STRINGSTRING
ABL2 ABL2 FGR FGR LIF LIF EPHA8 EPHA8 EPHB2 EPHB2 RET RET RELN RELN FYN FYN FRK FRK NOD2 NOD2 DYRK1A DYRK1A FGFRL1 FGFRL1 TEK TEK WEE1 WEE1 INSR INSR EPHA7 EPHA7 FGFR3 FGFR3 TYK2 TYK2 NTRK2 NTRK2 INSRR INSRR LYN LYN NTRK1 NTRK1 PTK2 PTK2 CLK2 CLK2 MATK MATK ERBB2 ERBB2 JAK3 JAK3 PTPRC PTPRC EPHA5 EPHA5 NTRK3 NTRK3 DDR2 DDR2 LOC111169254 LOC111169254 ROR2 ROR2 ROS1 ROS1 KIT KIT PDGFRA PDGFRA HPX HPX FES FES PTPN4 PTPN4 CLK4 CLK4 SYK SYK BMX BMX TEC TEC DDR1 DDR1 LOC111169208 LOC111169208 FGFR4 FGFR4 TXK TXK NRP2 NRP2 FGFR2 FGFR2 ERBB4 ERBB4 KDR KDR TNK2 TNK2 FLT4 FLT4 EPHB3 EPHB3 DYRK2 DYRK2 ERBB3 ERBB3 CLK1 CLK1 EPHA4 EPHA4 JAK2 JAK2 TWF1 TWF1 PKDCC PKDCC FGFR1 FGFR1 FLT3 FLT3 FLT1 FLT1 EPHA10 EPHA10 TIE1 TIE1 PDGFRL PDGFRL RPS6KA5 RPS6KA5 LOC111175797 LOC111175797 HTR2A HTR2A MST1R MST1R PIBF1 PIBF1 WEE2 WEE2 PTPN6 PTPN6 STYK1 STYK1 CLK3 CLK3 PEAK1 PEAK1 ABI1 ABI1 LCK LCK CSK CSK EPHA3 EPHA3 BTK BTK HIPK2 HIPK2 LOC111178990 LOC111178990 NRP1 NRP1 EPHA1 EPHA1 MUSK MUSK TTBK1 TTBK1 MET MET ABL1 ABL1 EPHB6 EPHB6 EPHB1 EPHB1 CAV1 CAV1 IL12RB2 IL12RB2 HIPK3 HIPK3 AXL AXL JAK1 JAK1 TYRO3 TYRO3 LTK LTK HIPK4 HIPK4 DYRK1B DYRK1B HIPK1 HIPK1 YES1 YES1 MAPK3 MAPK3 EPHB4 EPHB4 ITK ITK LOC111183175 LOC111183175 LEP LEP MAP2K6 MAP2K6 PDGFRB PDGFRB CNTF CNTF BAZ1B BAZ1B IL5 IL5 LOC111184310 LOC111184310 FER FER HMCN1 HMCN1 AATK AATK CSF1R CSF1R SRC SRC TTK TTK HCK HCK BLK BLK DSTYK DSTYK PDGFB PDGFB EGFR EGFR PTK2B PTK2B EFEMP1 EFEMP1 LRRK1 LRRK1 LOC111187417 LOC111187417 TNK1 TNK1 IL21 IL21 EPHA2 EPHA2 IGF1R IGF1R PTK6 PTK6 RSRC2 RSRC2 TESK1 TESK1 LOC111187154 LOC111187154 MERTK MERTK IL15 IL15 MELK MELK Ob Ob
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ABL2Tyrosine-protein kinase. (1174 aa)
FGRTyrosine-protein kinase. (526 aa)
LIFLeukemia inhibitory factor. (202 aa)
EPHA8Ephrin type-A receptor 8. (1005 aa)
EPHB2Ephrin type-B receptor 2 isoform X1. (987 aa)
RETProto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1113 aa)
RELNReelin isoform X1. (3460 aa)
FYNTyrosine-protein kinase. (537 aa)
FRKTyrosine-protein kinase. (513 aa)
NOD2Nucleotide-binding oligomerization domain-containing protein 2 isoform X1. (1086 aa)
DYRK1ADual specificity tyrosine-phosphorylation-regulated kinase 1A isoform X1. (845 aa)
FGFRL1Fibroblast growth factor receptor-like 1 isoform X1. (503 aa)
TEKAngiopoietin-1 receptor. (1125 aa)
WEE1Wee1-like protein kinase. (646 aa)
INSRTyrosine-protein kinase receptor. (1392 aa)
EPHA7Ephrin type-A receptor 7 isoform X1. (998 aa)
FGFR3Fibroblast growth factor receptor. (805 aa)
TYK2Tyrosine-protein kinase. (1188 aa)
NTRK2Tyrosine-protein kinase receptor. (822 aa)
INSRRTyrosine-protein kinase receptor. (1301 aa)
LYNTyrosine-protein kinase. (518 aa)
NTRK1Tyrosine-protein kinase receptor. (795 aa)
PTK2Focal adhesion kinase 1 isoform X22; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1116 aa)
CLK2Dual specificity protein kinase CLK2 isoform X1. (503 aa)
MATKTyrosine-protein kinase. (706 aa)
ERBB2Receptor protein-tyrosine kinase. (1255 aa)
JAK3Tyrosine-protein kinase. (1104 aa)
PTPRCReceptor-type tyrosine-protein phosphatase C isoform X1. (1258 aa)
EPHA5Ephrin type-A receptor 5 isoform X1. (1037 aa)
NTRK3Tyrosine-protein kinase receptor. (864 aa)
DDR2Discoidin domain-containing receptor 2. (565 aa)
LOC111169254Discoidin domain-containing receptor 2-like. (323 aa)
ROR2Tyrosine-protein kinase transmembrane receptor ROR2; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (940 aa)
ROS1Tyrosine-protein kinase receptor. (2348 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (977 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
HPXHemopexin; Binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation. (455 aa)
FESTyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (822 aa)
PTPN4Tyrosine-protein phosphatase non-receptor type; May act at junctions between the membrane and the cytoskeleton. (933 aa)
CLK4Dual specificity protein kinase CLK4 isoform X1; Belongs to the protein kinase superfamily. (481 aa)
SYKTyrosine-protein kinase. (626 aa)
BMXTyrosine-protein kinase. (692 aa)
TECTyrosine-protein kinase. (658 aa)
DDR1Tyrosine-protein kinase receptor. (917 aa)
LOC111169208Wee1-like protein kinase. (443 aa)
FGFR4Fibroblast growth factor receptor. (801 aa)
TXKTyrosine-protein kinase. (550 aa)
NRP2Neuropilin; Belongs to the neuropilin family. (931 aa)
FGFR2Fibroblast growth factor receptor. (841 aa)
ERBB4Receptor protein-tyrosine kinase. (1308 aa)
KDRVascular endothelial growth factor receptor 2 isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
TNK2Activated CDC42 kinase 1 isoform X3; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1086 aa)
FLT4Vascular endothelial growth factor receptor 3 isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1367 aa)
EPHB3Ephrin type-B receptor 3. (997 aa)
DYRK2Dual specificity tyrosine-phosphorylation-regulated kinase 2. (601 aa)
ERBB3Receptor tyrosine-protein kinase erbB-3. (1338 aa)
CLK1Dual specificity protein kinase CLK1 isoform X1; Belongs to the protein kinase superfamily. (485 aa)
EPHA4Ephrin type-A receptor 4 isoform X1. (986 aa)
JAK2Tyrosine-protein kinase. (1132 aa)
TWF1Twinfilin-1. (350 aa)
PKDCCExtracellular tyrosine-protein kinase PKDCC isoform X1. (498 aa)
FGFR1Fibroblast growth factor receptor. (823 aa)
FLT3Receptor-type tyrosine-protein kinase FLT3 isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (993 aa)
FLT1Vascular endothelial growth factor receptor 1 isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1340 aa)
EPHA10Ephrin type-A receptor 10 isoform X1. (1017 aa)
TIE1Tyrosine-protein kinase receptor Tie-1 isoform X1. (1139 aa)
PDGFRLPlatelet-derived growth factor receptor-like protein isoform X2. (375 aa)
RPS6KA5Ribosomal protein S6 kinase. (800 aa)
LOC111175797Ephrin type-A receptor 6-like. (409 aa)
HTR2A5-hydroxytryptamine receptor 2A. (470 aa)
MST1RMacrophage-stimulating protein receptor isoform X1. (1406 aa)
PIBF1Progesterone-induced-blocking factor 1 isoform X1. (757 aa)
WEE2Wee1-like protein kinase 2. (419 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
STYK1Tyrosine-protein kinase STYK1 isoform X1. (427 aa)
CLK3Dual specificity protein kinase CLK3 isoform X4. (566 aa)
PEAK1Pseudopodium-enriched atypical kinase 1. (1745 aa)
ABI1Abl interactor 1 isoform X1. (508 aa)
LCKTyrosine-protein kinase. (509 aa)
CSKTyrosine-protein kinase. (528 aa)
EPHA3Ephrin type-A receptor 3. (984 aa)
BTKTyrosine-protein kinase. (687 aa)
HIPK2Homeodomain-interacting protein kinase 2 isoform X1. (1248 aa)
LOC111178990Ephrin type-A receptor 6 isoform X1. (774 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (924 aa)
EPHA1Ephrin type-A receptor 1 isoform X1. (981 aa)
MUSKMuscle, skeletal receptor tyrosine-protein kinase isoform X1. (879 aa)
TTBK1Tau-tubulin kinase 1 isoform X1. (1311 aa)
METHepatocyte growth factor receptor isoform X1. (1382 aa)
ABL1Tyrosine-protein kinase. (1148 aa)
EPHB6Ephrin type-B receptor 6 isoform X1. (1010 aa)
EPHB1Ephrin type-B receptor 1 isoform X1. (984 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
IL12RB2Interleukin-12 receptor subunit beta-2 isoform X1. (861 aa)
HIPK3Homeodomain-interacting protein kinase 3 isoform X1. (1213 aa)
AXLLOW QUALITY PROTEIN: tyrosine-protein kinase receptor UFO. (887 aa)
JAK1Tyrosine-protein kinase. (1153 aa)
TYRO3Tyrosine-protein kinase receptor TYRO3 isoform X3. (896 aa)
LTKLOW QUALITY PROTEIN: leukocyte tyrosine kinase receptor. (922 aa)
HIPK4Homeodomain-interacting protein kinase 4. (610 aa)
DYRK1BDual specificity tyrosine-phosphorylation-regulated kinase 1B isoform X1. (686 aa)
HIPK1Homeodomain-interacting protein kinase 1 isoform X1. (1209 aa)
YES1Tyrosine-protein kinase. (541 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (382 aa)
EPHB4Ephrin type-B receptor 4. (987 aa)
ITKTyrosine-protein kinase. (620 aa)
LOC111183175Serine protease inhibitor Kazal-type 1-like. (79 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (166 aa)
MAP2K6Dual specificity mitogen-activated protein kinase kinase 6 isoform X1; Belongs to the protein kinase superfamily. (368 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1103 aa)
CNTFCiliary neurotrophic factor. (200 aa)
BAZ1BTyrosine-protein kinase BAZ1B. (1482 aa)
IL5Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. (135 aa)
LOC111184310Tyrosine-protein kinase. (369 aa)
FERTyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (822 aa)
HMCN1Hemicentin-1. (5635 aa)
AATKSerine/threonine-protein kinase LMTK1 isoform X5. (1442 aa)
CSF1RMacrophage colony-stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (961 aa)
SRCTyrosine-protein kinase. (562 aa)
TTKDual specificity protein kinase TTK isoform X1. (848 aa)
HCKTyrosine-protein kinase. (506 aa)
BLKTyrosine-protein kinase. (501 aa)
DSTYKDual serine/threonine and tyrosine protein kinase isoform X1. (929 aa)
PDGFBPlatelet-derived growth factor subunit B isoform X1; Belongs to the PDGF/VEGF growth factor family. (278 aa)
EGFRReceptor protein-tyrosine kinase. (1209 aa)
PTK2BProtein-tyrosine kinase 2-beta isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1015 aa)
EFEMP1EGF-containing fibulin-like extracellular matrix protein 1 isoform X1. (498 aa)
LRRK1Leucine-rich repeat serine/threonine-protein kinase 1. (2015 aa)
LOC111187417Tyrosine-protein kinase. (612 aa)
TNK1Non-receptor tyrosine-protein kinase TNK1 isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (699 aa)
IL21Interleukin; Belongs to the IL-15/IL-21 family. (146 aa)
EPHA2Ephrin type-A receptor 2. (975 aa)
IGF1RTyrosine-protein kinase receptor. (1368 aa)
PTK6Non-specific protein-tyrosine kinase. (354 aa)
RSRC2Arginine/serine-rich coiled-coil protein 2 isoform X1. (435 aa)
TESK1Dual specificity testis-specific protein kinase 1 isoform X1. (628 aa)
LOC111187154Ephrin type-A receptor 2-like. (171 aa)
MERTKTyrosine-protein kinase Mer. (999 aa)
IL15Interleukin; Belongs to the IL-15/IL-21 family. (180 aa)
MELKNon-specific serine/threonine protein kinase. (650 aa)
ObLeptin isoform X1. (167 aa)
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
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