STRINGSTRING
DCAF6 DCAF6 USP22 USP22 NCOA1 NCOA1 TMF1 TMF1 MED17 MED17 PSMC3IP PSMC3IP MED1 MED1 PKN1 PKN1 ELK1 ELK1 NCOA7 NCOA7 ETS1 ETS1 KDM1A KDM1A ACTN2 ACTN2 CNOT6 CNOT6 ACTN1 ACTN1 CALCOCO1 CALCOCO1 TACC1 TACC1 PPARGC1A PPARGC1A PPRC1 PPRC1 CCDC62 CCDC62 NCOA2 NCOA2 RBM14 RBM14 CCAR1 CCAR1 ZMIZ1 ZMIZ1 NCOA6 NCOA6 ZMIZ2 ZMIZ2 SRA1 SRA1 SS18 SS18 PRKCB PRKCB PPARGC1B PPARGC1B LOC111182488 LOC111182488 LOC111182487 LOC111182487 BUD31 BUD31 ACTN4 ACTN4 LOC111180037 LOC111180037 ENY2 ENY2 LOC111176288 LOC111176288 SFR1 SFR1 CNOT9 CNOT9 TADA3 TADA3 SLC30A9 SLC30A9 ATXN7L3 ATXN7L3 NCOA3 NCOA3 CCAR2 CCAR2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
DCAF6DDB1- and CUL4-associated factor 6 isoform X6. (939 aa)
USP22Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (514 aa)
NCOA1Nuclear receptor coactivator. (1441 aa)
TMF1TATA element modulatory factor isoform X1. (1093 aa)
MED17Mediator of RNA polymerase II transcription subunit 17; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (651 aa)
PSMC3IPHomologous-pairing protein 2 homolog. (217 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1579 aa)
PKN1Serine/threonine-protein kinase N1 isoform X1. (950 aa)
ELK1LOW QUALITY PROTEIN: ETS domain-containing protein Elk-1. (442 aa)
NCOA7Nuclear receptor coactivator 7 isoform X1. (943 aa)
ETS1Protein C-ets-1 isoform X1. (486 aa)
KDM1ALysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (876 aa)
ACTN2Alpha-actinin-2. (894 aa)
CNOT6CCR4-NOT transcription complex subunit 6 isoform X1. (557 aa)
ACTN1Alpha-actinin-1 isoform X2. (914 aa)
CALCOCO1Calcium-binding and coiled-coil domain-containing protein 1. (692 aa)
TACC1Transforming acidic coiled-coil-containing protein 1 isoform X1. (798 aa)
PPARGC1APeroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X1. (803 aa)
PPRC1Peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X1. (1673 aa)
CCDC62Coiled-coil domain-containing protein 62. (679 aa)
NCOA2Nuclear receptor coactivator. (1464 aa)
RBM14RNA-binding protein 14 isoform X1. (669 aa)
CCAR1Cell division cycle and apoptosis regulator protein 1. (1150 aa)
ZMIZ1Zinc finger MIZ domain-containing protein 1 isoform X1. (1071 aa)
NCOA6Nuclear receptor coactivator 6 isoform X1. (2037 aa)
ZMIZ2Zinc finger MIZ domain-containing protein 2 isoform X1. (933 aa)
SRA1Steroid receptor RNA activator 1. (225 aa)
SS18Protein SSXT isoform X1. (418 aa)
PRKCBProtein kinase C. (689 aa)
PPARGC1BPeroxisome proliferator-activated receptor gamma coactivator 1-beta isoform X1. (1173 aa)
LOC111182488Bromodomain-containing protein 8-like. (364 aa)
LOC111182487Bromodomain-containing protein 8 isoform X1. (951 aa)
BUD31Protein BUD31 homolog isoform X2. (144 aa)
ACTN4Alpha-actinin-4 isoform X5. (933 aa)
LOC111180037Methylosome protein 50-like. (290 aa)
ENY2Transcription and mRNA export factor ENY2; Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. The transcription regulatory histone acetylation (HAT) complex SAGA is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates to a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for trans [...] (101 aa)
LOC111176288Transcription and mRNA export factor ENY2; Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. The transcription regulatory histone acetylation (HAT) complex SAGA is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates to a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for trans [...] (119 aa)
SFR1Swi5-dependent recombination DNA repair protein 1 homolog isoform X1. (243 aa)
CNOT9CCR4-NOT transcription complex subunit 9. (299 aa)
TADA3Transcriptional adapter 3 isoform X1. (444 aa)
SLC30A9Zinc transporter 9 isoform X1. (566 aa)
ATXN7L3Ataxin-7-like protein 3; Component of the transcription regulatory histone acetylation (HAT) complex SAGA, a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation. Within the complex, it is required to recruit USP22 and EN [...] (373 aa)
NCOA3Nuclear receptor coactivator. (1406 aa)
CCAR2Cell cycle and apoptosis regulator protein 2 isoform X1. (947 aa)
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.