STRINGSTRING
CRKL CRKL BCR BCR FGR FGR KITLG KITLG KIDINS220 KIDINS220 FGF13 FGF13 FYN FYN PAG1 PAG1 FGFRL1 FGFRL1 TEK TEK FGF10 FGF10 PIK3CG PIK3CG INSR INSR SH3GL3 SH3GL3 VAV1 VAV1 IRS4 IRS4 FGFR3 FGFR3 NGFR NGFR NTRK2 NTRK2 PIK3R2 PIK3R2 SHC1 SHC1 INSRR INSRR LYN LYN NTRK1 NTRK1 PTK2 PTK2 KHDRBS3 KHDRBS3 MATK MATK SH3GL1 SH3GL1 ERBB2 ERBB2 CBL CBL TGFA TGFA SHC3 SHC3 LOC111167689 LOC111167689 PTPRC PTPRC FGF17 FGF17 NTRK3 NTRK3 PDGFA PDGFA KIT KIT PDGFRA PDGFRA LOC111167795 LOC111167795 PDGFD PDGFD VEGFD VEGFD TEC TEC LOC111170545 LOC111170545 KLB KLB LOC111171158 LOC111171158 FGFBP1 FGFBP1 FGFR4 FGFR4 IRS1 IRS1 TXK TXK ELMO2 ELMO2 DOCK1 DOCK1 FGFR2 FGFR2 ERBB4 ERBB4 INPPL1 INPPL1 KDR KDR LOC111171066 LOC111171066 SHC2 SHC2 FGF22 FGF22 GRB14 GRB14 FRS2 FRS2 INPP5D INPP5D FLT4 FLT4 SOS2 SOS2 PIK3CA PIK3CA VEGFC VEGFC ERBB3 ERBB3 SH3GL2 SH3GL2 NRG1 NRG1 SOS1 SOS1 FGF9 FGF9 FGFR1 FGFR1 TIAM1 TIAM1 BLNK BLNK FGF8 FGF8 FLT3 FLT3 FLT1 FLT1 KHDRBS1 KHDRBS1 PIK3R3 PIK3R3 ANGPT2 ANGPT2 IRS2 IRS2 FGF20 FGF20 FGF6 FGF6 NTF3 NTF3 PGF PGF KL KL VAV2 VAV2 FGF23 FGF23 MST1R MST1R RAPGEF1 RAPGEF1 FGF16 FGF16 BTK BTK VEGFA VEGFA PDGFC PDGFC NRG4 NRG4 MET MET PLCG2 PLCG2 BCAR1 BCAR1 PIK3CB PIK3CB SORT1 SORT1 FLT3LG FLT3LG BDNF BDNF AXL AXL FRS3 FRS3 VAV3 VAV3 ANGPT1 ANGPT1 ELMO1 ELMO1 GP6 GP6 FGF21 FGF21 SPIRE2 SPIRE2 NEDD9 NEDD9 ELMO3 ELMO3 YES1 YES1 NGF NGF NRG2 NRG2 NTF4 NTF4 SH2B1 SH2B1 HBEGF HBEGF ITK ITK GRB2 GRB2 FGF7 FGF7 PDGFRB PDGFRB RAC1 RAC1 PLCG1 PLCG1 LAT LAT IGF2 IGF2 LOC111184310 LOC111184310 ANGPT4 ANGPT4 FER FER FGF1 FGF1 SRC SRC HCK HCK NRG3 NRG3 FGF3 FGF3 INS INS DOCK5 DOCK5 VEGFB VEGFB CRK CRK CBLB CBLB LOC111186271 LOC111186271 DOCK2 DOCK2 PDGFB PDGFB EGFR EGFR GAB2 GAB2 SH2B3 SH2B3 LOC111186270 LOC111186270 PTK2B PTK2B FGF18 FGF18 LCP2 LCP2 AREG AREG PIK3R1 PIK3R1 PIK3R5 PIK3R5 PIK3R6 PIK3R6 IGF1R IGF1R EREG EREG EPGN EPGN PTK6 PTK6 GAB1 GAB1 PTPN1 PTPN1 PTPN11 PTPN11 LOC111187198 LOC111187198 PIK3CD PIK3CD BTC BTC FGF5 FGF5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CRKLCrk-like protein. (303 aa)
BCRBreakpoint cluster region protein isoform X1. (1275 aa)
FGRTyrosine-protein kinase. (526 aa)
KITLGKit ligand isoform X1. (295 aa)
KIDINS220Kinase D-interacting substrate of 220 kDa isoform X1. (1793 aa)
FGF13Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (255 aa)
FYNTyrosine-protein kinase. (537 aa)
PAG1Phosphoprotein associated with glycosphingolipid-enriched microdomains 1 isoform X2. (436 aa)
FGFRL1Fibroblast growth factor receptor-like 1 isoform X1. (503 aa)
TEKAngiopoietin-1 receptor. (1125 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
PIK3CGPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X1; Belongs to the PI3/PI4-kinase family. (1102 aa)
INSRTyrosine-protein kinase receptor. (1392 aa)
SH3GL3endophilin-A3 isoform X1. (347 aa)
VAV1Proto-oncogene vav isoform X1. (845 aa)
IRS4Insulin receptor substrate 4 isoform X1. (1267 aa)
FGFR3Fibroblast growth factor receptor. (805 aa)
NGFRTumor necrosis factor receptor superfamily member 16. (427 aa)
NTRK2Tyrosine-protein kinase receptor. (822 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (723 aa)
SHC1SHC-transforming protein 1 isoform X1. (609 aa)
INSRRTyrosine-protein kinase receptor. (1301 aa)
LYNTyrosine-protein kinase. (518 aa)
NTRK1Tyrosine-protein kinase receptor. (795 aa)
PTK2Focal adhesion kinase 1 isoform X22; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1116 aa)
KHDRBS3KH domain-containing, RNA-binding, signal transduction-associated protein 3 isoform X1. (346 aa)
MATKTyrosine-protein kinase. (706 aa)
SH3GL1endophilin-A2 isoform X1. (403 aa)
ERBB2Receptor protein-tyrosine kinase. (1255 aa)
CBLE3 ubiquitin-protein ligase CBL isoform X1. (910 aa)
TGFAProtransforming growth factor alpha isoform X1. (176 aa)
SHC3SHC-transforming protein 3. (588 aa)
LOC111167689GRB2-related adapter protein. (217 aa)
PTPRCReceptor-type tyrosine-protein phosphatase C isoform X1. (1258 aa)
FGF17Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (215 aa)
NTRK3Tyrosine-protein kinase receptor. (864 aa)
PDGFAPlatelet-derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (196 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (977 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
LOC111167795Rho-related GTP-binding protein RhoG-like isoform X1. (230 aa)
PDGFDPlatelet-derived growth factor D isoform X1. (402 aa)
VEGFDVascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (354 aa)
TECTyrosine-protein kinase. (658 aa)
LOC111170545Rho-related GTP-binding protein RhoG. (191 aa)
KLBLOW QUALITY PROTEIN: beta-klotho. (1046 aa)
LOC111171158Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (343 aa)
FGFBP1Fibroblast growth factor-binding protein 1. (237 aa)
FGFR4Fibroblast growth factor receptor. (801 aa)
IRS1Insulin receptor substrate 1. (1248 aa)
TXKTyrosine-protein kinase. (550 aa)
ELMO2Engulfment and cell motility protein 2 isoform X1. (720 aa)
DOCK1Dedicator of cytokinesis protein 1 isoform X1; Belongs to the DOCK family. (1886 aa)
FGFR2Fibroblast growth factor receptor. (841 aa)
ERBB4Receptor protein-tyrosine kinase. (1308 aa)
INPPL1Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 isoform X1. (1264 aa)
KDRVascular endothelial growth factor receptor 2 isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
LOC111171066Fibroblast growth factor 11-like. (90 aa)
SHC2SHC-transforming protein 2 isoform X1. (588 aa)
FGF22Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (255 aa)
GRB14Growth factor receptor-bound protein 14 isoform X1. (540 aa)
FRS2Fibroblast growth factor receptor substrate 2. (508 aa)
INPP5DPhosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1. (1150 aa)
FLT4Vascular endothelial growth factor receptor 3 isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1367 aa)
SOS2Son of sevenless homolog 2 isoform X1. (1332 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (420 aa)
ERBB3Receptor tyrosine-protein kinase erbB-3. (1338 aa)
SH3GL2endophilin-A1. (352 aa)
NRG1Pro-neuregulin-1, membrane-bound isoform isoform X1. (852 aa)
SOS1Son of sevenless homolog 1 isoform X1. (1333 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
FGFR1Fibroblast growth factor receptor. (823 aa)
TIAM1T-lymphoma invasion and metastasis-inducing protein 1 isoform X3. (1606 aa)
BLNKB-cell linker protein isoform X1. (528 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
FLT3Receptor-type tyrosine-protein kinase FLT3 isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (993 aa)
FLT1Vascular endothelial growth factor receptor 1 isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1340 aa)
KHDRBS1KH domain-containing, RNA-binding, signal transduction-associated protein 1. (443 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1. (461 aa)
ANGPT2Angiopoietin-2 isoform X1. (496 aa)
IRS2Insulin receptor substrate 2. (1347 aa)
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
NTF3Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. (265 aa)
PGFPlacenta growth factor isoform X1; Belongs to the PDGF/VEGF growth factor family. (170 aa)
KLKlotho. (1010 aa)
VAV2Guanine nucleotide exchange factor VAV2 isoform X1. (879 aa)
FGF23Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (315 aa)
MST1RMacrophage-stimulating protein receptor isoform X1. (1406 aa)
RAPGEF1Rap guanine nucleotide exchange factor 1 isoform X1. (1259 aa)
FGF16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
BTKTyrosine-protein kinase. (687 aa)
VEGFAVascular endothelial growth factor A isoform X1; Belongs to the PDGF/VEGF growth factor family. (214 aa)
PDGFCPlatelet-derived growth factor C isoform X2. (380 aa)
NRG4Pro-neuregulin-4, membrane-bound isoform. (116 aa)
METHepatocyte growth factor receptor isoform X1. (1382 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
BCAR1Breast cancer anti-estrogen resistance protein 1 isoform X4. (867 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1064 aa)
SORT1Sortilin. (864 aa)
FLT3LGFms-related tyrosine kinase 3 ligand isoform X1. (328 aa)
BDNFBrain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. (330 aa)
AXLLOW QUALITY PROTEIN: tyrosine-protein kinase receptor UFO. (887 aa)
FRS3Fibroblast growth factor receptor substrate 3. (495 aa)
VAV3Guanine nucleotide exchange factor VAV3. (954 aa)
ANGPT1Angiopoietin-1 isoform X1. (498 aa)
ELMO1Engulfment and cell motility protein 1 isoform X1. (727 aa)
GP6Platelet glycoprotein VI isoform X1. (464 aa)
FGF21Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
SPIRE2Protein spire homolog 2 isoform X1. (713 aa)
NEDD9Enhancer of filamentation 1 isoform X1. (829 aa)
ELMO3Engulfment and cell motility protein 3 isoform X1. (782 aa)
YES1Tyrosine-protein kinase. (541 aa)
NGFBeta-nerve growth factor; Belongs to the NGF-beta family. (241 aa)
NRG2Pro-neuregulin-2, membrane-bound isoform isoform X1. (845 aa)
NTF4Neurotrophin-4; Belongs to the NGF-beta family. (247 aa)
SH2B1SH2B adapter protein 1 isoform X1. (795 aa)
HBEGFProheparin-binding EGF-like growth factor. (208 aa)
ITKTyrosine-protein kinase. (620 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1103 aa)
RAC1Ras-related C3 botulinum toxin substrate 1. (192 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1291 aa)
LATLinker for activation of T-cells family member 1 isoform X1. (270 aa)
IGF2Insulin-like growth factor II isoform X3. (237 aa)
LOC111184310Tyrosine-protein kinase. (369 aa)
ANGPT4Angiopoietin-4. (498 aa)
FERTyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (822 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (189 aa)
SRCTyrosine-protein kinase. (562 aa)
HCKTyrosine-protein kinase. (506 aa)
NRG3Pro-neuregulin-3, membrane-bound isoform isoform X2. (725 aa)
FGF3Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (214 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
DOCK5Dedicator of cytokinesis protein 5 isoform X1; Belongs to the DOCK family. (1869 aa)
VEGFBVascular endothelial growth factor B isoform X1; Belongs to the PDGF/VEGF growth factor family. (209 aa)
CRKAdapter molecule crk isoform X1. (304 aa)
CBLBE3 ubiquitin-protein ligase CBL-B. (983 aa)
LOC111186271GRB2-related adapter protein 2-like isoform X1. (105 aa)
DOCK2Dedicator of cytokinesis protein 2 isoform X1; Belongs to the DOCK family. (1828 aa)
PDGFBPlatelet-derived growth factor subunit B isoform X1; Belongs to the PDGF/VEGF growth factor family. (278 aa)
EGFRReceptor protein-tyrosine kinase. (1209 aa)
GAB2GRB2-associated-binding protein 2 isoform X1. (678 aa)
SH2B3SH2B adapter protein 3 isoform X1. (618 aa)
LOC111186270GRB2-related adapter protein 2 isoform X1. (337 aa)
PTK2BProtein-tyrosine kinase 2-beta isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1015 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
LCP2Lymphocyte cytosolic protein 2 isoform X1. (534 aa)
AREGAmphiregulin isoform X1. (254 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
PIK3R5Phosphoinositide 3-kinase regulatory subunit 5 isoform X1. (871 aa)
PIK3R6Phosphoinositide 3-kinase regulatory subunit 6 isoform X1. (881 aa)
IGF1RTyrosine-protein kinase receptor. (1368 aa)
EREGProepiregulin. (163 aa)
EPGNEpigen. (153 aa)
PTK6Non-specific protein-tyrosine kinase. (354 aa)
GAB1GRB2-associated-binding protein 1 isoform X1. (757 aa)
PTPN1Tyrosine-protein phosphatase non-receptor type. (451 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (623 aa)
LOC111187198Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (617 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (919 aa)
BTCProbetacellulin. (178 aa)
FGF5Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (270 aa)
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
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