(17 nodes) Wnt signaling pathway network (Delphinapterus leucas)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	WNT4	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (361 aa)
	WNT3A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
	FZD5	Frizzled-5; Belongs to the G-protein coupled receptor Fz/Smo family. (588 aa)
	WNT5A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (458 aa)
	SFRP5	Secreted frizzled-related protein 5. (315 aa)
	WNT1	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
	WNT5B	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (361 aa)
	FZD8	Frizzled-8; Belongs to the G-protein coupled receptor Fz/Smo family. (531 aa)
	RYK	Tyrosine-protein kinase RYK isoform X1. (609 aa)
	FZD1	Frizzled-1; Belongs to the G-protein coupled receptor Fz/Smo family. (644 aa)
	FZD6	Frizzled-6; Belongs to the G-protein coupled receptor Fz/Smo family. (712 aa)
	WNT16	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (362 aa)
	WNT3	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (453 aa)
	WNT11	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
	FZD4	Frizzled-4; Belongs to the G-protein coupled receptor Fz/Smo family. (537 aa)
	FZD3	Frizzled-3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
	SFRP4	Secreted frizzled-related protein 4. (346 aa)

Your Current Organism:

Delphinapterus leucas

NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
FZD1	FZD5	A0A2Y9P4M0	A0A2Y9MML7	Frizzled-1; Belongs to the G-protein coupled receptor Fz/Smo family.	Frizzled-5; Belongs to the G-protein coupled receptor Fz/Smo family.	0.420
FZD1	FZD6	A0A2Y9P4M0	A0A2Y9P561	Frizzled-1; Belongs to the G-protein coupled receptor Fz/Smo family.	Frizzled-6; Belongs to the G-protein coupled receptor Fz/Smo family.	0.401
FZD1	FZD8	A0A2Y9P4M0	A0A2Y9NPK6	Frizzled-1; Belongs to the G-protein coupled receptor Fz/Smo family.	Frizzled-8; Belongs to the G-protein coupled receptor Fz/Smo family.	0.418
FZD1	RYK	A0A2Y9P4M0	A0A2Y9P4G1	Frizzled-1; Belongs to the G-protein coupled receptor Fz/Smo family.	Tyrosine-protein kinase RYK isoform X1.	0.938
FZD1	SFRP4	A0A2Y9P4M0	A0A2Y9Q046	Frizzled-1; Belongs to the G-protein coupled receptor Fz/Smo family.	Secreted frizzled-related protein 4.	0.669
FZD1	SFRP5	A0A2Y9P4M0	A0A2Y9N6H2	Frizzled-1; Belongs to the G-protein coupled receptor Fz/Smo family.	Secreted frizzled-related protein 5.	0.693
FZD1	WNT1	A0A2Y9P4M0	A0A2Y9NFI8	Frizzled-1; Belongs to the G-protein coupled receptor Fz/Smo family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.987
FZD1	WNT11	A0A2Y9P4M0	A0A2Y9PRI0	Frizzled-1; Belongs to the G-protein coupled receptor Fz/Smo family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.977
FZD1	WNT16	A0A2Y9P4M0	A0A2Y9P7C0	Frizzled-1; Belongs to the G-protein coupled receptor Fz/Smo family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.826
FZD1	WNT3	A0A2Y9P4M0	A0A2Y9PFS7	Frizzled-1; Belongs to the G-protein coupled receptor Fz/Smo family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.910
FZD1	WNT3A	A0A2Y9P4M0	A0A2Y9MBH2	Frizzled-1; Belongs to the G-protein coupled receptor Fz/Smo family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.948
FZD1	WNT4	A0A2Y9P4M0	A0A2Y9LDA2	Frizzled-1; Belongs to the G-protein coupled receptor Fz/Smo family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.926
FZD1	WNT5A	A0A2Y9P4M0	A0A2Y9N641	Frizzled-1; Belongs to the G-protein coupled receptor Fz/Smo family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.930
FZD1	WNT5B	A0A2Y9P4M0	A0A2Y9NIX6	Frizzled-1; Belongs to the G-protein coupled receptor Fz/Smo family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.918
FZD3	FZD4	A0A2Y9PYV8	A0A2Y9PX74	Frizzled-3; Belongs to the G-protein coupled receptor Fz/Smo family.	Frizzled-4; Belongs to the G-protein coupled receptor Fz/Smo family.	0.615
FZD3	FZD5	A0A2Y9PYV8	A0A2Y9MML7	Frizzled-3; Belongs to the G-protein coupled receptor Fz/Smo family.	Frizzled-5; Belongs to the G-protein coupled receptor Fz/Smo family.	0.542
FZD3	FZD6	A0A2Y9PYV8	A0A2Y9P561	Frizzled-3; Belongs to the G-protein coupled receptor Fz/Smo family.	Frizzled-6; Belongs to the G-protein coupled receptor Fz/Smo family.	0.560
FZD3	FZD8	A0A2Y9PYV8	A0A2Y9NPK6	Frizzled-3; Belongs to the G-protein coupled receptor Fz/Smo family.	Frizzled-8; Belongs to the G-protein coupled receptor Fz/Smo family.	0.443
FZD3	RYK	A0A2Y9PYV8	A0A2Y9P4G1	Frizzled-3; Belongs to the G-protein coupled receptor Fz/Smo family.	Tyrosine-protein kinase RYK isoform X1.	0.943
FZD3	SFRP4	A0A2Y9PYV8	A0A2Y9Q046	Frizzled-3; Belongs to the G-protein coupled receptor Fz/Smo family.	Secreted frizzled-related protein 4.	0.663