STRINGSTRING
IL1R2 IL1R2 EPHA8 EPHA8 TWSG1 TWSG1 TGFBR3 TGFBR3 TGFBR2 TGFBR2 FGFRL1 FGFRL1 INSR INSR EPHA7 EPHA7 FGFR3 FGFR3 NGFR NGFR WFIKKN2 WFIKKN2 NTRK2 NTRK2 PCSK6 PCSK6 SHC1 SHC1 S100A13 S100A13 NTRK1 NTRK1 ERBB2 ERBB2 HAX1 HAX1 CHRDL1 CHRDL1 TGFBR3L TGFBR3L CEP57 CEP57 IGFBP4 IGFBP4 COL1A1 COL1A1 IGFBP7 IGFBP7 NTRK3 NTRK3 PDGFRA PDGFRA SCN5A SCN5A IL6R IL6R FURIN FURIN IGF2R IGF2R IL2RG IL2RG KLB KLB FGFBP1 FGFBP1 FGFR4 FGFR4 IGFBP5 IGFBP5 HTRA1 HTRA1 ITGAV ITGAV COL3A1 COL3A1 FGFR2 FGFR2 KDR KDR GPC1 GPC1 ACVR1 ACVR1 FGFBP3 FGFBP3 NRROS NRROS ACVR1C ACVR1C IGFBP2 IGFBP2 FLT4 FLT4 ERBB3 ERBB3 COL2A1 COL2A1 KAZALD1 KAZALD1 FGFR1 FGFR1 FLT3 FLT3 FLT1 FLT1 ACVR1B ACVR1B ITGA6 ITGA6 LOC111174455 LOC111174455 IGFBP6 IGFBP6 ACVRL1 ACVRL1 KL KL ENG ENG HYAL2 HYAL2 COL5A1 COL5A1 LTBP1 LTBP1 COL4A1 COL4A1 TGFB3 TGFB3 NRP1 NRP1 SRPX2 SRPX2 GLG1 GLG1 SORT1 SORT1 IL2RA IL2RA LTBP4 LTBP4 FSTL4 FSTL4 ITGB3 ITGB3 GHRHR GHRHR SEC61B SEC61B COL1A2 COL1A2 FIBP FIBP THBS1 THBS1 PDGFRB PDGFRB API5 API5 LTBP3 LTBP3 ITGB4 ITGB4 HMCN1 HMCN1 RHBDF2 RHBDF2 CD109 CD109 IGFALS IGFALS IGFBP1 IGFBP1 IGFBP3 IGFBP3 LRRC32 LRRC32 TSKU TSKU WFIKKN1 WFIKKN1 PDGFB PDGFB EGFR EGFR RHBDF1 RHBDF1 IL9R IL9R VASN VASN IL2RB IL2RB COL6A1 COL6A1 IL6ST IL6ST LIFR LIFR EPHA2 EPHA2 IGFBPL1 IGFBPL1 IGF1R IGF1R IL1RN IL1RN IL36RN IL36RN TGFBR1 TGFBR1 LOC111187154 LOC111187154 IL1R1 IL1R1 CXCL13 CXCL13
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IL1R2Interleukin-1 receptor type 2. (421 aa)
EPHA8Ephrin type-A receptor 8. (1005 aa)
TWSG1Twisted gastrulation protein homolog 1. (223 aa)
TGFBR3Transforming growth factor beta receptor type 3 isoform X1. (851 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (567 aa)
FGFRL1Fibroblast growth factor receptor-like 1 isoform X1. (503 aa)
INSRTyrosine-protein kinase receptor. (1392 aa)
EPHA7Ephrin type-A receptor 7 isoform X1. (998 aa)
FGFR3Fibroblast growth factor receptor. (805 aa)
NGFRTumor necrosis factor receptor superfamily member 16. (427 aa)
WFIKKN2WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 2. (574 aa)
NTRK2Tyrosine-protein kinase receptor. (822 aa)
PCSK6Proprotein convertase subtilisin/kexin type 6 isoform X1; Belongs to the peptidase S8 family. (967 aa)
SHC1SHC-transforming protein 1 isoform X1. (609 aa)
S100A13Protein S100-A13; Belongs to the S-100 family. (98 aa)
NTRK1Tyrosine-protein kinase receptor. (795 aa)
ERBB2Receptor protein-tyrosine kinase. (1255 aa)
HAX1HCLS1-associated protein X-1; Recruits the Arp2/3 complex to the cell cortex and regulates reorganization of the cortical actin cytoskeleton via its interaction with KCNC3 and the Arp2/3 complex. Slows down the rate of inactivation of KCNC3 channels. Promotes GNA13-mediated cell migration. Involved in the clathrin-mediated endocytosis pathway. May be involved in internalization of ABC transporters such as ABCB11. May inhibit CASP9 and CASP3. Promotes cell survival. May regulate intracellular calcium pools. (276 aa)
CHRDL1Chordin-like protein 1 isoform X1. (527 aa)
TGFBR3LTransforming growth factor-beta receptor type 3-like protein isoform X1. (348 aa)
CEP57Centrosomal protein of 57 kDa. (500 aa)
IGFBP4Insulin-like growth factor-binding protein 4. (258 aa)
COL1A1Collagen alpha-1(I) chain. (1463 aa)
IGFBP7Insulin-like growth factor-binding protein 7. (282 aa)
NTRK3Tyrosine-protein kinase receptor. (864 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
SCN5ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (2016 aa)
IL6RInterleukin-6 receptor subunit alpha isoform X1. (465 aa)
FURINFurin; Belongs to the peptidase S8 family. (792 aa)
IGF2RCation-independent mannose-6-phosphate receptor. (2490 aa)
IL2RGCytokine receptor common subunit gamma isoform X1. (381 aa)
KLBLOW QUALITY PROTEIN: beta-klotho. (1046 aa)
FGFBP1Fibroblast growth factor-binding protein 1. (237 aa)
FGFR4Fibroblast growth factor receptor. (801 aa)
IGFBP5Insulin-like growth factor-binding protein 5. (271 aa)
HTRA1Serine protease HTRA1. (509 aa)
ITGAVIntegrin alpha-V isoform X2; Belongs to the integrin alpha chain family. (1048 aa)
COL3A1Collagen alpha-1(III) chain. (1464 aa)
FGFR2Fibroblast growth factor receptor. (841 aa)
KDRVascular endothelial growth factor receptor 2 isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
GPC1Glypican-1 isoform X1; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (559 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
FGFBP3Fibroblast growth factor-binding protein 3. (256 aa)
NRROSNegative regulator of reactive oxygen species isoform X1. (699 aa)
ACVR1CReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (493 aa)
IGFBP2Insulin-like growth factor-binding protein 2 isoform X1. (320 aa)
FLT4Vascular endothelial growth factor receptor 3 isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1367 aa)
ERBB3Receptor tyrosine-protein kinase erbB-3. (1338 aa)
COL2A1Collagen alpha-1(II) chain. (1487 aa)
KAZALD1Kazal-type serine protease inhibitor domain-containing protein 1. (305 aa)
FGFR1Fibroblast growth factor receptor. (823 aa)
FLT3Receptor-type tyrosine-protein kinase FLT3 isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (993 aa)
FLT1Vascular endothelial growth factor receptor 1 isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1340 aa)
ACVR1BReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (546 aa)
ITGA6Integrin alpha-6 isoform X1; Belongs to the integrin alpha chain family. (1091 aa)
LOC111174455LOW QUALITY PROTEIN: death domain-containing membrane protein NRADD-like. (248 aa)
IGFBP6Insulin-like growth factor-binding protein 6. (236 aa)
ACVRL1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (515 aa)
KLKlotho. (1010 aa)
ENGEndoglin. (652 aa)
HYAL2Hyaluronidase. (476 aa)
COL5A1Collagen alpha-1(V) chain isoform X3. (1844 aa)
LTBP1Latent-transforming growth factor beta-binding protein 1 isoform X1. (1711 aa)
COL4A1Collagen alpha-1(IV) chain isoform X1. (1668 aa)
TGFB3Transforming growth factor beta-3. (456 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (924 aa)
SRPX2Sushi repeat-containing protein SRPX2. (465 aa)
GLG1Golgi apparatus protein 1. (1181 aa)
SORT1Sortilin. (864 aa)
IL2RAInterleukin-2 receptor subunit alpha. (275 aa)
LTBP4Latent-transforming growth factor beta-binding protein 4 isoform X1. (1628 aa)
FSTL4Follistatin-related protein 4 isoform X1. (704 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (789 aa)
GHRHRGrowth hormone-releasing hormone receptor isoform X1; Belongs to the G-protein coupled receptor 2 family. (427 aa)
SEC61BProtein transport protein Sec61 subunit beta; Necessary for protein translocation in the endoplasmic reticulum. (96 aa)
COL1A2Collagen alpha-2(I) chain. (1366 aa)
FIBPAcidic fibroblast growth factor intracellular-binding protein isoform X1. (364 aa)
THBS1Thrombospondin-1. (1170 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1103 aa)
API5Apoptosis inhibitor 5 isoform X1. (524 aa)
LTBP3Latent-transforming growth factor beta-binding protein 3 isoform X1. (1557 aa)
ITGB4Integrin beta. (1826 aa)
HMCN1Hemicentin-1. (5635 aa)
RHBDF2Inactive rhomboid protein 2. (828 aa)
CD109CD109 antigen isoform X1. (1440 aa)
IGFALSInsulin-like growth factor-binding protein complex acid labile subunit. (605 aa)
IGFBP1Insulin-like growth factor-binding protein 1. (263 aa)
IGFBP3Insulin-like growth factor-binding protein 3. (293 aa)
LRRC32Leucine-rich repeat-containing protein 32 isoform X1. (676 aa)
TSKUTsukushin isoform X1. (367 aa)
WFIKKN1WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 1. (549 aa)
PDGFBPlatelet-derived growth factor subunit B isoform X1; Belongs to the PDGF/VEGF growth factor family. (278 aa)
EGFRReceptor protein-tyrosine kinase. (1209 aa)
RHBDF1Inactive rhomboid protein 1 isoform X2. (879 aa)
IL9RInterleukin-9 receptor. (469 aa)
VASNVasorin. (676 aa)
IL2RBInterleukin-2 receptor subunit beta isoform X1. (595 aa)
COL6A1Collagen alpha-1(VI) chain. (1027 aa)
IL6STInterleukin-6 receptor subunit beta. (918 aa)
LIFRLeukemia inhibitory factor receptor isoform X1. (1095 aa)
EPHA2Ephrin type-A receptor 2. (975 aa)
IGFBPL1Insulin-like growth factor-binding protein-like 1. (274 aa)
IGF1RTyrosine-protein kinase receptor. (1368 aa)
IL1RNInterleukin-1. (177 aa)
IL36RNInterleukin-1. (155 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
LOC111187154Ephrin type-A receptor 2-like. (171 aa)
IL1R1Interleukin-1 receptor type 1 isoform X1. (686 aa)
CXCL13C-X-C motif chemokine 13. (109 aa)
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
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