14 items (Delphinapterus leucas) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	FASLG	Tumor necrosis factor ligand superfamily member 6; Belongs to the tumor necrosis factor family. (262 aa)
	CFLAR	CASP8 and FADD-like apoptosis regulator isoform X1; Belongs to the peptidase C14A family. (547 aa)
	CASP10	Caspase-10; Belongs to the peptidase C14A family. (518 aa)
	CASP8	Caspase-8; Belongs to the peptidase C14A family. (486 aa)
	FAS	Tumor necrosis factor receptor superfamily member 6 isoform X1. (334 aa)
	TNFSF10	Tumor necrosis factor ligand superfamily member. (288 aa)
	TRAF2	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (516 aa)
	TRAF1	TNF receptor-associated factor. (415 aa)
	TRADD	Tumor necrosis factor receptor type 1-associated DEATH domain protein. (315 aa)
	RIPK1	Receptor-interacting serine/threonine-protein kinase 1 isoform X1. (687 aa)
	FADD	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (211 aa)
	LOC111184077	Tumor necrosis factor receptor superfamily member 26-like. (308 aa)
	LOC111185435	Tumor necrosis factor receptor superfamily member 10A-like isoform X1. (454 aa)
	LOC111185436	Tumor necrosis factor receptor superfamily member 10B-like isoform X1. (456 aa)

Your Current Organism:

Delphinapterus leucas

NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CASP10	CASP8	A0A2Y9MLF7	A0A2Y9MQ94	Caspase-10; Belongs to the peptidase C14A family.	Caspase-8; Belongs to the peptidase C14A family.	0.974
CASP10	CFLAR	A0A2Y9MLF7	A0A2Y9MLF1	Caspase-10; Belongs to the peptidase C14A family.	CASP8 and FADD-like apoptosis regulator isoform X1; Belongs to the peptidase C14A family.	0.984
CASP10	FADD	A0A2Y9MLF7	A0A2Y9PNL8	Caspase-10; Belongs to the peptidase C14A family.	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	0.995
CASP10	FAS	A0A2Y9MLF7	A0A2Y9MT08	Caspase-10; Belongs to the peptidase C14A family.	Tumor necrosis factor receptor superfamily member 6 isoform X1.	0.880
CASP10	FASLG	A0A2Y9MLF7	A0A2Y9MFA3	Caspase-10; Belongs to the peptidase C14A family.	Tumor necrosis factor ligand superfamily member 6; Belongs to the tumor necrosis factor family.	0.759
CASP10	LOC111184077	A0A2Y9MLF7	A0A2Y9PXW8	Caspase-10; Belongs to the peptidase C14A family.	Tumor necrosis factor receptor superfamily member 26-like.	0.499
CASP10	LOC111185435	A0A2Y9MLF7	A0A2Y9Q5N6	Caspase-10; Belongs to the peptidase C14A family.	Tumor necrosis factor receptor superfamily member 10A-like isoform X1.	0.658
CASP10	LOC111185436	A0A2Y9MLF7	A0A2Y9Q5P0	Caspase-10; Belongs to the peptidase C14A family.	Tumor necrosis factor receptor superfamily member 10B-like isoform X1.	0.658
CASP10	RIPK1	A0A2Y9MLF7	A0A2Y9PAG9	Caspase-10; Belongs to the peptidase C14A family.	Receptor-interacting serine/threonine-protein kinase 1 isoform X1.	0.888
CASP10	TNFSF10	A0A2Y9MLF7	A0A2Y9N0T6	Caspase-10; Belongs to the peptidase C14A family.	Tumor necrosis factor ligand superfamily member.	0.731
CASP10	TRADD	A0A2Y9MLF7	A0A2Y9P782	Caspase-10; Belongs to the peptidase C14A family.	Tumor necrosis factor receptor type 1-associated DEATH domain protein.	0.974
CASP10	TRAF1	A0A2Y9MLF7	A0A2Y9NTP2	Caspase-10; Belongs to the peptidase C14A family.	TNF receptor-associated factor.	0.655
CASP10	TRAF2	A0A2Y9MLF7	A0A2Y9NLV0	Caspase-10; Belongs to the peptidase C14A family.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.655
CASP8	CASP10	A0A2Y9MQ94	A0A2Y9MLF7	Caspase-8; Belongs to the peptidase C14A family.	Caspase-10; Belongs to the peptidase C14A family.	0.974
CASP8	CFLAR	A0A2Y9MQ94	A0A2Y9MLF1	Caspase-8; Belongs to the peptidase C14A family.	CASP8 and FADD-like apoptosis regulator isoform X1; Belongs to the peptidase C14A family.	0.985
CASP8	FADD	A0A2Y9MQ94	A0A2Y9PNL8	Caspase-8; Belongs to the peptidase C14A family.	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	0.999
CASP8	FAS	A0A2Y9MQ94	A0A2Y9MT08	Caspase-8; Belongs to the peptidase C14A family.	Tumor necrosis factor receptor superfamily member 6 isoform X1.	0.950
CASP8	FASLG	A0A2Y9MQ94	A0A2Y9MFA3	Caspase-8; Belongs to the peptidase C14A family.	Tumor necrosis factor ligand superfamily member 6; Belongs to the tumor necrosis factor family.	0.903
CASP8	LOC111184077	A0A2Y9MQ94	A0A2Y9PXW8	Caspase-8; Belongs to the peptidase C14A family.	Tumor necrosis factor receptor superfamily member 26-like.	0.520
CASP8	LOC111185435	A0A2Y9MQ94	A0A2Y9Q5N6	Caspase-8; Belongs to the peptidase C14A family.	Tumor necrosis factor receptor superfamily member 10A-like isoform X1.	0.658