STRINGSTRING
C7 C7 C9 C9 MASP2 MASP2 EXOSC3 EXOSC3 C1QBP C1QBP CSF2RB CSF2RB IL9R IL9R KIAA1841 KIAA1841 BCL3 BCL3 BCL10 BCL10 RNF8 RNF8 ERCC1 ERCC1 BATF BATF CARD9 CARD9 BTK BTK MORN5 MORN5 DEF6 DEF6 EXO1 EXO1 C5 C5 LIG4 LIG4 AICDA AICDA MSH2 MSH2 C1R C1R C1S C1S C8A C8A PRKCD PRKCD C8B C8B MSH6 MSH6 TREX1 TREX1 STAT6 STAT6 INPP5D INPP5D C2 C2 MBL2 MBL2 BCL6 BCL6 RNF168 RNF168 LOC111170700 LOC111170700 IRF7 IRF7 FOXP3 FOXP3 CCR6 CCR6 C3 C3 FCER1G FCER1G SWAP70 SWAP70 LOC111166100 LOC111166100 C1QB C1QB TRAF3IP2 TRAF3IP2 MYD88 MYD88 C1QC C1QC C1QA C1QA ATAD5 ATAD5 NBN NBN EXOSC6 EXOSC6 CD19 CD19 C6 C6 UNG UNG IL4R IL4R IL21R IL21R ZP3 ZP3 CD81 CD81 CD74 CD74 LOC111184729 LOC111184729 C4BPA C4BPA TCIRG1 TCIRG1 C4BPB C4BPB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
C7Complement component C7. (843 aa)
C9Complement component C9. (548 aa)
MASP2Mannan-binding lectin serine protease 2 isoform X1; Belongs to the peptidase S1 family. (686 aa)
EXOSC3Exosome complex component RRP40. (275 aa)
C1QBPComplement component 1 Q subcomponent-binding protein, mitochondrial. (278 aa)
CSF2RBCytokine receptor common subunit beta. (902 aa)
IL9RInterleukin-9 receptor. (469 aa)
KIAA1841Uncharacterized protein KIAA1841 homolog isoform X1. (717 aa)
BCL3B-cell lymphoma 3 protein. (454 aa)
BCL10B-cell lymphoma/leukemia 10. (233 aa)
RNF8E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (487 aa)
ERCC1DNA excision repair protein ERCC-1 isoform X1. (414 aa)
BATFBasic leucine zipper transcriptional factor ATF-like. (125 aa)
CARD9Caspase recruitment domain-containing protein 9 isoform X1. (539 aa)
BTKTyrosine-protein kinase. (687 aa)
MORN5MORN repeat-containing protein 5 isoform X1. (172 aa)
DEF6Differentially expressed in FDCP 6 homolog isoform X1. (673 aa)
EXO1Exonuclease 1. (801 aa)
C5Complement C5 isoform X1. (1677 aa)
LIG4DNA ligase. (911 aa)
AICDASingle-stranded DNA cytosine deaminase. (208 aa)
MSH2DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (934 aa)
C1RComplement C1r subcomponent isoform X1; Belongs to the peptidase S1 family. (713 aa)
C1SComplement C1s subcomponent; Belongs to the peptidase S1 family. (695 aa)
C8AComplement component C8 alpha chain isoform X1. (589 aa)
PRKCDProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (733 aa)
C8BComplement component C8 beta chain isoform X1. (590 aa)
MSH6DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1361 aa)
TREX1Three-prime repair exonuclease 1. (314 aa)
STAT6Signal transducer and activator of transcription. (847 aa)
INPP5DPhosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1. (1150 aa)
C2Complement C2 isoform X1; Belongs to the peptidase S1 family. (751 aa)
MBL2LOW QUALITY PROTEIN: mannose-binding protein C. (244 aa)
BCL6B-cell lymphoma 6 protein. (706 aa)
RNF168E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...] (592 aa)
LOC111170700Complement C4-like isoform X1. (1740 aa)
IRF7Interferon regulatory factor 7 isoform X1. (473 aa)
FOXP3Forkhead box protein P3. (431 aa)
CCR6C-C chemokine receptor type 6; Belongs to the G-protein coupled receptor 1 family. (375 aa)
C3Complement C3 isoform X1. (1695 aa)
FCER1GHigh affinity immunoglobulin epsilon receptor subunit gamma. (86 aa)
SWAP70Switch-associated protein 70. (585 aa)
LOC111166100Complement C3-like isoform X1. (1706 aa)
C1QBComplement C1q subcomponent subunit B. (290 aa)
TRAF3IP2Adapter protein CIKS isoform X1. (564 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (296 aa)
C1QCComplement C1q subcomponent subunit C. (245 aa)
C1QAComplement C1q subcomponent subunit A. (245 aa)
ATAD5ATPase family AAA domain-containing protein 5 isoform X1. (1898 aa)
NBNNibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (727 aa)
EXOSC6Exosome complex component MTR3. (272 aa)
CD19B-lymphocyte antigen CD19 isoform X1. (570 aa)
C6Complement component C6 isoform X1. (934 aa)
UNGUracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine; Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family. (304 aa)
IL4RInterleukin-4 receptor subunit alpha isoform X1. (831 aa)
IL21RInterleukin-21 receptor isoform X2. (560 aa)
ZP3Zona pellucida sperm-binding protein 3. (421 aa)
CD81Tetraspanin. (236 aa)
CD74HLA class II histocompatibility antigen gamma chain isoform X1. (278 aa)
LOC111184729Membrane cofactor protein-like isoform X1. (411 aa)
C4BPAC4b-binding protein alpha chain isoform X1. (616 aa)
TCIRG1V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (873 aa)
C4BPBC4b-binding protein beta chain isoform X1. (255 aa)
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
Server load: low (26%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.