STRINGSTRING
ATAD5 ATAD5 TMEM98 TMEM98 IL18R1 IL18R1 KIAA1841 KIAA1841 PTK2B PTK2B MFNG MFNG CD180 CD180 GAPT GAPT ADA ADA UNC13D UNC13D CUNH17orf99 CUNH17orf99 UNG UNG LOC111163131 LOC111163131 F2RL1 F2RL1 FGL2 FGL2 IFNE IFNE LOC111163130 LOC111163130 TBX21 TBX21 DLL1 DLL1 IL6R IL6R LOC111169074 LOC111169074 SEMA4A SEMA4A POU2AF1 POU2AF1 PLCL2 PLCL2 CCR6 CCR6 CD244 CD244 FCER1G FCER1G SLAMF6 SLAMF6 STAT3 STAT3 SWAP70 SWAP70 ST3GAL1 ST3GAL1 DEF6 DEF6 BATF BATF PSEN1 PSEN1 ITM2A ITM2A ABL1 ABL1 RAB44 RAB44 IRF8 IRF8 PLCG2 PLCG2 RC3H2 RC3H2 GATA3 GATA3 ERCC1 ERCC1 RNF8 RNF8 BCL3 BCL3 IRF4 IRF4 NBN NBN EXOSC6 EXOSC6 CDH17 CDH17 CD19 CD19 NOTCH2 NOTCH2 NKG7 NKG7 CD74 CD74 ITGAL ITGAL STAT6 STAT6 LOC111171122 LOC111171122 LOC111171053 LOC111171053 LOC111171121 LOC111171121 BCL6 BCL6 NKX2-3 NKX2-3 ENTPD7 ENTPD7 RNF168 RNF168 RC3H1 RC3H1 SLC11A1 SLC11A1 LEF1 LEF1 VAMP7 VAMP7 IL12B IL12B IFNB1 IFNB1 TNFSF18 TNFSF18 FOXP3 FOXP3 EOMES EOMES LFNG LFNG PTGER4 PTGER4 MTOR MTOR IL21 IL21 IL6 IL6 EXOSC3 EXOSC3 CORO1A CORO1A TSC1 TSC1 LCP1 LCP1 LOC111176721 LOC111176721 EXO1 EXO1 HLX HLX LIG4 LIG4 AICDA AICDA MSH2 MSH2 RORA RORA CRACR2A CRACR2A ITFG2 ITFG2 LOC111176429 LOC111176429 MSH6 MSH6
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ATAD5ATPase family AAA domain-containing protein 5 isoform X1. (1898 aa)
TMEM98Transmembrane protein 98. (226 aa)
IL18R1Interleukin-18 receptor 1 isoform X1. (539 aa)
KIAA1841Uncharacterized protein KIAA1841 homolog isoform X1. (717 aa)
PTK2BProtein-tyrosine kinase 2-beta isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1015 aa)
MFNGbeta-1,3-N-acetylglucosaminyltransferase manic fringe isoform X1. (345 aa)
CD180CD180 antigen. (661 aa)
GAPTProtein GAPT. (157 aa)
ADAAdenosine deaminase isoform X1. (416 aa)
UNC13DProtein unc-13 homolog D isoform X1. (1121 aa)
CUNH17orf99Uncharacterized protein C17orf99 homolog. (199 aa)
UNGUracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine; Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family. (304 aa)
LOC111163131Interferon alpha-13-like. (170 aa)
F2RL1Proteinase-activated receptor 2. (315 aa)
FGL2Fibroleukin. (440 aa)
IFNEInterferon epsilon. (193 aa)
LOC111163130Interferon alpha-1-like. (226 aa)
TBX21T-box transcription factor TBX21. (535 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (799 aa)
IL6RInterleukin-6 receptor subunit alpha isoform X1. (465 aa)
LOC111169074Dedicator of cytokinesis protein 11 isoform X1; Belongs to the DOCK family. (735 aa)
SEMA4Asemaphorin-4A; Belongs to the semaphorin family. (762 aa)
POU2AF1POU domain class 2-associating factor 1. (256 aa)
PLCL2Phosphoinositide phospholipase C. (1130 aa)
CCR6C-C chemokine receptor type 6; Belongs to the G-protein coupled receptor 1 family. (375 aa)
CD244Natural killer cell receptor 2B4. (369 aa)
FCER1GHigh affinity immunoglobulin epsilon receptor subunit gamma. (86 aa)
SLAMF6SLAM family member 6 isoform X1. (335 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
SWAP70Switch-associated protein 70. (585 aa)
ST3GAL1CMP-N-acetylneuraminate-beta-galactosamide- alpha-2,3-sialyltransferase 1; Belongs to the glycosyltransferase 29 family. (342 aa)
DEF6Differentially expressed in FDCP 6 homolog isoform X1. (673 aa)
BATFBasic leucine zipper transcriptional factor ATF-like. (125 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (468 aa)
ITM2AIntegral membrane protein 2A. (263 aa)
ABL1Tyrosine-protein kinase. (1148 aa)
RAB44Ras-related protein Rab-44 isoform X1. (1086 aa)
IRF8Interferon regulatory factor 8 isoform X1. (427 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
RC3H2Roquin-2. (1189 aa)
GATA3Trans-acting T-cell-specific transcription factor GATA-3 isoform X1. (444 aa)
ERCC1DNA excision repair protein ERCC-1 isoform X1. (414 aa)
RNF8E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (487 aa)
BCL3B-cell lymphoma 3 protein. (454 aa)
IRF4Interferon regulatory factor 4 isoform X1. (451 aa)
NBNNibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (727 aa)
EXOSC6Exosome complex component MTR3. (272 aa)
CDH17Cadherin-17 isoform X1. (832 aa)
CD19B-lymphocyte antigen CD19 isoform X1. (570 aa)
NOTCH2Neurogenic locus notch homolog protein 2 isoform X1. (2471 aa)
NKG7Protein NKG7. (165 aa)
CD74HLA class II histocompatibility antigen gamma chain isoform X1. (278 aa)
ITGALIntegrin alpha-L; Belongs to the integrin alpha chain family. (1166 aa)
STAT6Signal transducer and activator of transcription. (847 aa)
LOC111171122Interferon alpha-1-like isoform X1. (195 aa)
LOC111171053Dedicator of cytokinesis protein 11-like isoform X1. (456 aa)
LOC111171121Interferon alpha-1-like. (133 aa)
BCL6B-cell lymphoma 6 protein. (706 aa)
NKX2-3Homeobox protein Nkx-2.3. (366 aa)
ENTPD7Ectonucleoside triphosphate diphosphohydrolase 7; Belongs to the GDA1/CD39 NTPase family. (602 aa)
RNF168E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...] (592 aa)
RC3H1Roquin-1 isoform X1. (1135 aa)
SLC11A1Natural resistance-associated macrophage protein 1 isoform X1. (546 aa)
LEF1Lymphoid enhancer-binding factor 1 isoform X1. (414 aa)
VAMP7Vesicle-associated membrane protein 7; Belongs to the synaptobrevin family. (220 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (329 aa)
IFNB1Interferon beta. (185 aa)
TNFSF18Tumor necrosis factor ligand superfamily member 18. (178 aa)
FOXP3Forkhead box protein P3. (431 aa)
EOMESEomesodermin homolog isoform X1. (711 aa)
LFNGBeta-1,3-N-acetylglucosaminyltransferase. (378 aa)
PTGER4Prostaglandin E2 receptor EP4 subtype; Belongs to the G-protein coupled receptor 1 family. (486 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2548 aa)
IL21Interleukin; Belongs to the IL-15/IL-21 family. (146 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (208 aa)
EXOSC3Exosome complex component RRP40. (275 aa)
CORO1ACoronin; Belongs to the WD repeat coronin family. (461 aa)
TSC1Hamartin. (1169 aa)
LCP1Plastin-2. (627 aa)
LOC111176721C-type lectin domain family 4 member E-like. (212 aa)
EXO1Exonuclease 1. (801 aa)
HLXH2.0-like homeobox protein. (488 aa)
LIG4DNA ligase. (911 aa)
AICDASingle-stranded DNA cytosine deaminase. (208 aa)
MSH2DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (934 aa)
RORANuclear receptor ROR-alpha isoform X1. (523 aa)
CRACR2AEF-hand calcium-binding domain-containing protein 4B isoform X1. (722 aa)
ITFG2KICSTOR complex protein ITFG2 isoform X1. (450 aa)
LOC111176429G-protein coupled receptor 183; Belongs to the G-protein coupled receptor 1 family. (360 aa)
MSH6DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1361 aa)
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
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