(113 nodes) Regulation of cellular carbohydrate metabolic process network (Delphinapterus leucas)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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Your Input:
	PTPN2	Tyrosine-protein phosphatase non-receptor type 2 isoform X3. (474 aa)
	Ob	Leptin isoform X1. (167 aa)
	SCARB2	Lysosome membrane protein 2; Belongs to the CD36 family. (477 aa)
	CRY1	Cryptochrome-1 isoform X1. (587 aa)
	IGF1	Insulin-like growth factor I isoform X1. (186 aa)
	C1QTNF3	Complement C1q tumor necrosis factor-related protein 3 isoform X1. (319 aa)
	PPP1R3D	Protein phosphatase 1 regulatory subunit. (298 aa)
	PLEK	Pleckstrin. (350 aa)
	LOC111187540	E3 SUMO-protein ligase RanBP2-like. (3088 aa)
	C1QTNF6	Complement C1q tumor necrosis factor-related protein 6. (266 aa)
	C1QTNF12	Adipolin. (299 aa)
	NLN	Neurolysin, mitochondrial isoform X1. (704 aa)
	GIT1	ARF GTPase-activating protein GIT1 isoform X1. (770 aa)
	PTK2B	Protein-tyrosine kinase 2-beta isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1015 aa)
	EP300	Histone acetyltransferase p300. (2420 aa)
	PGP	Glycerol-3-phosphate phosphatase; Belongs to the HAD-like hydrolase superfamily. (321 aa)
	PPARA	Peroxisome proliferator-activated receptor alpha. (468 aa)
	AVPR1B	Vasopressin V1b receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (423 aa)
	INPP5K	Inositol polyphosphate 5-phosphatase K isoform X1. (476 aa)
	PHLDA2	Pleckstrin homology-like domain family A member 2. (131 aa)
	P2RY6	P2Y purinoceptor 6. (328 aa)
	BAD	Bcl2-associated agonist of cell death. (168 aa)
	DDB1	DNA damage-binding protein 1. (1140 aa)
	NCOA2	Nuclear receptor coactivator. (1464 aa)
	IGFBP3	Insulin-like growth factor-binding protein 3. (293 aa)
	INS	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
	GCK	Phosphotransferase. (537 aa)
	SLC45A3	Solute carrier family 45 member 3. (553 aa)
	GCGR	Glucagon receptor isoform X1; Belongs to the G-protein coupled receptor 2 family. (575 aa)
	C1QTNF1	LOW QUALITY PROTEIN: complement C1q tumor necrosis factor-related protein 1. (279 aa)
	ACTN3	Alpha-actinin-3 isoform X1. (902 aa)
	DDIT4	DNA damage-inducible transcript 4 protein. (229 aa)
	BCKDK	Protein-serine/threonine kinase. (412 aa)
	SIRT1	NAD-dependent protein deacetylase sirtuin-1 isoform X1. (735 aa)
	PPP1R3A	Protein phosphatase 1 regulatory subunit 3A. (1116 aa)
	FOXK2	Forkhead box protein K2 isoform X1. (614 aa)
	LEP	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (166 aa)
	LCMT1	Leucine carboxyl methyltransferase 1; Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha- leucine ester residues; Belongs to the methyltransferase superfamily. LCMT family. (344 aa)
	AKT2	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
	SIRT7	NAD-dependent protein deacetylase sirtuin-7 isoform X1. (400 aa)
	LOC111182058	General transcription factor II-I repeat domain-containing protein 2 isoform X1. (948 aa)
	NUPR1	Nuclear protein 1. (82 aa)
	PPP1R3G	Protein phosphatase 1 regulatory subunit 3G. (354 aa)
	CBFA2T3	Protein CBFA2T3 isoform X1. (648 aa)
	PDK4	Protein-serine/threonine kinase. (407 aa)
	PMAIP1	Phorbol-12-myristate-13-acetate-induced protein 1. (54 aa)
	ACADM	Medium-chain specific acyl-CoA dehydrogenase, mitochondrial. (421 aa)
	GNMT	Glycine N-methyltransferase. (295 aa)
	INMT	LOW QUALITY PROTEIN: indolethylamine N-methyltransferase. (263 aa)
	FAM3C	Protein FAM3C isoform X1. (234 aa)
	MLYCD	malonyl-CoA decarboxylase, mitochondrial isoform X1. (528 aa)
	LEPR	Leptin receptor isoform X1. (917 aa)
	SLC35B4	UDP-xylose and UDP-N-acetylglucosamine transporter. (331 aa)
	LOC111176690	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 isoform X1. (340 aa)
	TIGAR	Fructose-2,6-bisphosphatase TIGAR isoform X1. (325 aa)
	RUBCNL	Protein RUBCNL-like isoform X1. (667 aa)
	WDR5	WD repeat-containing protein 5. (334 aa)
	RORA	Nuclear receptor ROR-alpha isoform X1. (523 aa)
	GNB3	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 isoform X2. (299 aa)
	KHK	Ketohexokinase isoform X1. (298 aa)
	ZMPSTE24	CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (473 aa)
	IRS2	Insulin receptor substrate 2. (1347 aa)
	AKT1	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
	GCKR	LOW QUALITY PROTEIN: glucokinase regulatory protein. (618 aa)
	FOXO1	Forkhead box protein O1. (663 aa)
	PRKCE	Protein kinase C. (746 aa)
	LHCGR	Lutropin-choriogonadotropic hormone receptor; Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (700 aa)
	MST1	Hepatocyte growth factor-like protein isoform X1; Belongs to the peptidase S1 family. Plasminogen subfamily. (725 aa)
	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2. (601 aa)
	PPP1R3B	Protein phosphatase 1 regulatory subunit. (366 aa)
	PASK	PAS domain-containing serine/threonine-protein kinase. (1325 aa)
	HDAC4	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1083 aa)
	PPP1R3C	Protein phosphatase 1 regulatory subunit 3C; Acts as a glycogen-targeting subunit for PP1 and regulates its activity. Activates glycogen synthase, reduces glycogen phosphorylase activity and limits glycogen breakdown. (317 aa)
	FOXK1	Forkhead box protein K1. (609 aa)
	PDK1	Protein-serine/threonine kinase. (438 aa)
	SLC4A1	Anion exchange protein. (963 aa)
	GCG	Glucagon isoform X1. (180 aa)
	ERFE	Erythroferrone isoform X1. (367 aa)
	FAM3A	Protein FAM3A isoform X1. (304 aa)
	IRS1	Insulin receptor substrate 1. (1248 aa)
	ADIPOR1	Adiponectin receptor protein 1. (375 aa)
	ZNF692	Zinc finger protein 692 isoform X1. (512 aa)
	LOC111169221	LOW QUALITY PROTEIN: protein FAM3C-like. (227 aa)
	OGT	UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit isoform X1. (1046 aa)
	DUSP12	Dual specificity protein phosphatase 12. (353 aa)
	MIDN	Midnolin isoform X1. (496 aa)
	AGPAT4	1-acyl-sn-glycerol-3-phosphate acyltransferase delta isoform X1. (835 aa)
	PPP1R3F	Protein phosphatase 1 regulatory subunit 3F isoform X1. (811 aa)
	GPER1	G-protein coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (354 aa)
	PDK3	Protein-serine/threonine kinase. (415 aa)
	PDK2	Protein-serine/threonine kinase. (407 aa)
	IGFBP4	Insulin-like growth factor-binding protein 4. (258 aa)
	GPLD1	Phosphatidylinositol-glycan-specific phospholipase D isoform X1. (849 aa)
	FBP1	Fructose-1,6-bisphosphatase 1 isoform X1; Belongs to the FBPase class 1 family. (338 aa)
	ENPP1	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 isoform X1. (925 aa)
	NCOR1	Nuclear receptor corepressor 1 isoform X1. (2454 aa)
	FLCN	Folliculin isoform X1. (591 aa)
	KAT2A	Histone acetyltransferase KAT2A isoform X1. (878 aa)
	PTH	Parathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion; Belongs to the parathyroid hormone family. (115 aa)
	SIRT6	NAD-dependent protein deacetylase sirtuin-6 isoform X3. (375 aa)
	NNMT	Nicotinamide N-methyltransferase. (264 aa)
	STAT3	Signal transducer and activator of transcription. (770 aa)
	PPP1R3E	Protein phosphatase 1 regulatory subunit 3E isoform X1. (280 aa)
	NKX1-1	NK1 transcription factor-related protein 1. (428 aa)
	DGKQ	Diacylglycerol kinase. (976 aa)
	INSR	Tyrosine-protein kinase receptor. (1392 aa)
	KAT2B	Histone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (828 aa)
	EPM2AIP1	EPM2A-interacting protein 1. (608 aa)
	TFF3	Trefoil factor 3. (80 aa)
	SIK1	Serine/threonine-protein kinase SIK1. (784 aa)
	LOC111163647	Cytochrome c oxidase assembly protein COX11, mitochondrial. (271 aa)
	USP7	LOW QUALITY PROTEIN: ubiquitin carboxyl-terminal hydrolase 7; Belongs to the peptidase C19 family. (1102 aa)
	ACACB	acetyl-CoA carboxylase 2 isoform X1. (2456 aa)

Your Current Organism:

Delphinapterus leucas

NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACACB	ACADM	A0A2Y9LD97	A0A2Y9P3N1	acetyl-CoA carboxylase 2 isoform X1.	Medium-chain specific acyl-CoA dehydrogenase, mitochondrial.	0.459
ACACB	MLYCD	A0A2Y9LD97	A0A2Y9NXM8	acetyl-CoA carboxylase 2 isoform X1.	malonyl-CoA decarboxylase, mitochondrial isoform X1.	0.921
ACADM	ACACB	A0A2Y9P3N1	A0A2Y9LD97	Medium-chain specific acyl-CoA dehydrogenase, mitochondrial.	acetyl-CoA carboxylase 2 isoform X1.	0.459
ACADM	MLYCD	A0A2Y9P3N1	A0A2Y9NXM8	Medium-chain specific acyl-CoA dehydrogenase, mitochondrial.	malonyl-CoA decarboxylase, mitochondrial isoform X1.	0.420
ACADM	PDK4	A0A2Y9P3N1	A0A2Y9P869	Medium-chain specific acyl-CoA dehydrogenase, mitochondrial.	Protein-serine/threonine kinase.	0.411
ACADM	PPARA	A0A2Y9P3N1	A0A2Y9Q177	Medium-chain specific acyl-CoA dehydrogenase, mitochondrial.	Peroxisome proliferator-activated receptor alpha.	0.445
ADIPOR1	INS	A0A2Y9MKM7	A0A2Y9PTW5	Adiponectin receptor protein 1.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.626
ADIPOR1	LEP	A0A2Y9MKM7	A0A2Y9PHF5	Adiponectin receptor protein 1.	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...]	0.612
ADIPOR1	LEPR	A0A2Y9MKM7	A0A2Y9NSA2	Adiponectin receptor protein 1.	Leptin receptor isoform X1.	0.485
ADIPOR1	Ob	A0A2Y9MKM7	G8DLG4	Adiponectin receptor protein 1.	Leptin isoform X1.	0.612
ADIPOR1	PPARA	A0A2Y9MKM7	A0A2Y9Q177	Adiponectin receptor protein 1.	Peroxisome proliferator-activated receptor alpha.	0.530
AKT1	AKT2	A0A2Y9NBQ2	A0A2Y9PDM4	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.900
AKT1	BAD	A0A2Y9NBQ2	A0A2Y9PW98	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Bcl2-associated agonist of cell death.	0.948
AKT1	FOXO1	A0A2Y9NBQ2	A0A2Y9N6T9	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Forkhead box protein O1.	0.973
AKT1	IGF1	A0A2Y9NBQ2	A0A2Y9QDF3	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Insulin-like growth factor I isoform X1.	0.467
AKT1	INS	A0A2Y9NBQ2	A0A2Y9PTW5	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.556
AKT1	IRS1	A0A2Y9NBQ2	A0A2Y9MMM9	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Insulin receptor substrate 1.	0.529
AKT1	IRS2	A0A2Y9NBQ2	A0A2Y9NC55	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Insulin receptor substrate 2.	0.446
AKT1	OGT	A0A2Y9NBQ2	A0A2Y9MHL3	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit isoform X1.	0.924
AKT1	STAT3	A0A2Y9NBQ2	A0A2Y9LX05	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Signal transducer and activator of transcription.	0.498