STRINGSTRING
LBP LBP GPR18 GPR18 TSKU TSKU LRRC32 LRRC32 IL10 IL10 ATG12 ATG12 VSIR VSIR BPI BPI TWIST1 TWIST1 NDFIP1 NDFIP1 WNT11 WNT11 THBS1 THBS1 MAPKBP1 MAPKBP1 KAT5 KAT5 TMEM130 TMEM130 NPLOC4 NPLOC4 TYROBP TYROBP FOXJ1 FOXJ1 NDRG2 NDRG2 GPNMB GPNMB PGLYRP1 PGLYRP1 SMAD7 SMAD7 PTPN22 PTPN22 GATA6 GATA6 LGR4 LGR4 MUL1 MUL1 TWSG1 TWSG1 F2RL1 F2RL1 PLA2G10 PLA2G10 EPX EPX GPATCH3 GPATCH3 ATP2B1 ATP2B1 UFD1 UFD1 CIDEA CIDEA TRIB2 TRIB2 HGF HGF ADCY7 ADCY7 N4BP1 N4BP1 NOD2 NOD2 ATG5 ATG5 RARA RARA TBX21 TBX21 CCR7 CCR7 TNFAIP3 TNFAIP3 HOMER2 HOMER2 APOA1 APOA1 SYT11 SYT11 IL27RA IL27RA APOA2 APOA2 CD84 CD84 GBA GBA LOC111167004 LOC111167004 TIGIT TIGIT EZR EZR NLRX1 NLRX1 HOMER3 HOMER3 TIA1 TIA1 ANXA4 ANXA4 LOC111165753 LOC111165753 MMP8 MMP8 PTPRC PTPRC CACTIN CACTIN LOC111168424 LOC111168424 SLAMF1 SLAMF1 HFE HFE DHX58 DHX58 SLC37A4 SLC37A4 PGLYRP2 PGLYRP2 NMBR NMBR VSIG4 VSIG4 LOC111169442 LOC111169442 CX3CR1 CX3CR1 FURIN FURIN DLL1 DLL1 SLC2A10 SLC2A10 FOXP3 FOXP3 SIGIRR SIGIRR ELANE ELANE IL12B IL12B NLRP6 NLRP6 CHID1 CHID1 RNF128 RNF128 AGER AGER SERPINB1 SERPINB1 ABCD1 ABCD1 LEF1 LEF1 NFKBIL1 NFKBIL1 SLC11A1 SLC11A1 CCDC142 CCDC142 LOC111171320 LOC111171320 TNFSF4 TNFSF4 OTUD7B OTUD7B APOD APOD FFAR4 FFAR4 BCL6 BCL6 NMI NMI INPP5D INPP5D INHBB INHBB CUEDC2 CUEDC2 NCKAP1L NCKAP1L HDAC7 HDAC7 ABCD2 ABCD2 FN1 FN1 TRAIP TRAIP DDIT3 DDIT3 ANXA1 ANXA1 PYCARD PYCARD CD83 CD83 TNFRSF21 TNFRSF21 RNF125 RNF125 TGFB1 TGFB1 FFAR1 FFAR1 BCL3 BCL3 C5AR2 C5AR2 NFKB1 NFKB1 SARS SARS ZFP36 ZFP36 TREM2 TREM2 AXL AXL GATA3 GATA3 IL20RB IL20RB BANK1 BANK1 CDH3 CDH3 LOC111176900 LOC111176900 ZFPM1 ZFPM1 LAG3 LAG3 TGFB3 TGFB3 PML PML CD2AP CD2AP BTK BTK NPTN NPTN F2 F2 GAS6 GAS6 TGFB2 TGFB2 CHRNA7 CHRNA7 PTPN6 PTPN6 IL12A IL12A PIBF1 PIBF1 DICER1 DICER1 LAPTM4A LAPTM4A IFNG IFNG IDO1 IDO1 YY1 YY1 LTF LTF TUSC2 TUSC2 PPM1B PPM1B ZC3H12A ZC3H12A GHSR GHSR IRAK3 IRAK3 CD96 CD96 TLR9 TLR9 PDCD4 PDCD4 SOCS5 SOCS5 ARG2 ARG2 TRAF3IP1 TRAF3IP1 TNF TNF IL1R2 IL1R2 IL1RL1 IL1RL1 MERTK MERTK LOC111187154 LOC111187154 PTGER4 PTGER4 CMKLR1 CMKLR1 APPL2 APPL2 IGF1 IGF1 C1QTNF3 C1QTNF3 REL REL IL36RN IL36RN EPHA2 EPHA2 NR1H4 NR1H4 GIT1 GIT1 LGALS9 LGALS9 LOC111186676 LOC111186676 S100B S100B CPTP CPTP NLRC3 NLRC3 C1QBP C1QBP ARRB2 ARRB2 ARRB1 ARRB1 PPARA PPARA ERBIN ERBIN
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LBPLipopolysaccharide-binding protein isoform X1. (537 aa)
GPR18N-arachidonyl glycine receptor; Belongs to the G-protein coupled receptor 1 family. (338 aa)
TSKUTsukushin isoform X1. (367 aa)
LRRC32Leucine-rich repeat-containing protein 32 isoform X1. (676 aa)
IL10Interleukin-10. (178 aa)
ATG12Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family. (140 aa)
VSIRV-type immunoglobulin domain-containing suppressor of T-cell activation. (311 aa)
BPIBactericidal permeability-increasing protein isoform X1. (483 aa)
TWIST1Twist-related protein 1. (205 aa)
NDFIP1NEDD4 family-interacting protein 1. (221 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
THBS1Thrombospondin-1. (1170 aa)
MAPKBP1Mitogen-activated protein kinase-binding protein 1 isoform X1. (1510 aa)
KAT5Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (546 aa)
TMEM130Transmembrane protein 130 isoform X1. (435 aa)
NPLOC4Nuclear protein localization protein 4 homolog isoform X1. (614 aa)
TYROBPTYRO protein tyrosine kinase-binding protein isoform X1. (126 aa)
FOXJ1Forkhead box protein J1. (422 aa)
NDRG2Protein NDRG2 isoform X1. (357 aa)
GPNMBTransmembrane glycoprotein NMB. (553 aa)
PGLYRP1LOW QUALITY PROTEIN: peptidoglycan recognition protein 1. (185 aa)
SMAD7Mothers against decapentaplegic homolog. (426 aa)
PTPN22Tyrosine-protein phosphatase non-receptor type 22 isoform X1. (801 aa)
GATA6Transcription factor GATA-6. (592 aa)
LGR4Leucine-rich repeat-containing G-protein coupled receptor 4 isoform X1. (951 aa)
MUL1Mitochondrial ubiquitin ligase activator of NFKB 1 isoform X1. (352 aa)
TWSG1Twisted gastrulation protein homolog 1. (223 aa)
F2RL1Proteinase-activated receptor 2. (315 aa)
PLA2G10Phospholipase A(2). (159 aa)
EPXEosinophil peroxidase. (715 aa)
GPATCH3G patch domain-containing protein 3 isoform X1. (552 aa)
ATP2B1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1258 aa)
UFD1Ubiquitin recognition factor in ER-associated degradation protein 1. (307 aa)
CIDEACell death activator CIDE-A. (219 aa)
TRIB2Tribbles homolog 2. (343 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (729 aa)
ADCY7Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1079 aa)
N4BP1NEDD4-binding protein 1 isoform X1. (906 aa)
NOD2Nucleotide-binding oligomerization domain-containing protein 2 isoform X1. (1086 aa)
ATG5Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
RARARetinoic acid receptor alpha isoform X5. (584 aa)
TBX21T-box transcription factor TBX21. (535 aa)
CCR7C-C chemokine receptor type 7; Belongs to the G-protein coupled receptor 1 family. (379 aa)
TNFAIP3Tumor necrosis factor alpha-induced protein 3. (785 aa)
HOMER2Homer protein homolog 2 isoform X1. (343 aa)
APOA1Apolipoprotein A-I. (265 aa)
SYT11Synaptotagmin-11 isoform X1. (428 aa)
IL27RAInterleukin-27 receptor subunit alpha isoform X1. (656 aa)
APOA2Apolipoprotein A-II. (103 aa)
CD84SLAM family member 5 isoform X1. (341 aa)
GBAGlucosylceramidase. (585 aa)
LOC111167004LOW QUALITY PROTEIN: peptidoglycan recognition protein 3-like. (277 aa)
TIGITT-cell immunoreceptor with Ig and ITIM domains. (243 aa)
EZREzrin. (586 aa)
NLRX1NLR family member X1 isoform X1. (973 aa)
HOMER3Homer protein homolog 3. (360 aa)
TIA1Nucleolysin TIA-1 isoform X1. (399 aa)
ANXA4Annexin. (319 aa)
LOC111165753NACHT, LRR and PYD domains-containing protein 12 isoform X2. (1105 aa)
MMP8Neutrophil collagenase isoform X1. (468 aa)
PTPRCReceptor-type tyrosine-protein phosphatase C isoform X1. (1258 aa)
CACTINCactin. (755 aa)
LOC111168424Zinc finger protein RFP. (513 aa)
SLAMF1Signaling lymphocytic activation molecule isoform X1. (378 aa)
HFEHereditary hemochromatosis protein isoform X1; Belongs to the MHC class I family. (356 aa)
DHX58Probable ATP-dependent RNA helicase DHX58 isoform X1. (680 aa)
SLC37A4Glucose-6-phosphate exchanger SLC37A4 isoform X1. (429 aa)
PGLYRP2N-acetylmuramoyl-L-alanine amidase isoform X1. (581 aa)
NMBRLOW QUALITY PROTEIN: neuromedin-B receptor. (394 aa)
VSIG4V-set and immunoglobulin domain-containing protein 4. (399 aa)
LOC111169442Barrier-to-autointegration factor. (89 aa)
CX3CR1CX3C chemokine receptor 1 isoform X1; Belongs to the G-protein coupled receptor 1 family. (475 aa)
FURINFurin; Belongs to the peptidase S8 family. (792 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (799 aa)
SLC2A10Solute carrier family 2, facilitated glucose transporter member 10 isoform X1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (572 aa)
FOXP3Forkhead box protein P3. (431 aa)
SIGIRRSingle Ig IL-1-related receptor isoform X1. (479 aa)
ELANENeutrophil elastase; Belongs to the peptidase S1 family. (308 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (329 aa)
NLRP6LOW QUALITY PROTEIN: NACHT, LRR and PYD domains-containing protein 6. (876 aa)
CHID1Chitinase domain-containing protein 1 isoform X1; Belongs to the glycosyl hydrolase 18 family. (393 aa)
RNF128E3 ubiquitin-protein ligase RNF128 isoform X1. (431 aa)
AGERAdvanced glycosylation end product-specific receptor isoform X1. (631 aa)
SERPINB1Leukocyte elastase inhibitor; Belongs to the serpin family. (379 aa)
ABCD1ATP-binding cassette sub-family D member 1 isoform X1. (774 aa)
LEF1Lymphoid enhancer-binding factor 1 isoform X1. (414 aa)
NFKBIL1NF-kappa-B inhibitor-like protein 1 isoform X1. (380 aa)
SLC11A1Natural resistance-associated macrophage protein 1 isoform X1. (546 aa)
CCDC142Coiled-coil domain-containing protein 142 isoform X1. (771 aa)
LOC111171320Mucin-16-like. (855 aa)
TNFSF4Tumor necrosis factor ligand superfamily member 4; Belongs to the tumor necrosis factor family. (182 aa)
OTUD7BOTU domain-containing protein 7B isoform X1. (874 aa)
APODApolipoprotein D. (213 aa)
FFAR4Free fatty acid receptor 4 isoform X3. (375 aa)
BCL6B-cell lymphoma 6 protein. (706 aa)
NMIN-myc-interactor isoform X1. (309 aa)
INPP5DPhosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1. (1150 aa)
INHBBInhibin beta B chain. (407 aa)
CUEDC2CUE domain-containing protein 2 isoform X1. (284 aa)
NCKAP1LNck-associated protein 1-like isoform X1. (1156 aa)
HDAC7Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1049 aa)
ABCD2ATP-binding cassette sub-family D member 2. (741 aa)
FN1Fibronectin isoform X5. (2478 aa)
TRAIPE3 ubiquitin-protein ligase TRAIP isoform X1. (471 aa)
DDIT3DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...] (168 aa)
ANXA1Annexin. (346 aa)
PYCARDApoptosis-associated speck-like protein containing a CARD. (195 aa)
CD83CD83 antigen isoform X1. (195 aa)
TNFRSF21Tumor necrosis factor receptor superfamily member 21 isoform X3. (701 aa)
RNF125E3 ubiquitin-protein ligase RNF125 isoform X1. (274 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (391 aa)
FFAR1Free fatty acid receptor 1. (300 aa)
BCL3B-cell lymphoma 3 protein. (454 aa)
C5AR2C5a anaphylatoxin chemotactic receptor 2 isoform X1. (343 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit isoform X1. (972 aa)
SARSserine--tRNA ligase, cytoplasmic. (514 aa)
ZFP36mRNA decay activator protein ZFP36. (325 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (294 aa)
AXLLOW QUALITY PROTEIN: tyrosine-protein kinase receptor UFO. (887 aa)
GATA3Trans-acting T-cell-specific transcription factor GATA-3 isoform X1. (444 aa)
IL20RBInterleukin-20 receptor subunit beta isoform X1. (342 aa)
BANK1B-cell scaffold protein with ankyrin repeats isoform X1. (785 aa)
CDH3Cadherin-3 isoform X1; Cadherins are calcium-dependent cell adhesion proteins. (834 aa)
LOC111176900GTPase IMAP family member 5-like isoform X1. (332 aa)
ZFPM1Zinc finger protein ZFPM1 isoform X1. (1069 aa)
LAG3Lymphocyte activation gene 3 protein. (493 aa)
TGFB3Transforming growth factor beta-3. (456 aa)
PMLProtein PML isoform X1. (861 aa)
CD2APCD2-associated protein isoform X1. (680 aa)
BTKTyrosine-protein kinase. (687 aa)
NPTNNeuroplastin isoform X1. (398 aa)
F2Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. (623 aa)
GAS6Growth arrest-specific protein 6. (671 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
CHRNA7Neuronal acetylcholine receptor subunit alpha-7 isoform X2. (499 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (222 aa)
PIBF1Progesterone-induced-blocking factor 1 isoform X1. (757 aa)
DICER1Endoribonuclease Dicer; Belongs to the helicase family. Dicer subfamily. (1921 aa)
LAPTM4ALysosomal-associated transmembrane protein 4A. (233 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
IDO1Indoleamine 2,3-dioxygenase 1 isoform X1. (410 aa)
YY1Transcriptional repressor protein YY1. (412 aa)
LTFLactotransferrin; Belongs to the transferrin family. (710 aa)
TUSC2Tumor suppressor candidate 2. (110 aa)
PPM1BProtein phosphatase 1B isoform X1. (479 aa)
ZC3H12AEndoribonuclease ZC3H12A. (583 aa)
GHSRGrowth hormone secretagogue receptor type 1; Belongs to the G-protein coupled receptor 1 family. (366 aa)
IRAK3Interleukin-1 receptor-associated kinase 3 isoform X2. (674 aa)
CD96LOW QUALITY PROTEIN: T-cell surface protein tactile. (546 aa)
TLR9LOW QUALITY PROTEIN: toll-like receptor 9. (1323 aa)
PDCD4Programmed cell death protein 4 isoform X1. (469 aa)
SOCS5Suppressor of cytokine signaling 5. (536 aa)
ARG2Arginase. (354 aa)
TRAF3IP1TRAF3-interacting protein 1 isoform X1. (721 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (233 aa)
IL1R2Interleukin-1 receptor type 2. (421 aa)
IL1RL1Interleukin-1 receptor-like 1 isoform X1. (592 aa)
MERTKTyrosine-protein kinase Mer. (999 aa)
LOC111187154Ephrin type-A receptor 2-like. (171 aa)
PTGER4Prostaglandin E2 receptor EP4 subtype; Belongs to the G-protein coupled receptor 1 family. (486 aa)
CMKLR1Chemokine-like receptor 1; Belongs to the G-protein coupled receptor 1 family. (365 aa)
APPL2DCC-interacting protein 13-beta isoform X2. (661 aa)
IGF1Insulin-like growth factor I isoform X1. (186 aa)
C1QTNF3Complement C1q tumor necrosis factor-related protein 3 isoform X1. (319 aa)
RELProto-oncogene c-Rel. (594 aa)
IL36RNInterleukin-1. (155 aa)
EPHA2Ephrin type-A receptor 2. (975 aa)
NR1H4Bile acid receptor isoform X1. (486 aa)
GIT1ARF GTPase-activating protein GIT1 isoform X1. (770 aa)
LGALS9Galectin. (356 aa)
LOC111186676Uncharacterized protein C6orf106. (290 aa)
S100BProtein S100; Belongs to the S-100 family. (92 aa)
CPTPCeramide-1-phosphate transfer protein. (214 aa)
NLRC3NLR family CARD domain-containing protein 3 isoform X1. (1066 aa)
C1QBPComplement component 1 Q subcomponent-binding protein, mitochondrial. (278 aa)
ARRB2Beta-arrestin-2 isoform X1. (409 aa)
ARRB1Beta-arrestin-1 isoform X1. (430 aa)
PPARAPeroxisome proliferator-activated receptor alpha. (468 aa)
ERBINErbin isoform X1. (1457 aa)
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
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