STRINGSTRING
GP1BB GP1BB F2RL1 F2RL1 F3 F3 CD40LG CD40LG HGFAC HGFAC SERPIND1 SERPIND1 ADRA2C ADRA2C F9 F9 F2RL3 F2RL3 COMP COMP SLC7A11 SLC7A11 BLOC1S4 BLOC1S4 F5 F5 UBASH3B UBASH3B PLG PLG PEAR1 PEAR1 LOC111168748 LOC111168748 WNT3A WNT3A PDGFRA PDGFRA GATA1 GATA1 SERPINC1 SERPINC1 F12 F12 GP9 GP9 F8 F8 SERPINE2 SERPINE2 PRSS56 PRSS56 HPS6 HPS6 MPIG6B MPIG6B LOC111172293 LOC111172293 SLC4A1 SLC4A1 LOC111173428 LOC111173428 LNPK LNPK ADRA2A ADRA2A LOC111171268 LOC111171268 TFPI TFPI PAPSS2 PAPSS2 FN1 FN1 KNG1 KNG1 CPB2 CPB2 GP5 GP5 HABP2 HABP2 F10 F10 SHH SHH ANO6 ANO6 STXBP1 STXBP1 RAP2A RAP2A ENTPD2 ENTPD2 F13B F13B PTPN6 PTPN6 SERPINA10 SERPINA10 GAS6 GAS6 TREML1 TREML1 SRF SRF F7 F7 PROZ PROZ VWF VWF PROS1 PROS1 P2RY12 P2RY12 HPS5 HPS5 RAP2B RAP2B AXL AXL ENPP4 ENPP4 MMRN1 MMRN1 BLOC1S3 BLOC1S3 FZD6 FZD6 GP6 GP6 TYRO3 TYRO3 F13A1 F13A1 STXBP3 STXBP3 BLOC1S6 BLOC1S6 ITGB3 ITGB3 VKORC1 VKORC1 TFPI2 TFPI2 GNA13 GNA13 DTNBP1 DTNBP1 FERMT3 FERMT3 SERPING1 SERPING1 APOH APOH PROCR PROCR PROC PROC F2RL2 F2RL2 TSPAN32 TSPAN32 F2 F2 HNF4A HNF4A P2RX1 P2RX1 AP3B1 AP3B1 THBD THBD F2R F2R PPBP PPBP FGB FGB ANXA5 ANXA5 FBLN1 FBLN1 ADRA2B ADRA2B PLEK PLEK LOC111187580 LOC111187580 FGA FGA FGG FGG MERTK MERTK
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GP1BBPlatelet glycoprotein Ib beta chain. (205 aa)
F2RL1Proteinase-activated receptor 2. (315 aa)
F3Tissue factor; Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade. (292 aa)
CD40LGCD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching. (261 aa)
HGFACHepatocyte growth factor activator isoform X1. (702 aa)
SERPIND1Heparin cofactor 2 isoform X2; Belongs to the serpin family. (496 aa)
ADRA2Calpha-2C adrenergic receptor. (458 aa)
F9Coagulation factor IX. (462 aa)
F2RL3Proteinase-activated receptor 4; Belongs to the G-protein coupled receptor 1 family. (380 aa)
COMPCartilage oligomeric matrix protein. (756 aa)
SLC7A11Cystine/glutamate transporter isoform X1. (520 aa)
BLOC1S4Biogenesis of lysosome-related organelles complex 1 subunit 4. (217 aa)
F5Coagulation factor V isoform X1; Belongs to the multicopper oxidase family. (2169 aa)
UBASH3BUbiquitin-associated and SH3 domain-containing protein B isoform X1. (649 aa)
PLGPlasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...] (812 aa)
PEAR1Platelet endothelial aggregation receptor 1 isoform X1. (1041 aa)
LOC111168748Annexin. (327 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
GATA1Erythroid transcription factor isoform X1. (426 aa)
SERPINC1antithrombin-III isoform X1; Belongs to the serpin family. (501 aa)
F12LOW QUALITY PROTEIN: coagulation factor XII. (650 aa)
GP9Platelet glycoprotein IX. (177 aa)
F8Coagulation factor VIII; Belongs to the multicopper oxidase family. (2152 aa)
SERPINE2Glia-derived nexin isoform X2; Belongs to the serpin family. (397 aa)
PRSS56LOW QUALITY PROTEIN: serine protease 56; Belongs to the peptidase S1 family. (606 aa)
HPS6Hermansky-Pudlak syndrome 6 protein homolog; May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules. (803 aa)
MPIG6BMegakaryocyte and platelet inhibitory receptor G6b isoform X1. (286 aa)
LOC111172293Hyaluronan-binding protein 2. (553 aa)
SLC4A1Anion exchange protein. (963 aa)
LOC111173428Coagulation factor XI; Belongs to the peptidase S1 family. (633 aa)
LNPKProtein lunapark. (429 aa)
ADRA2Aalpha-2A adrenergic receptor. (465 aa)
LOC111171268Coagulation factor VIII-like. (177 aa)
TFPITissue factor pathway inhibitor isoform X1. (307 aa)
PAPSS2Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 isoform X1. (635 aa)
FN1Fibronectin isoform X5. (2478 aa)
KNG1Kininogen-1 isoform X1. (627 aa)
CPB2Carboxypeptidase B2. (423 aa)
GP5Platelet glycoprotein V. (569 aa)
HABP2Hyaluronan-binding protein 2. (433 aa)
F10Coagulation factor X isoform X1. (480 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (461 aa)
ANO6Anoctamin. (951 aa)
STXBP1Syntaxin-binding protein 1 isoform X1; Belongs to the STXBP/unc-18/SEC1 family. (603 aa)
RAP2ARas-related protein Rap-2a. (183 aa)
ENTPD2Ectonucleoside triphosphate diphosphohydrolase 2 isoform X1; Belongs to the GDA1/CD39 NTPase family. (588 aa)
F13BCoagulation factor XIII B chain. (660 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
SERPINA10Protein Z-dependent protease inhibitor; Belongs to the serpin family. (446 aa)
GAS6Growth arrest-specific protein 6. (671 aa)
TREML1Trem-like transcript 1 protein isoform X1. (315 aa)
SRFSerum response factor isoform X2. (535 aa)
F7Coagulation factor VII isoform X1. (447 aa)
PROZVitamin K-dependent protein Z; Belongs to the peptidase S1 family. (709 aa)
VWFVon Willebrand factor. (2806 aa)
PROS1Vitamin K-dependent protein S. (675 aa)
P2RY12P2Y purinoceptor 12. (339 aa)
HPS5Hermansky-Pudlak syndrome 5 protein homolog; May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules. (1146 aa)
RAP2BRas-related protein Rap-2b. (183 aa)
AXLLOW QUALITY PROTEIN: tyrosine-protein kinase receptor UFO. (887 aa)
ENPP4Bis(5'-adenosyl)-triphosphatase ENPP4. (456 aa)
MMRN1Multimerin-1. (1216 aa)
BLOC1S3Biogenesis of lysosome-related organelles complex 1 subunit 3 isoform X1. (233 aa)
FZD6Frizzled-6; Belongs to the G-protein coupled receptor Fz/Smo family. (712 aa)
GP6Platelet glycoprotein VI isoform X1. (464 aa)
TYRO3Tyrosine-protein kinase receptor TYRO3 isoform X3. (896 aa)
F13A1Coagulation factor XIII A chain. (732 aa)
STXBP3Syntaxin-binding protein 3; Belongs to the STXBP/unc-18/SEC1 family. (592 aa)
BLOC1S6Biogenesis of lysosome-related organelles complex 1 subunit 6; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. May play a role in intracellular vesicle trafficking, particular [...] (172 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (789 aa)
VKORC1Vitamin K epoxide reductase complex subunit 1 isoform X1. (163 aa)
TFPI2Tissue factor pathway inhibitor. (300 aa)
GNA13Guanine nucleotide-binding protein subunit alpha-13. (377 aa)
DTNBP1Dysbindin isoform X1. (341 aa)
FERMT3Fermitin family homolog 3. (663 aa)
SERPING1Plasma protease C1 inhibitor; Belongs to the serpin family. (471 aa)
APOHBeta-2-glycoprotein 1 isoform X1. (345 aa)
PROCREndothelial protein C receptor. (242 aa)
PROCVitamin K-dependent protein C. (480 aa)
F2RL2Proteinase-activated receptor 3 isoform X1; Belongs to the G-protein coupled receptor 1 family. (438 aa)
TSPAN32Tetraspanin-32 isoform X1; Belongs to the tetraspanin (TM4SF) family. (571 aa)
F2Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. (623 aa)
HNF4AHepatocyte nuclear factor 4-alpha isoform X1. (484 aa)
P2RX1P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (399 aa)
AP3B1AP-3 complex subunit beta; Belongs to the adaptor complexes large subunit family. (1087 aa)
THBDThrombomodulin. (584 aa)
F2RProteinase-activated receptor 1; Belongs to the G-protein coupled receptor 1 family. (427 aa)
PPBPC-X-C motif chemokine. (119 aa)
FGBFibrinogen beta chain isoform X1. (495 aa)
ANXA5Annexin. (370 aa)
FBLN1Fibulin-1; Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes. (705 aa)
ADRA2Balpha-2B adrenergic receptor. (446 aa)
PLEKPleckstrin. (350 aa)
LOC111187580C-X-C motif chemokine. (112 aa)
FGAFibrinogen alpha chain. (852 aa)
FGGFibrinogen gamma chain isoform X1. (445 aa)
MERTKTyrosine-protein kinase Mer. (999 aa)
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.