STRINGSTRING
RAB31 RAB31 LDLRAP1 LDLRAP1 ITSN1 ITSN1 GRK3 GRK3 FNBP1L FNBP1L CLTC CLTC AP1G2 AP1G2 WASF1 WASF1 GAK GAK SCARF2 SCARF2 KIAA1107 KIAA1107 SNAP25 SNAP25 LRRTM1 LRRTM1 LOC111164621 LOC111164621 DNM2 DNM2 REPS1 REPS1 FCHO1 FCHO1 RAMP2 RAMP2 LOC111164620 LOC111164620 CLEC17A CLEC17A RAB5A RAB5A FCER1G FCER1G DNM3 DNM3 EZR EZR SNX9 SNX9 SORL1 SORL1 ARR3 ARR3 LDLR LDLR CANX CANX MICALL2 MICALL2 SYK SYK CALCRL CALCRL CLTB CLTB CAV3 CAV3 CALY CALY INPP5F INPP5F AP2A2 AP2A2 LOC111170413 LOC111170413 ACKR3 ACKR3 RAMP1 RAMP1 LRP2 LRP2 AP2M1 AP2M1 SAG SAG TFRC TFRC SLC9B2 SLC9B2 LMBR1L LMBR1L HTR2B HTR2B VLDLR VLDLR DRD3 DRD3 PLA2R1 PLA2R1 MSR1 MSR1 LRP6 LRP6 EPS15 EPS15 GPR107 GPR107 AMN AMN CLEC9A CLEC9A MRC1 MRC1 SNX1 SNX1 DNM1 DNM1 PPT1 PPT1 NEDD4 NEDD4 RABEPK RABEPK AP1G1 AP1G1 DNAJC13 DNAJC13 LDLRAD3 LDLRAD3 ITGB1 ITGB1 CAV1 CAV1 CAV2 CAV2 SGIP1 SGIP1 DNAJC6 DNAJC6 TMEM108 TMEM108 CACNG8 CACNG8 TFR2 TFR2 AP4E1 AP4E1 LOC111180171 LOC111180171 AP2S1 AP2S1 AP2A1 AP2A1 ACHE ACHE SNAP91 SNAP91 CACNG7 CACNG7 HGS HGS CACNG5 CACNG5 CD81 CD81 GRK2 GRK2 GRB2 GRB2 HIP1 HIP1 GRIA1 GRIA1 CLN3 CLN3 TMEM248 TMEM248 TPCN2 TPCN2 CD14 CD14 ADRB2 ADRB2 CNTN2 CNTN2 CACNG4 CACNG4 LMBRD1 LMBRD1 PICALM PICALM DBNL DBNL FCHSD2 FCHSD2 FCHO2 FCHO2 SIGLEC1 SIGLEC1 RAMP3 RAMP3 ARRB1 ARRB1 ARRB2 ARRB2 CXCL16 CXCL16 SCARF1 SCARF1 RNASEK RNASEK CLTA CLTA ITGB2 ITGB2 CLHC1 CLHC1 HIP1R HIP1R SCARB2 SCARB2 CACNG2 CACNG2 SCYL2 SCYL2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RAB31Ras-related protein Rab-31 isoform X1. (194 aa)
LDLRAP1LOW QUALITY PROTEIN: low density lipoprotein receptor adapter protein 1. (309 aa)
ITSN1Intersectin-1 isoform X1. (1715 aa)
GRK3G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (688 aa)
FNBP1LFormin-binding protein 1-like isoform X3. (609 aa)
CLTCClathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1675 aa)
AP1G2AP-1 complex subunit gamma. (786 aa)
WASF1wiskott-Aldrich syndrome protein family member 1. (559 aa)
GAKcyclin-G-associated kinase isoform X1. (1273 aa)
SCARF2Scavenger receptor class F member 2 isoform X1. (871 aa)
KIAA1107Uncharacterized protein KIAA1107 homolog isoform X1. (1808 aa)
SNAP25Synaptosomal-associated protein; Belongs to the SNAP-25 family. (206 aa)
LRRTM1Leucine-rich repeat transmembrane neuronal protein 1. (522 aa)
LOC111164621Platelet glycoprotein 4; Belongs to the CD36 family. (472 aa)
DNM2Dynamin-2 isoform X1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (871 aa)
REPS1ralBP1-associated Eps domain-containing protein 1 isoform X1. (802 aa)
FCHO1F-BAR domain only protein 1. (887 aa)
RAMP2Receptor activity-modifying protein 2. (177 aa)
LOC111164620Platelet glycoprotein 4-like; Belongs to the CD36 family. (472 aa)
CLEC17AC-type lectin domain family 17, member A isoform X1. (334 aa)
RAB5ARas-related protein Rab-5A isoform X1. (215 aa)
FCER1GHigh affinity immunoglobulin epsilon receptor subunit gamma. (86 aa)
DNM3Dynamin-3 isoform X1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (873 aa)
EZREzrin. (586 aa)
SNX9Sorting nexin. (594 aa)
SORL1Sortilin-related receptor isoform X1. (2211 aa)
ARR3arrestin-C. (339 aa)
LDLRLow-density lipoprotein receptor. (857 aa)
CANXCalnexin. (593 aa)
MICALL2MICAL-like protein 2 isoform X1. (953 aa)
SYKTyrosine-protein kinase. (626 aa)
CALCRLCalcitonin gene-related peptide type 1 receptor; Belongs to the G-protein coupled receptor 2 family. (462 aa)
CLTBClathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (229 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
CALYNeuron-specific vesicular protein calcyon isoform X1. (269 aa)
INPP5FPhosphatidylinositide phosphatase SAC2 isoform X1. (1173 aa)
AP2A2AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (938 aa)
LOC111170413Low affinity immunoglobulin gamma Fc region receptor III-like isoform X1. (278 aa)
ACKR3Atypical chemokine receptor 3 isoform X1; Belongs to the G-protein coupled receptor 1 family. (417 aa)
RAMP1Receptor activity-modifying protein 1. (148 aa)
LRP2Low-density lipoprotein receptor-related protein 2. (4838 aa)
AP2M1AP-2 complex subunit mu isoform X1; Belongs to the adaptor complexes medium subunit family. (435 aa)
SAGS-arrestin. (408 aa)
TFRCTransferrin receptor protein 1 isoform X1. (772 aa)
SLC9B2Sodium/hydrogen exchanger 9B2 isoform X1. (536 aa)
LMBR1LProtein LMBR1L isoform X1; Belongs to the LIMR family. (521 aa)
HTR2B5-hydroxytryptamine receptor 2B. (490 aa)
VLDLRVery low-density lipoprotein receptor isoform X1. (873 aa)
DRD3D(3) dopamine receptor isoform X1; Belongs to the G-protein coupled receptor 1 family. (400 aa)
PLA2R1Secretory phospholipase A2 receptor. (1389 aa)
MSR1Macrophage scavenger receptor types I and II isoform X1. (454 aa)
LRP6Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1614 aa)
EPS15Epidermal growth factor receptor substrate 15 isoform X1. (902 aa)
GPR107Protein GPR107 isoform X1. (556 aa)
AMNProtein amnionless isoform X1. (485 aa)
CLEC9AC-type lectin domain family 9 member A isoform X1. (266 aa)
MRC1Macrophage mannose receptor 1. (1455 aa)
SNX1Sorting nexin-1 isoform X1. (522 aa)
DNM1Dynamin-1 isoform X1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (868 aa)
PPT1Palmitoyl-protein thioesterase 1. (306 aa)
NEDD4E3 ubiquitin-protein ligase NEDD4 isoform X3. (1319 aa)
RABEPKRab9 effector protein with kelch motifs isoform X1. (372 aa)
AP1G1AP-1 complex subunit gamma. (825 aa)
DNAJC13dnaJ homolog subfamily C member 13 isoform X1. (2248 aa)
LDLRAD3Low-density lipoprotein receptor class A domain-containing protein 3 isoform X1. (345 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (798 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
CAV2Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (162 aa)
SGIP1SH3-containing GRB2-like protein 3-interacting protein 1 isoform X1. (854 aa)
DNAJC6Putative tyrosine-protein phosphatase auxilin isoform X1. (971 aa)
TMEM108Transmembrane protein 108. (583 aa)
CACNG8Voltage-dependent calcium channel gamma-8 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (496 aa)
TFR2Transferrin receptor protein 2 isoform X1. (805 aa)
AP4E1AP-4 complex subunit epsilon-1 isoform X1. (1201 aa)
LOC111180171LOW QUALITY PROTEIN: phosphatidylinositide phosphatase SAC2-like. (615 aa)
AP2S1AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (142 aa)
AP2A1AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (1023 aa)
ACHECarboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (617 aa)
SNAP91Clathrin coat assembly protein AP180 isoform X1. (907 aa)
CACNG7Voltage-dependent calcium channel gamma-7 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Shows specificity only for GRIA1 and GRIA2. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (275 aa)
HGSHepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...] (777 aa)
CACNG5Voltage-dependent calcium channel gamma-5 subunit isoform X1. (275 aa)
CD81Tetraspanin. (236 aa)
GRK2G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (689 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
HIP1Huntingtin-interacting protein 1 isoform X1. (1037 aa)
GRIA1Glutamate receptor 1 isoform X1. (906 aa)
CLN3Battenin. (436 aa)
TMEM248Transmembrane protein 248 isoform X7. (971 aa)
TPCN2Two pore calcium channel protein 2 isoform X1. (783 aa)
CD14Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] (372 aa)
ADRB2Beta-2 adrenergic receptor isoform X1. (400 aa)
CNTN2Contactin-2. (1043 aa)
CACNG4Voltage-dependent calcium channel gamma-4 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs), including GRIA1 and GRIA4. Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (375 aa)
LMBRD1Probable lysosomal cobalamin transporter. (539 aa)
PICALMPhosphatidylinositol-binding clathrin assembly protein isoform X1. (696 aa)
DBNLDrebrin-like protein isoform X1. (430 aa)
FCHSD2F-BAR and double SH3 domains protein 2 isoform X1. (740 aa)
FCHO2F-BAR domain only protein 2 isoform X2. (810 aa)
SIGLEC1Sialoadhesin isoform X1. (1726 aa)
RAMP3Receptor activity-modifying protein 3. (151 aa)
ARRB1Beta-arrestin-1 isoform X1. (430 aa)
ARRB2Beta-arrestin-2 isoform X1. (409 aa)
CXCL16C-X-C motif chemokine 16 isoform X1. (316 aa)
SCARF1Scavenger receptor class F member 1 isoform X1. (870 aa)
RNASEKRibonuclease kappa. (98 aa)
CLTAClathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (243 aa)
ITGB2Integrin beta. (769 aa)
CLHC1Clathrin heavy chain linker domain-containing protein 1 isoform X1. (624 aa)
HIP1RHuntingtin-interacting protein 1-related protein isoform X1. (1068 aa)
SCARB2Lysosome membrane protein 2; Belongs to the CD36 family. (477 aa)
CACNG2Voltage-dependent calcium channel gamma-2 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (323 aa)
SCYL2SCY1-like protein 2 isoform X1. (929 aa)
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
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