35 items (Delphinapterus leucas) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PRR5	Proline-rich protein 5 isoform X1. (389 aa)
	NF1	Neurofibromin isoform X1. (2873 aa)
	PIK3R1	Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
	MYO16	Unconventional myosin-XVI isoform X1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1868 aa)
	HTR2A	5-hydroxytryptamine receptor 2A. (470 aa)
	ZFP36L1	mRNA decay activator protein ZFP36L1. (338 aa)
	PTEN	Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
	LOC111175271	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2-like isoform X1. (596 aa)
	HTR2B	5-hydroxytryptamine receptor 2B. (490 aa)
	ERBB3	Receptor tyrosine-protein kinase erbB-3. (1338 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
	PLEKHA1	Pleckstrin homology domain-containing family A member 1 isoform X1. (404 aa)
	CD28	T-cell-specific surface glycoprotein CD28. (265 aa)
	NYAP2	Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 2 isoform X1. (719 aa)
	IRS1	Insulin receptor substrate 1. (1248 aa)
	PEAR1	Platelet endothelial aggregation receptor 1 isoform X1. (1041 aa)
	ERBB2	Receptor protein-tyrosine kinase. (1255 aa)
	PIK3R2	Phosphatidylinositol 3-kinase regulatory subunit beta. (723 aa)
	PIK3C2A	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha isoform X1; Belongs to the PI3/PI4-kinase family. (1711 aa)
	PIK3CG	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X1; Belongs to the PI3/PI4-kinase family. (1102 aa)
	RPS6KB1	Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
	PIK3CD	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (919 aa)
	IGF1	Insulin-like growth factor I isoform X1. (186 aa)
	PREX2	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein isoform X1. (1720 aa)
	EDN1	Endothelin-1. (202 aa)
	NYAP1	LOW QUALITY PROTEIN: neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 1. (849 aa)
	SIRT2	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (389 aa)
	KBTBD2	Kelch repeat and BTB domain-containing protein 2. (623 aa)
	PRR5L	Proline-rich protein 5-like isoform X1. (428 aa)
	GATA3	Trans-acting T-cell-specific transcription factor GATA-3 isoform X1. (444 aa)
	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1064 aa)
	PPARD	Peroxisome proliferator-activated receptor delta isoform X1. (441 aa)
	PIK3C2G	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma; Belongs to the PI3/PI4-kinase family. (1483 aa)
	PIK3C2B	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta; Belongs to the PI3/PI4-kinase family. (1634 aa)
	C1QBP	Complement component 1 Q subcomponent-binding protein, mitochondrial. (278 aa)

Your Current Organism:

Delphinapterus leucas

NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CD28	PIK3CA	A0A2Y9MQH7	A0A2Y9MZW2	T-cell-specific surface glycoprotein CD28.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.921
CD28	PIK3CB	A0A2Y9MQH7	A0A2Y9NZC3	T-cell-specific surface glycoprotein CD28.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.913
CD28	PIK3CD	A0A2Y9MQH7	A0A2Y9QGK3	T-cell-specific surface glycoprotein CD28.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.915
CD28	PIK3R1	A0A2Y9MQH7	A0A2Y9Q8T5	T-cell-specific surface glycoprotein CD28.	Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1.	0.927
CD28	PIK3R2	A0A2Y9MQH7	A0A2Y9LXY5	T-cell-specific surface glycoprotein CD28.	Phosphatidylinositol 3-kinase regulatory subunit beta.	0.924
EDN1	IGF1	A0A2Y9PHR8	A0A2Y9QDF3	Endothelin-1.	Insulin-like growth factor I isoform X1.	0.438
ERBB2	ERBB3	A0A2Y9M2S5	A0A2Y9N080	Receptor protein-tyrosine kinase.	Receptor tyrosine-protein kinase erbB-3.	0.996
ERBB2	IGF1	A0A2Y9M2S5	A0A2Y9QDF3	Receptor protein-tyrosine kinase.	Insulin-like growth factor I isoform X1.	0.934
ERBB2	IRS1	A0A2Y9M2S5	A0A2Y9MMM9	Receptor protein-tyrosine kinase.	Insulin receptor substrate 1.	0.708
ERBB2	NF1	A0A2Y9M2S5	A0A2Y9Q715	Receptor protein-tyrosine kinase.	Neurofibromin isoform X1.	0.458
ERBB2	PIK3CA	A0A2Y9M2S5	A0A2Y9MZW2	Receptor protein-tyrosine kinase.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.985
ERBB2	PIK3CB	A0A2Y9M2S5	A0A2Y9NZC3	Receptor protein-tyrosine kinase.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.946
ERBB2	PIK3CD	A0A2Y9M2S5	A0A2Y9QGK3	Receptor protein-tyrosine kinase.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.942
ERBB2	PIK3CG	A0A2Y9M2S5	A0A2Y9LSJ4	Receptor protein-tyrosine kinase.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X1; Belongs to the PI3/PI4-kinase family.	0.476
ERBB2	PIK3R1	A0A2Y9M2S5	A0A2Y9Q8T5	Receptor protein-tyrosine kinase.	Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1.	0.983
ERBB2	PIK3R2	A0A2Y9M2S5	A0A2Y9LXY5	Receptor protein-tyrosine kinase.	Phosphatidylinositol 3-kinase regulatory subunit beta.	0.964
ERBB2	PTEN	A0A2Y9M2S5	A0A2Y9N7B6	Receptor protein-tyrosine kinase.	Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family.	0.657
ERBB3	ERBB2	A0A2Y9N080	A0A2Y9M2S5	Receptor tyrosine-protein kinase erbB-3.	Receptor protein-tyrosine kinase.	0.996
ERBB3	IGF1	A0A2Y9N080	A0A2Y9QDF3	Receptor tyrosine-protein kinase erbB-3.	Insulin-like growth factor I isoform X1.	0.730
ERBB3	IRS1	A0A2Y9N080	A0A2Y9MMM9	Receptor tyrosine-protein kinase erbB-3.	Insulin receptor substrate 1.	0.736