(16 nodes) Male genitalia development network (Delphinapterus leucas)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CTNNB1	Catenin beta-1. (781 aa)
	TBX3	T-box transcription factor TBX3 isoform X1. (745 aa)
	FGF10	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
	KLHL10	LOW QUALITY PROTEIN: kelch-like protein 10. (614 aa)
	AR	Androgen receptor. (893 aa)
	HSD17B3	Testosterone 17-beta-dehydrogenase 3; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (310 aa)
	PDGFRA	Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
	ASB1	Ankyrin repeat and SOCS box protein 1 isoform X1. (404 aa)
	HOXD13	Homeobox protein Hox-D13. (341 aa)
	SRD5A2	3-oxo-5-alpha-steroid 4-dehydrogenase (NADP(+)). (254 aa)
	FGF8	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
	DHCR24	Delta(24)-sterol reductase. (516 aa)
	SHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (461 aa)
	BMP6	Bone morphogenetic protein 6. (496 aa)
	LGR4	Leucine-rich repeat-containing G-protein coupled receptor 4 isoform X1. (951 aa)
	HOXA13	Homeobox protein Hox-A13. (387 aa)

Your Current Organism:

Delphinapterus leucas

NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AR	CTNNB1	A0A2Y9M4V8	A0A2Y9MAY9	Androgen receptor.	Catenin beta-1.	0.865
AR	SRD5A2	A0A2Y9M4V8	A0A2Y9N4D4	Androgen receptor.	3-oxo-5-alpha-steroid 4-dehydrogenase (NADP(+)).	0.503
BMP6	PDGFRA	A0A2Y9P5G7	A0A2Y9MC65	Bone morphogenetic protein 6.	Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development.	0.640
CTNNB1	AR	A0A2Y9MAY9	A0A2Y9M4V8	Catenin beta-1.	Androgen receptor.	0.865
CTNNB1	FGF10	A0A2Y9MAY9	A0A2Y9LQ50	Catenin beta-1.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.542
CTNNB1	FGF8	A0A2Y9MAY9	A0A2Y9N7L2	Catenin beta-1.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.510
CTNNB1	LGR4	A0A2Y9MAY9	A0A2Y9PAM0	Catenin beta-1.	Leucine-rich repeat-containing G-protein coupled receptor 4 isoform X1.	0.484
CTNNB1	PDGFRA	A0A2Y9MAY9	A0A2Y9MC65	Catenin beta-1.	Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development.	0.496
CTNNB1	SHH	A0A2Y9MAY9	A0A2Y9NDZ2	Catenin beta-1.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.612
FGF10	CTNNB1	A0A2Y9LQ50	A0A2Y9MAY9	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Catenin beta-1.	0.542
FGF10	FGF8	A0A2Y9LQ50	A0A2Y9N7L2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.539
FGF10	PDGFRA	A0A2Y9LQ50	A0A2Y9MC65	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development.	0.873
FGF10	SHH	A0A2Y9LQ50	A0A2Y9NDZ2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.771
FGF8	CTNNB1	A0A2Y9N7L2	A0A2Y9MAY9	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Catenin beta-1.	0.510
FGF8	FGF10	A0A2Y9N7L2	A0A2Y9LQ50	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.539
FGF8	HOXD13	A0A2Y9N7L2	A0A2Y9MVJ6	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Homeobox protein Hox-D13.	0.466
FGF8	PDGFRA	A0A2Y9N7L2	A0A2Y9MC65	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development.	0.875
FGF8	SHH	A0A2Y9N7L2	A0A2Y9NDZ2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.850
HOXD13	FGF8	A0A2Y9MVJ6	A0A2Y9N7L2	Homeobox protein Hox-D13.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.466
HOXD13	SHH	A0A2Y9MVJ6	A0A2Y9NDZ2	Homeobox protein Hox-D13.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.438