31 items (Delphinapterus leucas) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	DAB2IP	Disabled homolog 2-interacting protein isoform X1. (1193 aa)
	ITPRIPL2	Inositol 1,4,5-trisphosphate receptor-interacting protein-like 2. (532 aa)
	CASP8AP2	CASP8-associated protein 2 isoform X2. (1974 aa)
	DDX3X	ATP-dependent RNA helicase DDX3X isoform X1; Belongs to the DEAD box helicase family. (662 aa)
	DAPK1	Death-associated protein kinase 1 isoform X1. (1440 aa)
	DEDD	Death effector domain-containing protein. (318 aa)
	FASLG	Tumor necrosis factor ligand superfamily member 6; Belongs to the tumor necrosis factor family. (262 aa)
	TNF	Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (233 aa)
	PIK3R1	Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
	NF1	Neurofibromin isoform X1. (2873 aa)
	LOC111185436	Tumor necrosis factor receptor superfamily member 10B-like isoform X1. (456 aa)
	LOC111185435	Tumor necrosis factor receptor superfamily member 10A-like isoform X1. (454 aa)
	CASP10	Caspase-10; Belongs to the peptidase C14A family. (518 aa)
	LOC111184077	Tumor necrosis factor receptor superfamily member 26-like. (308 aa)
	STK4	Serine/threonine-protein kinase 4 isoform X1. (487 aa)
	BAD	Bcl2-associated agonist of cell death. (168 aa)
	FADD	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (211 aa)
	KIAA0141	Death ligand signal enhancer isoform X1. (517 aa)
	STK3	Serine/threonine-protein kinase 3. (491 aa)
	NGF	Beta-nerve growth factor; Belongs to the NGF-beta family. (241 aa)
	BCL2	Apoptosis regulator Bcl-2. (233 aa)
	DAXX	Death domain-associated protein 6 isoform X1. (742 aa)
	RAF1	RAF proto-oncogene serine/threonine-protein kinase isoform X1. (648 aa)
	DEDD2	DNA-binding death effector domain-containing protein 2. (322 aa)
	CASP8	Caspase-8; Belongs to the peptidase C14A family. (486 aa)
	ITPRIP	Inositol 1,4,5-trisphosphate receptor-interacting protein isoform X1. (667 aa)
	BAG3	BAG family molecular chaperone regulator 3. (577 aa)
	PIDD1	P53-induced death domain-containing protein 1 isoform X1. (971 aa)
	SKIL	Ski-like protein isoform X1. (684 aa)
	DDX47	Probable ATP-dependent RNA helicase DDX47; Belongs to the DEAD box helicase family. (455 aa)
	SORT1	Sortilin. (864 aa)

Your Current Organism:

Delphinapterus leucas

NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BAD	BCL2	A0A2Y9PW98	A0A2Y9P9P5	Bcl2-associated agonist of cell death.	Apoptosis regulator Bcl-2.	0.998
BAD	FADD	A0A2Y9PW98	A0A2Y9PNL8	Bcl2-associated agonist of cell death.	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	0.508
BAD	RAF1	A0A2Y9PW98	A0A2Y9MMZ0	Bcl2-associated agonist of cell death.	RAF proto-oncogene serine/threonine-protein kinase isoform X1.	0.940
BAG3	BCL2	A0A2Y9MTQ1	A0A2Y9P9P5	BAG family molecular chaperone regulator 3.	Apoptosis regulator Bcl-2.	0.771
BCL2	BAD	A0A2Y9P9P5	A0A2Y9PW98	Apoptosis regulator Bcl-2.	Bcl2-associated agonist of cell death.	0.998
BCL2	BAG3	A0A2Y9P9P5	A0A2Y9MTQ1	Apoptosis regulator Bcl-2.	BAG family molecular chaperone regulator 3.	0.771
BCL2	CASP10	A0A2Y9P9P5	A0A2Y9MLF7	Apoptosis regulator Bcl-2.	Caspase-10; Belongs to the peptidase C14A family.	0.482
BCL2	CASP8	A0A2Y9P9P5	A0A2Y9MQ94	Apoptosis regulator Bcl-2.	Caspase-8; Belongs to the peptidase C14A family.	0.810
BCL2	FADD	A0A2Y9P9P5	A0A2Y9PNL8	Apoptosis regulator Bcl-2.	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	0.617
BCL2	FASLG	A0A2Y9P9P5	A0A2Y9MFA3	Apoptosis regulator Bcl-2.	Tumor necrosis factor ligand superfamily member 6; Belongs to the tumor necrosis factor family.	0.661
BCL2	NGF	A0A2Y9P9P5	A0A2Y9PB93	Apoptosis regulator Bcl-2.	Beta-nerve growth factor; Belongs to the NGF-beta family.	0.506
BCL2	RAF1	A0A2Y9P9P5	A0A2Y9MMZ0	Apoptosis regulator Bcl-2.	RAF proto-oncogene serine/threonine-protein kinase isoform X1.	0.527
BCL2	TNF	A0A2Y9P9P5	Q8WNR1	Apoptosis regulator Bcl-2.	Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...]	0.651
CASP10	BCL2	A0A2Y9MLF7	A0A2Y9P9P5	Caspase-10; Belongs to the peptidase C14A family.	Apoptosis regulator Bcl-2.	0.482
CASP10	CASP8	A0A2Y9MLF7	A0A2Y9MQ94	Caspase-10; Belongs to the peptidase C14A family.	Caspase-8; Belongs to the peptidase C14A family.	0.974
CASP10	FADD	A0A2Y9MLF7	A0A2Y9PNL8	Caspase-10; Belongs to the peptidase C14A family.	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	0.995
CASP10	FASLG	A0A2Y9MLF7	A0A2Y9MFA3	Caspase-10; Belongs to the peptidase C14A family.	Tumor necrosis factor ligand superfamily member 6; Belongs to the tumor necrosis factor family.	0.759
CASP10	LOC111184077	A0A2Y9MLF7	A0A2Y9PXW8	Caspase-10; Belongs to the peptidase C14A family.	Tumor necrosis factor receptor superfamily member 26-like.	0.499
CASP10	LOC111185435	A0A2Y9MLF7	A0A2Y9Q5N6	Caspase-10; Belongs to the peptidase C14A family.	Tumor necrosis factor receptor superfamily member 10A-like isoform X1.	0.658
CASP10	LOC111185436	A0A2Y9MLF7	A0A2Y9Q5P0	Caspase-10; Belongs to the peptidase C14A family.	Tumor necrosis factor receptor superfamily member 10B-like isoform X1.	0.658