STRINGSTRING
LOC111166174 LOC111166174 NGFR NGFR NAGLU NAGLU ZPBP2 ZPBP2 NR1D1 NR1D1 NTRK2 NTRK2 PROKR2 PROKR2 DRD2 DRD2 NTRK1 NTRK1 USP2 USP2 CRY2 CRY2 KDM2A KDM2A LOC111183698 LOC111183698 PROX1 PROX1 NCOA2 NCOA2 ATF4 ATF4 NUDT12 NUDT12 PER1 PER1 PPARA PPARA LOC111185989 LOC111185989 MYBBP1A MYBBP1A LOC111186244 LOC111186244 EP300 EP300 HNRNPD HNRNPD RAI1 RAI1 PPP1CC PPP1CC PER3 PER3 GPR157 GPR157 NPAS2 NPAS2 CRY1 CRY1 TP53 TP53 AHR AHR SIRT1 SIRT1 GFPT1 GFPT1 NFIL3 NFIL3 CSNK1D CSNK1D LOC111183699 LOC111183699 ID1 ID1 ID3 ID3 ID2 ID2 NR0B2 NR0B2 PRMT5 PRMT5 NOCT NOCT NAMPT NAMPT DYRK1A DYRK1A NR1D2 NR1D2 ARNTL ARNTL CARTPT CARTPT KMT2A KMT2A CLOCK CLOCK CIART CIART OGT OGT CAVIN3 CAVIN3 HUWE1 HUWE1 PPARGC1A PPARGC1A CREB1 CREB1 PER2 PER2 MAGED1 MAGED1 CUNH3orf70 CUNH3orf70 BHLHE40 BHLHE40 PROK2 PROK2 IMPDH2 IMPDH2 HDAC1 HDAC1 PPP1CB PPP1CB TIMELESS TIMELESS BHLHE41 BHLHE41 MYCBP2 MYCBP2 KDM5A KDM5A NDUFA9 NDUFA9 THRAP3 THRAP3 KLF9 KLF9 ASS1 ASS1 RORA RORA NRIP1 NRIP1 HNRNPU HNRNPU SETX SETX ARNTL2 ARNTL2 PML PML MTTP MTTP BTBD9 BTBD9 HCRTR2 HCRTR2 ATF5 ATF5 LOC111178406 LOC111178406 DBP DBP TNFRSF11A TNFRSF11A ID4 ID4 LGR4 LGR4 KDM8 KDM8 EGR1 EGR1 KLF10 KLF10 ATOH7 ATOH7 GPR176 GPR176 PPP1CA PPP1CA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC111166174Uncharacterized protein LOC111166174. (283 aa)
NGFRTumor necrosis factor receptor superfamily member 16. (427 aa)
NAGLUalpha-N-acetylglucosaminidase. (744 aa)
ZPBP2Zona pellucida-binding protein 2 isoform X1. (326 aa)
NR1D1Nuclear receptor subfamily 1 group D member 1. (613 aa)
NTRK2Tyrosine-protein kinase receptor. (822 aa)
PROKR2Prokineticin receptor 2; Belongs to the G-protein coupled receptor 1 family. (384 aa)
DRD2D(2) dopamine receptor; Belongs to the G-protein coupled receptor 1 family. (443 aa)
NTRK1Tyrosine-protein kinase receptor. (795 aa)
USP2Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (603 aa)
CRY2Cryptochrome-2. (588 aa)
KDM2ALysine-specific demethylase 2A isoform X1. (1162 aa)
LOC111183698RNA-binding protein 4B isoform X1. (369 aa)
PROX1Prospero homeobox protein 1 isoform X1. (738 aa)
NCOA2Nuclear receptor coactivator. (1464 aa)
ATF4Cyclic AMP-dependent transcription factor ATF-4 isoform X1. (350 aa)
NUDT12Peroxisomal NADH pyrophosphatase NUDT12 isoform X1. (465 aa)
PER1Period circadian protein homolog 1 isoform X1. (1267 aa)
PPARAPeroxisome proliferator-activated receptor alpha. (468 aa)
LOC111185989Nitric oxide synthase; Produces nitric oxide (NO). (1146 aa)
MYBBP1AMyb-binding protein 1A. (1407 aa)
LOC111186244Casein kinase I isoform X1; Belongs to the protein kinase superfamily. (416 aa)
EP300Histone acetyltransferase p300. (2420 aa)
HNRNPDHeterogeneous nuclear ribonucleoprotein D0 isoform X1. (355 aa)
RAI1Retinoic acid-induced protein 1 isoform X1. (1948 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (337 aa)
PER3Period circadian protein homolog 3 isoform X1. (1151 aa)
GPR157G-protein coupled receptor 157 isoform X1. (337 aa)
NPAS2Neuronal PAS domain-containing protein 2 isoform X1. (822 aa)
CRY1Cryptochrome-1 isoform X1. (587 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (387 aa)
AHRAryl hydrocarbon receptor; Ligand-activated transcriptional activator. Binds to the XRE promoter region of genes it activates. Activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes (such as the CYP1A1 gene). Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons. Involved in cell-cycle regulation. Likely to play an important role in the development and maturation of many tissues. Regulates the circadian clock by inhibiting the basal and circadian expression of the core circadian component PER1. Inhibits PER1 by repressing [...] (845 aa)
SIRT1NAD-dependent protein deacetylase sirtuin-1 isoform X1. (735 aa)
GFPT1Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1. (681 aa)
NFIL3Nuclear factor interleukin-3-regulated protein; Acts as a transcriptional regulator that recognizes and binds to the sequence 5'-[GA]TTA[CT]GTAA[CT]-3', a sequence present in many cellular and viral promoters. Represses transcription from promoters with activating transcription factor (ATF) sites. Represses promoter activity in osteoblasts. Represses transcriptional activity of PER1. Represses transcriptional activity of PER2 via the B-site on the promoter. Activates transcription from the interleukin-3 promoter in T- cells. Competes for the same consensus-binding site with PAR DNA- bi [...] (462 aa)
CSNK1DCasein kinase I isoform X4; Belongs to the protein kinase superfamily. (428 aa)
LOC111183699RNA-binding protein 4 isoform X1. (363 aa)
ID1DNA-binding protein inhibitor ID-1. (154 aa)
ID3DNA-binding protein inhibitor ID-3. (227 aa)
ID2DNA-binding protein inhibitor ID-2. (134 aa)
NR0B2Nuclear receptor subfamily 0 group B member 2. (260 aa)
PRMT5Protein arginine N-methyltransferase 5; Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA); Belongs to the class I-like SAM-binding methyltransferase superfamily. (637 aa)
NOCTNocturnin. (538 aa)
NAMPTNicotinamide phosphoribosyltransferase; Belongs to the NAPRTase family. (491 aa)
DYRK1ADual specificity tyrosine-phosphorylation-regulated kinase 1A isoform X1. (845 aa)
NR1D2Nuclear receptor subfamily 1 group D member 2 isoform X1. (575 aa)
ARNTLAryl hydrocarbon receptor nuclear translocator-like protein 1 isoform X1. (631 aa)
CARTPTCocaine- and amphetamine-regulated transcript protein. (116 aa)
KMT2AHistone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. TRX/MLL subfamily. (4012 aa)
CLOCKLOW QUALITY PROTEIN: circadian locomoter output cycles protein kaput. (858 aa)
CIARTCircadian-associated transcriptional repressor. (396 aa)
OGTUDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit isoform X1. (1046 aa)
CAVIN3Caveolae-associated protein 3. (262 aa)
HUWE1E3 ubiquitin-protein ligase HUWE1. (4400 aa)
PPARGC1APeroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X1. (803 aa)
CREB1Cyclic AMP-responsive element-binding protein 1 isoform X1. (341 aa)
PER2Period circadian protein homolog 2. (1294 aa)
MAGED1Melanoma-associated antigen D1 isoform X1. (841 aa)
CUNH3orf70UPF0524 protein C3orf70 homolog. (250 aa)
BHLHE40Class E basic helix-loop-helix protein 40. (412 aa)
PROK2Prokineticin-2 isoform X2. (129 aa)
IMPDH2Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. (514 aa)
HDAC1Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (393 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (327 aa)
TIMELESSProtein timeless homolog isoform X1. (1202 aa)
BHLHE41Class E basic helix-loop-helix protein 41. (483 aa)
MYCBP2E3 ubiquitin-protein ligase MYCBP2 isoform X1. (4763 aa)
KDM5ALysine-specific demethylase 5A isoform X1. (1689 aa)
NDUFA9NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial. (377 aa)
THRAP3Thyroid hormone receptor-associated protein 3. (958 aa)
KLF9Krueppel-like factor 9. (244 aa)
ASS1Argininosuccinate synthase. (412 aa)
RORANuclear receptor ROR-alpha isoform X1. (523 aa)
NRIP1Nuclear receptor-interacting protein 1. (1156 aa)
HNRNPUHeterogeneous nuclear ribonucleoprotein U isoform X1. (825 aa)
SETXProbable helicase senataxin. (2685 aa)
ARNTL2Aryl hydrocarbon receptor nuclear translocator-like protein 2 isoform X1. (607 aa)
PMLProtein PML isoform X1. (861 aa)
MTTPMicrosomal triglyceride transfer protein large subunit. (894 aa)
BTBD9BTB/POZ domain-containing protein 9 isoform X1. (637 aa)
HCRTR2Orexin receptor type 2 isoform X1; Belongs to the G-protein coupled receptor 1 family. (457 aa)
ATF5Cyclic AMP-dependent transcription factor ATF-5. (279 aa)
LOC111178406Protein arginine N-methyltransferase 5; Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA); Belongs to the class I-like SAM-binding methyltransferase superfamily. (596 aa)
DBPD site-binding protein. (325 aa)
TNFRSF11ATumor necrosis factor receptor superfamily member 11A isoform X1. (551 aa)
ID4DNA-binding protein inhibitor ID-4. (161 aa)
LGR4Leucine-rich repeat-containing G-protein coupled receptor 4 isoform X1. (951 aa)
KDM8Lysine-specific demethylase 8. (406 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (531 aa)
KLF10Krueppel-like factor 10 isoform X2. (494 aa)
ATOH7Protein atonal homolog 7. (152 aa)
GPR176G-protein coupled receptor 176. (515 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (330 aa)
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
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