STRINGSTRING
PLA2G3 PLA2G3 UNG UNG BCR BCR C1QA C1QA LOC111163731 LOC111163731 C1QC C1QC MYD88 MYD88 TRAF3IP2 TRAF3IP2 CTSH CTSH KMT2E KMT2E C1QB C1QB EMP2 EMP2 LOC111166100 LOC111166100 LYST LYST LOC111166170 LOC111166170 LOC111164234 LOC111164234 LOC111166483 LOC111166483 SWAP70 SWAP70 CLNK CLNK FCER1G FCER1G S100A13 S100A13 C3 C3 CD8A CD8A CCR6 CCR6 JAG1 JAG1 ADORA2B ADORA2B SH2D1A SH2D1A LOC111166880 LOC111166880 BTN3A3 BTN3A3 KIT KIT FOXP3 FOXP3 IRF7 IRF7 CD40 CD40 SYK SYK AZU1 AZU1 JAGN1 JAGN1 ELANE ELANE VAMP7 VAMP7 LOC111170700 LOC111170700 NLRP6 NLRP6 RFTN1 RFTN1 RNF168 RNF168 GZMM GZMM BCL6 BCL6 MBL2 MBL2 WDR1 WDR1 PTGDR PTGDR C2 C2 INPP5D INPP5D STAT6 STAT6 TREX1 TREX1 MSH6 MSH6 IRAK4 IRAK4 C8B C8B CHGA CHGA PRKCD PRKCD C8A C8A TUSC2 TUSC2 C1S C1S RNF19B RNF19B PTPN6 PTPN6 C1R C1R MSH2 MSH2 AICDA AICDA PTGDS PTGDS LIG4 LIG4 KIF5B KIF5B C5 C5 EXO1 EXO1 LOC111178659 LOC111178659 DEF6 DEF6 MORN5 MORN5 BTK BTK CARD9 CARD9 BATF BATF LAG3 LAG3 DBH DBH RAB44 RAB44 EPHB6 EPHB6 ERCC1 ERCC1 RNF8 RNF8 CEBPG CEBPG BCL10 BCL10 FCAR FCAR BCL3 BCL3 NBN NBN CD2 CD2 EXOSC6 EXOSC6 STXBP3 STXBP3 GRP GRP CD19 CD19 SNAP23 SNAP23 RASGRP1 RASGRP1 IL4R IL4R IL21R IL21R ZP3 ZP3 NKG7 NKG7 MILR1 MILR1 CD81 CD81 CD74 CD74 PRF1 PRF1 CORO1A CORO1A PPP3CB PPP3CB SCNN1B SCNN1B UNC13D UNC13D LOC111184729 LOC111184729 CTSC CTSC NDST2 NDST2 LOC111184601 LOC111184601 C4BPA C4BPA LOC111184602 LOC111184602 TCIRG1 TCIRG1 C4BPB C4BPB F2 F2 VAMP2 VAMP2 MYO1G MYO1G CSF2RB CSF2RB CD55 CD55 C1QBP C1QBP AIRE AIRE IL9R IL9R PLEKHM2 PLEKHM2 CPLX2 CPLX2 KIAA1841 KIAA1841 IL7R IL7R ATAD5 ATAD5 C6 C6 C7 C7 C9 C9 ANXA3 ANXA3 MASP2 MASP2 EXOSC3 EXOSC3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PLA2G3Group 3 secretory phospholipase A2 isoform X1. (516 aa)
UNGUracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine; Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family. (304 aa)
BCRBreakpoint cluster region protein isoform X1. (1275 aa)
C1QAComplement C1q subcomponent subunit A. (245 aa)
LOC111163731C-C motif chemokine. (93 aa)
C1QCComplement C1q subcomponent subunit C. (245 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (296 aa)
TRAF3IP2Adapter protein CIKS isoform X1. (564 aa)
CTSHPro-cathepsin H; Belongs to the peptidase C1 family. (335 aa)
KMT2ELOW QUALITY PROTEIN: histone-lysine N-methyltransferase 2E. (1857 aa)
C1QBComplement C1q subcomponent subunit B. (290 aa)
EMP2Epithelial membrane protein 2; Functions as a key regulator of cell membrane composition by regulating proteins surface expression. Also, plays a role in regulation of processes including cell migration, cell proliferation, cell contraction and cell adhesion; Belongs to the PMP-22/EMP/MP20 family. (167 aa)
LOC111166100Complement C3-like isoform X1. (1706 aa)
LYSTLysosomal-trafficking regulator isoform X1. (3861 aa)
LOC111166170C-type lectin domain family 4 member G-like isoform X1. (313 aa)
LOC111164234Granzyme B-like isoform X1; Belongs to the peptidase S1 family. (248 aa)
LOC111166483Signal transducer and activator of transcription. (787 aa)
SWAP70Switch-associated protein 70. (585 aa)
CLNKCytokine-dependent hematopoietic cell linker isoform X1. (452 aa)
FCER1GHigh affinity immunoglobulin epsilon receptor subunit gamma. (86 aa)
S100A13Protein S100-A13; Belongs to the S-100 family. (98 aa)
C3Complement C3 isoform X1. (1695 aa)
CD8AT-cell surface glycoprotein CD8 alpha chain isoform X1. (239 aa)
CCR6C-C chemokine receptor type 6; Belongs to the G-protein coupled receptor 1 family. (375 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1221 aa)
ADORA2BAdenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (333 aa)
SH2D1ASH2 domain-containing protein 1A; Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as SLAMF1, CD244, LY9, CD84, SLAMF6 and SLAMF7. In SLAM signaling seems to cooperate with SH2D1B/EAT-2. (128 aa)
LOC111166880LOW QUALITY PROTEIN: NKG2D ligand 4-like. (234 aa)
BTN3A3Butyrophilin subfamily 3 member A3 isoform X1. (630 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (977 aa)
FOXP3Forkhead box protein P3. (431 aa)
IRF7Interferon regulatory factor 7 isoform X1. (473 aa)
CD40Tumor necrosis factor receptor superfamily member 5 isoform X1. (284 aa)
SYKTyrosine-protein kinase. (626 aa)
AZU1Azurocidin. (252 aa)
JAGN1Protein jagunal homolog 1. (183 aa)
ELANENeutrophil elastase; Belongs to the peptidase S1 family. (308 aa)
VAMP7Vesicle-associated membrane protein 7; Belongs to the synaptobrevin family. (220 aa)
LOC111170700Complement C4-like isoform X1. (1740 aa)
NLRP6LOW QUALITY PROTEIN: NACHT, LRR and PYD domains-containing protein 6. (876 aa)
RFTN1Raftlin. (567 aa)
RNF168E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...] (592 aa)
GZMMGranzyme M; Belongs to the peptidase S1 family. (257 aa)
BCL6B-cell lymphoma 6 protein. (706 aa)
MBL2LOW QUALITY PROTEIN: mannose-binding protein C. (244 aa)
WDR1WD repeat-containing protein 1. (606 aa)
PTGDRProstaglandin D2 receptor. (361 aa)
C2Complement C2 isoform X1; Belongs to the peptidase S1 family. (751 aa)
INPP5DPhosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1. (1150 aa)
STAT6Signal transducer and activator of transcription. (847 aa)
TREX1Three-prime repair exonuclease 1. (314 aa)
MSH6DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1361 aa)
IRAK4Interleukin-1 receptor-associated kinase 4 isoform X1. (460 aa)
C8BComplement component C8 beta chain isoform X1. (590 aa)
CHGAchromogranin-A isoform X1. (445 aa)
PRKCDProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (733 aa)
C8AComplement component C8 alpha chain isoform X1. (589 aa)
TUSC2Tumor suppressor candidate 2. (110 aa)
C1SComplement C1s subcomponent; Belongs to the peptidase S1 family. (695 aa)
RNF19BRBR-type E3 ubiquitin transferase. (732 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
C1RComplement C1r subcomponent isoform X1; Belongs to the peptidase S1 family. (713 aa)
MSH2DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (934 aa)
AICDASingle-stranded DNA cytosine deaminase. (208 aa)
PTGDSprostaglandin-H2 D-isomerase; Belongs to the calycin superfamily. Lipocalin family. (191 aa)
LIG4DNA ligase. (911 aa)
KIF5BKinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (964 aa)
C5Complement C5 isoform X1. (1677 aa)
EXO1Exonuclease 1. (801 aa)
LOC111178659Antigen peptide transporter 2-like isoform X4. (758 aa)
DEF6Differentially expressed in FDCP 6 homolog isoform X1. (673 aa)
MORN5MORN repeat-containing protein 5 isoform X1. (172 aa)
BTKTyrosine-protein kinase. (687 aa)
CARD9Caspase recruitment domain-containing protein 9 isoform X1. (539 aa)
BATFBasic leucine zipper transcriptional factor ATF-like. (125 aa)
LAG3Lymphocyte activation gene 3 protein. (493 aa)
DBHDopamine beta-hydroxylase. (610 aa)
RAB44Ras-related protein Rab-44 isoform X1. (1086 aa)
EPHB6Ephrin type-B receptor 6 isoform X1. (1010 aa)
ERCC1DNA excision repair protein ERCC-1 isoform X1. (414 aa)
RNF8E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (487 aa)
CEBPGCCAAT/enhancer-binding protein gamma. (149 aa)
BCL10B-cell lymphoma/leukemia 10. (233 aa)
FCARImmunoglobulin alpha Fc receptor isoform X1. (290 aa)
BCL3B-cell lymphoma 3 protein. (454 aa)
NBNNibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (727 aa)
CD2T-cell surface antigen CD2 isoform X1. (340 aa)
EXOSC6Exosome complex component MTR3. (272 aa)
STXBP3Syntaxin-binding protein 3; Belongs to the STXBP/unc-18/SEC1 family. (592 aa)
GRPGastrin-releasing peptide isoform X2. (237 aa)
CD19B-lymphocyte antigen CD19 isoform X1. (570 aa)
SNAP23Synaptosomal-associated protein; Belongs to the SNAP-25 family. (211 aa)
RASGRP1RAS guanyl-releasing protein 1 isoform X1. (870 aa)
IL4RInterleukin-4 receptor subunit alpha isoform X1. (831 aa)
IL21RInterleukin-21 receptor isoform X2. (560 aa)
ZP3Zona pellucida sperm-binding protein 3. (421 aa)
NKG7Protein NKG7. (165 aa)
MILR1Allergin-1 isoform X1. (318 aa)
CD81Tetraspanin. (236 aa)
CD74HLA class II histocompatibility antigen gamma chain isoform X1. (278 aa)
PRF1Perforin-1. (555 aa)
CORO1ACoronin; Belongs to the WD repeat coronin family. (461 aa)
PPP3CBSerine/threonine-protein phosphatase. (525 aa)
SCNN1BAmiloride-sensitive sodium channel subunit beta; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (641 aa)
UNC13DProtein unc-13 homolog D isoform X1. (1121 aa)
LOC111184729Membrane cofactor protein-like isoform X1. (411 aa)
CTSCDipeptidyl peptidase 1 isoform X1; Belongs to the peptidase C1 family. (463 aa)
NDST2Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2. (883 aa)
LOC111184601Membrane cofactor protein; Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. (336 aa)
C4BPAC4b-binding protein alpha chain isoform X1. (616 aa)
LOC111184602Membrane cofactor protein; Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. (367 aa)
TCIRG1V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (873 aa)
C4BPBC4b-binding protein beta chain isoform X1. (255 aa)
F2Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. (623 aa)
VAMP2Vesicle-associated membrane protein 2. (116 aa)
MYO1GUnconventional myosin-Ig isoform X1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1013 aa)
CSF2RBCytokine receptor common subunit beta. (902 aa)
CD55Complement decay-accelerating factor isoform X1. (590 aa)
C1QBPComplement component 1 Q subcomponent-binding protein, mitochondrial. (278 aa)
AIREAutoimmune regulator. (553 aa)
IL9RInterleukin-9 receptor. (469 aa)
PLEKHM2Pleckstrin homology domain-containing family M member 2 isoform X1. (1024 aa)
CPLX2Complexin-2. (134 aa)
KIAA1841Uncharacterized protein KIAA1841 homolog isoform X1. (717 aa)
IL7RInterleukin-7 receptor subunit alpha isoform X1. (459 aa)
ATAD5ATPase family AAA domain-containing protein 5 isoform X1. (1898 aa)
C6Complement component C6 isoform X1. (934 aa)
C7Complement component C7. (843 aa)
C9Complement component C9. (548 aa)
ANXA3Annexin. (323 aa)
MASP2Mannan-binding lectin serine protease 2 isoform X1; Belongs to the peptidase S1 family. (686 aa)
EXOSC3Exosome complex component RRP40. (275 aa)
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
Server load: low (38%) [HD]