STRINGSTRING
HOMER3 HOMER3 LAMA1 LAMA1 ERCC4 ERCC4 USP7 USP7 HSPG2 HSPG2 EPB41 EPB41 TOP2B TOP2B HIC2 HIC2 AGO2 AGO2 MID1IP1 MID1IP1 LOC111163551 LOC111163551 SCLT1 SCLT1 LOC111165935 LOC111165935 CTGF CTGF SNTG1 SNTG1 PCNA PCNA SNF8 SNF8 VTA1 VTA1 PHB PHB TNFAIP3 TNFAIP3 LOC111166741 LOC111166741 TOP2A TOP2A IFT46 IFT46 ATP1B1 ATP1B1 EZR EZR ERBB2 ERBB2 MCAM MCAM PDZD3 PDZD3 LOC111168051 LOC111168051 MRE11 MRE11 VGLL2 VGLL2 CTNNB1 CTNNB1 CEP135 CEP135 PCGF1 PCGF1 ECM1 ECM1 ERCC6 ERCC6 PRRC2C PRRC2C HRAS HRAS MED12 MED12 PDZD11 PDZD11 LOC111171019 LOC111171019 PEX12 PEX12 YAP1 YAP1 CAV3 CAV3 PRDX3 PRDX3 MKI67 MKI67 DLG1 DLG1 XRCC5 XRCC5 NUMA1 NUMA1 LOC111172806 LOC111172806 CITED1 CITED1 ARL6IP5 ARL6IP5 FN1 FN1 LOC111172805 LOC111172805 PXK PXK SYNJ2BP SYNJ2BP CALCOCO1 CALCOCO1 SP1 SP1 MAPRE3 MAPRE3 VPS36 VPS36 YEATS4 YEATS4 GRIP1 GRIP1 MPDZ MPDZ SDC1 SDC1 FOXN3 FOXN3 PEX5 PEX5 CACNA1B CACNA1B PHB2 PHB2 CATSPERE CATSPERE PATJ PATJ MSH2 MSH2 FBLN5 FBLN5 BRCA2 BRCA2 PAXIP1 PAXIP1 LIG4 LIG4 KPNA3 KPNA3 DNM1 DNM1 PEX26 PEX26 LCK LCK PEX6 PEX6 ABL1 ABL1 MAP2K1 MAP2K1 GPSM2 GPSM2 NEIL1 NEIL1 TERT TERT TERF2 TERF2 VPS4A VPS4A VGLL3 VGLL3 VPS4B VPS4B SAE1 SAE1 ERCC1 ERCC1 ERCC2 ERCC2 BCAM BCAM BCL10 BCL10 ITGB3BP ITGB3BP TCF4 TCF4 RAD51 RAD51 PIAS3 PIAS3 CEP120 CEP120 PEX1 PEX1 ATXN1 ATXN1 PPP2CA PPP2CA MIF4GD MIF4GD ERCC3 ERCC3 SIRT1 SIRT1 CORO1A CORO1A NCF2 NCF2 SRC SRC SDCBP2 SDCBP2 XRCC4 XRCC4 CENPF CENPF PEX16 PEX16 IFT52 IFT52 AXIN1 AXIN1 CDK7 CDK7 CEP250 CEP250 NEFL NEFL DLG4 DLG4 PLEKHB1 PLEKHB1 TAX1BP3 TAX1BP3 MAD2L1 MAD2L1 SLC9A3R2 SLC9A3R2 XRCC6 XRCC6 PICK1 PICK1 EP300 EP300 PTK2B PTK2B CNRIP1 CNRIP1 MYO1C MYO1C DAB2 DAB2 FBLN1 FBLN1 SREBF2 SREBF2 TESK1 TESK1 NIPBL NIPBL
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
HOMER3Homer protein homolog 3. (360 aa)
LAMA1Laminin subunit alpha-1 isoform X1. (3081 aa)
ERCC4DNA repair endonuclease XPF. (916 aa)
USP7LOW QUALITY PROTEIN: ubiquitin carboxyl-terminal hydrolase 7; Belongs to the peptidase C19 family. (1102 aa)
HSPG2Basement membrane-specific heparan sulfate proteoglycan core protein isoform X1. (4408 aa)
EPB41Protein 4.1 isoform X2. (891 aa)
TOP2BDNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1620 aa)
HIC2Hypermethylated in cancer 2 protein. (613 aa)
AGO2Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...] (902 aa)
MID1IP1Mid1-interacting protein 1. (183 aa)
LOC111163551RNA binding protein fox-1 homolog 1 isoform X1. (459 aa)
SCLT1Sodium channel and clathrin linker 1 isoform X1. (706 aa)
LOC111165935Ras-like protein isoform X1. (285 aa)
CTGFConnective tissue growth factor isoform X1. (349 aa)
SNTG1Gamma-1-syntrophin. (517 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
SNF8Vacuolar-sorting protein SNF8; Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. Belongs to the SNF8 family. (258 aa)
VTA1Vacuolar protein sorting-associated protein VTA1 homolog. (309 aa)
PHBProhibitin. (272 aa)
TNFAIP3Tumor necrosis factor alpha-induced protein 3. (785 aa)
LOC111166741SAM and SH3 domain-containing protein 1 isoform X1. (1513 aa)
TOP2ADNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1533 aa)
IFT46Intraflagellar transport protein 46 homolog isoform X1. (345 aa)
ATP1B1Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (303 aa)
EZREzrin. (586 aa)
ERBB2Receptor protein-tyrosine kinase. (1255 aa)
MCAMCell surface glycoprotein MUC18 isoform X1. (638 aa)
PDZD3Na(+)/H(+) exchange regulatory cofactor NHE-RF4. (501 aa)
LOC111168051Protein NPAT. (1440 aa)
MRE11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (707 aa)
VGLL2Transcription cofactor vestigial-like protein 2 isoform X1. (338 aa)
CTNNB1Catenin beta-1. (781 aa)
CEP135Centrosomal protein of 135 kDa isoform X1. (1148 aa)
PCGF1Polycomb group RING finger protein 1. (259 aa)
ECM1Extracellular matrix protein 1 isoform X1. (544 aa)
ERCC6DNA excision repair protein ERCC-6. (1485 aa)
PRRC2CProtein PRRC2C isoform X1. (2873 aa)
HRASGTPase HRas isoform X1. (189 aa)
MED12Mediator of RNA polymerase II transcription subunit 12. (2177 aa)
PDZD11PDZ domain-containing protein 11. (140 aa)
LOC111171019Glutamate receptor-interacting protein 1-like. (206 aa)
PEX12LOW QUALITY PROTEIN: peroxisome assembly protein 12. (228 aa)
YAP1Transcriptional coactivator YAP1 isoform X1. (511 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
PRDX3Thioredoxin-dependent peroxide reductase, mitochondrial. (257 aa)
MKI67Proliferation marker protein Ki-67 isoform X1. (1527 aa)
DLG1Disks large homolog 1 isoform X1; Belongs to the MAGUK family. (927 aa)
XRCC5X-ray repair cross-complementing protein 5. (733 aa)
NUMA1Nuclear mitotic apparatus protein 1 isoform X1. (2125 aa)
LOC111172806Fidgetin-like isoform X1; Belongs to the AAA ATPase family. (759 aa)
CITED1Cbp/p300-interacting transactivator 1 isoform X1. (359 aa)
ARL6IP5PRA1 family protein. (188 aa)
FN1Fibronectin isoform X5. (2478 aa)
LOC111172805Fidgetin; Belongs to the AAA ATPase family. (748 aa)
PXKPX domain-containing protein kinase-like protein isoform X9. (583 aa)
SYNJ2BPSynaptojanin-2-binding protein isoform X1. (150 aa)
CALCOCO1Calcium-binding and coiled-coil domain-containing protein 1. (692 aa)
SP1Transcription factor Sp1. (786 aa)
MAPRE3Microtubule-associated protein RP/EB family member 3 isoform X1. (301 aa)
VPS36Vacuolar protein-sorting-associated protein 36. (386 aa)
YEATS4YEATS domain-containing protein 4. (227 aa)
GRIP1Glutamate receptor-interacting protein 1. (886 aa)
MPDZMultiple PDZ domain protein isoform X1. (2071 aa)
SDC1Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (310 aa)
FOXN3Forkhead box protein N3 isoform X1. (535 aa)
PEX5Peroxisomal biogenesis factor 5 isoform X1. (640 aa)
CACNA1BVoltage-dependent N-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1B gives rise to N-type calcium currents. (1749 aa)
PHB2Prohibitin. (299 aa)
CATSPERECation channel sperm-associated protein subunit epsilon. (952 aa)
PATJinaD-like protein isoform X1. (1900 aa)
MSH2DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (934 aa)
FBLN5Fibulin-5 isoform X1. (461 aa)
BRCA2Breast cancer type 2 susceptibility protein. (3435 aa)
PAXIP1PAX-interacting protein 1 isoform X1. (1030 aa)
LIG4DNA ligase. (911 aa)
KPNA3Importin subunit alpha; Functions in nuclear protein import. (521 aa)
DNM1Dynamin-1 isoform X1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (868 aa)
PEX26Peroxisome assembly protein 26. (300 aa)
LCKTyrosine-protein kinase. (509 aa)
PEX6Peroxisome biogenesis factor 6. (980 aa)
ABL1Tyrosine-protein kinase. (1148 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
GPSM2G-protein-signaling modulator 2. (681 aa)
NEIL1Endonuclease 8-like 1 isoform X1. (447 aa)
TERTTelomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (1203 aa)
TERF2Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (539 aa)
VPS4AVacuolar protein sorting-associated protein 4A isoform X1; Belongs to the AAA ATPase family. (437 aa)
VGLL3Transcription cofactor vestigial-like protein 3 isoform X1. (332 aa)
VPS4BVacuolar protein sorting-associated protein 4B; Belongs to the AAA ATPase family. (444 aa)
SAE1SUMO-activating enzyme subunit 1 isoform X1. (346 aa)
ERCC1DNA excision repair protein ERCC-1 isoform X1. (414 aa)
ERCC2TFIIH basal transcription factor complex helicase XPD subunit isoform X1. (823 aa)
BCAMBasal cell adhesion molecule. (628 aa)
BCL10B-cell lymphoma/leukemia 10. (233 aa)
ITGB3BPCentromere protein R; Transcription coregulator that can have both coactivator and corepressor functions. (164 aa)
TCF4Transcription factor 4 isoform X1. (671 aa)
RAD51DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (339 aa)
PIAS3E3 SUMO-protein ligase PIAS3 isoform X1. (628 aa)
CEP120Centrosomal protein of 120 kDa isoform X1. (982 aa)
PEX1Peroxisome biogenesis factor 1 isoform X1. (1283 aa)
ATXN1Ataxin-1. (807 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
MIF4GDMIF4G domain-containing protein isoform X1; Belongs to the mitochondrial carrier (TC 2.A.29) family. (453 aa)
ERCC3TFIIH basal transcription factor complex helicase XPB subunit isoform X1. (782 aa)
SIRT1NAD-dependent protein deacetylase sirtuin-1 isoform X1. (735 aa)
CORO1ACoronin; Belongs to the WD repeat coronin family. (461 aa)
NCF2Neutrophil cytosol factor 2 isoform X1. (526 aa)
SRCTyrosine-protein kinase. (562 aa)
SDCBP2Syntenin-2 isoform X1. (291 aa)
XRCC4DNA repair protein XRCC4 isoform X1. (333 aa)
CENPFCentromere protein F. (3077 aa)
PEX16Peroxisomal membrane protein PEX16. (402 aa)
IFT52Intraflagellar transport protein 52 homolog isoform X1. (446 aa)
AXIN1Axin-1 isoform X1. (866 aa)
CDK7Cyclin-dependent kinase 7 isoform X1; Belongs to the protein kinase superfamily. (346 aa)
CEP250Centrosome-associated protein CEP250 isoform X1. (2445 aa)
NEFLNeurofilament light polypeptide; Belongs to the intermediate filament family. (554 aa)
DLG4Disks large homolog 4 isoform X1; Belongs to the MAGUK family. (752 aa)
PLEKHB1Pleckstrin homology domain-containing family B member 1 isoform X2. (223 aa)
TAX1BP3Tax1-binding protein 3; May regulate a number of protein-protein interactions by competing for PDZ domain binding sites. (124 aa)
MAD2L1Mitotic spindle assembly checkpoint protein MAD2A. (205 aa)
SLC9A3R2Na(+)/H(+) exchange regulatory cofactor NHE-RF2 isoform X1. (360 aa)
XRCC6X-ray repair cross-complementing protein 6. (609 aa)
PICK1PRKCA-binding protein isoform X1. (417 aa)
EP300Histone acetyltransferase p300. (2420 aa)
PTK2BProtein-tyrosine kinase 2-beta isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1015 aa)
CNRIP1CB1 cannabinoid receptor-interacting protein 1. (164 aa)
MYO1CUnconventional myosin-Ic isoform X1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1063 aa)
DAB2Disabled homolog 2 isoform X1. (769 aa)
FBLN1Fibulin-1; Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes. (705 aa)
SREBF2Sterol regulatory element-binding protein 2 isoform X1. (1135 aa)
TESK1Dual specificity testis-specific protein kinase 1 isoform X1. (628 aa)
NIPBLNipped-B protein. (2803 aa)
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
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