STRINGSTRING
MAP3K3 MAP3K3 AGT AGT PRKD1 PRKD1 PPM1F PPM1F ITGB1BP1 ITGB1BP1 CTSH CTSH TEK TEK ATOH8 ATOH8 FGF10 FGF10 ETS1 ETS1 PIK3CG PIK3CG STAT5A STAT5A LOC111166071 LOC111166071 LOC111166741 LOC111166741 INSL3 INSL3 NUS1 NUS1 RAB25 RAB25 ENPP2 ENPP2 ATP5A1 ATP5A1 GPLD1 GPLD1 CALR CALR HDAC6 HDAC6 MAP2K3 MAP2K3 SMOC2 SMOC2 CD40 CD40 EPB41L5 EPB41L5 CAPN7 CAPN7 CIB1 CIB1 FGFBP1 FGFBP1 BMPR2 BMPR2 MMP9 MMP9 VIL1 VIL1 KDR KDR BMP4 BMP4 ARF6 ARF6 FLT4 FLT4 HIF1A HIF1A HDAC7 HDAC7 AAMP AAMP ANXA1 ANXA1 SP1 SP1 PRKCE PRKCE WNT5A WNT5A ADGRA2 ADGRA2 FGFR1 FGFR1 HYAL1 HYAL1 ZC3H12A ZC3H12A RHOJ RHOJ JUN JUN IRS2 IRS2 ADAM9 ADAM9 HMOX1 HMOX1 PIK3CD PIK3CD GLIPR2 GLIPR2 RTN4 RTN4 ANXA3 ANXA3 MTOR MTOR P2RX4 P2RX4 PLK2 PLK2 FGF18 FGF18 PTK2B PTK2B PDPK1 PDPK1 PDGFB PDGFB ALOX12 ALOX12 RIN2 RIN2 PROX1 PROX1 DOCK5 DOCK5 SRC SRC FGF1 FGF1 ANGPT4 ANGPT4 PLCG1 PLCG1 SIRT1 SIRT1 THBS1 THBS1 FGF7 FGF7 PRKCA PRKCA RREB1 RREB1 HBEGF HBEGF LOC111182889 LOC111182889 HSPB1 HSPB1 ZNF580 ZNF580 ITGB3 ITGB3 CCBE1 CCBE1 MAPRE2 MAPRE2 RRAS RRAS TGFB1 TGFB1 EMC10 EMC10 GPI GPI PRKD2 PRKD2 GATA3 GATA3 FUT1 FUT1 RAB11A RAB11A PIK3CB PIK3CB BCAR1 BCAR1 PLCG2 PLCG2 ABL1 ABL1 MET MET PDCD6 PDCD6 SRPX2 SRPX2 NRP1 NRP1 VEGFA VEGFA FGF16 FGF16 JCAD JCAD TGFB2 TGFB2 EPB41L4B EPB41L4B LGMN LGMN AKT3 AKT3 FOXP1 FOXP1 NOS3 NOS3 PLPP3 PLPP3 ATP5B ATP5B IFNG IFNG
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MAP3K3Mitogen-activated protein kinase kinase kinase 3 isoform X1. (657 aa)
AGTAngiotensinogen; Belongs to the serpin family. (477 aa)
PRKD1Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (910 aa)
PPM1FProtein phosphatase 1F. (433 aa)
ITGB1BP1Integrin beta-1-binding protein 1 isoform X1. (206 aa)
CTSHPro-cathepsin H; Belongs to the peptidase C1 family. (335 aa)
TEKAngiopoietin-1 receptor. (1125 aa)
ATOH8Protein atonal homolog 8 isoform X1. (354 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
ETS1Protein C-ets-1 isoform X1. (486 aa)
PIK3CGPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X1; Belongs to the PI3/PI4-kinase family. (1102 aa)
STAT5ASignal transducer and activator of transcription. (818 aa)
LOC111166071Phospholipid phosphatase 3-like. (264 aa)
LOC111166741SAM and SH3 domain-containing protein 1 isoform X1. (1513 aa)
INSL3Insulin-like 3. (133 aa)
NUS1Dehydrodolichyl diphosphate synthase complex subunit NUS1 isoform X1. (326 aa)
RAB25Ras-related protein Rab-25 isoform X2. (208 aa)
ENPP2Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 isoform X1. (955 aa)
ATP5A1ATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane. (553 aa)
GPLD1Phosphatidylinositol-glycan-specific phospholipase D isoform X1. (849 aa)
CALRCalreticulin. (417 aa)
HDAC6Histone deacetylase 6 isoform X1. (1149 aa)
MAP2K3Dual specificity mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (347 aa)
SMOC2SPARC-related modular calcium-binding protein 2 isoform X1. (456 aa)
CD40Tumor necrosis factor receptor superfamily member 5 isoform X1. (284 aa)
EPB41L5Band 4.1-like protein 5 isoform X1. (726 aa)
CAPN7Calpain-7; Belongs to the peptidase C2 family. (813 aa)
CIB1Calcium and integrin-binding protein 1. (191 aa)
FGFBP1Fibroblast growth factor-binding protein 1. (237 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
MMP9Matrix metalloproteinase-9. (709 aa)
VIL1Villin-1 isoform X1. (827 aa)
KDRVascular endothelial growth factor receptor 2 isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
BMP4Bone morphogenetic protein 4 isoform X2. (408 aa)
ARF6ADP-ribosylation factor 6; Belongs to the small GTPase superfamily. Arf family. (175 aa)
FLT4Vascular endothelial growth factor receptor 3 isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1367 aa)
HIF1AHypoxia-inducible factor 1-alpha isoform X1. (823 aa)
HDAC7Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1049 aa)
AAMPAngio-associated migratory cell protein isoform X1. (435 aa)
ANXA1Annexin. (346 aa)
SP1Transcription factor Sp1. (786 aa)
PRKCEProtein kinase C. (746 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (458 aa)
ADGRA2Adhesion G protein-coupled receptor A2; Belongs to the G-protein coupled receptor 2 family. (1337 aa)
FGFR1Fibroblast growth factor receptor. (823 aa)
HYAL1Hyaluronidase. (448 aa)
ZC3H12AEndoribonuclease ZC3H12A. (583 aa)
RHOJRho-related GTP-binding protein RhoJ. (236 aa)
JUNTranscription factor AP-1; Belongs to the bZIP family. (343 aa)
IRS2Insulin receptor substrate 2. (1347 aa)
ADAM9Disintegrin and metalloproteinase domain-containing protein 9 isoform X1. (841 aa)
HMOX1Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. (288 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (919 aa)
GLIPR2Golgi-associated plant pathogenesis-related protein 1 isoform X1; Belongs to the CRISP family. (154 aa)
RTN4Reticulon. (1192 aa)
ANXA3Annexin. (323 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2548 aa)
P2RX4P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (388 aa)
PLK2Serine/threonine-protein kinase PLK. (685 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
PTK2BProtein-tyrosine kinase 2-beta isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1015 aa)
PDPK13-phosphoinositide-dependent protein kinase 1 isoform X1. (558 aa)
PDGFBPlatelet-derived growth factor subunit B isoform X1; Belongs to the PDGF/VEGF growth factor family. (278 aa)
ALOX12Arachidonate 12-lipoxygenase, 12S-type. (663 aa)
RIN2Ras and Rab interactor 2 isoform X1. (899 aa)
PROX1Prospero homeobox protein 1 isoform X1. (738 aa)
DOCK5Dedicator of cytokinesis protein 5 isoform X1; Belongs to the DOCK family. (1869 aa)
SRCTyrosine-protein kinase. (562 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (189 aa)
ANGPT4Angiopoietin-4. (498 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1291 aa)
SIRT1NAD-dependent protein deacetylase sirtuin-1 isoform X1. (735 aa)
THBS1Thrombospondin-1. (1170 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (670 aa)
RREB1Ras-responsive element-binding protein 1 isoform X1. (1760 aa)
HBEGFProheparin-binding EGF-like growth factor. (208 aa)
LOC111182889LOW QUALITY PROTEIN: transcription factor SOX-9-like. (510 aa)
HSPB1Heat shock protein beta-1; Belongs to the small heat shock protein (HSP20) family. (201 aa)
ZNF580Zinc finger protein 580 isoform X1. (182 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (789 aa)
CCBE1Collagen and calcium-binding EGF domain-containing protein 1 isoform X1. (407 aa)
MAPRE2Microtubule-associated protein RP/EB family member 2 isoform X1. (326 aa)
RRASRas-related protein R-Ras isoform X1. (251 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (391 aa)
EMC10ER membrane protein complex subunit 10 isoform X1. (260 aa)
GPIGlucose-6-phosphate isomerase; Belongs to the GPI family. (558 aa)
PRKD2Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (878 aa)
GATA3Trans-acting T-cell-specific transcription factor GATA-3 isoform X1. (444 aa)
FUT1L-Fucosyltransferase; Belongs to the glycosyltransferase 11 family. (536 aa)
RAB11ARas-related protein Rab-11A isoform X1. (218 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1064 aa)
BCAR1Breast cancer anti-estrogen resistance protein 1 isoform X4. (867 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
ABL1Tyrosine-protein kinase. (1148 aa)
METHepatocyte growth factor receptor isoform X1. (1382 aa)
PDCD6Programmed cell death protein 6 isoform X1. (189 aa)
SRPX2Sushi repeat-containing protein SRPX2. (465 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (924 aa)
VEGFAVascular endothelial growth factor A isoform X1; Belongs to the PDGF/VEGF growth factor family. (214 aa)
FGF16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
JCADJunctional protein associated with coronary artery disease. (1281 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
EPB41L4BBand 4.1-like protein 4B isoform X1. (901 aa)
LGMNLegumain. (433 aa)
AKT3Non-specific serine/threonine protein kinase. (541 aa)
FOXP1Forkhead box protein P1 isoform X1. (673 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1205 aa)
PLPP3Phospholipid phosphatase 3. (312 aa)
ATP5BATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane. (528 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
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