(13 nodes) Regulation of ketone biosynthetic process network (Delphinapterus leucas)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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Known Interactions

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Predicted Interactions

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Your Input:
	PPTC7	Protein phosphatase; Belongs to the PP2C family. (304 aa)
	DKK3	Dickkopf-related protein 3. (349 aa)
	DGKQ	Diacylglycerol kinase. (976 aa)
	BMP2	Bone morphogenetic protein 2. (395 aa)
	LOC111169295	RE1-silencing transcription factor-like isoform X1. (981 aa)
	LOC111169240	RE1-silencing transcription factor-like isoform X2. (976 aa)
	CLCN2	Chloride channel protein 2 isoform X1. (908 aa)
	BMP5	Bone morphogenetic protein 5 isoform X1. (454 aa)
	DKKL1	Dickkopf-like protein 1. (235 aa)
	BMP6	Bone morphogenetic protein 6. (496 aa)
	SIRT5	NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting. Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species. Modulates ketogenesis through the desuccinyl [...] (344 aa)
	EGR1	Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (531 aa)
	H6PD	GDH/6PGL endoplasmic bifunctional protein isoform X1. (822 aa)

Your Current Organism:

Delphinapterus leucas

NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BMP2	BMP5	A0A2Y9LYV6	A0A2Y9NT83	Bone morphogenetic protein 2.	Bone morphogenetic protein 5 isoform X1.	0.566
BMP2	BMP6	A0A2Y9LYV6	A0A2Y9P5G7	Bone morphogenetic protein 2.	Bone morphogenetic protein 6.	0.956
BMP5	BMP2	A0A2Y9NT83	A0A2Y9LYV6	Bone morphogenetic protein 5 isoform X1.	Bone morphogenetic protein 2.	0.566
BMP6	BMP2	A0A2Y9P5G7	A0A2Y9LYV6	Bone morphogenetic protein 6.	Bone morphogenetic protein 2.	0.956
LOC111169240	LOC111169295	A0A2Y9MIZ9	A0A2Y9MA63	RE1-silencing transcription factor-like isoform X2.	RE1-silencing transcription factor-like isoform X1.	0.900
LOC111169295	LOC111169240	A0A2Y9MA63	A0A2Y9MIZ9	RE1-silencing transcription factor-like isoform X1.	RE1-silencing transcription factor-like isoform X2.	0.900