STRINGSTRING
ROCK1 ROCK1 NT5E NT5E UMOD UMOD SELPLG SELPLG EXT1 EXT1 LRG1 LRG1 S100A8 S100A8 EZR EZR LOC111167106 LOC111167106 SEMA4D SEMA4D PTPRC PTPRC PODXL2 PODXL2 SELP SELP SELE SELE CX3CR1 CX3CR1 F11R F11R SELL SELL MSN MSN SYK SYK ADD2 ADD2 ITGA4 ITGA4 MADCAM1 MADCAM1 ITGB7 ITGB7 JAM2 JAM2 GCNT1 GCNT1 LOC111176755 LOC111176755 SLC39A8 SLC39A8 CD44 CD44 CD177 CD177 LOC111182630 LOC111182630 FERMT3 FERMT3 TNIP1 TNIP1 ITGAL ITGAL PECAM1 PECAM1 STK10 STK10 RAC2 RAC2 BMP7 BMP7 GOLPH3 GOLPH3 TNF TNF IL1B IL1B
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1354 aa)
NT5E5'-nucleotidase; Belongs to the 5'-nucleotidase family. (574 aa)
UMODUromodulin. (643 aa)
SELPLGP-selectin glycoprotein ligand 1. (450 aa)
EXT1Exostosin-1; Belongs to the glycosyltransferase 47 family. (746 aa)
LRG1Leucine-rich alpha-2-glycoprotein isoform X1. (354 aa)
S100A8Protein S100; Belongs to the S-100 family. (89 aa)
EZREzrin. (586 aa)
LOC111167106Protein S100-A9-like; Belongs to the S-100 family. (135 aa)
SEMA4Dsemaphorin-4D isoform X1; Belongs to the semaphorin family. (863 aa)
PTPRCReceptor-type tyrosine-protein phosphatase C isoform X1. (1258 aa)
PODXL2Podocalyxin-like protein 2 isoform X1. (607 aa)
SELPP-selectin isoform X1. (768 aa)
SELEE-selectin. (531 aa)
CX3CR1CX3C chemokine receptor 1 isoform X1; Belongs to the G-protein coupled receptor 1 family. (475 aa)
F11RJunctional adhesion molecule A. (299 aa)
SELLL-selectin; Calcium-dependent lectin that mediates cell adhesion by binding to glycoproteins on neighboring cells. Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia. (372 aa)
MSNMoesin isoform X1. (579 aa)
SYKTyrosine-protein kinase. (626 aa)
ADD2Beta-adducin isoform X1. (836 aa)
ITGA4Integrin alpha-4 isoform X1; Belongs to the integrin alpha chain family. (1033 aa)
MADCAM1Mucosal addressin cell adhesion molecule 1. (406 aa)
ITGB7Integrin beta; Belongs to the integrin beta chain family. (819 aa)
JAM2Junctional adhesion molecule B isoform X1. (350 aa)
GCNT1beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase isoform X1. (485 aa)
LOC111176755Oxidized low-density lipoprotein receptor 1-like isoform X1. (273 aa)
SLC39A8Zinc transporter ZIP8 isoform X1. (461 aa)
CD44CD44 antigen isoform X1. (742 aa)
CD177CD177 antigen isoform X1. (443 aa)
LOC111182630Platelet endothelial cell adhesion molecule-like isoform X2. (305 aa)
FERMT3Fermitin family homolog 3. (663 aa)
TNIP1TNFAIP3-interacting protein 1 isoform X1. (634 aa)
ITGALIntegrin alpha-L; Belongs to the integrin alpha chain family. (1166 aa)
PECAM1Platelet endothelial cell adhesion molecule isoform X1. (701 aa)
STK10Serine/threonine-protein kinase 10. (967 aa)
RAC2Ras-related C3 botulinum toxin substrate 2 isoform X2. (192 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
GOLPH3Golgi phosphoprotein 3. (298 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (233 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (266 aa)
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
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