23 items (Delphinapterus leucas) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	BRWD1	Bromodomain and WD repeat-containing protein 1 isoform X1. (2273 aa)
	IRS4	Insulin receptor substrate 4 isoform X1. (1267 aa)
	SHC1	SHC-transforming protein 1 isoform X1. (609 aa)
	ENPP1	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 isoform X1. (925 aa)
	IRS1	Insulin receptor substrate 1. (1248 aa)
	SORBS1	Sorbin and SH3 domain-containing protein 1 isoform X30. (1291 aa)
	SNX4	Sorting nexin-4. (450 aa)
	ELP6	Elongator complex protein 6. (418 aa)
	IRS2	Insulin receptor substrate 2. (1347 aa)
	SNX1	Sorting nexin-1 isoform X1. (522 aa)
	BRWD3	Bromodomain and WD repeat-containing protein 3 isoform X1. (1800 aa)
	PHIP	PH-interacting protein isoform X2. (1650 aa)
	LOC111181964	Uncharacterized protein LOC111181964 isoform X1. (833 aa)
	SNX2	Sorting nexin-2. (519 aa)
	GRB10	Growth factor receptor-bound protein 10 isoform X1. (588 aa)
	LMBRD1	Probable lysosomal cobalamin transporter. (539 aa)
	INS	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
	PIK3R1	Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
	LOC111187339	LOW QUALITY PROTEIN: growth factor receptor-bound protein 10-like. (665 aa)
	IGF1R	Tyrosine-protein kinase receptor. (1368 aa)
	CCDC88A	Girdin isoform X1. (2055 aa)
	IGF1	Insulin-like growth factor I isoform X1. (186 aa)
	PTPN11	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (623 aa)

Your Current Organism:

Delphinapterus leucas

NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BRWD1	PHIP	A0A2Y9LIQ6	A0A2Y9PGI5	Bromodomain and WD repeat-containing protein 1 isoform X1.	PH-interacting protein isoform X2.	0.716
BRWD3	PHIP	A0A2Y9NRB4	A0A2Y9PGI5	Bromodomain and WD repeat-containing protein 3 isoform X1.	PH-interacting protein isoform X2.	0.426
GRB10	IGF1R	A0A2Y9PPV4	A0A2Y9QAK7	Growth factor receptor-bound protein 10 isoform X1.	Tyrosine-protein kinase receptor.	0.973
GRB10	INS	A0A2Y9PPV4	A0A2Y9PTW5	Growth factor receptor-bound protein 10 isoform X1.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.656
GRB10	IRS1	A0A2Y9PPV4	A0A2Y9MMM9	Growth factor receptor-bound protein 10 isoform X1.	Insulin receptor substrate 1.	0.566
GRB10	IRS2	A0A2Y9PPV4	A0A2Y9NC55	Growth factor receptor-bound protein 10 isoform X1.	Insulin receptor substrate 2.	0.401
GRB10	LOC111181964	A0A2Y9PPV4	A0A2Y9PK20	Growth factor receptor-bound protein 10 isoform X1.	Uncharacterized protein LOC111181964 isoform X1.	0.401
GRB10	LOC111187339	A0A2Y9PPV4	A0A2Y9QAJ0	Growth factor receptor-bound protein 10 isoform X1.	LOW QUALITY PROTEIN: growth factor receptor-bound protein 10-like.	0.901
GRB10	PIK3R1	A0A2Y9PPV4	A0A2Y9Q8T5	Growth factor receptor-bound protein 10 isoform X1.	Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1.	0.844
IGF1	IGF1R	A0A2Y9QDF3	A0A2Y9QAK7	Insulin-like growth factor I isoform X1.	Tyrosine-protein kinase receptor.	0.999
IGF1	INS	A0A2Y9QDF3	A0A2Y9PTW5	Insulin-like growth factor I isoform X1.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.985
IGF1	IRS1	A0A2Y9QDF3	A0A2Y9MMM9	Insulin-like growth factor I isoform X1.	Insulin receptor substrate 1.	0.843
IGF1	IRS2	A0A2Y9QDF3	A0A2Y9NC55	Insulin-like growth factor I isoform X1.	Insulin receptor substrate 2.	0.737
IGF1	IRS4	A0A2Y9QDF3	A0A2Y9LSZ2	Insulin-like growth factor I isoform X1.	Insulin receptor substrate 4 isoform X1.	0.704
IGF1	LOC111181964	A0A2Y9QDF3	A0A2Y9PK20	Insulin-like growth factor I isoform X1.	Uncharacterized protein LOC111181964 isoform X1.	0.749
IGF1	SHC1	A0A2Y9QDF3	A0A2Y9LZK9	Insulin-like growth factor I isoform X1.	SHC-transforming protein 1 isoform X1.	0.623
IGF1R	GRB10	A0A2Y9QAK7	A0A2Y9PPV4	Tyrosine-protein kinase receptor.	Growth factor receptor-bound protein 10 isoform X1.	0.973
IGF1R	IGF1	A0A2Y9QAK7	A0A2Y9QDF3	Tyrosine-protein kinase receptor.	Insulin-like growth factor I isoform X1.	0.999
IGF1R	INS	A0A2Y9QAK7	A0A2Y9PTW5	Tyrosine-protein kinase receptor.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.997
IGF1R	IRS1	A0A2Y9QAK7	A0A2Y9MMM9	Tyrosine-protein kinase receptor.	Insulin receptor substrate 1.	0.989