STRINGSTRING
MRE11 MRE11 UPF1 UPF1 DSCC1 DSCC1 MCM4 MCM4 MCM9 MCM9 ASCC3 ASCC3 DDX3X DDX3X MCM8 MCM8 HFM1 HFM1 CHD9 CHD9 CUNH17orf64 CUNH17orf64 RECQL4 RECQL4 BRIP1 BRIP1 DQX1 DQX1 BLM BLM POLQ POLQ ERCC6L ERCC6L RUVBL1 RUVBL1 MCM2 MCM2 TWNK TWNK XRCC5 XRCC5 TM4SF19 TM4SF19 FANCM FANCM WRN WRN MCM6 MCM6 RFC3 RFC3 RFC4 RFC4 GTF2F2 GTF2F2 HELB HELB CHD4 CHD4 RECQL RECQL DDX11 DDX11 PIF1 PIF1 FBXO18 FBXO18 LOC111179605 LOC111179605 ERCC2 ERCC2 ATRX ATRX DHX36 DHX36 MCM3 MCM3 SMARCAD1 SMARCAD1 RAD51 RAD51 NAV2 NAV2 CHD1L CHD1L RFC2 RFC2 WRNIP1 WRNIP1 CHD8 CHD8 RUVBL2 RUVBL2 RAD50 RAD50 G3BP1 G3BP1 SUPV3L1 SUPV3L1 MCM7 MCM7 ERCC3 ERCC3 DNA2 DNA2 IGHMBP2 IGHMBP2 RECQL5 RECQL5 DHX9 DHX9 CHD1 CHD1 CHD6 CHD6 CHD7 CHD7 CHTF18 CHTF18 XRCC6 XRCC6 CHD2 CHD2 RTEL1 RTEL1 CHD3 CHD3 HELQ HELQ MCM5 MCM5 CHD5 CHD5 SUB1 SUB1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MRE11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (707 aa)
UPF1Regulator of nonsense transcripts 1 isoform X1. (1127 aa)
DSCC1Sister chromatid cohesion protein DCC1. (392 aa)
MCM4DNA helicase; Belongs to the MCM family. (836 aa)
MCM9DNA helicase MCM9 isoform X1; Belongs to the MCM family. (1144 aa)
ASCC3Activating signal cointegrator 1 complex subunit 3. (2201 aa)
DDX3XATP-dependent RNA helicase DDX3X isoform X1; Belongs to the DEAD box helicase family. (662 aa)
MCM8DNA helicase MCM8; Belongs to the MCM family. (832 aa)
HFM1Probable ATP-dependent DNA helicase HFM1 isoform X4. (1476 aa)
CHD9chromodomain-helicase-DNA-binding protein 9 isoform X1. (2902 aa)
CUNH17orf64Uncharacterized protein C17orf64 homolog. (262 aa)
RECQL4LOW QUALITY PROTEIN: ATP-dependent DNA helicase Q4. (1211 aa)
BRIP1Fanconi anemia group J protein. (1186 aa)
DQX1ATP-dependent RNA helicase DQX1. (719 aa)
BLMBloom syndrome protein isoform X1. (1429 aa)
POLQDNA polymerase theta isoform X1. (2608 aa)
ERCC6LDNA excision repair protein ERCC-6-like. (1249 aa)
RUVBL1RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (456 aa)
MCM2DNA helicase; Belongs to the MCM family. (903 aa)
TWNKTwinkle protein, mitochondrial isoform X1. (684 aa)
XRCC5X-ray repair cross-complementing protein 5. (733 aa)
TM4SF19Transmembrane 4 L6 family member 19. (202 aa)
FANCMFanconi anemia group M protein isoform X1. (2057 aa)
WRNWerner syndrome ATP-dependent helicase isoform X1. (1454 aa)
MCM6DNA helicase; Belongs to the MCM family. (821 aa)
RFC3Replication factor C subunit 3. (356 aa)
RFC4Replication factor C subunit 4. (364 aa)
GTF2F2General transcription factor IIF subunit 2; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. This subunit shows ATP-dependent DNA-helicase activity. (249 aa)
HELBDNA helicase B isoform X1. (1079 aa)
CHD4chromodomain-helicase-DNA-binding protein 4 isoform X1. (1940 aa)
RECQLATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (649 aa)
DDX11ATP-dependent DNA helicase DDX11 isoform X1. (905 aa)
PIF1ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA [...] (670 aa)
FBXO18F-box DNA helicase 1. (1040 aa)
LOC111179605LOW QUALITY PROTEIN: ras GTPase-activating protein-binding protein 1-like. (470 aa)
ERCC2TFIIH basal transcription factor complex helicase XPD subunit isoform X1. (823 aa)
ATRXTranscriptional regulator ATRX isoform X1. (2510 aa)
DHX36ATP-dependent RNA helicase DHX36 isoform X1. (1020 aa)
MCM3DNA helicase; Belongs to the MCM family. (808 aa)
SMARCAD1annotation not available (1028 aa)
RAD51DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (339 aa)
NAV2Neuron navigator 2 isoform X4. (2486 aa)
CHD1Lchromodomain-helicase-DNA-binding protein 1-like isoform X1. (898 aa)
RFC2Replication factor C subunit 2. (352 aa)
WRNIP1ATPase WRNIP1 isoform X1. (638 aa)
CHD8Chromodomain-helicase-DNA-binding protein 8; DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive [...] (2590 aa)
RUVBL2RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (463 aa)
RAD50DNA repair protein RAD50 isoform X1. (1344 aa)
G3BP1Ras GTPase-activating protein-binding protein 1 isoform X2. (504 aa)
SUPV3L1ATP-dependent RNA helicase SUPV3L1, mitochondrial. (787 aa)
MCM7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (719 aa)
ERCC3TFIIH basal transcription factor complex helicase XPB subunit isoform X1. (782 aa)
DNA2DNA replication ATP-dependent helicase/nuclease DNA2 isoform X1. (1097 aa)
IGHMBP2DNA-binding protein SMUBP-2 isoform X1. (982 aa)
RECQL5ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (990 aa)
DHX9ATP-dependent RNA helicase A isoform X1. (1253 aa)
CHD1chromodomain-helicase-DNA-binding protein 1 isoform X1. (1798 aa)
CHD6chromodomain-helicase-DNA-binding protein 6. (2720 aa)
CHD7chromodomain-helicase-DNA-binding protein 7 isoform X1. (3050 aa)
CHTF18Chromosome transmission fidelity protein 18 homolog. (1006 aa)
XRCC6X-ray repair cross-complementing protein 6. (609 aa)
CHD2chromodomain-helicase-DNA-binding protein 2 isoform X1. (1862 aa)
RTEL1Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1355 aa)
CHD3chromodomain-helicase-DNA-binding protein 3 isoform X1. (2155 aa)
HELQHelicase POLQ-like isoform X1. (1079 aa)
MCM5DNA helicase; Belongs to the MCM family. (734 aa)
CHD5chromodomain-helicase-DNA-binding protein 5 isoform X1. (1954 aa)
SUB1Activated RNA polymerase II transcriptional coactivator p15. (127 aa)
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
Server load: low (26%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.