(35 nodes) Regulation of keratinocyte proliferation network (Delphinapterus leucas)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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protein homology

Your Input:
	PRKD1	Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (910 aa)
	LOC111184716	Interferon regulatory factor 6 isoform X2. (485 aa)
	IFT57	Intraflagellar transport protein 57 homolog isoform X1. (427 aa)
	IFT52	Intraflagellar transport protein 52 homolog isoform X1. (446 aa)
	LOC111184719	Interferon regulatory factor 6 isoform X1. (467 aa)
	CD109	CD109 antigen isoform X1. (1440 aa)
	SRSF6	Serine/arginine-rich splicing factor 6 isoform X1. (345 aa)
	OVOL1	Putative transcription factor Ovo-like 1. (267 aa)
	FGF7	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
	NOTCH2	Neurogenic locus notch homolog protein 2 isoform X1. (2471 aa)
	ZFP36	mRNA decay activator protein ZFP36. (325 aa)
	ZEB1	Zinc finger E-box-binding homeobox 1 isoform X2. (1110 aa)
	CDH3	Cadherin-3 isoform X1; Cadherins are calcium-dependent cell adhesion proteins. (834 aa)
	LOC111177240	LOW QUALITY PROTEIN: serine/arginine-rich splicing factor 6-like. (346 aa)
	KLF9	Krueppel-like factor 9. (244 aa)
	BCL11B	B-cell lymphoma/leukemia 11B isoform X1. (903 aa)
	ZFP36L1	mRNA decay activator protein ZFP36L1. (338 aa)
	TP63	Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
	IFT80	Intraflagellar transport protein 80 homolog isoform X1. (777 aa)
	VDR	Vitamin D3 receptor isoform X1. (503 aa)
	FGFR2	Fibroblast growth factor receptor. (841 aa)
	YAP1	Transcriptional coactivator YAP1 isoform X1. (511 aa)
	SNAI2	Zinc finger protein SNAI2. (268 aa)
	PTCH1	Protein patched homolog 1 isoform X1. (1447 aa)
	MED1	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1579 aa)
	CASK	Peripheral plasma membrane protein CASK isoform X1; Belongs to the MAGUK family. (926 aa)
	INTU	Protein inturned isoform X1. (934 aa)
	LRG1	Leucine-rich alpha-2-glycoprotein isoform X1. (354 aa)
	PTPRK	Receptor-type tyrosine-protein phosphatase kappa isoform X1. (1485 aa)
	FGF10	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
	STXBP4	Syntaxin-binding protein 4 isoform X1. (558 aa)
	IFT74	Intraflagellar transport protein 74 homolog isoform X1. (600 aa)
	TGM1	Protein-glutamine gamma-glutamyltransferase K isoform X2. (849 aa)
	KDF1	Keratinocyte differentiation factor 1. (398 aa)
	SFN	14-3-3 protein sigma; Belongs to the 14-3-3 family. (248 aa)

Your Current Organism:

Delphinapterus leucas

NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CASK	STXBP4	A0A2Y9LTT7	A0A2Y9LMP8	Peripheral plasma membrane protein CASK isoform X1; Belongs to the MAGUK family.	Syntaxin-binding protein 4 isoform X1.	0.496
FGF10	FGF7	A0A2Y9LQ50	A0A2Y9PJK8	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.418
FGF10	FGFR2	A0A2Y9LQ50	A0A2Y9MQL8	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor receptor.	0.993
FGF7	FGF10	A0A2Y9PJK8	A0A2Y9LQ50	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.418
FGF7	FGFR2	A0A2Y9PJK8	A0A2Y9MQL8	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor receptor.	0.992
FGFR2	FGF10	A0A2Y9MQL8	A0A2Y9LQ50	Fibroblast growth factor receptor.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.993
FGFR2	FGF7	A0A2Y9MQL8	A0A2Y9PJK8	Fibroblast growth factor receptor.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.992
IFT52	IFT57	A0A2Y9PXI4	A0A2Y9PZE3	Intraflagellar transport protein 52 homolog isoform X1.	Intraflagellar transport protein 57 homolog isoform X1.	0.998
IFT52	IFT74	A0A2Y9PXI4	A0A2Y9LK26	Intraflagellar transport protein 52 homolog isoform X1.	Intraflagellar transport protein 74 homolog isoform X1.	0.995
IFT52	IFT80	A0A2Y9PXI4	A0A2Y9N7W5	Intraflagellar transport protein 52 homolog isoform X1.	Intraflagellar transport protein 80 homolog isoform X1.	0.992
IFT52	INTU	A0A2Y9PXI4	A0A2Y9LTG0	Intraflagellar transport protein 52 homolog isoform X1.	Protein inturned isoform X1.	0.638
IFT52	STXBP4	A0A2Y9PXI4	A0A2Y9LMP8	Intraflagellar transport protein 52 homolog isoform X1.	Syntaxin-binding protein 4 isoform X1.	0.488
IFT57	IFT52	A0A2Y9PZE3	A0A2Y9PXI4	Intraflagellar transport protein 57 homolog isoform X1.	Intraflagellar transport protein 52 homolog isoform X1.	0.998
IFT57	IFT74	A0A2Y9PZE3	A0A2Y9LK26	Intraflagellar transport protein 57 homolog isoform X1.	Intraflagellar transport protein 74 homolog isoform X1.	0.992
IFT57	IFT80	A0A2Y9PZE3	A0A2Y9N7W5	Intraflagellar transport protein 57 homolog isoform X1.	Intraflagellar transport protein 80 homolog isoform X1.	0.996
IFT57	INTU	A0A2Y9PZE3	A0A2Y9LTG0	Intraflagellar transport protein 57 homolog isoform X1.	Protein inturned isoform X1.	0.529
IFT57	STXBP4	A0A2Y9PZE3	A0A2Y9LMP8	Intraflagellar transport protein 57 homolog isoform X1.	Syntaxin-binding protein 4 isoform X1.	0.526
IFT74	IFT52	A0A2Y9LK26	A0A2Y9PXI4	Intraflagellar transport protein 74 homolog isoform X1.	Intraflagellar transport protein 52 homolog isoform X1.	0.995
IFT74	IFT57	A0A2Y9LK26	A0A2Y9PZE3	Intraflagellar transport protein 74 homolog isoform X1.	Intraflagellar transport protein 57 homolog isoform X1.	0.992
IFT74	IFT80	A0A2Y9LK26	A0A2Y9N7W5	Intraflagellar transport protein 74 homolog isoform X1.	Intraflagellar transport protein 80 homolog isoform X1.	0.981