(88 nodes) Mammary gland development network (Delphinapterus leucas)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CCND1	G1/S-specific cyclin-D1; Belongs to the cyclin family. (295 aa)
	TBX3	T-box transcription factor TBX3 isoform X1. (745 aa)
	MAPK1	Mitogen-activated protein kinase. (380 aa)
	SOCS2	Suppressor of cytokine signaling 2. (198 aa)
	ID2	DNA-binding protein inhibitor ID-2. (134 aa)
	TBX2	T-box transcription factor TBX2. (713 aa)
	TPH1	Tryptophan 5-hydroxylase 1. (455 aa)
	FGF10	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
	STAT5A	Signal transducer and activator of transcription. (818 aa)
	LOC111166483	Signal transducer and activator of transcription. (787 aa)
	HOXB9	Homeobox protein; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Belongs to the Abd-B homeobox family. (250 aa)
	MED1	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1579 aa)
	LATS1	Serine/threonine-protein kinase LATS1. (1128 aa)
	PTCH1	Protein patched homolog 1 isoform X1. (1447 aa)
	PYGO2	LOW QUALITY PROTEIN: pygopus homolog 2. (406 aa)
	ESR1	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (595 aa)
	TGFA	Protransforming growth factor alpha isoform X1. (176 aa)
	AR	Androgen receptor. (893 aa)
	CSN3	Kappa-casein; Kappa-casein stabilizes micelle formation, preventing casein precipitation in milk; Belongs to the kappa-casein family. (187 aa)
	KDM5B	Lysine-specific demethylase 5B. (1539 aa)
	ZBTB7B	Zinc finger and BTB domain-containing protein 7B. (541 aa)
	LOC111166328	Nucleoside diphosphate kinase. (152 aa)
	CSN2	Beta-casein; Important role in determination of the surface properties of the casein micelles; Belongs to the beta-casein family. (239 aa)
	WNT3A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
	BSX	Brain-specific homeobox protein homolog. (232 aa)
	DDR1	Tyrosine-protein kinase receptor. (917 aa)
	NOTCH4	Neurogenic locus notch homolog protein 4 isoform X1. (1993 aa)
	ELF3	ETS-related transcription factor Elf-3. (372 aa)
	MSX1	Homeobox protein MSX-1. (303 aa)
	LEF1	Lymphoid enhancer-binding factor 1 isoform X1. (414 aa)
	NEURL1	E3 ubiquitin-protein ligase NEURL1 isoform X1. (574 aa)
	ERBB4	Receptor protein-tyrosine kinase. (1308 aa)
	BTRC	F-box/WD repeat-containing protein 1A isoform X1. (607 aa)
	BMP4	Bone morphogenetic protein 4 isoform X2. (408 aa)
	HOXD9	Homeobox protein Hox-D9. (343 aa)
	CREB1	Cyclic AMP-responsive element-binding protein 1 isoform X1. (341 aa)
	CSMD1	CUB and sushi domain-containing protein 1. (3564 aa)
	ZNF703	Zinc finger protein 703. (585 aa)
	HIF1A	Hypoxia-inducible factor 1-alpha isoform X1. (823 aa)
	STAT6	Signal transducer and activator of transcription. (847 aa)
	GPAT4	Glycerol-3-phosphate acyltransferase 4. (456 aa)
	MST1	Hepatocyte growth factor-like protein isoform X1; Belongs to the peptidase S1 family. Plasminogen subfamily. (725 aa)
	VDR	Vitamin D3 receptor isoform X1. (503 aa)
	WNT5A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (458 aa)
	TNFSF11	Tumor necrosis factor ligand superfamily member 11; Belongs to the tumor necrosis factor family. (322 aa)
	CSMD2	CUB and sushi domain-containing protein 2. (3609 aa)
	IRS2	Insulin receptor substrate 2. (1347 aa)
	AGAP2	arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 isoform X1. (1192 aa)
	PHB2	Prohibitin. (299 aa)
	SMO	Smoothened homolog; Belongs to the G-protein coupled receptor Fz/Smo family. (782 aa)
	LOC111178657	Leucine-rich repeat-containing protein 1-like isoform X1. (174 aa)
	PML	Protein PML isoform X1. (861 aa)
	LRRC1	Leucine-rich repeat-containing protein 1. (395 aa)
	ATP2C2	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (955 aa)
	FOXB1	Forkhead box protein B1. (325 aa)
	SLC6A3	Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (617 aa)
	FOXF1	Forkhead box protein F1. (375 aa)
	CAV1	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
	RXFP1	Relaxin receptor 1 isoform X1. (785 aa)
	TNFRSF11A	Tumor necrosis factor receptor superfamily member 11A isoform X1. (551 aa)
	NFKB1	Nuclear factor NF-kappa-B p105 subunit isoform X1. (972 aa)
	WNT2	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
	HOXA9	Homeobox protein; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Belongs to the Abd-B homeobox family. (272 aa)
	HOXA5	Homeobox protein Hox-A5. (381 aa)
	TGFB1	Transforming growth factor beta; Belongs to the TGF-beta family. (391 aa)
	ARHGAP35	Rho GTPase-activating protein 35. (1500 aa)
	CSF1	Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] (554 aa)
	FASN	Fatty acid synthase isoform X1. (2680 aa)
	LOC111182889	LOW QUALITY PROTEIN: transcription factor SOX-9-like. (510 aa)
	GHRHR	Growth hormone-releasing hormone receptor isoform X1; Belongs to the G-protein coupled receptor 2 family. (427 aa)
	WNT3	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (453 aa)
	USF2	Upstream stimulatory factor 2. (347 aa)
	PRL	Prolactin isoform X1. (230 aa)
	SOSTDC1	Sclerostin domain-containing protein 1. (206 aa)
	SRC	Tyrosine-protein kinase. (562 aa)
	NRG3	Pro-neuregulin-3, membrane-bound isoform isoform X2. (725 aa)
	LRP5	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1622 aa)
	LOC111184719	Interferon regulatory factor 6 isoform X1. (467 aa)
	GLI3	Transcriptional activator GLI3 isoform X1. (1587 aa)
	LOC111184716	Interferon regulatory factor 6 isoform X2. (485 aa)
	LOC111185794	C-C motif chemokine. (97 aa)
	NTN1	Netrin-1. (604 aa)
	CEBPB	CCAAT/enhancer-binding protein. (345 aa)
	BCL2L11	Bcl-2-like protein 11 isoform X1. (288 aa)
	ORAI1	Calcium release-activated calcium channel protein 1. (410 aa)
	AREG	Amphiregulin isoform X1. (254 aa)
	EPHA2	Ephrin type-A receptor 2. (975 aa)
	LOC111187154	Ephrin type-A receptor 2-like. (171 aa)

Your Current Organism:

Delphinapterus leucas

NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AGAP2	NEURL1	A0A2Y9NDS3	A0A2Y9MQF6	arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 isoform X1.	E3 ubiquitin-protein ligase NEURL1 isoform X1.	0.614
AR	CCND1	A0A2Y9M4V8	A0A2Y9PNM2	Androgen receptor.	G1/S-specific cyclin-D1; Belongs to the cyclin family.	0.726
AR	ESR1	A0A2Y9M4V8	A0A2Y9M1Z4	Androgen receptor.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	0.570
AR	HIF1A	A0A2Y9M4V8	A0A2Y9MZ41	Androgen receptor.	Hypoxia-inducible factor 1-alpha isoform X1.	0.528
AR	MED1	A0A2Y9M4V8	A0A2Y9LY66	Androgen receptor.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.595
AR	SRC	A0A2Y9M4V8	A0A2Y9PSD7	Androgen receptor.	Tyrosine-protein kinase.	0.644
AR	STAT6	A0A2Y9M4V8	A0A2Y9N001	Androgen receptor.	Signal transducer and activator of transcription.	0.403
AREG	EPHA2	A0A2Y9Q7W5	A0A2Y9Q9I4	Amphiregulin isoform X1.	Ephrin type-A receptor 2.	0.677
AREG	ERBB4	A0A2Y9Q7W5	A0A2Y9MQV3	Amphiregulin isoform X1.	Receptor protein-tyrosine kinase.	0.914
AREG	ESR1	A0A2Y9Q7W5	A0A2Y9M1Z4	Amphiregulin isoform X1.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	0.440
AREG	SRC	A0A2Y9Q7W5	A0A2Y9PSD7	Amphiregulin isoform X1.	Tyrosine-protein kinase.	0.660
AREG	TGFA	A0A2Y9Q7W5	A0A2Y9M4R3	Amphiregulin isoform X1.	Protransforming growth factor alpha isoform X1.	0.764
ARHGAP35	SRC	A0A2Y9P6Y8	A0A2Y9PSD7	Rho GTPase-activating protein 35.	Tyrosine-protein kinase.	0.933
BCL2L11	BTRC	A0A2Y9Q748	A0A2Y9MUS6	Bcl-2-like protein 11 isoform X1.	F-box/WD repeat-containing protein 1A isoform X1.	0.494
BCL2L11	MAPK1	A0A2Y9Q748	A0A2Y9LEH4	Bcl-2-like protein 11 isoform X1.	Mitogen-activated protein kinase.	0.915
BMP4	FGF10	A0A2Y9MV04	A0A2Y9LQ50	Bone morphogenetic protein 4 isoform X2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.765
BMP4	FOXF1	A0A2Y9MV04	A0A2Y9NXD1	Bone morphogenetic protein 4 isoform X2.	Forkhead box protein F1.	0.488
BMP4	ID2	A0A2Y9MV04	A0A2Y9LJP9	Bone morphogenetic protein 4 isoform X2.	DNA-binding protein inhibitor ID-2.	0.497
BMP4	LEF1	A0A2Y9MV04	A0A2Y9MLC4	Bone morphogenetic protein 4 isoform X2.	Lymphoid enhancer-binding factor 1 isoform X1.	0.605
BMP4	LOC111182889	A0A2Y9MV04	A0A2Y9PEX3	Bone morphogenetic protein 4 isoform X2.	LOW QUALITY PROTEIN: transcription factor SOX-9-like.	0.602