(62 nodes) Regulation of fatty acid metabolic process network (Delphinapterus leucas)

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second shell of interactors

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proteins of unknown 3D structure

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Predicted Interactions

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Your Input:
	PLA2G3	Group 3 secretory phospholipase A2 isoform X1. (516 aa)
	ACACB	acetyl-CoA carboxylase 2 isoform X1. (2456 aa)
	SIRT4	NAD-dependent protein lipoamidase sirtuin-4, mitochondrial; Acts as NAD-dependent protein lipoamidase, ADP-ribosyl transferase and deacetylase. Catalyzes more efficiently removal of lipoyl- and biotinyl- than acetyl-lysine modifications. Inhibits the pyruvate dehydrogenase complex (PDH) activity via the enzymatic hydrolysis of the lipoamide cofactor from the E2 component, DLAT, in a phosphorylation-independent manner. Catalyzes the transfer of ADP- ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitoc [...] (314 aa)
	LONP2	Lon protease homolog 2, peroxisomal; ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import. May indirectly regulate peroxisomal fatty acid beta- oxidation through degradation of the self-processed forms of TYSND1. (852 aa)
	FABP5	Fatty acid-binding protein, epidermal isoform X1. (140 aa)
	WDTC1	WD and tetratricopeptide repeats protein 1 isoform X1. (680 aa)
	MID1IP1	Mid1-interacting protein 1. (183 aa)
	PLIN5	Perilipin; Belongs to the perilipin family. (454 aa)
	BRCA1	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1866 aa)
	APOC3	Apolipoprotein C-III. (99 aa)
	FMO4	Dimethylaniline monooxygenase [N-oxide-forming]. (557 aa)
	FMO1	Dimethylaniline monooxygenase [N-oxide-forming]. (537 aa)
	FMO3	Dimethylaniline monooxygenase [N-oxide-forming]. (532 aa)
	NCOR1	Nuclear receptor corepressor 1 isoform X1. (2454 aa)
	APOA4	Apolipoprotein A-IV isoform X1. (380 aa)
	PDK2	Protein-serine/threonine kinase. (407 aa)
	LOC111167328	Dimethylaniline monooxygenase [N-oxide-forming]. (537 aa)
	APOA5	Apolipoprotein A-V isoform X1. (390 aa)
	ABCD1	ATP-binding cassette sub-family D member 1 isoform X1. (774 aa)
	IRS1	Insulin receptor substrate 1. (1248 aa)
	ERFE	Erythroferrone isoform X1. (367 aa)
	ABCB11	Bile salt export pump isoform X1. (1340 aa)
	ERLIN1	Erlin-1 isoform X1. (369 aa)
	PDK1	Protein-serine/threonine kinase. (438 aa)
	LOC111173503	Erlin-2 isoform X1. (368 aa)
	ABCD2	ATP-binding cassette sub-family D member 2. (741 aa)
	TREX1	Three-prime repair exonuclease 1. (314 aa)
	ANXA1	Annexin. (346 aa)
	MFSD2A	Sodium-dependent lysophosphatidylcholine symporter 1 isoform X1. (565 aa)
	AKT1	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
	IRS2	Insulin receptor substrate 2. (1347 aa)
	SCAP	Sterol regulatory element-binding protein cleavage-activating protein isoform X1. (1280 aa)
	PIBF1	Progesterone-induced-blocking factor 1 isoform X1. (757 aa)
	PRKAG2	5'-AMP-activated protein kinase subunit gamma-2 isoform X1. (566 aa)
	INSIG1	Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. (294 aa)
	PPARD	Peroxisome proliferator-activated receptor delta isoform X1. (441 aa)
	ETFBKMT	Electron transfer flavoprotein beta subunit lysine methyltransferase. (266 aa)
	MLYCD	malonyl-CoA decarboxylase, mitochondrial isoform X1. (528 aa)
	ELOVL5	Elongation of very long chain fatty acids protein 5; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C18:3(n-6) acyl-CoA. May participate to the production of monounsaturated and of polyunsaturated VLCFAs of different chain lengths that are involv [...] (295 aa)
	CAV1	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
	NR1H2	Oxysterols receptor LXR-beta isoform X1. (450 aa)
	PDK4	Protein-serine/threonine kinase. (407 aa)
	AKT2	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
	LOC111182889	LOW QUALITY PROTEIN: transcription factor SOX-9-like. (510 aa)
	CD74	HLA class II histocompatibility antigen gamma chain isoform X1. (278 aa)
	SIRT1	NAD-dependent protein deacetylase sirtuin-1 isoform X1. (735 aa)
	TYSND1	Peroxisomal leader peptide-processing protease isoform X1. (568 aa)
	MLXIPL	Carbohydrate-responsive element-binding protein isoform X1. (929 aa)
	PANK2	Pantothenate kinase 2, mitochondrial isoform X1. (481 aa)
	NR1H3	Oxysterols receptor LXR-alpha isoform X1. (447 aa)
	SLC45A3	Solute carrier family 45 member 3. (553 aa)
	TWIST1	Twist-related protein 1. (205 aa)
	TRIB3	LOW QUALITY PROTEIN: tribbles homolog 3. (357 aa)
	INSIG2	Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. (229 aa)
	INS	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
	EIF6	Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Behaves as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (RACK1)- dependent protein kinase C activity. In tissues responsive to insulin, contro [...] (245 aa)
	PTGS2	Prostaglandin G/H synthase 2. (604 aa)
	LPGAT1	acyl-CoA:lysophosphatidylglycerol acyltransferase 1 isoform X1. (420 aa)
	PPARA	Peroxisome proliferator-activated receptor alpha. (468 aa)
	ACADVL	Very long-chain specific acyl-CoA dehydrogenase, mitochondrial isoform X1. (655 aa)
	APPL2	DCC-interacting protein 13-beta isoform X2. (661 aa)
	IL1B	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (266 aa)

Your Current Organism:

Delphinapterus leucas

NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABCD1	ABCD2	A0A2Y9MKI9	A0A2Y9N1V0	ATP-binding cassette sub-family D member 1 isoform X1.	ATP-binding cassette sub-family D member 2.	0.917
ABCD2	ABCD1	A0A2Y9N1V0	A0A2Y9MKI9	ATP-binding cassette sub-family D member 2.	ATP-binding cassette sub-family D member 1 isoform X1.	0.917
ACACB	BRCA1	A0A2Y9LD97	A0A2Y9LXF5	acetyl-CoA carboxylase 2 isoform X1.	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	0.639
ACACB	MLYCD	A0A2Y9LD97	A0A2Y9NXM8	acetyl-CoA carboxylase 2 isoform X1.	malonyl-CoA decarboxylase, mitochondrial isoform X1.	0.921
ACACB	PRKAG2	A0A2Y9LD97	A0A2Y9NJ94	acetyl-CoA carboxylase 2 isoform X1.	5'-AMP-activated protein kinase subunit gamma-2 isoform X1.	0.914
ACADVL	MLYCD	A0A2Y9Q6R5	A0A2Y9NXM8	Very long-chain specific acyl-CoA dehydrogenase, mitochondrial isoform X1.	malonyl-CoA decarboxylase, mitochondrial isoform X1.	0.472
ACADVL	PDK2	A0A2Y9Q6R5	A0A2Y9M940	Very long-chain specific acyl-CoA dehydrogenase, mitochondrial isoform X1.	Protein-serine/threonine kinase.	0.402
ACADVL	PDK4	A0A2Y9Q6R5	A0A2Y9P869	Very long-chain specific acyl-CoA dehydrogenase, mitochondrial isoform X1.	Protein-serine/threonine kinase.	0.486
ACADVL	PPARA	A0A2Y9Q6R5	A0A2Y9Q177	Very long-chain specific acyl-CoA dehydrogenase, mitochondrial isoform X1.	Peroxisome proliferator-activated receptor alpha.	0.447
AKT1	AKT2	A0A2Y9NBQ2	A0A2Y9PDM4	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.900
AKT1	APPL2	A0A2Y9NBQ2	A0A2Y9QDV1	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	DCC-interacting protein 13-beta isoform X2.	0.783
AKT1	BRCA1	A0A2Y9NBQ2	A0A2Y9LXF5	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	0.936
AKT1	INS	A0A2Y9NBQ2	A0A2Y9PTW5	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.556
AKT1	IRS1	A0A2Y9NBQ2	A0A2Y9MMM9	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Insulin receptor substrate 1.	0.529
AKT1	IRS2	A0A2Y9NBQ2	A0A2Y9NC55	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Insulin receptor substrate 2.	0.446
AKT1	TRIB3	A0A2Y9NBQ2	A0A2Y9PTE5	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	LOW QUALITY PROTEIN: tribbles homolog 3.	0.984
AKT2	AKT1	A0A2Y9PDM4	A0A2Y9NBQ2	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.900
AKT2	APPL2	A0A2Y9PDM4	A0A2Y9QDV1	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	DCC-interacting protein 13-beta isoform X2.	0.783
AKT2	BRCA1	A0A2Y9PDM4	A0A2Y9LXF5	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	0.936
AKT2	INS	A0A2Y9PDM4	A0A2Y9PTW5	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.556