46 items (Delphinapterus leucas) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PTPN3	Tyrosine-protein phosphatase non-receptor type; May act at junctions between the membrane and the cytoskeleton. (949 aa)
	SAMSN1	SAM domain-containing protein SAMSN-1. (373 aa)
	VAV2	Guanine nucleotide exchange factor VAV2 isoform X1. (879 aa)
	PIK3R3	Phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1. (461 aa)
	IRS1	Insulin receptor substrate 1. (1248 aa)
	SYK	Tyrosine-protein kinase. (626 aa)
	SHE	SH2 domain-containing adapter protein E. (499 aa)
	SH2D3A	SH2 domain-containing protein 3A isoform X1. (601 aa)
	LOC111167689	GRB2-related adapter protein. (217 aa)
	SHC3	SHC-transforming protein 3. (588 aa)
	ABL2	Tyrosine-protein kinase. (1174 aa)
	SHC1	SHC-transforming protein 1 isoform X1. (609 aa)
	PTPN6	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
	LCK	Tyrosine-protein kinase. (509 aa)
	SH2D3C	SH2 domain-containing protein 3C isoform X1. (861 aa)
	ABL1	Tyrosine-protein kinase. (1148 aa)
	PLCG2	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
	CRKL	Crk-like protein. (303 aa)
	LDLRAP1	LOW QUALITY PROTEIN: low density lipoprotein receptor adapter protein 1. (309 aa)
	FGR	Tyrosine-protein kinase. (526 aa)
	MAPK1	Mitogen-activated protein kinase. (380 aa)
	BCAR3	Breast cancer anti-estrogen resistance protein 3 isoform X1. (832 aa)
	VAV1	Proto-oncogene vav isoform X1. (845 aa)
	PTPN5	Tyrosine-protein phosphatase non-receptor type 5. (539 aa)
	YES1	Tyrosine-protein kinase. (541 aa)
	MAPK3	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (382 aa)
	SHF	LOW QUALITY PROTEIN: SH2 domain-containing adapter protein F. (489 aa)
	SOCS3	Suppressor of cytokine signaling 3. (237 aa)
	GRB2	Growth factor receptor-bound protein 2. (217 aa)
	LOC111184310	Tyrosine-protein kinase. (369 aa)
	RASA1	Ras GTPase-activating protein 1 isoform X1. (1040 aa)
	HCK	Tyrosine-protein kinase. (506 aa)
	CRK	Adapter molecule crk isoform X1. (304 aa)
	SH3BP2	SH3 domain-binding protein 2 isoform X1. (617 aa)
	SHD	SH2 domain-containing adapter protein D. (340 aa)
	PIK3R2	Phosphatidylinositol 3-kinase regulatory subunit beta. (723 aa)
	CBLB	E3 ubiquitin-protein ligase CBL-B. (983 aa)
	LOC111186271	GRB2-related adapter protein 2-like isoform X1. (105 aa)
	LOC111186270	GRB2-related adapter protein 2 isoform X1. (337 aa)
	LOC111187417	Tyrosine-protein kinase. (612 aa)
	PIK3R1	Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
	NCK2	Cytoplasmic protein. (376 aa)
	PTPN11	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (623 aa)
	LOC111187198	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (617 aa)
	SHB	SH2 domain-containing adapter protein B. (507 aa)
	CBL	E3 ubiquitin-protein ligase CBL isoform X1. (910 aa)

Your Current Organism:

Delphinapterus leucas

NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABL1	ABL2	A0A2Y9NX24	A0A2Y9LZ58	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.939
ABL1	CBL	A0A2Y9NX24	A0A2Y9M339	Tyrosine-protein kinase.	E3 ubiquitin-protein ligase CBL isoform X1.	0.952
ABL1	CBLB	A0A2Y9NX24	A0A2Y9PXU9	Tyrosine-protein kinase.	E3 ubiquitin-protein ligase CBL-B.	0.534
ABL1	CRK	A0A2Y9NX24	A0A2Y9PWG4	Tyrosine-protein kinase.	Adapter molecule crk isoform X1.	0.970
ABL1	CRKL	A0A2Y9NX24	A0A2Y9LB74	Tyrosine-protein kinase.	Crk-like protein.	0.961
ABL1	FGR	A0A2Y9NX24	A0A2Y9LD17	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.436
ABL1	GRB2	A0A2Y9NX24	A0A2Y9PJ90	Tyrosine-protein kinase.	Growth factor receptor-bound protein 2.	0.959
ABL1	NCK2	A0A2Y9NX24	A0A2Y9QBN6	Tyrosine-protein kinase.	Cytoplasmic protein.	0.404
ABL1	SHC1	A0A2Y9NX24	A0A2Y9LZK9	Tyrosine-protein kinase.	SHC-transforming protein 1 isoform X1.	0.927
ABL1	SHC3	A0A2Y9NX24	A0A2Y9M5N9	Tyrosine-protein kinase.	SHC-transforming protein 3.	0.927
ABL1	SYK	A0A2Y9NX24	A0A2Y9MGM5	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.462
ABL2	ABL1	A0A2Y9LZ58	A0A2Y9NX24	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.939
ABL2	CBL	A0A2Y9LZ58	A0A2Y9M339	Tyrosine-protein kinase.	E3 ubiquitin-protein ligase CBL isoform X1.	0.610
ABL2	CBLB	A0A2Y9LZ58	A0A2Y9PXU9	Tyrosine-protein kinase.	E3 ubiquitin-protein ligase CBL-B.	0.534
ABL2	CRK	A0A2Y9LZ58	A0A2Y9PWG4	Tyrosine-protein kinase.	Adapter molecule crk isoform X1.	0.970
ABL2	CRKL	A0A2Y9LZ58	A0A2Y9LB74	Tyrosine-protein kinase.	Crk-like protein.	0.961
ABL2	GRB2	A0A2Y9LZ58	A0A2Y9PJ90	Tyrosine-protein kinase.	Growth factor receptor-bound protein 2.	0.610
ABL2	NCK2	A0A2Y9LZ58	A0A2Y9QBN6	Tyrosine-protein kinase.	Cytoplasmic protein.	0.404
CBL	ABL1	A0A2Y9M339	A0A2Y9NX24	E3 ubiquitin-protein ligase CBL isoform X1.	Tyrosine-protein kinase.	0.952
CBL	ABL2	A0A2Y9M339	A0A2Y9LZ58	E3 ubiquitin-protein ligase CBL isoform X1.	Tyrosine-protein kinase.	0.610