STRINGSTRING
UPF1 UPF1 DSCC1 DSCC1 SUB1 SUB1 DDX51 DDX51 DDX55 DDX55 DDX4 DDX4 SNRNP200 SNRNP200 MOV10L1 MOV10L1 CHD5 CHD5 MCM5 MCM5 ZGRF1 ZGRF1 DDX54 DDX54 DDX52 DDX52 BRIP1 BRIP1 TRANK1 TRANK1 RECQL4 RECQL4 CUNH17orf64 CUNH17orf64 CHD9 CHD9 HFM1 HFM1 DDX25 DDX25 DHX33 DHX33 HELQ HELQ EIF4A1 EIF4A1 CHD3 CHD3 SKIV2L2 SKIV2L2 DDX27 DDX27 DHX29 DHX29 RTEL1 RTEL1 CHD2 CHD2 ZNFX1 ZNFX1 XRCC6 XRCC6 CHTF18 CHTF18 DHX37 DHX37 DDX17 DDX17 CHD7 CHD7 DDX56 DDX56 DHX35 DHX35 CHD6 CHD6 CHD1 CHD1 DDX21 DDX21 DHX9 DHX9 YTHDC2 YTHDC2 DDX5 DDX5 RECQL5 RECQL5 IGHMBP2 IGHMBP2 DDX18 DDX18 DNA2 DNA2 ERCC3 ERCC3 DDX43 DDX43 MCM7 MCM7 HELZ HELZ EIF4A3 EIF4A3 SUPV3L1 SUPV3L1 G3BP1 G3BP1 RAD50 RAD50 DHX34 DHX34 RUVBL2 RUVBL2 CHD8 CHD8 AQR AQR DDX42 DDX42 DDX46 DDX46 MCM8 MCM8 DHX40 DHX40 DDX3X DDX3X ASCC3 ASCC3 MCM9 MCM9 SMARCA4 SMARCA4 DDX1 DDX1 DDX49 DDX49 DDX20 DDX20 WRNIP1 WRNIP1 DDX28 DDX28 RFC2 RFC2 DDX19B DDX19B TTF2 TTF2 CHD1L CHD1L NAV2 NAV2 RAD51 RAD51 MCM4 MCM4 TWNK TWNK MCM2 MCM2 XRCC5 XRCC5 IFIH1 IFIH1 DHX32 DHX32 BTAF1 BTAF1 EIF4A2 EIF4A2 TM4SF19 TM4SF19 FANCM FANCM DDX23 DDX23 SMARCAL1 SMARCAL1 WRN WRN ZRANB3 ZRANB3 MCM6 MCM6 RFC3 RFC3 RFC4 RFC4 TDRD9 TDRD9 DHX30 DHX30 GTF2F2 GTF2F2 HELB HELB CHD4 CHD4 DHX57 DHX57 RECQL RECQL DICER1 DICER1 DDX24 DDX24 DDX31 DDX31 DDX47 DDX47 DDX11 DDX11 SETX SETX PIF1 PIF1 FBXO18 FBXO18 DHX38 DHX38 LOC111179605 LOC111179605 ERCC2 ERCC2 ATRX ATRX MOV10 MOV10 DHX36 DHX36 MCM3 MCM3 SMARCAD1 SMARCAD1 RUVBL1 RUVBL1 DDX59 DDX59 DHX15 DHX15 ERCC6L ERCC6L SKIV2L SKIV2L DHX8 DHX8 DHX16 DHX16 DDX39B DDX39B DDX41 DDX41 DDX10 DDX10 POLQ POLQ BLM BLM DQX1 DQX1 ERCC6L2 ERCC6L2 DHX58 DHX58 MRE11 MRE11 DDX6 DDX6 DDX53 DDX53 DDX39A DDX39A
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
UPF1Regulator of nonsense transcripts 1 isoform X1. (1127 aa)
DSCC1Sister chromatid cohesion protein DCC1. (392 aa)
SUB1Activated RNA polymerase II transcriptional coactivator p15. (127 aa)
DDX51ATP-dependent RNA helicase DDX51 isoform X1; Belongs to the DEAD box helicase family. (680 aa)
DDX55RNA helicase. (599 aa)
DDX4Probable ATP-dependent RNA helicase DDX4; Belongs to the DEAD box helicase family. (728 aa)
SNRNP200U5 small nuclear ribonucleoprotein 200 kDa helicase. (2136 aa)
MOV10L1RNA helicase Mov10l1 isoform X1. (1177 aa)
CHD5chromodomain-helicase-DNA-binding protein 5 isoform X1. (1954 aa)
MCM5DNA helicase; Belongs to the MCM family. (734 aa)
ZGRF1Protein ZGRF1. (2100 aa)
DDX54ATP-dependent RNA helicase DDX54; Belongs to the DEAD box helicase family. DDX54/DBP10 subfamily. (876 aa)
DDX52Probable ATP-dependent RNA helicase DDX52. (598 aa)
BRIP1Fanconi anemia group J protein. (1186 aa)
TRANK1TPR and ankyrin repeat-containing protein 1 isoform X1. (2997 aa)
RECQL4LOW QUALITY PROTEIN: ATP-dependent DNA helicase Q4. (1211 aa)
CUNH17orf64Uncharacterized protein C17orf64 homolog. (262 aa)
CHD9chromodomain-helicase-DNA-binding protein 9 isoform X1. (2902 aa)
HFM1Probable ATP-dependent DNA helicase HFM1 isoform X4. (1476 aa)
DDX25ATP-dependent RNA helicase DDX25. (483 aa)
DHX33Putative ATP-dependent RNA helicase DHX33 isoform X1. (708 aa)
HELQHelicase POLQ-like isoform X1. (1079 aa)
EIF4A1Eukaryotic initiation factor 4A-I isoform X1; Belongs to the DEAD box helicase family. (406 aa)
CHD3chromodomain-helicase-DNA-binding protein 3 isoform X1. (2155 aa)
SKIV2L2Superkiller viralicidic activity 2-like 2. (1040 aa)
DDX27Probable ATP-dependent RNA helicase DDX27 isoform X1; Belongs to the DEAD box helicase family. (770 aa)
DHX29ATP-dependent RNA helicase DHX29; ATP-binding RNA helicase involved in translation initiation. Part of the 43S pre-initiation complex that is required for efficient initiation on mRNAs of higher eukaryotes with structured 5'-UTRs by promoting efficient NTPase-dependent 48S complex formation. Specifically binds to the 40S ribosome near the mRNA entrance. Does not possess a processive helicase activity; Belongs to the DEAD box helicase family. DEAH subfamily. (1364 aa)
RTEL1Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1355 aa)
CHD2chromodomain-helicase-DNA-binding protein 2 isoform X1. (1862 aa)
ZNFX1NFX1-type zinc finger-containing protein 1. (1918 aa)
XRCC6X-ray repair cross-complementing protein 6. (609 aa)
CHTF18Chromosome transmission fidelity protein 18 homolog. (1006 aa)
DHX37Probable ATP-dependent RNA helicase DHX37 isoform X1. (1146 aa)
DDX17Probable ATP-dependent RNA helicase DDX17 isoform X1; Belongs to the DEAD box helicase family. (652 aa)
CHD7chromodomain-helicase-DNA-binding protein 7 isoform X1. (3050 aa)
DDX56Probable ATP-dependent RNA helicase DDX56 isoform X1. (546 aa)
DHX35Probable ATP-dependent RNA helicase DHX35 isoform X1. (728 aa)
CHD6chromodomain-helicase-DNA-binding protein 6. (2720 aa)
CHD1chromodomain-helicase-DNA-binding protein 1 isoform X1. (1798 aa)
DDX21Nucleolar RNA helicase 2. (785 aa)
DHX9ATP-dependent RNA helicase A isoform X1. (1253 aa)
YTHDC2Probable ATP-dependent RNA helicase YTHDC2 isoform X1. (1429 aa)
DDX5Probable ATP-dependent RNA helicase DDX5; Belongs to the DEAD box helicase family. (614 aa)
RECQL5ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (990 aa)
IGHMBP2DNA-binding protein SMUBP-2 isoform X1. (982 aa)
DDX18RNA helicase. (721 aa)
DNA2DNA replication ATP-dependent helicase/nuclease DNA2 isoform X1. (1097 aa)
ERCC3TFIIH basal transcription factor complex helicase XPB subunit isoform X1. (782 aa)
DDX43Probable ATP-dependent RNA helicase DDX43 isoform X1; Belongs to the DEAD box helicase family. (647 aa)
MCM7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (719 aa)
HELZProbable helicase with zinc finger domain isoform X1. (1941 aa)
EIF4A3Eukaryotic initiation factor 4A-III; Belongs to the DEAD box helicase family. (411 aa)
SUPV3L1ATP-dependent RNA helicase SUPV3L1, mitochondrial. (787 aa)
G3BP1Ras GTPase-activating protein-binding protein 1 isoform X2. (504 aa)
RAD50DNA repair protein RAD50 isoform X1. (1344 aa)
DHX34Probable ATP-dependent RNA helicase DHX34 isoform X1. (1145 aa)
RUVBL2RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (463 aa)
CHD8Chromodomain-helicase-DNA-binding protein 8; DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive [...] (2590 aa)
AQRRNA helicase aquarius; Intron-binding spliceosomal protein required to link pre-mRNA splicing and snoRNP (small nucleolar ribonucleoprotein) biogenesis. Plays a key role in position-dependent assembly of intron-encoded box C/D small snoRNP, splicing being required for snoRNP assembly. May act by helping the folding of the snoRNA sequence. Binds to intron of pre- mRNAs in a sequence-independent manner, contacting the region between snoRNA and the branchpoint of introns (40 nucleotides upstream of the branchpoint) during the late stages of splicing. (1485 aa)
DDX42ATP-dependent RNA helicase DDX42. (940 aa)
DDX46Probable ATP-dependent RNA helicase DDX46 isoform X1. (1032 aa)
MCM8DNA helicase MCM8; Belongs to the MCM family. (832 aa)
DHX40Probable ATP-dependent RNA helicase DHX40 isoform X1. (820 aa)
DDX3XATP-dependent RNA helicase DDX3X isoform X1; Belongs to the DEAD box helicase family. (662 aa)
ASCC3Activating signal cointegrator 1 complex subunit 3. (2201 aa)
MCM9DNA helicase MCM9 isoform X1; Belongs to the MCM family. (1144 aa)
SMARCA4Transcription activator BRG1 isoform X4. (1648 aa)
DDX1ATP-dependent RNA helicase DDX1. (740 aa)
DDX49Probable ATP-dependent RNA helicase DDX49; Belongs to the DEAD box helicase family. (483 aa)
DDX20Probable ATP-dependent RNA helicase DDX20. (824 aa)
WRNIP1ATPase WRNIP1 isoform X1. (638 aa)
DDX28Probable ATP-dependent RNA helicase DDX28. (507 aa)
RFC2Replication factor C subunit 2. (352 aa)
DDX19BATP-dependent RNA helicase DDX19B isoform X2. (479 aa)
TTF2Transcription termination factor 2 isoform X1. (1171 aa)
CHD1Lchromodomain-helicase-DNA-binding protein 1-like isoform X1. (898 aa)
NAV2Neuron navigator 2 isoform X4. (2486 aa)
RAD51DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (339 aa)
MCM4DNA helicase; Belongs to the MCM family. (836 aa)
TWNKTwinkle protein, mitochondrial isoform X1. (684 aa)
MCM2DNA helicase; Belongs to the MCM family. (903 aa)
XRCC5X-ray repair cross-complementing protein 5. (733 aa)
IFIH1Interferon-induced helicase C domain-containing protein 1. (1023 aa)
DHX32Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX32 isoform X1. (745 aa)
BTAF1TATA-binding protein-associated factor 172 isoform X1. (1849 aa)
EIF4A2Eukaryotic initiation factor 4A-II isoform X1; Belongs to the DEAD box helicase family. (408 aa)
TM4SF19Transmembrane 4 L6 family member 19. (202 aa)
FANCMFanconi anemia group M protein isoform X1. (2057 aa)
DDX23Probable ATP-dependent RNA helicase DDX23. (818 aa)
SMARCAL1SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1; Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily. (951 aa)
WRNWerner syndrome ATP-dependent helicase isoform X1. (1454 aa)
ZRANB3DNA annealing helicase and endonuclease ZRANB3 isoform X1. (1077 aa)
MCM6DNA helicase; Belongs to the MCM family. (821 aa)
RFC3Replication factor C subunit 3. (356 aa)
RFC4Replication factor C subunit 4. (364 aa)
TDRD9Putative ATP-dependent RNA helicase TDRD9 isoform X1. (1286 aa)
DHX30Putative ATP-dependent RNA helicase DHX30 isoform X1. (1222 aa)
GTF2F2General transcription factor IIF subunit 2; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. This subunit shows ATP-dependent DNA-helicase activity. (249 aa)
HELBDNA helicase B isoform X1. (1079 aa)
CHD4chromodomain-helicase-DNA-binding protein 4 isoform X1. (1940 aa)
DHX57Putative ATP-dependent RNA helicase DHX57 isoform X1. (1383 aa)
RECQLATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (649 aa)
DICER1Endoribonuclease Dicer; Belongs to the helicase family. Dicer subfamily. (1921 aa)
DDX24ATP-dependent RNA helicase DDX24. (863 aa)
DDX31RNA helicase. (796 aa)
DDX47Probable ATP-dependent RNA helicase DDX47; Belongs to the DEAD box helicase family. (455 aa)
DDX11ATP-dependent DNA helicase DDX11 isoform X1. (905 aa)
SETXProbable helicase senataxin. (2685 aa)
PIF1ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA [...] (670 aa)
FBXO18F-box DNA helicase 1. (1040 aa)
DHX38pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 isoform X1. (1250 aa)
LOC111179605LOW QUALITY PROTEIN: ras GTPase-activating protein-binding protein 1-like. (470 aa)
ERCC2TFIIH basal transcription factor complex helicase XPD subunit isoform X1. (823 aa)
ATRXTranscriptional regulator ATRX isoform X1. (2510 aa)
MOV10Putative helicase MOV-10 isoform X1. (1001 aa)
DHX36ATP-dependent RNA helicase DHX36 isoform X1. (1020 aa)
MCM3DNA helicase; Belongs to the MCM family. (808 aa)
SMARCAD1annotation not available (1028 aa)
RUVBL1RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (456 aa)
DDX59Probable ATP-dependent RNA helicase DDX59. (621 aa)
DHX15pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15. (795 aa)
ERCC6LDNA excision repair protein ERCC-6-like. (1249 aa)
SKIV2LHelicase SKI2W. (1247 aa)
DHX8ATP-dependent RNA helicase DHX8 isoform X1. (1216 aa)
DHX16Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16. (1045 aa)
DDX39BSpliceosome RNA helicase DDX39B. (428 aa)
DDX41Probable ATP-dependent RNA helicase DDX41. (622 aa)
DDX10RNA helicase. (911 aa)
POLQDNA polymerase theta isoform X1. (2608 aa)
BLMBloom syndrome protein isoform X1. (1429 aa)
DQX1ATP-dependent RNA helicase DQX1. (719 aa)
ERCC6L2DNA excision repair protein ERCC-6-like 2 isoform X1. (1626 aa)
DHX58Probable ATP-dependent RNA helicase DHX58 isoform X1. (680 aa)
MRE11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (707 aa)
DDX6Probable ATP-dependent RNA helicase DDX6; Belongs to the DEAD box helicase family. (483 aa)
DDX53LOW QUALITY PROTEIN: DEAD box protein 53. (630 aa)
DDX39AATP-dependent RNA helicase DDX39A. (427 aa)
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
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