(29 nodes) Prostate gland development network (Delphinapterus leucas)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	RARG	Retinoic acid receptor gamma isoform X1. (458 aa)
	NOG	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
	FGF10	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
	PLAG1	Zinc finger protein PLAG1 isoform X1. (499 aa)
	HOXB13	Homeobox protein Hox-B13. (285 aa)
	ESR1	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (595 aa)
	AR	Androgen receptor. (893 aa)
	CTNNB1	Catenin beta-1. (781 aa)
	EAF2	ELL-associated factor 2. (264 aa)
	BMP4	Bone morphogenetic protein 4 isoform X2. (408 aa)
	HOXD13	Homeobox protein Hox-D13. (341 aa)
	STK11	Serine/threonine-protein kinase STK11 isoform X1. (544 aa)
	SFRP1	Secreted frizzled-related protein 1. (308 aa)
	FRS2	Fibroblast growth factor receptor substrate 2. (508 aa)
	ANXA1	Annexin. (346 aa)
	FOXA1	Hepatocyte nuclear factor 3-alpha. (466 aa)
	TP63	Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
	SHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (461 aa)
	CDKN1B	Cyclin-dependent kinase inhibitor 1B. (198 aa)
	NOTCH1	Neurogenic locus notch homolog protein 1 isoform X1. (2521 aa)
	TNC	Tenascin isoform X1. (2201 aa)
	FEM1B	Protein fem-1 homolog B. (627 aa)
	LOC111180037	Methylosome protein 50-like. (290 aa)
	SERPINB5	Serpin B5; Belongs to the serpin family. (375 aa)
	LOC111182889	LOW QUALITY PROTEIN: transcription factor SOX-9-like. (510 aa)
	HOXA13	Homeobox protein Hox-A13. (387 aa)
	SERPINF1	Pigment epithelium-derived factor isoform X1; Belongs to the serpin family. (416 aa)
	NKX3-1	Homeobox protein Nkx-3.1. (241 aa)
	UBE3A	Ubiquitin-protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. (875 aa)

Your Current Organism:

Delphinapterus leucas

NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AR	CTNNB1	A0A2Y9M4V8	A0A2Y9MAY9	Androgen receptor.	Catenin beta-1.	0.865
AR	ESR1	A0A2Y9M4V8	A0A2Y9M1Z4	Androgen receptor.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	0.570
AR	FOXA1	A0A2Y9M4V8	A0A2Y9N4R7	Androgen receptor.	Hepatocyte nuclear factor 3-alpha.	0.802
AR	HOXB13	A0A2Y9M4V8	A0A2Y9LYD5	Androgen receptor.	Homeobox protein Hox-B13.	0.445
AR	NKX3-1	A0A2Y9M4V8	A0A2Y9Q538	Androgen receptor.	Homeobox protein Nkx-3.1.	0.554
BMP4	CTNNB1	A0A2Y9MV04	A0A2Y9MAY9	Bone morphogenetic protein 4 isoform X2.	Catenin beta-1.	0.619
BMP4	FGF10	A0A2Y9MV04	A0A2Y9LQ50	Bone morphogenetic protein 4 isoform X2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.765
BMP4	LOC111182889	A0A2Y9MV04	A0A2Y9PEX3	Bone morphogenetic protein 4 isoform X2.	LOW QUALITY PROTEIN: transcription factor SOX-9-like.	0.602
BMP4	NOG	A0A2Y9MV04	A0A2Y9LFG3	Bone morphogenetic protein 4 isoform X2.	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite.	0.995
BMP4	SHH	A0A2Y9MV04	A0A2Y9NDZ2	Bone morphogenetic protein 4 isoform X2.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.683
CDKN1B	NOG	A0A2Y9NV03	A0A2Y9LFG3	Cyclin-dependent kinase inhibitor 1B.	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite.	0.839
CDKN1B	PLAG1	A0A2Y9NV03	A0A2Y9LUW5	Cyclin-dependent kinase inhibitor 1B.	Zinc finger protein PLAG1 isoform X1.	0.841
CDKN1B	SHH	A0A2Y9NV03	A0A2Y9NDZ2	Cyclin-dependent kinase inhibitor 1B.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.662
CDKN1B	TP63	A0A2Y9NV03	A0A2Y9N7Z3	Cyclin-dependent kinase inhibitor 1B.	Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes.	0.401
CTNNB1	AR	A0A2Y9MAY9	A0A2Y9M4V8	Catenin beta-1.	Androgen receptor.	0.865
CTNNB1	BMP4	A0A2Y9MAY9	A0A2Y9MV04	Catenin beta-1.	Bone morphogenetic protein 4 isoform X2.	0.619
CTNNB1	ESR1	A0A2Y9MAY9	A0A2Y9M1Z4	Catenin beta-1.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	0.636
CTNNB1	FGF10	A0A2Y9MAY9	A0A2Y9LQ50	Catenin beta-1.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.542
CTNNB1	LOC111182889	A0A2Y9MAY9	A0A2Y9PEX3	Catenin beta-1.	LOW QUALITY PROTEIN: transcription factor SOX-9-like.	0.861
CTNNB1	NOG	A0A2Y9MAY9	A0A2Y9LFG3	Catenin beta-1.	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite.	0.515