STRINGSTRING
CD40LG CD40LG ADRA2C ADRA2C F2RL3 F2RL3 COMP COMP SLC7A11 SLC7A11 BLOC1S4 BLOC1S4 UBASH3B UBASH3B PEAR1 PEAR1 WNT3A WNT3A PDGFRA PDGFRA GATA1 GATA1 SERPINE2 SERPINE2 ADRA2A ADRA2A FN1 FN1 STXBP1 STXBP1 RAP2A RAP2A ENTPD2 ENTPD2 PTPN6 PTPN6 TREML1 TREML1 SRF SRF MERTK MERTK FGG FGG FGA FGA LOC111187580 LOC111187580 PLEK PLEK ADRA2B ADRA2B FGB FGB PPBP PPBP F2R F2R P2RX1 P2RX1 F2 F2 TSPAN32 TSPAN32 FERMT3 FERMT3 GNA13 GNA13 ITGB3 ITGB3 STXBP3 STXBP3 TYRO3 TYRO3 FZD6 FZD6 BLOC1S3 BLOC1S3 AXL AXL RAP2B RAP2B P2RY12 P2RY12 VWF VWF
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CD40LGCD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching. (261 aa)
ADRA2Calpha-2C adrenergic receptor. (458 aa)
F2RL3Proteinase-activated receptor 4; Belongs to the G-protein coupled receptor 1 family. (380 aa)
COMPCartilage oligomeric matrix protein. (756 aa)
SLC7A11Cystine/glutamate transporter isoform X1. (520 aa)
BLOC1S4Biogenesis of lysosome-related organelles complex 1 subunit 4. (217 aa)
UBASH3BUbiquitin-associated and SH3 domain-containing protein B isoform X1. (649 aa)
PEAR1Platelet endothelial aggregation receptor 1 isoform X1. (1041 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
GATA1Erythroid transcription factor isoform X1. (426 aa)
SERPINE2Glia-derived nexin isoform X2; Belongs to the serpin family. (397 aa)
ADRA2Aalpha-2A adrenergic receptor. (465 aa)
FN1Fibronectin isoform X5. (2478 aa)
STXBP1Syntaxin-binding protein 1 isoform X1; Belongs to the STXBP/unc-18/SEC1 family. (603 aa)
RAP2ARas-related protein Rap-2a. (183 aa)
ENTPD2Ectonucleoside triphosphate diphosphohydrolase 2 isoform X1; Belongs to the GDA1/CD39 NTPase family. (588 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
TREML1Trem-like transcript 1 protein isoform X1. (315 aa)
SRFSerum response factor isoform X2. (535 aa)
MERTKTyrosine-protein kinase Mer. (999 aa)
FGGFibrinogen gamma chain isoform X1. (445 aa)
FGAFibrinogen alpha chain. (852 aa)
LOC111187580C-X-C motif chemokine. (112 aa)
PLEKPleckstrin. (350 aa)
ADRA2Balpha-2B adrenergic receptor. (446 aa)
FGBFibrinogen beta chain isoform X1. (495 aa)
PPBPC-X-C motif chemokine. (119 aa)
F2RProteinase-activated receptor 1; Belongs to the G-protein coupled receptor 1 family. (427 aa)
P2RX1P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (399 aa)
F2Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. (623 aa)
TSPAN32Tetraspanin-32 isoform X1; Belongs to the tetraspanin (TM4SF) family. (571 aa)
FERMT3Fermitin family homolog 3. (663 aa)
GNA13Guanine nucleotide-binding protein subunit alpha-13. (377 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (789 aa)
STXBP3Syntaxin-binding protein 3; Belongs to the STXBP/unc-18/SEC1 family. (592 aa)
TYRO3Tyrosine-protein kinase receptor TYRO3 isoform X3. (896 aa)
FZD6Frizzled-6; Belongs to the G-protein coupled receptor Fz/Smo family. (712 aa)
BLOC1S3Biogenesis of lysosome-related organelles complex 1 subunit 3 isoform X1. (233 aa)
AXLLOW QUALITY PROTEIN: tyrosine-protein kinase receptor UFO. (887 aa)
RAP2BRas-related protein Rap-2b. (183 aa)
P2RY12P2Y purinoceptor 12. (339 aa)
VWFVon Willebrand factor. (2806 aa)
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
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