STRINGSTRING
PLA2G3 PLA2G3 RAB12 RAB12 BCR BCR RPH3A RPH3A FGR FGR SEPT5 SEPT5 F2RL1 F2RL1 CNR1 CNR1 SEPT4 SEPT4 RAB33B RAB33B SYT17 SYT17 VSNL1 VSNL1 MICAL1 MICAL1 RAB3D RAB3D GIPC3 GIPC3 SNF8 SNF8 RAB3A RAB3A VAMP8 VAMP8 BACE1 BACE1 RAB5A RAB5A SYT11 SYT11 DRD2 DRD2 CD84 CD84 LYN LYN RAB13 RAB13 SYT1 SYT1 HAP1 HAP1 ADORA2B ADORA2B CACNA1A CACNA1A STXBP5 STXBP5 PRAM1 PRAM1 SNAPIN SNAPIN SYT4 SYT4 EXPH5 EXPH5 FBXL20 FBXL20 RAB8A RAB8A LOC111169295 LOC111169295 GIPC1 GIPC1 SYT9 SYT9 STXBP5L STXBP5L GSK3B GSK3B SYT2 SYT2 FES FES AGPAT4 AGPAT4 RAB24 RAB24 SYK SYK RAB7A RAB7A LGI3 LGI3 CHMP2A CHMP2A RAB9A RAB9A VAMP7 VAMP7 LOC111169240 LOC111169240 IL1RAPL1 IL1RAPL1 SYP SYP LOC111168746 LOC111168746 CDK5R2 CDK5R2 SYT8 SYT8 LOC111170528 LOC111170528 IL1RAPL2 IL1RAPL2 SEPT2 SEPT2 CACNB4 CACNB4 LOC111170526 LOC111170526 RAPGEF4 RAPGEF4 NLGN1 NLGN1 LOC111171171 LOC111171171 ADRA2A ADRA2A LOC111171395 LOC111171395 NCKAP1L NCKAP1L LRRK2 LRRK2 SNX4 SNX4 ANXA1 ANXA1 APBA1 APBA1 CADPS CADPS SLC4A8 SLC4A8 RAB3B RAB3B RAB15 RAB15 SDC1 SDC1 HYAL3 HYAL3 SYT10 SYT10 RAP1B RAP1B CUNH12orf4 CUNH12orf4 PREPL PREPL CACNA1B CACNA1B SYNPR SYNPR LAMP1 LAMP1 STXBP1 STXBP1 CSPG5 CSPG5 RAB27A RAB27A RAB10 RAB10 CHRNA5 CHRNA5 SYTL4 SYTL4 RAB8B RAB8B DNM1 DNM1 CDK5 CDK5 STAM STAM BRAF BRAF AP1G1 AP1G1 NOTCH1 NOTCH1 SCAMP5 SCAMP5 FOXF1 FOXF1 CFTR CFTR RIMS2 RIMS2 TSG101 TSG101 VPS4A VPS4A VPS4B VPS4B DGKI DGKI CACNB2 CACNB2 SYT6 SYT6 RAP1A RAP1A GIPC2 GIPC2 PFN2 PFN2 CADPS2 CADPS2 STXBP3 STXBP3 RAB27B RAB27B SEPT1 SEPT1 DOC2A DOC2A VPS18 VPS18 IL13 IL13 SNAP23 SNAP23 CD177 CD177 SPHK2 SPHK2 ITGAM ITGAM PRKCB PRKCB SYT5 SYT5 ZP3 ZP3 DTNBP1 DTNBP1 SYT3 SYT3 LOC111182867 LOC111182867 HGS HGS STX1A STX1A SYT7 SYT7 RAB2B RAB2B TMEM248 TMEM248 STX1B STX1B TPCN2 TPCN2 UNC13D UNC13D FER FER SYT13 SYT13 ADCY1 ADCY1 RAB26 RAB26 LOC111183660 LOC111183660 SYT12 SYT12 BLK BLK CACNA1H CACNA1H RAC2 RAC2 RALA RALA CACNA1I CACNA1I KIAA0100 KIAA0100 DOC2B DOC2B GAB2 GAB2 P2RX7 P2RX7 BAIAP3 BAIAP3 PDPK1 PDPK1 RAB3C RAB3C GIT1 GIT1 RPH3AL RPH3AL FGB FGB DVL1 DVL1 FGG FGG ATP9A ATP9A ATP2A2 ATP2A2 GRIN3A GRIN3A ATP13A2 ATP13A2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PLA2G3Group 3 secretory phospholipase A2 isoform X1. (516 aa)
RAB12Ras-related protein Rab-12 isoform X1. (244 aa)
BCRBreakpoint cluster region protein isoform X1. (1275 aa)
RPH3Arabphilin-3A isoform X1. (704 aa)
FGRTyrosine-protein kinase. (526 aa)
SEPT5Septin-5 isoform X1; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (400 aa)
F2RL1Proteinase-activated receptor 2. (315 aa)
CNR1Cannabinoid receptor 1; G-protein coupled receptor for cannabinoids (eCBs), including N-arachidonoylethanolamide (also called anandamide or AEA) and 2- arachidonoylglycerol (2-AG). Mediates many cannabinoid-induced effects, acting, among others, on food intake, memory loss, gastrointestinal motility, catalepsy, ambulatory activity, anxiety, chronic pain. Signaling typically involves reduction in cyclic AMP. In the hypothalamus, may have a dual effect on mitochondrial respiration depending upon the agonist dose and possibly upon the cell type. Increases respiration at low doses, while d [...] (472 aa)
SEPT4Septin-4 isoform X1; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (487 aa)
RAB33BRas-related protein Rab-33B. (229 aa)
SYT17Synaptotagmin-17 isoform X1. (505 aa)
VSNL1Visinin-like protein 1. (191 aa)
MICAL1F-actin-methionine sulfoxide oxidase MICAL1 isoform X1. (1067 aa)
RAB3DRas-related protein Rab-3D. (219 aa)
GIPC3PDZ domain-containing protein GIPC3. (318 aa)
SNF8Vacuolar-sorting protein SNF8; Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. Belongs to the SNF8 family. (258 aa)
RAB3ARas-related protein Rab-3A. (220 aa)
VAMP8Vesicle-associated membrane protein 8. (100 aa)
BACE1Beta-secretase 1; Belongs to the peptidase A1 family. (498 aa)
RAB5ARas-related protein Rab-5A isoform X1. (215 aa)
SYT11Synaptotagmin-11 isoform X1. (428 aa)
DRD2D(2) dopamine receptor; Belongs to the G-protein coupled receptor 1 family. (443 aa)
CD84SLAM family member 5 isoform X1. (341 aa)
LYNTyrosine-protein kinase. (518 aa)
RAB13Ras-related protein Rab-13. (203 aa)
SYT1Synaptotagmin-1 isoform X1. (422 aa)
HAP1LOW QUALITY PROTEIN: huntingtin-associated protein 1. (651 aa)
ADORA2BAdenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (333 aa)
CACNA1AVoltage-dependent P/Q-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q- type calcium currents. (2501 aa)
STXBP5Syntaxin-binding protein 5 isoform X5. (1181 aa)
PRAM1PML-RARA-regulated adapter molecule 1 isoform X2. (541 aa)
SNAPINSNARE-associated protein Snapin; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking and synaptic vesicle recycling; Belongs to t [...] (136 aa)
SYT4Synaptotagmin-4. (425 aa)
EXPH5Exophilin-5 isoform X1. (2002 aa)
FBXL20F-box/LRR-repeat protein 20 isoform X1. (438 aa)
RAB8ARas-related protein Rab-8A. (207 aa)
LOC111169295RE1-silencing transcription factor-like isoform X1. (981 aa)
GIPC1PDZ domain-containing protein GIPC1. (333 aa)
SYT9Synaptotagmin-9 isoform X1. (503 aa)
STXBP5LSyntaxin-binding protein 5-like isoform X1. (1234 aa)
GSK3BGlycogen synthase kinase-3 beta isoform X1; Belongs to the protein kinase superfamily. (433 aa)
SYT2Synaptotagmin-2 isoform X1. (428 aa)
FESTyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (822 aa)
AGPAT41-acyl-sn-glycerol-3-phosphate acyltransferase delta isoform X1. (835 aa)
RAB24Ras-related protein Rab-24. (203 aa)
SYKTyrosine-protein kinase. (626 aa)
RAB7ARas-related protein Rab-7a. (207 aa)
LGI3Leucine-rich repeat LGI family member 3 isoform X1. (548 aa)
CHMP2ACharged multivesicular body protein 2a isoform X1. (305 aa)
RAB9ARas-related protein Rab-9A. (201 aa)
VAMP7Vesicle-associated membrane protein 7; Belongs to the synaptobrevin family. (220 aa)
LOC111169240RE1-silencing transcription factor-like isoform X2. (976 aa)
IL1RAPL1Interleukin-1 receptor accessory protein-like 1. (449 aa)
SYPSynaptophysin. (313 aa)
LOC111168746Synaptotagmin-15-like isoform X1. (417 aa)
CDK5R2Cyclin-dependent kinase 5 activator. (369 aa)
SYT8LOW QUALITY PROTEIN: synaptotagmin-8. (385 aa)
LOC111170528Voltage-dependent calcium channel beta subunit-associated regulatory protein-like. (398 aa)
IL1RAPL2X-linked interleukin-1 receptor accessory protein-like 2. (686 aa)
SEPT2Septin-2 isoform X1; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (361 aa)
CACNB4Voltage-dependent L-type calcium channel subunit beta-4 isoform X1. (519 aa)
LOC111170526Voltage-dependent calcium channel beta subunit-associated regulatory protein-like. (513 aa)
RAPGEF4Rap guanine nucleotide exchange factor 4 isoform X1. (1011 aa)
NLGN1Neuroligin-1 isoform X1. (843 aa)
LOC111171171Integrin alpha-M-like. (296 aa)
ADRA2Aalpha-2A adrenergic receptor. (465 aa)
LOC111171395Cation-transporting ATPase 13A2-like. (209 aa)
NCKAP1LNck-associated protein 1-like isoform X1. (1156 aa)
LRRK2Leucine-rich repeat serine/threonine-protein kinase 2 isoform X1. (2527 aa)
SNX4Sorting nexin-4. (450 aa)
ANXA1Annexin. (346 aa)
APBA1Amyloid beta A4 precursor protein-binding family A member 1 isoform X1. (832 aa)
CADPSCalcium-dependent secretion activator 1 isoform X1. (1428 aa)
SLC4A8Anion exchange protein. (1109 aa)
RAB3BRas-related protein Rab-3B. (219 aa)
RAB15Ras-related protein Rab-15 isoform X1. (212 aa)
SDC1Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (310 aa)
HYAL3Hyaluronidase. (415 aa)
SYT10Synaptotagmin-10. (523 aa)
RAP1BRas-related protein Rap-1b. (184 aa)
CUNH12orf4Protein C12orf4 homolog isoform X1. (552 aa)
PREPLProlyl endopeptidase-like isoform X1. (727 aa)
CACNA1BVoltage-dependent N-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1B gives rise to N-type calcium currents. (1749 aa)
SYNPRSynaptoporin isoform X1. (285 aa)
LAMP1Lysosome-associated membrane glycoprotein 1. (411 aa)
STXBP1Syntaxin-binding protein 1 isoform X1; Belongs to the STXBP/unc-18/SEC1 family. (603 aa)
CSPG5Chondroitin sulfate proteoglycan 5 isoform X1. (544 aa)
RAB27ARas-related protein Rab-27A isoform X1. (221 aa)
RAB10Ras-related protein Rab-10. (200 aa)
CHRNA5Neuronal acetylcholine receptor subunit alpha-5 isoform X1. (475 aa)
SYTL4Synaptotagmin-like protein 4. (672 aa)
RAB8BRas-related protein Rab-8B isoform X1. (207 aa)
DNM1Dynamin-1 isoform X1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (868 aa)
CDK5Cyclin-dependent-like kinase 5; Belongs to the protein kinase superfamily. (292 aa)
STAMSignal transducing adapter molecule 1. (526 aa)
BRAFSerine/threonine-protein kinase B-raf isoform X1. (762 aa)
AP1G1AP-1 complex subunit gamma. (825 aa)
NOTCH1Neurogenic locus notch homolog protein 1 isoform X1. (2521 aa)
SCAMP5Secretory carrier-associated membrane protein. (235 aa)
FOXF1Forkhead box protein F1. (375 aa)
CFTRCystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. (1482 aa)
RIMS2Regulating synaptic membrane exocytosis protein 2 isoform X2. (1549 aa)
TSG101Tumor susceptibility gene 101 protein isoform X1. (429 aa)
VPS4AVacuolar protein sorting-associated protein 4A isoform X1; Belongs to the AAA ATPase family. (437 aa)
VPS4BVacuolar protein sorting-associated protein 4B; Belongs to the AAA ATPase family. (444 aa)
DGKIDiacylglycerol kinase. (1079 aa)
CACNB2Voltage-dependent L-type calcium channel subunit beta-2 isoform X1. (604 aa)
SYT6Synaptotagmin-6 isoform X1. (442 aa)
RAP1ARas-related protein Rap-1A. (184 aa)
GIPC2PDZ domain-containing protein GIPC2. (311 aa)
PFN2Profilin; Belongs to the profilin family. (197 aa)
CADPS2Calcium-dependent secretion activator 2 isoform X1. (1305 aa)
STXBP3Syntaxin-binding protein 3; Belongs to the STXBP/unc-18/SEC1 family. (592 aa)
RAB27BRas-related protein Rab-27B. (217 aa)
SEPT1Septin-1 isoform X1; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (367 aa)
DOC2ADouble C2-like domain-containing protein alpha isoform X3. (428 aa)
VPS18Vacuolar protein sorting-associated protein 18 homolog. (973 aa)
IL13Interleukin-13. (131 aa)
SNAP23Synaptosomal-associated protein; Belongs to the SNAP-25 family. (211 aa)
CD177CD177 antigen isoform X1. (443 aa)
SPHK2Sphingosine kinase 2 isoform X1. (655 aa)
ITGAMIntegrin alpha-M; Belongs to the integrin alpha chain family. (872 aa)
PRKCBProtein kinase C. (689 aa)
SYT5Synaptotagmin-5 isoform X1. (386 aa)
ZP3Zona pellucida sperm-binding protein 3. (421 aa)
DTNBP1Dysbindin isoform X1. (341 aa)
SYT3Synaptotagmin-3. (591 aa)
LOC111182867CMRF35-like molecule 8 isoform X1. (313 aa)
HGSHepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...] (777 aa)
STX1Asyntaxin-1A isoform X1; Belongs to the syntaxin family. (288 aa)
SYT7Synaptotagmin-7 isoform X1. (705 aa)
RAB2BRas-related protein Rab-2B isoform X1. (216 aa)
TMEM248Transmembrane protein 248 isoform X7. (971 aa)
STX1Bsyntaxin-1B; Belongs to the syntaxin family. (288 aa)
TPCN2Two pore calcium channel protein 2 isoform X1. (783 aa)
UNC13DProtein unc-13 homolog D isoform X1. (1121 aa)
FERTyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (822 aa)
SYT13Synaptotagmin-13. (425 aa)
ADCY1Adenylate cyclase type 1. (907 aa)
RAB26Ras-related protein Rab-26 isoform X1. (319 aa)
LOC111183660LOW QUALITY PROTEIN: double C2-like domain-containing protein gamma. (383 aa)
SYT12Synaptotagmin-12 isoform X1. (422 aa)
BLKTyrosine-protein kinase. (501 aa)
CACNA1HVoltage-dependent T-type calcium channel subunit alpha-1H isoform X1. (2335 aa)
RAC2Ras-related C3 botulinum toxin substrate 2 isoform X2. (192 aa)
RALARas-related protein Ral-A. (206 aa)
CACNA1IVoltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...] (2193 aa)
KIAA0100Protein KIAA0100 homolog isoform X2. (2233 aa)
DOC2BDouble C2-like domain-containing protein beta isoform X1. (416 aa)
GAB2GRB2-associated-binding protein 2 isoform X1. (678 aa)
P2RX7P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (595 aa)
BAIAP3BAI1-associated protein 3 isoform X1. (1177 aa)
PDPK13-phosphoinositide-dependent protein kinase 1 isoform X1. (558 aa)
RAB3CRas-related protein Rab-3C. (227 aa)
GIT1ARF GTPase-activating protein GIT1 isoform X1. (770 aa)
RPH3ALLOW QUALITY PROTEIN: rab effector Noc2. (302 aa)
FGBFibrinogen beta chain isoform X1. (495 aa)
DVL1Segment polarity protein dishevelled homolog DVL-1 isoform X1. (700 aa)
FGGFibrinogen gamma chain isoform X1. (445 aa)
ATP9APhospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (1047 aa)
ATP2A2Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1042 aa)
GRIN3AGlutamate receptor ionotropic, NMDA 3A; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (1115 aa)
ATP13A2Cation-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. (966 aa)
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
Server load: medium (46%) [HD]