21 items (Delphinapterus leucas) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	HOXA5	Homeobox protein Hox-A5. (381 aa)
	MAPK3	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (382 aa)
	EDN1	Endothelin-1. (202 aa)
	NKX2-5	Homeobox protein Nkx-2.5. (323 aa)
	EDNRA	Endothelin-1 receptor isoform X1; Belongs to the G-protein coupled receptor 1 family. (427 aa)
	PAX8	Paired box protein Pax-8. (457 aa)
	FOXE1	Forkhead box protein E1. (373 aa)
	FGF10	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
	MAPK1	Mitogen-activated protein kinase. (380 aa)
	HOXB3	LOW QUALITY PROTEIN: homeobox protein Hox-B3. (421 aa)
	RAF1	RAF proto-oncogene serine/threonine-protein kinase isoform X1. (648 aa)
	SIX1	Homeobox protein SIX1. (284 aa)
	FGF8	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
	HOXD3	Homeobox protein Hox-D3. (432 aa)
	NKX2-1	Homeobox protein Nkx-2.1 isoform X1. (396 aa)
	SHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (461 aa)
	BRAF	Serine/threonine-protein kinase B-raf isoform X1. (762 aa)
	SRF	Serum response factor isoform X2. (535 aa)
	SMAD3	Mothers against decapentaplegic homolog. (425 aa)
	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
	HOXA3	Homeobox protein Hox-A3. (443 aa)

Your Current Organism:

Delphinapterus leucas

NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BRAF	MAP2K1	A0A2Y9NQW5	A0A2Y9P0A4	Serine/threonine-protein kinase B-raf isoform X1.	Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily.	0.987
BRAF	MAPK1	A0A2Y9NQW5	A0A2Y9LEH4	Serine/threonine-protein kinase B-raf isoform X1.	Mitogen-activated protein kinase.	0.827
BRAF	MAPK3	A0A2Y9NQW5	A0A2Y9PDR5	Serine/threonine-protein kinase B-raf isoform X1.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.826
BRAF	PAX8	A0A2Y9NQW5	A0A2Y9QHE6	Serine/threonine-protein kinase B-raf isoform X1.	Paired box protein Pax-8.	0.437
BRAF	RAF1	A0A2Y9NQW5	A0A2Y9MMZ0	Serine/threonine-protein kinase B-raf isoform X1.	RAF proto-oncogene serine/threonine-protein kinase isoform X1.	0.992
EDN1	EDNRA	A0A2Y9PHR8	A0A2Y9QCT9	Endothelin-1.	Endothelin-1 receptor isoform X1; Belongs to the G-protein coupled receptor 1 family.	0.999
EDNRA	EDN1	A0A2Y9QCT9	A0A2Y9PHR8	Endothelin-1 receptor isoform X1; Belongs to the G-protein coupled receptor 1 family.	Endothelin-1.	0.999
FGF10	FGF8	A0A2Y9LQ50	A0A2Y9N7L2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.539
FGF10	NKX2-1	A0A2Y9LQ50	A0A2Y9NB78	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Homeobox protein Nkx-2.1 isoform X1.	0.491
FGF10	SHH	A0A2Y9LQ50	A0A2Y9NDZ2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.771
FGF8	FGF10	A0A2Y9N7L2	A0A2Y9LQ50	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.539
FGF8	SHH	A0A2Y9N7L2	A0A2Y9NDZ2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.850
FOXE1	NKX2-1	A0A2Y9QK70	A0A2Y9NB78	Forkhead box protein E1.	Homeobox protein Nkx-2.1 isoform X1.	0.628
FOXE1	PAX8	A0A2Y9QK70	A0A2Y9QHE6	Forkhead box protein E1.	Paired box protein Pax-8.	0.628
HOXA3	HOXA5	A0A2Y9PAD0	A0A2Y9P4W7	Homeobox protein Hox-A3.	Homeobox protein Hox-A5.	0.717
HOXA5	HOXA3	A0A2Y9P4W7	A0A2Y9PAD0	Homeobox protein Hox-A5.	Homeobox protein Hox-A3.	0.717
MAP2K1	BRAF	A0A2Y9P0A4	A0A2Y9NQW5	Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily.	Serine/threonine-protein kinase B-raf isoform X1.	0.987
MAP2K1	MAPK1	A0A2Y9P0A4	A0A2Y9LEH4	Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily.	Mitogen-activated protein kinase.	0.994
MAP2K1	MAPK3	A0A2Y9P0A4	A0A2Y9PDR5	Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.995
MAP2K1	RAF1	A0A2Y9P0A4	A0A2Y9MMZ0	Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily.	RAF proto-oncogene serine/threonine-protein kinase isoform X1.	0.971