1C-Jun-amino-terminal kinase-interacting protein 1 isoform X1. (718 aa)
MAP2K4Dual specificity mitogen-activated protein kinase kinase 4 isoform X4; Belongs to the protein kinase superfamily. (410 aa)
CREBBPCREB-binding protein isoform X1. (2442 aa)
ATF4Cyclic AMP-dependent transcription factor ATF-4 isoform X1. (350 aa)
CREBRFCREB3 regulatory factor. (639 aa)
MAPK8IP3C-Jun-amino-terminal kinase-interacting protein 3 isoform X4. (1336 aa)
MAPK12Mitogen-activated protein kinase. (456 aa)
EP300Histone acetyltransferase p300. (2420 aa)
DUSP1Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (367 aa)
MAP3K1Mitogen-activated protein kinase kinase kinase 1 isoform X1. (1508 aa)
CEBPBCCAAT/enhancer-binding protein. (345 aa)
MAPK8IP2C-Jun-amino-terminal kinase-interacting protein 2. (813 aa)
MAPK11Mitogen-activated protein kinase. (366 aa)
CREB3Cyclic AMP-responsive element-binding protein 3. (370 aa)
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
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