STRINGSTRING
POU4F2 POU4F2 PLA2G3 PLA2G3 LIF LIF LOC111163731 LOC111163731 C1QC C1QC RUNX1 RUNX1 MYC MYC PTPN2 PTPN2 HSF1 HSF1 GPR137B GPR137B TRIB1 TRIB1 LRRC17 LRRC17 RARA RARA APCS APCS LYN LYN FBXW9 FBXW9 TNFRSF11B TNFRSF11B UBASH3B UBASH3B HAX1 HAX1 RASSF2 RASSF2 CTNNB1 CTNNB1 HCLS1 HCLS1 FES FES IL12B IL12B FSTL3 FSTL3 TFE3 TFE3 LEF1 LEF1 CASP10 CASP10 GPR55 GPR55 CASP8 CASP8 TNFAIP6 TNFAIP6 OCSTAMP OCSTAMP CREB1 CREB1 SFRP1 SFRP1 INPP5D INPP5D SLC9B2 SLC9B2 MITF MITF LOC111174848 LOC111174848 TCTA TCTA TNFSF11 TNFSF11 ZFP36L1 ZFP36L1 GPR68 GPR68 LTF LTF IFNG IFNG FSHR FSHR FOXP1 FOXP1 POU4F1 POU4F1 TAL1 TAL1 LOC111174846 LOC111174846 CUL4A CUL4A IL17A IL17A ZFPM1 ZFPM1 DCSTAMP DCSTAMP IL34 IL34 TREM2 TREM2 CDK6 CDK6 TGFB1 TGFB1 TMEM64 TMEM64 PPP3CA PPP3CA NEDD9 NEDD9 CD101 CD101 TRAF6 TRAF6 RIPK1 RIPK1 PIAS3 PIAS3 NOTCH2 NOTCH2 CSF1 CSF1 KLF10 KLF10 HOXA7 HOXA7 PPARGC1B PPARGC1B PRKCA PRKCA FBN1 FBN1 CD74 CD74 FAM213A FAM213A FADD FADD NDFIP1 NDFIP1 MAFB MAFB GPR137 GPR137 ZBTB46 ZBTB46 NF1 NF1 CEBPB CEBPB EVI2B EVI2B PIK3R1 PIK3R1 TNF TNF MTOR MTOR TOB2 TOB2 FBXW7 FBXW7 TESC TESC CTNNBIP1 CTNNBIP1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
POU4F2POU domain protein. (407 aa)
PLA2G3Group 3 secretory phospholipase A2 isoform X1. (516 aa)
LIFLeukemia inhibitory factor. (202 aa)
LOC111163731C-C motif chemokine. (93 aa)
C1QCComplement C1q subcomponent subunit C. (245 aa)
RUNX1Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (480 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (439 aa)
PTPN2Tyrosine-protein phosphatase non-receptor type 2 isoform X3. (474 aa)
HSF1Heat shock factor protein 1 isoform X1. (564 aa)
GPR137BIntegral membrane protein GPR137B. (385 aa)
TRIB1Tribbles homolog 1. (372 aa)
LRRC17Leucine-rich repeat-containing protein 17 isoform X1. (440 aa)
RARARetinoic acid receptor alpha isoform X5. (584 aa)
APCSLOW QUALITY PROTEIN: serum amyloid P-component. (139 aa)
LYNTyrosine-protein kinase. (518 aa)
FBXW9F-box/WD repeat-containing protein 9 isoform X1. (461 aa)
TNFRSF11BTumor necrosis factor receptor superfamily member 11B; Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. (401 aa)
UBASH3BUbiquitin-associated and SH3 domain-containing protein B isoform X1. (649 aa)
HAX1HCLS1-associated protein X-1; Recruits the Arp2/3 complex to the cell cortex and regulates reorganization of the cortical actin cytoskeleton via its interaction with KCNC3 and the Arp2/3 complex. Slows down the rate of inactivation of KCNC3 channels. Promotes GNA13-mediated cell migration. Involved in the clathrin-mediated endocytosis pathway. May be involved in internalization of ABC transporters such as ABCB11. May inhibit CASP9 and CASP3. Promotes cell survival. May regulate intracellular calcium pools. (276 aa)
RASSF2Ras association domain-containing protein 2 isoform X1. (420 aa)
CTNNB1Catenin beta-1. (781 aa)
HCLS1Hematopoietic lineage cell-specific protein. (481 aa)
FESTyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (822 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (329 aa)
FSTL3Follistatin-related protein 3. (262 aa)
TFE3Transcription factor E3 isoform X1. (575 aa)
LEF1Lymphoid enhancer-binding factor 1 isoform X1. (414 aa)
CASP10Caspase-10; Belongs to the peptidase C14A family. (518 aa)
GPR55G-protein coupled receptor 55 isoform X1; Belongs to the G-protein coupled receptor 1 family. (407 aa)
CASP8Caspase-8; Belongs to the peptidase C14A family. (486 aa)
TNFAIP6Tumor necrosis factor-inducible gene 6 protein isoform X1. (284 aa)
OCSTAMPLOW QUALITY PROTEIN: osteoclast stimulatory transmembrane protein. (566 aa)
CREB1Cyclic AMP-responsive element-binding protein 1 isoform X1. (341 aa)
SFRP1Secreted frizzled-related protein 1. (308 aa)
INPP5DPhosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1. (1150 aa)
SLC9B2Sodium/hydrogen exchanger 9B2 isoform X1. (536 aa)
MITFMicrophthalmia-associated transcription factor isoform X1. (526 aa)
LOC111174848Uncharacterized protein LOC111174848 isoform X1. (334 aa)
TCTAT-cell leukemia translocation-altered gene protein homolog; May be required for cellular fusion during osteoclastogenesis; Belongs to the TCTA family. (106 aa)
TNFSF11Tumor necrosis factor ligand superfamily member 11; Belongs to the tumor necrosis factor family. (322 aa)
ZFP36L1mRNA decay activator protein ZFP36L1. (338 aa)
GPR68Ovarian cancer G-protein coupled receptor 1; Belongs to the G-protein coupled receptor 1 family. (371 aa)
LTFLactotransferrin; Belongs to the transferrin family. (710 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
FSHRFollicle-stimulating hormone receptor; G protein-coupled receptor for follitropin, the follicle- stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways. (695 aa)
FOXP1Forkhead box protein P1 isoform X1. (673 aa)
POU4F1POU domain protein. (422 aa)
TAL1T-cell acute lymphocytic leukemia protein 1 isoform X1. (328 aa)
LOC111174846Transmembrane protein 178A-like isoform X1. (177 aa)
CUL4Acullin-4A; Belongs to the cullin family. (761 aa)
IL17Ainterleukin-17A. (155 aa)
ZFPM1Zinc finger protein ZFPM1 isoform X1. (1069 aa)
DCSTAMPLOW QUALITY PROTEIN: dendritic cell-specific transmembrane protein. (510 aa)
IL34Interleukin-34. (235 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (294 aa)
CDK6Cyclin-dependent kinase 6 isoform X1; Belongs to the protein kinase superfamily. (326 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (391 aa)
TMEM64Transmembrane protein 64. (382 aa)
PPP3CASerine/threonine-protein phosphatase. (521 aa)
NEDD9Enhancer of filamentation 1 isoform X1. (829 aa)
CD101Immunoglobulin superfamily member 2 isoform X1. (1018 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (561 aa)
RIPK1Receptor-interacting serine/threonine-protein kinase 1 isoform X1. (687 aa)
PIAS3E3 SUMO-protein ligase PIAS3 isoform X1. (628 aa)
NOTCH2Neurogenic locus notch homolog protein 2 isoform X1. (2471 aa)
CSF1Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] (554 aa)
KLF10Krueppel-like factor 10 isoform X2. (494 aa)
HOXA7Homeobox protein Hox-A7. (233 aa)
PPARGC1BPeroxisome proliferator-activated receptor gamma coactivator 1-beta isoform X1. (1173 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (670 aa)
FBN1Fibrillin-1 isoform X1. (2871 aa)
CD74HLA class II histocompatibility antigen gamma chain isoform X1. (278 aa)
FAM213ARedox-regulatory protein FAM213A isoform X3. (289 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (211 aa)
NDFIP1NEDD4 family-interacting protein 1. (221 aa)
MAFBTranscription factor MafB. (323 aa)
GPR137Integral membrane protein GPR137 isoform X1. (395 aa)
ZBTB46Zinc finger and BTB domain-containing protein 46. (590 aa)
NF1Neurofibromin isoform X1. (2873 aa)
CEBPBCCAAT/enhancer-binding protein. (345 aa)
EVI2BProtein EVI2B. (451 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (233 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2548 aa)
TOB2Protein Tob2. (343 aa)
FBXW7F-box/WD repeat-containing protein 7 isoform X1. (707 aa)
TESCCalcineurin B homologous protein 3. (214 aa)
CTNNBIP1Beta-catenin-interacting protein 1. (81 aa)
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
Server load: low (22%) [HD]