STRINGSTRING
CLDN5 CLDN5 E2F2 E2F2 KIAA1024 KIAA1024 TBC1D31 TBC1D31 PTPRM PTPRM WISP3 WISP3 TEK TEK AMOT AMOT KLF2 KLF2 EFNA3 EFNA3 NAXE NAXE ADGRB1 ADGRB1 PDE3B PDE3B EPN2 EPN2 THBS2 THBS2 SEMA4A SEMA4A CTNNB1 CTNNB1 FOXO4 FOXO4 FASLG FASLG MECP2 MECP2 SEMA3E SEMA3E COL4A3 COL4A3 STAT1 STAT1 ALOX5 ALOX5 STAB1 STAB1 ADAMTS1 ADAMTS1 SYNJ2BP SYNJ2BP ADGRB2 ADGRB2 ATF2 ATF2 TIE1 TIE1 CNMD CNMD VASH1 VASH1 ANGPT2 ANGPT2 COL4A2 COL4A2 FOXJ2 FOXJ2 EMILIN1 EMILIN1 TGFB2 TGFB2 SPRY2 SPRY2 AGO1 AGO1 PML PML IL17F IL17F DAB2IP DAB2IP TNMD TNMD PIK3CB PIK3CB PGK1 PGK1 SARS SARS HOXA5 HOXA5 EPN1 EPN1 GTF2I GTF2I ROCK1 ROCK1 SPRED1 SPRED1 KRIT1 KRIT1 HGS HGS THBS1 THBS1 SEMA6A SEMA6A SERPINE1 SERPINE1 ANGPT4 ANGPT4 ECSCR ECSCR CREB3L1 CREB3L1 APOH APOH THBS4 THBS4 ADGRB3 ADGRB3 ATP2B4 ATP2B4 SERPINF1 SERPINF1 ISM1 ISM1 PLK2 PLK2 SULF1 SULF1 NF1 NF1 CXCL10 CXCL10 EPHA2 EPHA2 LOC111187154 LOC111187154 TNF TNF
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CLDN5Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (218 aa)
E2F2Transcription factor E2F2 isoform X1. (437 aa)
KIAA1024UPF0258 protein KIAA1024 homolog. (917 aa)
TBC1D31TBC1 domain family member 31 isoform X1. (1073 aa)
PTPRMReceptor-type tyrosine-protein phosphatase mu isoform X2. (1531 aa)
WISP3WNT1-inducible-signaling pathway protein 3. (210 aa)
TEKAngiopoietin-1 receptor. (1125 aa)
AMOTAngiomotin isoform X1. (1081 aa)
KLF2Krueppel-like factor 2. (355 aa)
EFNA3ephrin-A3 isoform X1; Belongs to the ephrin family. (238 aa)
NAXENAD(P)H-hydrate epimerase; Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX. (288 aa)
ADGRB1Brain-specific angiogenesis inhibitor 1 isoform X1. (888 aa)
PDE3BPhosphodiesterase. (1120 aa)
EPN2Epsin-2 isoform X1. (582 aa)
THBS2Thrombospondin-2. (1171 aa)
SEMA4Asemaphorin-4A; Belongs to the semaphorin family. (762 aa)
CTNNB1Catenin beta-1. (781 aa)
FOXO4Forkhead box protein O4. (512 aa)
FASLGTumor necrosis factor ligand superfamily member 6; Belongs to the tumor necrosis factor family. (262 aa)
MECP2Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). (486 aa)
SEMA3Esemaphorin-3E; Belongs to the semaphorin family. (775 aa)
COL4A3Collagen alpha-3(IV) chain. (1670 aa)
STAT1Signal transducer and activator of transcription. (749 aa)
ALOX5Arachidonate 5-lipoxygenase. (674 aa)
STAB1Stabilin-1 isoform X1. (2596 aa)
ADAMTS1A disintegrin and metalloproteinase with thrombospondin motifs 1. (940 aa)
SYNJ2BPSynaptojanin-2-binding protein isoform X1. (150 aa)
ADGRB2Adhesion G protein-coupled receptor B2 isoform X1; Belongs to the G-protein coupled receptor 2 family. (1606 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2 isoform X1. (505 aa)
TIE1Tyrosine-protein kinase receptor Tie-1 isoform X1. (1139 aa)
CNMDLeukocyte cell-derived chemotaxin 1 isoform X1. (335 aa)
VASH1Vasohibin-1 isoform X1. (387 aa)
ANGPT2Angiopoietin-2 isoform X1. (496 aa)
COL4A2Collagen alpha-2(IV) chain isoform X1. (1760 aa)
FOXJ2Forkhead box protein J2. (568 aa)
EMILIN1EMILIN-1. (1015 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
SPRY2Protein sprouty homolog 2. (315 aa)
AGO1Protein argonaute-1 isoform X1; Belongs to the argonaute family. (857 aa)
PMLProtein PML isoform X1. (861 aa)
IL17Finterleukin-17F. (165 aa)
DAB2IPDisabled homolog 2-interacting protein isoform X1. (1193 aa)
TNMDTenomodulin. (317 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1064 aa)
PGK1Phosphoglycerate kinase. (417 aa)
SARSserine--tRNA ligase, cytoplasmic. (514 aa)
HOXA5Homeobox protein Hox-A5. (381 aa)
EPN1LOW QUALITY PROTEIN: epsin-1. (576 aa)
GTF2IGeneral transcription factor II-I isoform X1. (999 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1354 aa)
SPRED1Sprouty-related, EVH1 domain-containing protein 1 isoform X1. (445 aa)
KRIT1Krev interaction trapped protein 1 isoform X1. (736 aa)
HGSHepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...] (777 aa)
THBS1Thrombospondin-1. (1170 aa)
SEMA6Asemaphorin-6A isoform X1; Belongs to the semaphorin family. (1044 aa)
SERPINE1Plasminogen activator inhibitor 1; Belongs to the serpin family. (402 aa)
ANGPT4Angiopoietin-4. (498 aa)
ECSCREndothelial cell-specific chemotaxis regulator isoform X5. (203 aa)
CREB3L1Cyclic AMP-responsive element-binding protein 3-like protein 1. (520 aa)
APOHBeta-2-glycoprotein 1 isoform X1. (345 aa)
THBS4Thrombospondin-4. (961 aa)
ADGRB3Adhesion G protein-coupled receptor B3 isoform X1; Belongs to the G-protein coupled receptor 2 family. (1522 aa)
ATP2B4Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1243 aa)
SERPINF1Pigment epithelium-derived factor isoform X1; Belongs to the serpin family. (416 aa)
ISM1Isthmin-1 isoform X1. (473 aa)
PLK2Serine/threonine-protein kinase PLK. (685 aa)
SULF1Extracellular sulfatase; Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C- 6 position of glucosamine within specific subregions of intact heparin. Belongs to the sulfatase family. (882 aa)
NF1Neurofibromin isoform X1. (2873 aa)
CXCL10C-X-C motif chemokine. (103 aa)
EPHA2Ephrin type-A receptor 2. (975 aa)
LOC111187154Ephrin type-A receptor 2-like. (171 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (233 aa)
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
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