STRINGSTRING
ETS1 ETS1 NR2E1 NR2E1 EMP2 EMP2 PIK3CG PIK3CG STAT5A STAT5A LOC111166071 LOC111166071 JUP JUP LOC111166741 LOC111166741 INSL3 INSL3 FBXW9 FBXW9 NUS1 NUS1 RAB25 RAB25 ADGRB1 ADGRB1 TNF TNF HMOX1 HMOX1 CXCL13 CXCL13 PIK3CD PIK3CD LOC111187154 LOC111187154 GLIPR2 GLIPR2 FBXW7 FBXW7 RTN4 RTN4 ANXA3 ANXA3 NR2F2 NR2F2 MTOR MTOR EPHA2 EPHA2 P2RX4 P2RX4 NF1 NF1 PLK2 PLK2 FGF18 FGF18 PTK2B PTK2B LOC111186398 LOC111186398 PDPK1 PDPK1 LOC111186242 LOC111186242 ARSJ ARSJ PDGFB PDGFB ALOX12 ALOX12 RIN2 RIN2 ARSB ARSB PRCP PRCP ATP2B4 ATP2B4 PROX1 PROX1 DOCK5 DOCK5 SRC SRC VIL1 VIL1 KDR KDR BMP4 BMP4 ARF6 ARF6 FLT4 FLT4 HIF1A HIF1A HDAC7 HDAC7 AAMP AAMP PTPRR PTPRR ANXA1 ANXA1 SYNJ2BP SYNJ2BP SP1 SP1 PRKCE PRKCE WNT5A WNT5A MMP9 MMP9 BMPR2 BMPR2 LOC111170713 LOC111170713 FGFBP1 FGFBP1 CIB1 CIB1 ADIPOR1 ADIPOR1 MECP2 MECP2 SLIT2 SLIT2 CAPN7 CAPN7 EPB41L5 EPB41L5 BMP10 BMP10 HDAC5 HDAC5 CD40 CD40 GDF2 GDF2 MEOX2 MEOX2 THBS1 THBS1 SIRT1 SIRT1 ARSI ARSI FGF4 FGF4 PLCG1 PLCG1 MAP3K3 MAP3K3 ANGPT4 ANGPT4 MEF2C MEF2C FGF1 FGF1 APOH APOH ENPP2 ENPP2 GLUL GLUL TBXA2R TBXA2R ATP5A1 ATP5A1 GPLD1 GPLD1 SEMA4A SEMA4A CALR CALR MMRN2 MMRN2 SMOC2 SMOC2 EFNA1 EFNA1 MAP2K3 MAP2K3 NOTCH1 NOTCH1 BMPER BMPER PDCD6 PDCD6 SRPX2 SRPX2 NRP1 NRP1 GADD45A GADD45A VEGFA VEGFA FGF16 FGF16 TACSTD2 TACSTD2 JCAD JCAD STARD13 STARD13 TGFB2 TGFB2 PTN PTN EPB41L4B EPB41L4B LGMN LGMN AKT3 AKT3 ADGRA2 ADGRA2 PDCD10 PDCD10 FOXP1 FOXP1 EVL EVL NOS3 NOS3 ACVRL1 ACVRL1 PLPP3 PLPP3 ATP5B ATP5B IFNG IFNG ADAM9 ADAM9 IRS2 IRS2 RHOA RHOA ANGPT2 ANGPT2 VASH1 VASH1 JUN JUN PTPRG PTPRG SVBP SVBP RHOJ RHOJ ZC3H12A ZC3H12A PTPN23 PTPN23 HYAL1 HYAL1 FGFR1 FGFR1 CORO1C CORO1C AGT AGT PATZ1 PATZ1 PRKD1 PRKD1 PPM1F PPM1F ITGB1BP1 ITGB1BP1 HDAC6 HDAC6 MET MET ABL1 ABL1 DNAJA4 DNAJA4 PLCG2 PLCG2 DAB2IP DAB2IP BCAR1 BCAR1 DUSP10 DUSP10 PIK3CB PIK3CB RAB11A RAB11A FUT1 FUT1 GATA3 GATA3 PRKD2 PRKD2 GPI GPI EMC10 EMC10 PFN2 PFN2 TGFB1 TGFB1 RRAS RRAS DLL4 DLL4 MARVELD3 MARVELD3 MAPRE2 MAPRE2 CCBE1 CCBE1 ITGB3 ITGB3 SPRED1 SPRED1 ZNF580 ZNF580 HSPB1 HSPB1 LOC111182889 LOC111182889 HBEGF HBEGF KRIT1 KRIT1 RREB1 RREB1 PRKCA PRKCA MCC MCC FGF7 FGF7 CTSH CTSH PTPRM PTPRM TEK TEK ATOH8 ATOH8 FGF10 FGF10
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ETS1Protein C-ets-1 isoform X1. (486 aa)
NR2E1Nuclear receptor subfamily 2 group E member 1 isoform X1. (385 aa)
EMP2Epithelial membrane protein 2; Functions as a key regulator of cell membrane composition by regulating proteins surface expression. Also, plays a role in regulation of processes including cell migration, cell proliferation, cell contraction and cell adhesion; Belongs to the PMP-22/EMP/MP20 family. (167 aa)
PIK3CGPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X1; Belongs to the PI3/PI4-kinase family. (1102 aa)
STAT5ASignal transducer and activator of transcription. (818 aa)
LOC111166071Phospholipid phosphatase 3-like. (264 aa)
JUPJunction plakoglobin. (744 aa)
LOC111166741SAM and SH3 domain-containing protein 1 isoform X1. (1513 aa)
INSL3Insulin-like 3. (133 aa)
FBXW9F-box/WD repeat-containing protein 9 isoform X1. (461 aa)
NUS1Dehydrodolichyl diphosphate synthase complex subunit NUS1 isoform X1. (326 aa)
RAB25Ras-related protein Rab-25 isoform X2. (208 aa)
ADGRB1Brain-specific angiogenesis inhibitor 1 isoform X1. (888 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (233 aa)
HMOX1Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. (288 aa)
CXCL13C-X-C motif chemokine 13. (109 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (919 aa)
LOC111187154Ephrin type-A receptor 2-like. (171 aa)
GLIPR2Golgi-associated plant pathogenesis-related protein 1 isoform X1; Belongs to the CRISP family. (154 aa)
FBXW7F-box/WD repeat-containing protein 7 isoform X1. (707 aa)
RTN4Reticulon. (1192 aa)
ANXA3Annexin. (323 aa)
NR2F2COUP transcription factor 2 isoform X1. (414 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2548 aa)
EPHA2Ephrin type-A receptor 2. (975 aa)
P2RX4P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (388 aa)
NF1Neurofibromin isoform X1. (2873 aa)
PLK2Serine/threonine-protein kinase PLK. (685 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
PTK2BProtein-tyrosine kinase 2-beta isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1015 aa)
LOC111186398Caspase recruitment domain-containing protein 10 isoform X1. (1027 aa)
PDPK13-phosphoinositide-dependent protein kinase 1 isoform X1. (558 aa)
LOC111186242SH3 domain-binding protein 1 isoform X1. (693 aa)
ARSJArylsulfatase J. (599 aa)
PDGFBPlatelet-derived growth factor subunit B isoform X1; Belongs to the PDGF/VEGF growth factor family. (278 aa)
ALOX12Arachidonate 12-lipoxygenase, 12S-type. (663 aa)
RIN2Ras and Rab interactor 2 isoform X1. (899 aa)
ARSBArylsulfatase B isoform X1. (534 aa)
PRCPLysosomal Pro-X carboxypeptidase. (499 aa)
ATP2B4Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1243 aa)
PROX1Prospero homeobox protein 1 isoform X1. (738 aa)
DOCK5Dedicator of cytokinesis protein 5 isoform X1; Belongs to the DOCK family. (1869 aa)
SRCTyrosine-protein kinase. (562 aa)
VIL1Villin-1 isoform X1. (827 aa)
KDRVascular endothelial growth factor receptor 2 isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
BMP4Bone morphogenetic protein 4 isoform X2. (408 aa)
ARF6ADP-ribosylation factor 6; Belongs to the small GTPase superfamily. Arf family. (175 aa)
FLT4Vascular endothelial growth factor receptor 3 isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1367 aa)
HIF1AHypoxia-inducible factor 1-alpha isoform X1. (823 aa)
HDAC7Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1049 aa)
AAMPAngio-associated migratory cell protein isoform X1. (435 aa)
PTPRRReceptor-type tyrosine-protein phosphatase R. (653 aa)
ANXA1Annexin. (346 aa)
SYNJ2BPSynaptojanin-2-binding protein isoform X1. (150 aa)
SP1Transcription factor Sp1. (786 aa)
PRKCEProtein kinase C. (746 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (458 aa)
MMP9Matrix metalloproteinase-9. (709 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
LOC111170713Lymphocyte antigen 6 complex locus protein G5b isoform X2. (299 aa)
FGFBP1Fibroblast growth factor-binding protein 1. (237 aa)
CIB1Calcium and integrin-binding protein 1. (191 aa)
ADIPOR1Adiponectin receptor protein 1. (375 aa)
MECP2Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). (486 aa)
SLIT2Slit homolog 2 protein isoform X1. (1534 aa)
CAPN7Calpain-7; Belongs to the peptidase C2 family. (813 aa)
EPB41L5Band 4.1-like protein 5 isoform X1. (726 aa)
BMP10Bone morphogenetic protein 10. (423 aa)
HDAC5Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1123 aa)
CD40Tumor necrosis factor receptor superfamily member 5 isoform X1. (284 aa)
GDF2Growth/differentiation factor 2. (431 aa)
MEOX2Homeobox protein MOX-2. (303 aa)
THBS1Thrombospondin-1. (1170 aa)
SIRT1NAD-dependent protein deacetylase sirtuin-1 isoform X1. (735 aa)
ARSIArylsulfatase I. (573 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1291 aa)
MAP3K3Mitogen-activated protein kinase kinase kinase 3 isoform X1. (657 aa)
ANGPT4Angiopoietin-4. (498 aa)
MEF2CMyocyte-specific enhancer factor 2C isoform X6. (483 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (189 aa)
APOHBeta-2-glycoprotein 1 isoform X1. (345 aa)
ENPP2Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 isoform X1. (955 aa)
GLULGlutamine synthetase. (381 aa)
TBXA2RThromboxane A2 receptor; Belongs to the G-protein coupled receptor 1 family. (343 aa)
ATP5A1ATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane. (553 aa)
GPLD1Phosphatidylinositol-glycan-specific phospholipase D isoform X1. (849 aa)
SEMA4Asemaphorin-4A; Belongs to the semaphorin family. (762 aa)
CALRCalreticulin. (417 aa)
MMRN2Multimerin-2 isoform X1. (935 aa)
SMOC2SPARC-related modular calcium-binding protein 2 isoform X1. (456 aa)
EFNA1ephrin-A1 isoform X3; Belongs to the ephrin family. (211 aa)
MAP2K3Dual specificity mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (347 aa)
NOTCH1Neurogenic locus notch homolog protein 1 isoform X1. (2521 aa)
BMPERBMP-binding endothelial regulator protein isoform X1. (685 aa)
PDCD6Programmed cell death protein 6 isoform X1. (189 aa)
SRPX2Sushi repeat-containing protein SRPX2. (465 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (924 aa)
GADD45AGrowth arrest and DNA damage-inducible protein GADD45 alpha. (165 aa)
VEGFAVascular endothelial growth factor A isoform X1; Belongs to the PDGF/VEGF growth factor family. (214 aa)
FGF16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
TACSTD2Tumor-associated calcium signal transducer 2. (323 aa)
JCADJunctional protein associated with coronary artery disease. (1281 aa)
STARD13stAR-related lipid transfer protein 13 isoform X1. (1126 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
PTNPleiotrophin isoform X1. (168 aa)
EPB41L4BBand 4.1-like protein 4B isoform X1. (901 aa)
LGMNLegumain. (433 aa)
AKT3Non-specific serine/threonine protein kinase. (541 aa)
ADGRA2Adhesion G protein-coupled receptor A2; Belongs to the G-protein coupled receptor 2 family. (1337 aa)
PDCD10Programmed cell death protein 10. (212 aa)
FOXP1Forkhead box protein P1 isoform X1. (673 aa)
EVLena/VASP-like protein isoform X1. (436 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1205 aa)
ACVRL1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (515 aa)
PLPP3Phospholipid phosphatase 3. (312 aa)
ATP5BATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane. (528 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
ADAM9Disintegrin and metalloproteinase domain-containing protein 9 isoform X1. (841 aa)
IRS2Insulin receptor substrate 2. (1347 aa)
RHOATransforming protein RhoA. (193 aa)
ANGPT2Angiopoietin-2 isoform X1. (496 aa)
VASH1Vasohibin-1 isoform X1. (387 aa)
JUNTranscription factor AP-1; Belongs to the bZIP family. (343 aa)
PTPRGReceptor-type tyrosine-protein phosphatase gamma isoform X1. (1440 aa)
SVBPSmall vasohibin-binding protein. (66 aa)
RHOJRho-related GTP-binding protein RhoJ. (236 aa)
ZC3H12AEndoribonuclease ZC3H12A. (583 aa)
PTPN23Tyrosine-protein phosphatase non-receptor type 23 isoform X1. (1630 aa)
HYAL1Hyaluronidase. (448 aa)
FGFR1Fibroblast growth factor receptor. (823 aa)
CORO1CCoronin; Belongs to the WD repeat coronin family. (474 aa)
AGTAngiotensinogen; Belongs to the serpin family. (477 aa)
PATZ1POZ-, AT hook-, and zinc finger-containing protein 1 isoform X1. (687 aa)
PRKD1Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (910 aa)
PPM1FProtein phosphatase 1F. (433 aa)
ITGB1BP1Integrin beta-1-binding protein 1 isoform X1. (206 aa)
HDAC6Histone deacetylase 6 isoform X1. (1149 aa)
METHepatocyte growth factor receptor isoform X1. (1382 aa)
ABL1Tyrosine-protein kinase. (1148 aa)
DNAJA4dnaJ homolog subfamily A member 4 isoform X1. (423 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
DAB2IPDisabled homolog 2-interacting protein isoform X1. (1193 aa)
BCAR1Breast cancer anti-estrogen resistance protein 1 isoform X4. (867 aa)
DUSP10Dual specificity protein phosphatase 10; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (482 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1064 aa)
RAB11ARas-related protein Rab-11A isoform X1. (218 aa)
FUT1L-Fucosyltransferase; Belongs to the glycosyltransferase 11 family. (536 aa)
GATA3Trans-acting T-cell-specific transcription factor GATA-3 isoform X1. (444 aa)
PRKD2Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (878 aa)
GPIGlucose-6-phosphate isomerase; Belongs to the GPI family. (558 aa)
EMC10ER membrane protein complex subunit 10 isoform X1. (260 aa)
PFN2Profilin; Belongs to the profilin family. (197 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (391 aa)
RRASRas-related protein R-Ras isoform X1. (251 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (685 aa)
MARVELD3MARVEL domain-containing protein 3. (384 aa)
MAPRE2Microtubule-associated protein RP/EB family member 2 isoform X1. (326 aa)
CCBE1Collagen and calcium-binding EGF domain-containing protein 1 isoform X1. (407 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (789 aa)
SPRED1Sprouty-related, EVH1 domain-containing protein 1 isoform X1. (445 aa)
ZNF580Zinc finger protein 580 isoform X1. (182 aa)
HSPB1Heat shock protein beta-1; Belongs to the small heat shock protein (HSP20) family. (201 aa)
LOC111182889LOW QUALITY PROTEIN: transcription factor SOX-9-like. (510 aa)
HBEGFProheparin-binding EGF-like growth factor. (208 aa)
KRIT1Krev interaction trapped protein 1 isoform X1. (736 aa)
RREB1Ras-responsive element-binding protein 1 isoform X1. (1760 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (670 aa)
MCCColorectal mutant cancer protein isoform X1. (1049 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
CTSHPro-cathepsin H; Belongs to the peptidase C1 family. (335 aa)
PTPRMReceptor-type tyrosine-protein phosphatase mu isoform X2. (1531 aa)
TEKAngiopoietin-1 receptor. (1125 aa)
ATOH8Protein atonal homolog 8 isoform X1. (354 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
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