50 items (Delphinapterus leucas) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	HIP1R	Huntingtin-interacting protein 1-related protein isoform X1. (1068 aa)
	ITSN1	Intersectin-1 isoform X1. (1715 aa)
	CLTC	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1675 aa)
	RAB35	Ras-related protein Rab-35 isoform X1. (201 aa)
	DNM2	Dynamin-2 isoform X1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (871 aa)
	REPS1	ralBP1-associated Eps domain-containing protein 1 isoform X1. (802 aa)
	FCHO1	F-BAR domain only protein 1. (887 aa)
	AAK1	AP2-associated protein kinase 1 isoform X1. (968 aa)
	LDLR	Low-density lipoprotein receptor. (857 aa)
	EPS15L1	Epidermal growth factor receptor substrate 15-like 1 isoform X1. (947 aa)
	SLC18A3	Vesicular acetylcholine transporter. (528 aa)
	ATAT1	Alpha-tubulin N-acetyltransferase 1; Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dyn [...] (447 aa)
	CLTB	Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (229 aa)
	BMPR2	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
	AP1S3	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (154 aa)
	DGKD	Diacylglycerol kinase. (1237 aa)
	SH3BP4	SH3 domain-binding protein 4 isoform X1. (959 aa)
	INPP5F	Phosphatidylinositide phosphatase SAC2 isoform X1. (1173 aa)
	AP2A2	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (938 aa)
	ACKR3	Atypical chemokine receptor 3 isoform X1; Belongs to the G-protein coupled receptor 1 family. (417 aa)
	LRP2	Low-density lipoprotein receptor-related protein 2. (4838 aa)
	AP2M1	AP-2 complex subunit mu isoform X1; Belongs to the adaptor complexes medium subunit family. (435 aa)
	TNK2	Activated CDC42 kinase 1 isoform X3; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1086 aa)
	STON1	Stonin-1; Belongs to the Stoned B family. (730 aa)
	VLDLR	Very low-density lipoprotein receptor isoform X1. (873 aa)
	NUMB	Protein numb homolog isoform X1. (653 aa)
	EPS15	Epidermal growth factor receptor substrate 15 isoform X1. (902 aa)
	DNM1L	Dynamin-1-like protein isoform X1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (763 aa)
	NECAP1	Adaptin ear-binding coat-associated protein 1. (275 aa)
	APP	Amyloid beta A4 protein isoform X1. (767 aa)
	ITSN2	Intersectin-2 isoform X1. (1667 aa)
	SGIP1	SH3-containing GRB2-like protein 3-interacting protein 1 isoform X1. (854 aa)
	SORT1	Sortilin. (864 aa)
	CUBN	Cubilin isoform X1. (3620 aa)
	LOC111179199	Serotransferrin-like; Belongs to the transferrin family. (706 aa)
	LOC111180171	LOW QUALITY PROTEIN: phosphatidylinositide phosphatase SAC2-like. (615 aa)
	AP2S1	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (142 aa)
	AP2A1	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (1023 aa)
	AP1S1	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (158 aa)
	SNAP91	Clathrin coat assembly protein AP180 isoform X1. (907 aa)
	SPHK1	Sphingosine kinase 1 isoform X2. (484 aa)
	MYO6	Unconventional myosin-VI isoform X1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1262 aa)
	PICALM	Phosphatidylinositol-binding clathrin assembly protein isoform X1. (696 aa)
	FCHSD2	F-BAR and double SH3 domains protein 2 isoform X1. (740 aa)
	FCHO2	F-BAR domain only protein 2 isoform X2. (810 aa)
	ARRB1	Beta-arrestin-1 isoform X1. (430 aa)
	ARRB2	Beta-arrestin-2 isoform X1. (409 aa)
	DAB2	Disabled homolog 2 isoform X1. (769 aa)
	CLTA	Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (243 aa)
	CLHC1	Clathrin heavy chain linker domain-containing protein 1 isoform X1. (624 aa)

Your Current Organism:

Delphinapterus leucas

NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AAK1	AP2A1	A0A2Y9M5G8	A0A2Y9PDU9	AP2-associated protein kinase 1 isoform X1.	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]	0.596
AAK1	AP2A2	A0A2Y9M5G8	A0A2Y9MPY2	AP2-associated protein kinase 1 isoform X1.	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]	0.428
AAK1	AP2M1	A0A2Y9M5G8	A0A2Y9MW21	AP2-associated protein kinase 1 isoform X1.	AP-2 complex subunit mu isoform X1; Belongs to the adaptor complexes medium subunit family.	0.818
AAK1	AP2S1	A0A2Y9M5G8	A0A2Y9PCF4	AP2-associated protein kinase 1 isoform X1.	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.	0.670
AAK1	CLHC1	A0A2Y9M5G8	A0A2Y9QBY5	AP2-associated protein kinase 1 isoform X1.	Clathrin heavy chain linker domain-containing protein 1 isoform X1.	0.489
AAK1	CLTA	A0A2Y9M5G8	A0A2Y9QAA4	AP2-associated protein kinase 1 isoform X1.	Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family.	0.423
AAK1	CLTB	A0A2Y9M5G8	A0A2Y9MLX1	AP2-associated protein kinase 1 isoform X1.	Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family.	0.424
AAK1	CLTC	A0A2Y9M5G8	A0A2Y9LHQ9	AP2-associated protein kinase 1 isoform X1.	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	0.547
AAK1	DAB2	A0A2Y9M5G8	A0A2Y9QA11	AP2-associated protein kinase 1 isoform X1.	Disabled homolog 2 isoform X1.	0.420
AAK1	EPS15	A0A2Y9M5G8	A0A2Y9NEK3	AP2-associated protein kinase 1 isoform X1.	Epidermal growth factor receptor substrate 15 isoform X1.	0.784
AAK1	EPS15L1	A0A2Y9M5G8	A0A2Y9MAI7	AP2-associated protein kinase 1 isoform X1.	Epidermal growth factor receptor substrate 15-like 1 isoform X1.	0.713
AAK1	FCHO1	A0A2Y9M5G8	A0A2Y9LWV8	AP2-associated protein kinase 1 isoform X1.	F-BAR domain only protein 1.	0.466
AAK1	FCHO2	A0A2Y9M5G8	A0A2Y9PZG9	AP2-associated protein kinase 1 isoform X1.	F-BAR domain only protein 2 isoform X2.	0.424
AAK1	HIP1R	A0A2Y9M5G8	A0A2Y9QEP8	AP2-associated protein kinase 1 isoform X1.	Huntingtin-interacting protein 1-related protein isoform X1.	0.592
AAK1	ITSN1	A0A2Y9M5G8	A0A2Y9LGB7	AP2-associated protein kinase 1 isoform X1.	Intersectin-1 isoform X1.	0.418
AAK1	ITSN2	A0A2Y9M5G8	A0A2Y9NL63	AP2-associated protein kinase 1 isoform X1.	Intersectin-2 isoform X1.	0.622
AAK1	NECAP1	A0A2Y9M5G8	A0A2Y9NGN1	AP2-associated protein kinase 1 isoform X1.	Adaptin ear-binding coat-associated protein 1.	0.490
AAK1	NUMB	A0A2Y9M5G8	A0A2Y9NE12	AP2-associated protein kinase 1 isoform X1.	Protein numb homolog isoform X1.	0.592
AAK1	PICALM	A0A2Y9M5G8	A0A2Y9PSA4	AP2-associated protein kinase 1 isoform X1.	Phosphatidylinositol-binding clathrin assembly protein isoform X1.	0.603
AAK1	REPS1	A0A2Y9M5G8	A0A2Y9LVQ3	AP2-associated protein kinase 1 isoform X1.	ralBP1-associated Eps domain-containing protein 1 isoform X1.	0.790