STRINGSTRING
KDR KDR ERBB4 ERBB4 CD28 CD28 SEMA3E SEMA3E PDGFD PDGFD HCLS1 HCLS1 GPER1 GPER1 ROR2 ROR2 PDGFA PDGFA NTRK3 NTRK3 SELP SELP MYDGF MYDGF SEMA4D SEMA4D HAX1 HAX1 CBL CBL MYOC MYOC NTRK1 NTRK1 NTRK2 NTRK2 CSF3 CSF3 INSR INSR TEK TEK RELN RELN HGF HGF OSM OSM AGT AGT F2RL1 F2RL1 FGR FGR Ob Ob UBE3A UBE3A IGF1 IGF1 IGF1R IGF1R NKX3-1 NKX3-1 F2R F2R PRR5 PRR5 PDGFB PDGFB F2 F2 INS INS UNC5B UNC5B SIRT1 SIRT1 LEP LEP MAZ MAZ LOC111182889 LOC111182889 NCF1 NCF1 WNT16 WNT16 TREM2 TREM2 PRR5L PRR5L RGL2 RGL2 CAT CAT PPARD PPARD ROR1 ROR1 PDGFC PDGFC NEDD4 NEDD4 TGFB2 TGFB2 PTPN6 PTPN6 FSHR FSHR FLT1 FLT1 LOC111172458 LOC111172458 PIK3AP1 PIK3AP1 PLXNB1 PLXNB1 FN1 FN1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
KDRVascular endothelial growth factor receptor 2 isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
ERBB4Receptor protein-tyrosine kinase. (1308 aa)
CD28T-cell-specific surface glycoprotein CD28. (265 aa)
SEMA3Esemaphorin-3E; Belongs to the semaphorin family. (775 aa)
PDGFDPlatelet-derived growth factor D isoform X1. (402 aa)
HCLS1Hematopoietic lineage cell-specific protein. (481 aa)
GPER1G-protein coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (354 aa)
ROR2Tyrosine-protein kinase transmembrane receptor ROR2; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (940 aa)
PDGFAPlatelet-derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (196 aa)
NTRK3Tyrosine-protein kinase receptor. (864 aa)
SELPP-selectin isoform X1. (768 aa)
MYDGFMyeloid-derived growth factor isoform X1. (175 aa)
SEMA4Dsemaphorin-4D isoform X1; Belongs to the semaphorin family. (863 aa)
HAX1HCLS1-associated protein X-1; Recruits the Arp2/3 complex to the cell cortex and regulates reorganization of the cortical actin cytoskeleton via its interaction with KCNC3 and the Arp2/3 complex. Slows down the rate of inactivation of KCNC3 channels. Promotes GNA13-mediated cell migration. Involved in the clathrin-mediated endocytosis pathway. May be involved in internalization of ABC transporters such as ABCB11. May inhibit CASP9 and CASP3. Promotes cell survival. May regulate intracellular calcium pools. (276 aa)
CBLE3 ubiquitin-protein ligase CBL isoform X1. (910 aa)
MYOCMyocilin. (476 aa)
NTRK1Tyrosine-protein kinase receptor. (795 aa)
NTRK2Tyrosine-protein kinase receptor. (822 aa)
CSF3Granulocyte colony-stimulating factor. (195 aa)
INSRTyrosine-protein kinase receptor. (1392 aa)
TEKAngiopoietin-1 receptor. (1125 aa)
RELNReelin isoform X1. (3460 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (729 aa)
OSMoncostatin-M. (246 aa)
AGTAngiotensinogen; Belongs to the serpin family. (477 aa)
F2RL1Proteinase-activated receptor 2. (315 aa)
FGRTyrosine-protein kinase. (526 aa)
ObLeptin isoform X1. (167 aa)
UBE3AUbiquitin-protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. (875 aa)
IGF1Insulin-like growth factor I isoform X1. (186 aa)
IGF1RTyrosine-protein kinase receptor. (1368 aa)
NKX3-1Homeobox protein Nkx-3.1. (241 aa)
F2RProteinase-activated receptor 1; Belongs to the G-protein coupled receptor 1 family. (427 aa)
PRR5Proline-rich protein 5 isoform X1. (389 aa)
PDGFBPlatelet-derived growth factor subunit B isoform X1; Belongs to the PDGF/VEGF growth factor family. (278 aa)
F2Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. (623 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
UNC5BNetrin receptor UNC5B isoform X1. (945 aa)
SIRT1NAD-dependent protein deacetylase sirtuin-1 isoform X1. (735 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (166 aa)
MAZMyc-associated zinc finger protein isoform X1. (495 aa)
LOC111182889LOW QUALITY PROTEIN: transcription factor SOX-9-like. (510 aa)
NCF1Neutrophil cytosol factor 1 isoform X2. (405 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (362 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (294 aa)
PRR5LProline-rich protein 5-like isoform X1. (428 aa)
RGL2Ral guanine nucleotide dissociation stimulator-like 2 isoform X1. (781 aa)
CATCatalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. (527 aa)
PPARDPeroxisome proliferator-activated receptor delta isoform X1. (441 aa)
ROR1Inactive tyrosine-protein kinase transmembrane receptor ROR1; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (937 aa)
PDGFCPlatelet-derived growth factor C isoform X2. (380 aa)
NEDD4E3 ubiquitin-protein ligase NEDD4 isoform X3. (1319 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
FSHRFollicle-stimulating hormone receptor; G protein-coupled receptor for follitropin, the follicle- stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways. (695 aa)
FLT1Vascular endothelial growth factor receptor 1 isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1340 aa)
LOC111172458LOW QUALITY PROTEIN: ral guanine nucleotide dissociation stimulator-like 2. (776 aa)
PIK3AP1Phosphoinositide 3-kinase adapter protein 1 isoform X1. (806 aa)
PLXNB1plexin-B1 isoform X1. (2182 aa)
FN1Fibronectin isoform X5. (2478 aa)
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
Server load: medium (44%) [HD]