STRINGSTRING
ATP2B1 ATP2B1 KREMEN1 KREMEN1 TMEM119 TMEM119 INTU INTU COMP COMP BMP2 BMP2 PTH PTH BCOR BCOR ENPP1 ENPP1 ZBTB16 ZBTB16 BMPR1A BMPR1A TXLNG TXLNG SCUBE2 SCUBE2 DDR2 DDR2 LOC111169254 LOC111169254 BGLAP BGLAP ECM1 ECM1 GATA1 GATA1 EGR2 EGR2 SOX11 SOX11 BMPR2 BMPR2 GPM6B GPM6B ALOX5 ALOX5 OMD OMD NBR1 NBR1 SOST SOST BMP4 BMP4 SFRP1 SFRP1 HIF1A HIF1A LOC111171371 LOC111171371 PKDCC PKDCC WNT5A WNT5A ACVR2A ACVR2A AHSG AHSG WNT10B WNT10B SIX2 SIX2 LTF LTF ZMPSTE24 ZMPSTE24 ANO6 ANO6 KL KL FGF23 FGF23 MATN1 MATN1 SLC8A1 SLC8A1 ATRAID ATRAID PTN PTN TGFB2 TGFB2 MGP MGP TGFB3 TGFB3 CYR61 CYR61 RUNX2 RUNX2 ANKH ANKH NOTCH1 NOTCH1 SMAD6 SMAD6 S1PR1 S1PR1 TGFB1 TGFB1 BMP6 BMP6 BMPR1B BMPR1B BCL2 BCL2 GREM1 GREM1 OSR2 OSR2 TFAP2A TFAP2A CSF1 CSF1 FZD9 FZD9 SMAD7 SMAD7 MAPK3 MAPK3 LOC111182889 LOC111182889 FAM46A FAM46A CALCR CALCR FBN2 FBN2 SRGN SRGN ACTN3 ACTN3 LTBP3 LTBP3 MEF2C MEF2C NOTUM NOTUM ADRB2 ADRB2 TWIST1 TWIST1 GPR137 GPR137 LRP4 LRP4 RFLNB RFLNB P2RX7 P2RX7 PTK2B PTK2B TOB2 TOB2 MAPK1 MAPK1 BMP7 BMP7 LOC111186948 LOC111186948 PTPN11 PTPN11 DHRS3 DHRS3 PTGER4 PTGER4 CHSY1 CHSY1 NIPBL NIPBL BMP2K BMP2K
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ATP2B1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1258 aa)
KREMEN1Kremen protein; Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6. (459 aa)
TMEM119Transmembrane protein 119. (282 aa)
INTUProtein inturned isoform X1. (934 aa)
COMPCartilage oligomeric matrix protein. (756 aa)
BMP2Bone morphogenetic protein 2. (395 aa)
PTHParathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion; Belongs to the parathyroid hormone family. (115 aa)
BCORBCL-6 corepressor isoform X1. (1757 aa)
ENPP1Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 isoform X1. (925 aa)
ZBTB16Zinc finger and BTB domain-containing protein 16. (673 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
TXLNGGamma-taxilin. (512 aa)
SCUBE2Signal peptide, CUB and EGF-like domain-containing protein 2 isoform X1. (1100 aa)
DDR2Discoidin domain-containing receptor 2. (565 aa)
LOC111169254Discoidin domain-containing receptor 2-like. (323 aa)
BGLAPOsteocalcin; Binds strongly to apatite and calcium. (148 aa)
ECM1Extracellular matrix protein 1 isoform X1. (544 aa)
GATA1Erythroid transcription factor isoform X1. (426 aa)
EGR2E3 SUMO-protein ligase EGR2 isoform X1. (422 aa)
SOX11Transcription factor SOX. (454 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
GPM6BNeuronal membrane glycoprotein M6-b isoform X1. (324 aa)
ALOX5Arachidonate 5-lipoxygenase. (674 aa)
OMDOsteomodulin. (418 aa)
NBR1Next to BRCA1 gene 1 protein. (257 aa)
SOSTSclerostin. (212 aa)
BMP4Bone morphogenetic protein 4 isoform X2. (408 aa)
SFRP1Secreted frizzled-related protein 1. (308 aa)
HIF1AHypoxia-inducible factor 1-alpha isoform X1. (823 aa)
LOC111171371Next to BRCA1 gene 1 protein-like. (129 aa)
PKDCCExtracellular tyrosine-protein kinase PKDCC isoform X1. (498 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (458 aa)
ACVR2ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (513 aa)
AHSGalpha-2-HS-glycoprotein. (360 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
SIX2Homeobox protein SIX2. (296 aa)
LTFLactotransferrin; Belongs to the transferrin family. (710 aa)
ZMPSTE24CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (473 aa)
ANO6Anoctamin. (951 aa)
KLKlotho. (1010 aa)
FGF23Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (315 aa)
MATN1Cartilage matrix protein. (495 aa)
SLC8A1Sodium/calcium exchanger 1 isoform X7; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (1004 aa)
ATRAIDAll-trans retinoic acid-induced differentiation factor. (229 aa)
PTNPleiotrophin isoform X1. (168 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
MGPMatrix Gla protein; Associates with the organic matrix of bone and cartilage. (103 aa)
TGFB3Transforming growth factor beta-3. (456 aa)
CYR61Protein CYR61. (382 aa)
RUNX2Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (524 aa)
ANKHProgressive ankylosis protein homolog. (492 aa)
NOTCH1Neurogenic locus notch homolog protein 1 isoform X1. (2521 aa)
SMAD6Mothers against decapentaplegic homolog. (495 aa)
S1PR1Sphingosine 1-phosphate receptor 1 isoform X1; Belongs to the G-protein coupled receptor 1 family. (455 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (391 aa)
BMP6Bone morphogenetic protein 6. (496 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (540 aa)
BCL2Apoptosis regulator Bcl-2. (233 aa)
GREM1Gremlin. (184 aa)
OSR2Protein odd-skipped-related 2 isoform X1. (312 aa)
TFAP2ATranscription factor AP-2-alpha isoform X1. (439 aa)
CSF1Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] (554 aa)
FZD9Frizzled-9; Belongs to the G-protein coupled receptor Fz/Smo family. (590 aa)
SMAD7Mothers against decapentaplegic homolog. (426 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (382 aa)
LOC111182889LOW QUALITY PROTEIN: transcription factor SOX-9-like. (510 aa)
FAM46AProtein FAM46A isoform X1. (450 aa)
CALCRCalcitonin receptor isoform X1; Belongs to the G-protein coupled receptor 2 family. (524 aa)
FBN2Fibrillin-2. (2912 aa)
SRGNSerglycin. (151 aa)
ACTN3Alpha-actinin-3 isoform X1. (902 aa)
LTBP3Latent-transforming growth factor beta-binding protein 3 isoform X1. (1557 aa)
MEF2CMyocyte-specific enhancer factor 2C isoform X6. (483 aa)
NOTUMPalmitoleoyl-protein carboxylesterase NOTUM. (499 aa)
ADRB2Beta-2 adrenergic receptor isoform X1. (400 aa)
TWIST1Twist-related protein 1. (205 aa)
GPR137Integral membrane protein GPR137 isoform X1. (395 aa)
LRP4Low-density lipoprotein receptor-related protein 4. (1905 aa)
RFLNBrefilin-B. (217 aa)
P2RX7P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (595 aa)
PTK2BProtein-tyrosine kinase 2-beta isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1015 aa)
TOB2Protein Tob2. (343 aa)
MAPK1Mitogen-activated protein kinase. (380 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
LOC111186948refilin-A. (135 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (623 aa)
DHRS3Short-chain dehydrogenase/reductase 3 isoform X1. (360 aa)
PTGER4Prostaglandin E2 receptor EP4 subtype; Belongs to the G-protein coupled receptor 1 family. (486 aa)
CHSY1Hexosyltransferase. (803 aa)
NIPBLNipped-B protein. (2803 aa)
BMP2KBMP-2-inducible protein kinase isoform X1. (1124 aa)
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
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