(42 nodes) Osteoclast differentiation network (Delphinapterus leucas)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

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Your Input:
	CD81	Tetraspanin. (236 aa)
	CSF1	Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] (554 aa)
	SBNO2	Protein strawberry notch homolog 2 isoform X1. (1383 aa)
	EFNA2	ephrin-A2; Belongs to the ephrin family. (214 aa)
	FARP2	FERM, RhoGEF and pleckstrin domain-containing protein 2 isoform X1. (1116 aa)
	OCSTAMP	LOW QUALITY PROTEIN: osteoclast stimulatory transmembrane protein. (566 aa)
	TRAF6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (561 aa)
	LOC111176429	G-protein coupled receptor 183; Belongs to the G-protein coupled receptor 1 family. (360 aa)
	GPR68	Ovarian cancer G-protein coupled receptor 1; Belongs to the G-protein coupled receptor 1 family. (371 aa)
	TNFSF11	Tumor necrosis factor ligand superfamily member 11; Belongs to the tumor necrosis factor family. (322 aa)
	TCTA	T-cell leukemia translocation-altered gene protein homolog; May be required for cellular fusion during osteoclastogenesis; Belongs to the TCTA family. (106 aa)
	MITF	Microphthalmia-associated transcription factor isoform X1. (526 aa)
	ATP6AP1	V-type proton ATPase subunit S1. (469 aa)
	SFRP1	Secreted frizzled-related protein 1. (308 aa)
	TGFB1	Transforming growth factor beta; Belongs to the TGF-beta family. (391 aa)
	LOC111179199	Serotransferrin-like; Belongs to the transferrin family. (706 aa)
	TNFRSF11A	Tumor necrosis factor receptor superfamily member 11A isoform X1. (551 aa)
	TREM2	Triggering receptor expressed on myeloid cells 2. (294 aa)
	SNX10	Sorting nexin-10 isoform X1. (201 aa)
	CREB1	Cyclic AMP-responsive element-binding protein 1 isoform X1. (341 aa)
	DCSTAMP	LOW QUALITY PROTEIN: dendritic cell-specific transmembrane protein. (510 aa)
	GLO1	Lactoylglutathione lyase; Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. (184 aa)
	IREB2	Iron-responsive element-binding protein 2; Belongs to the aconitase/IPM isomerase family. (964 aa)
	FOXP1	Forkhead box protein P1 isoform X1. (673 aa)
	CSF1R	Macrophage colony-stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (961 aa)
	CALCR	Calcitonin receptor isoform X1; Belongs to the G-protein coupled receptor 2 family. (524 aa)
	LOC111165062	WNT1-inducible-signaling pathway protein 1-like. (398 aa)
	GPC3	Glypican-3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (580 aa)
	JUNB	Transcription factor jun-B. (347 aa)
	CTNNB1	Catenin beta-1. (781 aa)
	SRC	Tyrosine-protein kinase. (562 aa)
	CD109	CD109 antigen isoform X1. (1440 aa)
	TCIRG1	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (873 aa)
	GAB2	GRB2-associated-binding protein 2 isoform X1. (678 aa)
	PAFAH1B1	Platelet-activating factor acetylhydrolase IB subunit alpha; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ven [...] (410 aa)
	LRRK1	Leucine-rich repeat serine/threonine-protein kinase 1. (2015 aa)
	NF1	Neurofibromin isoform X1. (2873 aa)
	PIK3R1	Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
	EPHA2	Ephrin type-A receptor 2. (975 aa)
	TOB2	Protein Tob2. (343 aa)
	LOC111187154	Ephrin type-A receptor 2-like. (171 aa)
	TNF	Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (233 aa)

Your Current Organism:

Delphinapterus leucas

NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATP6AP1	TCIRG1	A0A2Y9MYY4	A0A2Y9PV78	V-type proton ATPase subunit S1.	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.	0.984
CALCR	CSF1	A0A2Y9PGI2	A0A2Y9PBL1	Calcitonin receptor isoform X1; Belongs to the G-protein coupled receptor 2 family.	Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...]	0.438
CALCR	DCSTAMP	A0A2Y9PGI2	A0A2Y9NZI3	Calcitonin receptor isoform X1; Belongs to the G-protein coupled receptor 2 family.	LOW QUALITY PROTEIN: dendritic cell-specific transmembrane protein.	0.575
CALCR	OCSTAMP	A0A2Y9PGI2	A0A2Y9MUA1	Calcitonin receptor isoform X1; Belongs to the G-protein coupled receptor 2 family.	LOW QUALITY PROTEIN: osteoclast stimulatory transmembrane protein.	0.501
CALCR	TRAF6	A0A2Y9PGI2	A0A2Y9PAB2	Calcitonin receptor isoform X1; Belongs to the G-protein coupled receptor 2 family.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.501
CD109	DCSTAMP	A0A2Y9PT01	A0A2Y9NZI3	CD109 antigen isoform X1.	LOW QUALITY PROTEIN: dendritic cell-specific transmembrane protein.	0.438
CD109	OCSTAMP	A0A2Y9PT01	A0A2Y9MUA1	CD109 antigen isoform X1.	LOW QUALITY PROTEIN: osteoclast stimulatory transmembrane protein.	0.507
CD109	TGFB1	A0A2Y9PT01	A0A2Y9P5D5	CD109 antigen isoform X1.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.454
CD81	TNF	A0A2Y9PIM8	Q8WNR1	Tetraspanin.	Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...]	0.458
CREB1	CTNNB1	A0A2Y9MW12	A0A2Y9MAY9	Cyclic AMP-responsive element-binding protein 1 isoform X1.	Catenin beta-1.	0.658
CREB1	MITF	A0A2Y9MW12	A0A2Y9N0U2	Cyclic AMP-responsive element-binding protein 1 isoform X1.	Microphthalmia-associated transcription factor isoform X1.	0.573
CREB1	SRC	A0A2Y9MW12	A0A2Y9PSD7	Cyclic AMP-responsive element-binding protein 1 isoform X1.	Tyrosine-protein kinase.	0.571
CREB1	TNF	A0A2Y9MW12	Q8WNR1	Cyclic AMP-responsive element-binding protein 1 isoform X1.	Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...]	0.531
CSF1	CALCR	A0A2Y9PBL1	A0A2Y9PGI2	Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...]	Calcitonin receptor isoform X1; Belongs to the G-protein coupled receptor 2 family.	0.438
CSF1	CSF1R	A0A2Y9PBL1	A0A2Y9PSB0	Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...]	Macrophage colony-stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.999
CSF1	DCSTAMP	A0A2Y9PBL1	A0A2Y9NZI3	Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...]	LOW QUALITY PROTEIN: dendritic cell-specific transmembrane protein.	0.507
CSF1	EPHA2	A0A2Y9PBL1	A0A2Y9Q9I4	Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...]	Ephrin type-A receptor 2.	0.681
CSF1	SRC	A0A2Y9PBL1	A0A2Y9PSD7	Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...]	Tyrosine-protein kinase.	0.655
CSF1	TGFB1	A0A2Y9PBL1	A0A2Y9P5D5	Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...]	Transforming growth factor beta; Belongs to the TGF-beta family.	0.631
CSF1	TNF	A0A2Y9PBL1	Q8WNR1	Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...]	Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...]	0.645