STRINGSTRING
HOXA7 HOXA7 FOXJ1 FOXJ1 GPNMB GPNMB SMAD7 SMAD7 IRF1 IRF1 SOCS6 SOCS6 PTPN22 PTPN22 ADTRP ADTRP GCNT2 GCNT2 CDH1 CDH1 MYADM MYADM TNFRSF21 TNFRSF21 IL4I1 IL4I1 ADAMTS18 ADAMTS18 ACTN4 ACTN4 BMP6 BMP6 TGFB1 TGFB1 PLXNA4 PLXNA4 PODXL PODXL PKHD1L1 PKHD1L1 IL20RB IL20RB RC3H2 RC3H2 ABL1 ABL1 NOTCH1 NOTCH1 TRPV4 TRPV4 CORO2A CORO2A PTPN11 PTPN11 TMEM131L TMEM131L PELI1 PELI1 C1QTNF6 C1QTNF6 FBLN1 FBLN1 AJAP1 AJAP1 MAD2L2 MAD2L2 PHLDB2 PHLDB2 PIK3R1 PIK3R1 CCL28 CCL28 CD80 CD80 FOXP3 FOXP3 TNFAIP8L2 TNFAIP8L2 ADAM15 ADAM15 LOXL3 LOXL3 VSIG4 VSIG4 COL1A1 COL1A1 PLXND1 PLXND1 HFE HFE PLXNA1 PLXNA1 ZBTB7B ZBTB7B MUC1 MUC1 RIPOR2 RIPOR2 PTPRC PTPRC PLG PLG CRTAM CRTAM TNR TNR JAG1 JAG1 SEMA4D SEMA4D MAPK7 MAPK7 JAM3 JAM3 ARHGAP6 ARHGAP6 UBASH3B UBASH3B ERBB2 ERBB2 MYOC MYOC PDE3B PDE3B ILDR2 ILDR2 MBP MBP PAWR PAWR TIGIT TIGIT SNAI2 SNAI2 APOA1 APOA1 BMP2 BMP2 SWAP70 SWAP70 TBX21 TBX21 LOC111166170 LOC111166170 CASK CASK DSCAM DSCAM YTHDF2 YTHDF2 ADORA2A ADORA2A FGL2 FGL2 PAG1 PAG1 PLA2G2D PLA2G2D GLMN GLMN ITGB1BP1 ITGB1BP1 PTPN2 PTPN2 PPM1F PPM1F NF2 NF2 EPHB2 EPHB2 CCL21 CCL21 TWSG1 TWSG1 SOCS1 SOCS1 RCC2 RCC2 PLA2G2F PLA2G2F CORO1C CORO1C DUSP3 DUSP3 PLXNC1 PLXNC1 PLXNB3 PLXNB3 EPB41L5 EPB41L5 NOTCH4 NOTCH4 CD86 CD86 SEMA3E SEMA3E DMTN DMTN SERPINE2 SERPINE2 RC3H1 RC3H1 MAD1L1 MAD1L1 DLG1 DLG1 MELTF MELTF CXCL12 CXCL12 APOD APOD IHH IHH MARCH7 MARCH7 BCL6 BCL6 PLXNA3 PLXNA3 BMP4 BMP4 CTLA4 CTLA4 ZNF703 ZNF703 RND1 RND1 ERBB3 ERBB3 NCKAP1L NCKAP1L DLC1 DLC1 FZD7 FZD7 EPHA4 EPHA4 PLXNB1 PLXNB1 KNG1 KNG1 ANXA1 ANXA1 ARG2 ARG2 SOCS5 SOCS5 PRKG1 PRKG1 CD274 CD274 ZC3H12A ZC3H12A PRKCD PRKCD ANGPT2 ANGPT2 RHOA RHOA FGL1 FGL1 IDO1 IDO1 LOC111175407 LOC111175407 ZC3H8 ZC3H8 CEBPB CEBPB NF1 NF1 LGALS9 LGALS9 DUSP1 DUSP1 PLXNB2 PLXNB2 SH2B3 SH2B3 PPARA PPARA GLI3 GLI3 CBLL1 CBLL1 AP1AR AP1AR ALOX12 ALOX12 ITCH ITCH CBLB CBLB FZD4 FZD4 DLG2 DLG2 LRRC32 LRRC32 LAMB1 LAMB1 TSPAN32 TSPAN32 DLG5 DLG5 VSIR VSIR NDFIP1 NDFIP1 LAX1 LAX1 PLXNA2 PLXNA2 SPRY4 SPRY4 PRKAR1A PRKAR1A TBCD TBCD RASA1 RASA1 LPXN LPXN C1QTNF1 C1QTNF1 EFNA5 EFNA5 SEMA6A SEMA6A CD74 CD74 THBS1 THBS1 LOC111182867 LOC111182867 LOC111181354 LOC111181354 SPINT2 SPINT2 PDCD1LG2 PDCD1LG2 ACER2 ACER2 SHH SHH ATP5B ATP5B LOC111174870 LOC111174870 ACVRL1 ACVRL1 WNT1 WNT1 NRARP NRARP KANK1 KANK1 ASS1 ASS1 PTPN6 PTPN6 TACSTD2 TACSTD2 NEXMIF NEXMIF HLX HLX LOC111178657 LOC111178657 DEF6 DEF6 ADAM10 ADAM10 CORO2B CORO2B LRRC1 LRRC1 AKNA AKNA WNK1 WNK1 LAG3 LAG3 CDH13 CDH13 LOC111176900 LOC111176900 SPOCK1 SPOCK1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
HOXA7Homeobox protein Hox-A7. (233 aa)
FOXJ1Forkhead box protein J1. (422 aa)
GPNMBTransmembrane glycoprotein NMB. (553 aa)
SMAD7Mothers against decapentaplegic homolog. (426 aa)
IRF1Interferon regulatory factor. (322 aa)
SOCS6Suppressor of cytokine signaling 6. (535 aa)
PTPN22Tyrosine-protein phosphatase non-receptor type 22 isoform X1. (801 aa)
ADTRPAndrogen-dependent TFPI-regulating protein isoform X1. (230 aa)
GCNT2N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase isoform X1. (419 aa)
CDH1Cadherin-1; Cadherins are calcium-dependent cell adhesion proteins. (885 aa)
MYADMMyeloid-associated differentiation marker. (321 aa)
TNFRSF21Tumor necrosis factor receptor superfamily member 21 isoform X3. (701 aa)
IL4I1L-amino-acid oxidase isoform X1. (653 aa)
ADAMTS18A disintegrin and metalloproteinase with thrombospondin motifs 18 isoform X1. (1227 aa)
ACTN4Alpha-actinin-4 isoform X5. (933 aa)
BMP6Bone morphogenetic protein 6. (496 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (391 aa)
PLXNA4plexin-A4 isoform X1. (1981 aa)
PODXLPodocalyxin; Involved in the regulation of both adhesion and cell morphology and cancer progression. Function as an anti-adhesive molecule that maintains an open filtration pathway between neighboring foot processes in the podocyte by charge repulsion. Belongs to the podocalyxin family. (532 aa)
PKHD1L1fibrocystin-L. (4254 aa)
IL20RBInterleukin-20 receptor subunit beta isoform X1. (342 aa)
RC3H2Roquin-2. (1189 aa)
ABL1Tyrosine-protein kinase. (1148 aa)
NOTCH1Neurogenic locus notch homolog protein 1 isoform X1. (2521 aa)
TRPV4Transient receptor potential cation channel subfamily V member 4; Belongs to the transient receptor (TC 1.A.4) family. (870 aa)
CORO2ACoronin; Belongs to the WD repeat coronin family. (525 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (623 aa)
TMEM131LTransmembrane protein 131-like isoform X1. (1608 aa)
PELI1E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (418 aa)
C1QTNF6Complement C1q tumor necrosis factor-related protein 6. (266 aa)
FBLN1Fibulin-1; Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes. (705 aa)
AJAP1Adherens junction-associated protein 1. (410 aa)
MAD2L2Mitotic spindle assembly checkpoint protein MAD2B. (211 aa)
PHLDB2Pleckstrin homology-like domain family B member 2 isoform X1. (1364 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
CCL28C-C motif chemokine. (178 aa)
CD80T-lymphocyte activation antigen CD80 isoform X1. (295 aa)
FOXP3Forkhead box protein P3. (431 aa)
TNFAIP8L2Tumor necrosis factor alpha-induced protein 8-like protein 2 isoform X1. (204 aa)
ADAM15Disintegrin and metalloproteinase domain-containing protein 15 isoform X1. (866 aa)
LOXL3Lysyl oxidase homolog 3 isoform X1. (772 aa)
VSIG4V-set and immunoglobulin domain-containing protein 4. (399 aa)
COL1A1Collagen alpha-1(I) chain. (1463 aa)
PLXND1plexin-D1. (1927 aa)
HFEHereditary hemochromatosis protein isoform X1; Belongs to the MHC class I family. (356 aa)
PLXNA1plexin-A1 isoform X1. (1954 aa)
ZBTB7BZinc finger and BTB domain-containing protein 7B. (541 aa)
MUC1Mucin-1. (363 aa)
RIPOR2Rho family-interacting cell polarization regulator 2 isoform X2. (1048 aa)
PTPRCReceptor-type tyrosine-protein phosphatase C isoform X1. (1258 aa)
PLGPlasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...] (812 aa)
CRTAMCytotoxic and regulatory T-cell molecule isoform X1. (391 aa)
TNRtenascin-R isoform X1. (1358 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1221 aa)
SEMA4Dsemaphorin-4D isoform X1; Belongs to the semaphorin family. (863 aa)
MAPK7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (775 aa)
JAM3Junctional adhesion molecule C. (301 aa)
ARHGAP6Rho GTPase-activating protein 6 isoform X1. (977 aa)
UBASH3BUbiquitin-associated and SH3 domain-containing protein B isoform X1. (649 aa)
ERBB2Receptor protein-tyrosine kinase. (1255 aa)
MYOCMyocilin. (476 aa)
PDE3BPhosphodiesterase. (1120 aa)
ILDR2Immunoglobulin-like domain-containing receptor 2. (639 aa)
MBPMyelin basic protein isoform X1. (326 aa)
PAWRPRKC apoptosis WT1 regulator protein. (345 aa)
TIGITT-cell immunoreceptor with Ig and ITIM domains. (243 aa)
SNAI2Zinc finger protein SNAI2. (268 aa)
APOA1Apolipoprotein A-I. (265 aa)
BMP2Bone morphogenetic protein 2. (395 aa)
SWAP70Switch-associated protein 70. (585 aa)
TBX21T-box transcription factor TBX21. (535 aa)
LOC111166170C-type lectin domain family 4 member G-like isoform X1. (313 aa)
CASKPeripheral plasma membrane protein CASK isoform X1; Belongs to the MAGUK family. (926 aa)
DSCAMDown syndrome cell adhesion molecule isoform X2. (1577 aa)
YTHDF2YTH domain-containing family protein 2. (580 aa)
ADORA2AAdenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (408 aa)
FGL2Fibroleukin. (440 aa)
PAG1Phosphoprotein associated with glycosphingolipid-enriched microdomains 1 isoform X2. (436 aa)
PLA2G2DPhospholipase A(2). (161 aa)
GLMNGlomulin. (592 aa)
ITGB1BP1Integrin beta-1-binding protein 1 isoform X1. (206 aa)
PTPN2Tyrosine-protein phosphatase non-receptor type 2 isoform X3. (474 aa)
PPM1FProtein phosphatase 1F. (433 aa)
NF2Merlin isoform X3. (619 aa)
EPHB2Ephrin type-B receptor 2 isoform X1. (987 aa)
CCL21C-C motif chemokine 21 isoform X1. (131 aa)
TWSG1Twisted gastrulation protein homolog 1. (223 aa)
SOCS1Suppressor of cytokine signaling 1. (215 aa)
RCC2Protein RCC2 isoform X1. (543 aa)
PLA2G2FPhospholipase A(2). (300 aa)
CORO1CCoronin; Belongs to the WD repeat coronin family. (474 aa)
DUSP3Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (185 aa)
PLXNC1plexin-C1 isoform X1. (1572 aa)
PLXNB3plexin-B3 isoform X1. (1986 aa)
EPB41L5Band 4.1-like protein 5 isoform X1. (726 aa)
NOTCH4Neurogenic locus notch homolog protein 4 isoform X1. (1993 aa)
CD86T-lymphocyte activation antigen CD86 isoform X1. (344 aa)
SEMA3Esemaphorin-3E; Belongs to the semaphorin family. (775 aa)
DMTNDematin isoform X1. (405 aa)
SERPINE2Glia-derived nexin isoform X2; Belongs to the serpin family. (397 aa)
RC3H1Roquin-1 isoform X1. (1135 aa)
MAD1L1Mitotic spindle assembly checkpoint protein MAD1 isoform X2. (735 aa)
DLG1Disks large homolog 1 isoform X1; Belongs to the MAGUK family. (927 aa)
MELTFMelanotransferrin; Belongs to the transferrin family. (739 aa)
CXCL12Stromal cell-derived factor 1 isoform X1; Belongs to the intercrine alpha (chemokine CxC) family. (119 aa)
APODApolipoprotein D. (213 aa)
IHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (410 aa)
MARCH7E3 ubiquitin-protein ligase MARCH7 isoform X1. (717 aa)
BCL6B-cell lymphoma 6 protein. (706 aa)
PLXNA3plexin-A3. (1872 aa)
BMP4Bone morphogenetic protein 4 isoform X2. (408 aa)
CTLA4Cytotoxic T-lymphocyte protein 4 isoform X1. (223 aa)
ZNF703Zinc finger protein 703. (585 aa)
RND1Rho-related GTP-binding protein Rho6. (232 aa)
ERBB3Receptor tyrosine-protein kinase erbB-3. (1338 aa)
NCKAP1LNck-associated protein 1-like isoform X1. (1156 aa)
DLC1Rho GTPase-activating protein 7 isoform X1. (1528 aa)
FZD7Frizzled-7; Belongs to the G-protein coupled receptor Fz/Smo family. (574 aa)
EPHA4Ephrin type-A receptor 4 isoform X1. (986 aa)
PLXNB1plexin-B1 isoform X1. (2182 aa)
KNG1Kininogen-1 isoform X1. (627 aa)
ANXA1Annexin. (346 aa)
ARG2Arginase. (354 aa)
SOCS5Suppressor of cytokine signaling 5. (536 aa)
PRKG1cGMP-dependent protein kinase. (686 aa)
CD274Programmed cell death 1 ligand 1 isoform X2. (312 aa)
ZC3H12AEndoribonuclease ZC3H12A. (583 aa)
PRKCDProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (733 aa)
ANGPT2Angiopoietin-2 isoform X1. (496 aa)
RHOATransforming protein RhoA. (193 aa)
FGL1Fibrinogen-like protein 1. (315 aa)
IDO1Indoleamine 2,3-dioxygenase 1 isoform X1. (410 aa)
LOC111175407Amine oxidase. (524 aa)
ZC3H8Zinc finger CCCH domain-containing protein 8 isoform X1. (308 aa)
CEBPBCCAAT/enhancer-binding protein. (345 aa)
NF1Neurofibromin isoform X1. (2873 aa)
LGALS9Galectin. (356 aa)
DUSP1Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (367 aa)
PLXNB2plexin-B2. (1841 aa)
SH2B3SH2B adapter protein 3 isoform X1. (618 aa)
PPARAPeroxisome proliferator-activated receptor alpha. (468 aa)
GLI3Transcriptional activator GLI3 isoform X1. (1587 aa)
CBLL1E3 ubiquitin-protein ligase Hakai isoform X1. (503 aa)
AP1ARAP-1 complex-associated regulatory protein isoform X1. (302 aa)
ALOX12Arachidonate 12-lipoxygenase, 12S-type. (663 aa)
ITCHE3 ubiquitin-protein ligase. (862 aa)
CBLBE3 ubiquitin-protein ligase CBL-B. (983 aa)
FZD4Frizzled-4; Belongs to the G-protein coupled receptor Fz/Smo family. (537 aa)
DLG2Disks large homolog 2 isoform X1. (994 aa)
LRRC32Leucine-rich repeat-containing protein 32 isoform X1. (676 aa)
LAMB1Laminin subunit beta-1. (1786 aa)
TSPAN32Tetraspanin-32 isoform X1; Belongs to the tetraspanin (TM4SF) family. (571 aa)
DLG5Disks large homolog 5 isoform X1; Belongs to the MAGUK family. (1980 aa)
VSIRV-type immunoglobulin domain-containing suppressor of T-cell activation. (311 aa)
NDFIP1NEDD4 family-interacting protein 1. (221 aa)
LAX1LOW QUALITY PROTEIN: lymphocyte transmembrane adapter 1. (430 aa)
PLXNA2plexin-A2 isoform X1. (1894 aa)
SPRY4Protein sprouty homolog 4. (299 aa)
PRKAR1AcAMP-dependent protein kinase type I-alpha regulatory subunit. (380 aa)
TBCDTubulin-specific chaperone D. (1197 aa)
RASA1Ras GTPase-activating protein 1 isoform X1. (1040 aa)
LPXNLeupaxin isoform X2; Belongs to the paxillin family. (387 aa)
C1QTNF1LOW QUALITY PROTEIN: complement C1q tumor necrosis factor-related protein 1. (279 aa)
EFNA5ephrin-A5 isoform X1; Belongs to the ephrin family. (228 aa)
SEMA6Asemaphorin-6A isoform X1; Belongs to the semaphorin family. (1044 aa)
CD74HLA class II histocompatibility antigen gamma chain isoform X1. (278 aa)
THBS1Thrombospondin-1. (1170 aa)
LOC111182867CMRF35-like molecule 8 isoform X1. (313 aa)
LOC111181354N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase-like. (321 aa)
SPINT2Kunitz-type protease inhibitor 2. (249 aa)
PDCD1LG2Programmed cell death 1 ligand 2 isoform X1. (337 aa)
ACER2Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (276 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (461 aa)
ATP5BATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane. (528 aa)
LOC111174870Cytochrome P450 1B1; Belongs to the cytochrome P450 family. (543 aa)
ACVRL1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (515 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
NRARPNotch-regulated ankyrin repeat-containing protein. (114 aa)
KANK1KN motif and ankyrin repeat domain-containing protein 1 isoform X3. (1351 aa)
ASS1Argininosuccinate synthase. (412 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
TACSTD2Tumor-associated calcium signal transducer 2. (323 aa)
NEXMIFProtein KIAA2022 homolog. (1515 aa)
HLXH2.0-like homeobox protein. (488 aa)
LOC111178657Leucine-rich repeat-containing protein 1-like isoform X1. (174 aa)
DEF6Differentially expressed in FDCP 6 homolog isoform X1. (673 aa)
ADAM10Disintegrin and metalloproteinase domain-containing protein 10. (748 aa)
CORO2BCoronin; Belongs to the WD repeat coronin family. (475 aa)
LRRC1Leucine-rich repeat-containing protein 1. (395 aa)
AKNAAT-hook-containing transcription factor isoform X1. (1416 aa)
WNK1Serine/threonine-protein kinase WNK1 isoform X1. (2825 aa)
LAG3Lymphocyte activation gene 3 protein. (493 aa)
CDH13Cadherin-13 isoform X1. (713 aa)
LOC111176900GTPase IMAP family member 5-like isoform X1. (332 aa)
SPOCK1Testican-1 isoform X1. (442 aa)
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
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