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| | LIPC | Hepatic triacylglycerol lipase isoform X1. (510 aa) |
| | HNF1A | Hepatocyte nuclear factor 1-alpha. (632 aa) |
| | ACACB | acetyl-CoA carboxylase 2 isoform X1. (2456 aa) |
| | MECR | Enoyl-[acyl-carrier-protein] reductase, mitochondrial. (388 aa) |
| | PLA2G10 | Phospholipase A(2). (159 aa) |
| | OXSM | 3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial; May play a role in the biosynthesis of lipoic acid as well as longer chain fatty acids required for optimal mitochondrial function. Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. (460 aa) |
| | ACACA | acetyl-CoA carboxylase 1 isoform X1. (2383 aa) |
| | PLA2G1B | Phospholipase A(2). (160 aa) |
| | ABCD3 | ATP-binding cassette sub-family D member 3 isoform X1. (656 aa) |
| | THNSL2 | Threonine synthase-like 2. (484 aa) |
| | BRCA1 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1866 aa) |
| | ACSBG2 | long-chain-fatty-acid--CoA ligase ACSBG2. (685 aa) |
| | LPL | Lipoprotein lipase; Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans. (478 aa) |
| | TECR | Very-long-chain enoyl-CoA reductase isoform X2. (308 aa) |
| | LTC4S | Leukotriene C4 synthase. (146 aa) |
| | MGLL | Monoglyceride lipase isoform X1. (313 aa) |
| | PLP1 | Myelin proteolipid protein isoform X1. (277 aa) |
| | ABHD2 | Monoacylglycerol lipase ABHD2 isoform X1. (425 aa) |
| | LIAS | Lipoyl synthase, mitochondrial; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (372 aa) |
| | ABCD1 | ATP-binding cassette sub-family D member 1 isoform X1. (774 aa) |
| | TECRL | trans-2,3-enoyl-CoA reductase-like. (363 aa) |
| | SCD | acyl-CoA desaturase; Belongs to the fatty acid desaturase type 1 family. (359 aa) |
| | ALOX5 | Arachidonate 5-lipoxygenase. (674 aa) |
| | ASAH2 | Neutral ceramidase. (757 aa) |
| | ACSM1 | Acyl-coenzyme A synthetase ACSM1, mitochondrial. (453 aa) |
| | LIPH | Lipase member H isoform X1. (451 aa) |
| | PRKAG3 | 5'-AMP-activated protein kinase subunit gamma-3. (464 aa) |
| | PRKAG1 | 5'-AMP-activated protein kinase subunit gamma-1 isoform X1. (330 aa) |
| | HACD2 | Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase; Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors [...] (278 aa) |
| | ELOVL3 | Elongation of very long chain fatty acids protein. (225 aa) |
| | PTGES3 | Prostaglandin E synthase 3 isoform X1. (177 aa) |
| | ELOVL1 | Elongation of very long chain fatty acids protein 1; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that exhibits activity toward saturated C18 to C26 acyl-CoA substrates, with the highest activity towards C22:0 acyl-CoA. May participate to the production of both saturated and monounsaturated VLCFAs of different chain lengths that [...] (314 aa) |
| | EDN2 | Endothelin-2. (147 aa) |
| | HACD4 | Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase; Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors [...] (232 aa) |
| | LIPI | Lipase member I isoform X1. (460 aa) |
| | LOC111174244 | Hydroxyacyl-thioester dehydratase type 2, mitochondrial-like. (168 aa) |
| | PTGS1 | Prostaglandin G/H synthase 1 isoform X1. (600 aa) |
| | PTGES2 | Prostaglandin E synthase 2 isoform X1. (372 aa) |
| | PTGDS | prostaglandin-H2 D-isomerase; Belongs to the calycin superfamily. Lipocalin family. (191 aa) |
| | ACSBG1 | long-chain-fatty-acid--CoA ligase ACSBG1 isoform X1. (730 aa) |
| | THNSL1 | Threonine synthase-like 1. (743 aa) |
| | DEGS1 | Sphingolipid delta(4)-desaturase DES1 isoform X1. (323 aa) |
| | TBXAS1 | thromboxane-A synthase isoform X1; Belongs to the cytochrome P450 family. (585 aa) |
| | HACD3 | Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase; Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors [...] (362 aa) |
| | PTGES | Prostaglandin E synthase. (153 aa) |
| | MLYCD | malonyl-CoA decarboxylase, mitochondrial isoform X1. (528 aa) |
| | ELOVL5 | Elongation of very long chain fatty acids protein 5; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C18:3(n-6) acyl-CoA. May participate to the production of monounsaturated and of polyunsaturated VLCFAs of different chain lengths that are involv [...] (295 aa) |
| | LIPG | Endothelial lipase. (505 aa) |
| | EDN1 | Endothelin-1. (202 aa) |
| | HSD17B8 | Estradiol 17-beta-dehydrogenase 8 isoform X1. (259 aa) |
| | LOC111180753 | LOW QUALITY PROTEIN: very-long-chain 3-oxoacyl-CoA reductase-B-like. (377 aa) |
| | HACD1 | Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase; Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors [...] (289 aa) |
| | ACSF3 | acyl-CoA synthetase family member 3, mitochondrial isoform X1. (634 aa) |
| | HSDL1 | Inactive hydroxysteroid dehydrogenase-like protein 1; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (330 aa) |
| | FA2H | Fatty acid 2-hydroxylase; Catalyzes stereospecific hydroxylation of free fatty acids at the C-2 position to produce (R)-2-hydroxy fatty acids, which are building blocks of sphingolipids and glycosphingolipids common in neural tissue and epidermis. Plays an essential role in the synthesis of galactosphingolipids of the myelin sheath. Responsible for the synthesis of sphingolipids and glycosphingolipids involved in the formation of epidermal lamellar bodies critical for skin permeability barrier. Participates in the synthesis of glycosphingolipids and a fraction of type II wax diesters i [...] (396 aa) |
| | PLA2G4F | Phospholipase A2. (849 aa) |
| | PRKAB2 | 5'-AMP-activated protein kinase subunit beta-2 isoform X2. (272 aa) |
| | ELOVL2 | Elongation of very long chain fatty acids protein 2; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C20:4(n-6) acyl-CoA. Condensing enzyme that catalyzes the synthesis of polyunsaturated very long chain fatty acid (C20- and C22-PUFA). May participate to the production [...] (296 aa) |
| | NDUFAB1 | Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis. (156 aa) |
| | FASN | Fatty acid synthase isoform X1. (2680 aa) |
| | TMEM196 | Transmembrane protein 196 isoform X1. (188 aa) |
| | ACSM3 | LOW QUALITY PROTEIN: acyl-coenzyme A synthetase ACSM3, mitochondrial. (576 aa) |
| | ABHD3 | Phospholipase ABHD3 isoform X1. (411 aa) |
| | PRKAB1 | 5'-AMP-activated protein kinase subunit beta-1. (270 aa) |
| | SCD5 | stearoyl-CoA desaturase 5; Belongs to the fatty acid desaturase type 1 family. (334 aa) |
| | MCAT | malonyl-CoA-acyl carrier protein transacylase, mitochondrial. (381 aa) |
| | ELOVL6 | Elongation of very long chain fatty acids protein 6; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that elongates fatty acids with 12, 14 and 16 carbons with higher activity toward C16:0 acyl-CoAs. Catalyzes the synthesis of unsaturated C16 long chain fatty acids and, to a lesser extent, C18:0 and those with low desaturation degre [...] (265 aa) |
| | FAM213B | Prostamide/prostaglandin F synthase isoform X1. (200 aa) |
| | ACOT7 | Cytosolic acyl coenzyme A thioester hydrolase isoform X1. (375 aa) |
| | ELOVL7 | Elongation of very long chain fatty acids protein 7; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme with higher activity toward C18 acyl-CoAs, especially C18:3(n-3) acyl-CoAs and C18:3(n-6)-CoAs. Also active toward C20:4-, C18:0-, C18:1-, C18:2- and C16:0-CoAs, and weakly toward C20:0-CoA. Little or no activity toward C22:0-, C24:0 [...] (281 aa) |
| | ALOX15 | LOW QUALITY PROTEIN: arachidonate 15-lipoxygenase. (663 aa) |
| | PTGIS | Prostacyclin synthase; Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2); Belongs to the cytochrome P450 family. (500 aa) |
| | LOC111185769 | Arachidonate 15-lipoxygenase B-like. (677 aa) |
| | ALOXE3 | LOW QUALITY PROTEIN: hydroperoxide isomerase ALOXE3. (710 aa) |
| | PLA2G4A | Phospholipase A2. (749 aa) |
| | PTGS2 | Prostaglandin G/H synthase 2. (604 aa) |
| | PNPLA8 | Calcium-independent phospholipase A2-gamma isoform X1. (784 aa) |
| | CBR4 | Carbonyl reductase family member 4. (237 aa) |
| | ALOX12 | Arachidonate 12-lipoxygenase, 12S-type. (663 aa) |
| | DECR2 | Peroxisomal 2,4-dienoyl-CoA reductase. (292 aa) |
| | HSD17B12 | Very-long-chain 3-oxoacyl-CoA reductase isoform X1; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (348 aa) |
| | FADS1 | Fatty acid desaturase 1. (440 aa) |
| | FADS2 | Fatty acid desaturase 2. (444 aa) |
| | LOC111183661 | Glutathione S-transferase P. (208 aa) |
| | SUGCT | Succinate--hydroxymethylglutarate CoA-transferase isoform X1. (463 aa) |
| | ARMC7 | Armadillo repeat-containing protein 7 isoform X1. (198 aa) |
| | FADS3 | Fatty acid desaturase 3. (443 aa) |
| | FADS6 | Fatty acid desaturase 6 isoform X1. (456 aa) |
| | LOC111183662 | Glutathione S-transferase P-like isoform X1; Belongs to the GST superfamily. (390 aa) |
| | CD74 | HLA class II histocompatibility antigen gamma chain isoform X1. (278 aa) |
| | ELOVL4 | Elongation of very long chain fatty acids protein 4; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that specifically elongates C24:0 and C26:0 acyl-CoAs. May participate to the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane [...] (314 aa) |
| | DAGLB | Sn1-specific diacylglycerol lipase beta isoform X1. (669 aa) |
