STRINGSTRING
NOTCH1 NOTCH1 LHX1 LHX1 MMP15 MMP15 CTR9 CTR9 EXT1 EXT1 ARC ARC NOG NOG MMP2 MMP2 SOX17 SOX17 MMP8 MMP8 BMPR1A BMPR1A CTNNB1 CTNNB1 EOMES EOMES NR0B1 NR0B1 MED12 MED12 EPB41L5 EPB41L5 ITGB5 ITGB5 MMP9 MMP9 ITGA4 ITGA4 ITGAV ITGAV LDB1 LDB1 BMP4 BMP4 PAX9 PAX9 DUSP5 DUSP5 FN1 FN1 SETD2 SETD2 DUSP4 DUSP4 HMGA2 HMGA2 FGF8 FGF8 HDAC1 HDAC1 ITGA7 ITGA7 ZFP36L1 ZFP36L1 NKX2-1 NKX2-1 COL4A2 COL4A2 COL7A1 COL7A1 LEO1 LEO1 ONECUT1 ONECUT1 SSBP3 SSBP3 LOC111177621 LOC111177621 SMAD3 SMAD3 SMAD4 SMAD4 MAP2K1 MAP2K1 APELA APELA TGFB1 TGFB1 PAF1 PAF1 LAMA3 LAMA3 COL11A1 COL11A1 RTF1 RTF1 GATA6 GATA6 COL8A1 COL8A1 WNT8A WNT8A BPTF BPTF GRB2 GRB2 COL12A1 COL12A1 INHBA INHBA LAMB1 LAMB1 LAMB3 LAMB3 SOX7 SOX7 COL6A1 COL6A1 DUSP1 DUSP1 VTN VTN DUSP2 DUSP2 PELO PELO MMP14 MMP14
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NOTCH1Neurogenic locus notch homolog protein 1 isoform X1. (2521 aa)
LHX1LIM/homeobox protein Lhx1. (406 aa)
MMP15Matrix metalloproteinase-15 isoform X1. (691 aa)
CTR9RNA polymerase-associated protein CTR9 homolog isoform X1. (1214 aa)
EXT1Exostosin-1; Belongs to the glycosyltransferase 47 family. (746 aa)
ARCActivity-regulated cytoskeleton-associated protein. (396 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
MMP272 kDa type IV collagenase. (661 aa)
SOX17Transcription factor SOX-17. (408 aa)
MMP8Neutrophil collagenase isoform X1. (468 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
CTNNB1Catenin beta-1. (781 aa)
EOMESEomesodermin homolog isoform X1. (711 aa)
NR0B1Nuclear receptor subfamily 0 group B member 1. (464 aa)
MED12Mediator of RNA polymerase II transcription subunit 12. (2177 aa)
EPB41L5Band 4.1-like protein 5 isoform X1. (726 aa)
ITGB5Integrin beta; Belongs to the integrin beta chain family. (800 aa)
MMP9Matrix metalloproteinase-9. (709 aa)
ITGA4Integrin alpha-4 isoform X1; Belongs to the integrin alpha chain family. (1033 aa)
ITGAVIntegrin alpha-V isoform X2; Belongs to the integrin alpha chain family. (1048 aa)
LDB1LIM domain-binding protein 1 isoform X3. (436 aa)
BMP4Bone morphogenetic protein 4 isoform X2. (408 aa)
PAX9Paired box protein Pax-9 isoform X1. (342 aa)
DUSP5Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (384 aa)
FN1Fibronectin isoform X5. (2478 aa)
SETD2Histone-lysine N-methyltransferase SETD2 isoform X1. (2570 aa)
DUSP4Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (396 aa)
HMGA2High mobility group protein HMGI-C. (109 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
HDAC1Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (393 aa)
ITGA7Integrin alpha-7 isoform X1; Belongs to the integrin alpha chain family. (1141 aa)
ZFP36L1mRNA decay activator protein ZFP36L1. (338 aa)
NKX2-1Homeobox protein Nkx-2.1 isoform X1. (396 aa)
COL4A2Collagen alpha-2(IV) chain isoform X1. (1760 aa)
COL7A1Collagen alpha-1(VII) chain. (2942 aa)
LEO1RNA polymerase-associated protein LEO1 isoform X1. (672 aa)
ONECUT1One cut domain family member. (465 aa)
SSBP3Single-stranded DNA-binding protein 3 isoform X1. (388 aa)
LOC111177621RNA polymerase-associated protein LEO1-like. (292 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
SMAD4Mothers against decapentaplegic homolog. (553 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
APELAApelin receptor early endogenous ligand. (54 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (391 aa)
PAF1RNA polymerase II-associated factor 1 homolog isoform X1. (533 aa)
LAMA3Laminin subunit alpha-3 isoform X3. (3335 aa)
COL11A1Collagen alpha-1(XI) chain isoform X1. (1805 aa)
RTF1RNA polymerase-associated protein RTF1 homolog. (710 aa)
GATA6Transcription factor GATA-6. (592 aa)
COL8A1Collagen alpha-1(VIII) chain isoform X1. (745 aa)
WNT8AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (398 aa)
BPTFNucleosome-remodeling factor subunit BPTF isoform X1. (2871 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
COL12A1Collagen alpha-1(XII) chain isoform X1. (3120 aa)
INHBAInhibin beta A chain. (425 aa)
LAMB1Laminin subunit beta-1. (1786 aa)
LAMB3Laminin subunit beta-3. (1172 aa)
SOX7Transcription factor SOX-7. (390 aa)
COL6A1Collagen alpha-1(VI) chain. (1027 aa)
DUSP1Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (367 aa)
VTNVitronectin. (565 aa)
DUSP2Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (311 aa)
PELOProtein pelota homolog; May function in recognizing stalled ribosomes and triggering endonucleolytic cleavage of the mRNA, a mechanism to release non- functional ribosomes and degrade damaged mRNAs. (385 aa)
MMP14Matrix metalloproteinase-14. (582 aa)
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
Server load: low (26%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.